Clinical trials: Hypotension
Anesthesia, Hemodynamic Instability
Anesthesia Induction with the Target-controlled Infusion of Propofol in High-risk Patients
The purpose of this study is to compare the risk of hypotension following induction of anesthesia in high-risk patients (American Society of Anesthesiologists risk scores III and IV) using target-controlled infusion (TCI) of…
- Trial name
- NCT06535230
- Testing
- Manual anesthesia induction, Anesthesia induction with Target controlled infusions (TCI), Hemodynamic monitoring with pressure recording analytical method (PRAM)
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Acibadem University
Intraoperative Hypotension
Advanced Cardiovascular Management in Major Non-cardiac Surgery.
This is a single center, randomised and controlled clinical triaI whose aim is to predict and treat in advance, intraoperative hypotension episodes.
- Trial name
- NCT07134530
- Testing
- HPI-driven intraoperative hemodynamic management strategy, GDT strategy
- Where
- Italy
- Volunteers
- 534 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Vital Sign Monitoring, Post Operative Complications
Continuous Vital Sign Monitoring Versus Routine Spot-checks in Patients After Non-cardiac Surgery
The "COME ON, NOW!" trial is a randomized, single-center trial in patients recovering from non-cardiac surgery on normal wards investigating whether continuous vital sign monitoring - compared to routine spot-checks by nurses …
- Conditions
- Vital Sign Monitoring, Post Operative Complications, Non-cardiac Surgery, RCT
- Trial name
- COME ON NOW (NCT07385092)
- Testing
- Unblinded continuous vital sign monitoring, Blinded continuous vital sign monitoring
- Where
- Germany
- Volunteers
- 264 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Circulatory Shock, Hemodynamic Instability
Peripheral pULSe Assessment and Arterial pRessure (PULSAR)
This prospective multicenter observational study aims to investigate the relationship between palpable peripheral pulses and simultaneously measured arterial blood pressure in adult patients with circulatory shock or impending…
- Conditions
- Circulatory Shock, Hemodynamic Instability, Hypotension, Shock
- Trial name
- PULSAR (NCT07609095)
- Testing
- Peripheral Pulse Palpation
- Where
- Sweden
- Volunteers
- 5,000 people
- Sponsor
- Region Stockholm
Hypotension, Cirrhosis
Comparison of the Concentration of Estrogen and Testosterone Ratio in Male Patients With Cirrhosis and Hypotension
Cirrhosis is an end stage in liver disease leading to replacement of normal liver tissue with regenerative nodules surrounded by fibrous bands in response to chronic liver injury.
- Trial name
- NCT05051293
- Testing
- serum concentration of estrogen (E1 and E2) and testosterone ratio measurement
- Sponsor
- Methodist Health System
Spinal Cord Injury
Cardiovascular Autonomic Function After Resistance Training
The purpose of this clinical trial is to evaluate whether an 8-week upper-limb resistance training program improves cardiovascular autonomic function in adults with chronic spinal cord injury (SCI).
- Trial name
- NCT07725952
- Testing
- Upper-Limb Resistance Training
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- Pusan National University Yangsan Hospital
Hypotension
Changes in Cerebral Oxygenation During Deliberate Hypotensive Anesthesia
This is a study using cerebral oximetry to evaluate the safety of traditionally adopted hypotensive anesthesia.
- Trial name
- NCT00207987
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- China Medical University Hospital
Blood Pressure, Intraoperative Hypotension
Perioperative Personalized Blood Pressure Management: IMPROVE-multi
Rates of major complications and mortality in the first weeks after surgery remain very high: postoperative mortality is still around 2% in central Europe and the United States.
- Conditions
- Blood Pressure, Intraoperative Hypotension, Postoperative Complications, Surgery
- Trial name
- IMPROVE (NCT05416944)
- Testing
- Personalized blood pressure management
- Where
- Germany
- Volunteers
- 1,272 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Adverse Effect
Phenylephrine Prophylaxis for Postspinal Anesthesia Hypotension in Parturients With Preeclampsia
The purpose of this study is to investigate the suitable infusion dose of phenylephrine for prophylaxis against postspinal anesthesia hypotension in parturients with preeclampsia undergoing cesarean section.
- Trial name
- NCT04576663
- Testing
- Normal saline, Phenylephrine
- Volunteers
- 95 people
- Sponsor
- General Hospital of Ningxia Medical University
Anesthesia, General, Hypotension
Can Continuous Cardiac Output Monitoring Before General Anesthesia Predict Hypotension After Induction?
Post-induction hypotension (PIH) is very common with high incidence about 9-60%. There are multiple factors that may cause PIH, like pre-operative fasting, bowel preparation, vasodilatation due to anesthetics, and reduced…
- Conditions
- Anesthesia, General, Hypotension, Cardiac Output
- Trial name
- NCT03718949
- Where
- Taiwan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Post-induction Hypotension
Management of Post-Induction Hypotension in Emergency Abdominal Surgery
The goal of this clinical trial is to compare the efficacy of two vasopressors (norepinephrine vs. ephedrine) in treating hypotension in adult patients (aged 18+, ASA I-III) undergoing general anesthesia for abdominal surgical…
- Trial name
- NCT07259655
- Testing
- Ephedrine (6 mg boluses), Norepinephrine (10 µg boluses)
- Where
- Tunisia
- Volunteers
- 100 people
- Sponsor
- Hopital Charles Nicolle
Hypotension
NOX-100 for Preventing Hypotension During Hemodialysis
This study is designed to evaluate the safety, tolerability and efficacy profile of NOX-100 to reduce intradialytic hypotension (IDH) in patients undergoing chronic hemodialysis (HD).
- Trial name
- NCT01672008
- Testing
- NOX-100
- Where
- 6 sites in Taiwan
- Volunteers
- 62 people
- Sponsor
- Medinox, Inc.
Hemodynamic Instability, Post-induction Hypotension (PIH)
Preoperative Neutrophil-to-Albumin Ratio and Post-Induction Hemodynamic Vulnerability in Major Oncologic Surgery
This prospective observational study aims to evaluate whether the preoperative neutrophil percentage-to-albumin ratio (NPAR) is associated with post-induction hemodynamic vulnerability in adult patients undergoing elective major…
- Trial name
- NCT07804706
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
Intracranial Hypotension
The Blood Patch in the Management of Intracranial Hypotension
Intracranial hypotension results from leakage and/or hypotension of cerebrospinal fluid. It can be spontaneous or secondary to a dural puncture complicating perimedullary anesthesia or a lumbar puncture.
- Trial name
- BPIH (NCT06498804)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Strasbourg, France
Cesarean Section Complications, Spinal Anesthesia
Norepinephrine Versus Phenylephrine Continuous Variable Infusion in Cesarean Delivery
Comparison will be conducted between continuous variable infusions of Phenylephrine with starting dose of 0.75 mcg/Kg/min and Norepinephrine Bitartrate with starting dose of 0.1 mcg/Kg/min (with norepinephrine base of 0.05…
- Trial name
- NCT03328533
- Testing
- Phenylephrine, Norepinephrine, Bupivacaine
- Where
- Egypt
- Volunteers
- 123 people
- Sponsor
- Cairo University
Anemia, Diabetes
A Comparative Clinical Trial of the TensorTip, a Novel Non Invasive Device for Measurement Blood Parameters
1. Aim: The aim of the clinical trial is to study the accuracy of the TensorTip device compared with registered (FDA-approved) invasive and non-invasive devices. 2.
- Conditions
- Anemia, Diabetes, Heart Disease, High Blood Pressure
- Trial name
- NCT01196533
- Testing
- Non invasive peripheral blood monitoring
- Where
- United States
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Cnoga Medical Ltd.
End Stage Renal Disease, Hypertension
Blood Pressure Slopes and Ultrafiltration in Hemodialysis Patients
Kidney failure has been recognized as one of the most costly chronic conditions among United States Veterans. Approximately 13,000 Veterans develop kidney failure each year, and most require hemodialysis initiation.
- Conditions
- End Stage Renal Disease, Hypertension, Extracellular Volume Overload, Intradialytic Hypotension
- Trial name
- NCT04163614
- Testing
- IBPS-Guided Ultrafiltration
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- VA Office of Research and Development
Syncope
Propranolol to Treat Fainting in Children With Sympathoadrenal Imbalance
This study will examine the effectiveness of the drug propranolol in preventing fainting in patients with sympathoadrenal imbalance (SAI).
- Trial name
- NCT00093860
- Testing
- Propranolol
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Hypotension, Cesarean Section
Comparison of Hypotension During Spinal Anaesthesia for C-section
Maternal hypotension during C section has been reported due to aortocaval compression (ACC) by full term uterus in supine position. This study aimed at reporting the effect of left tilt on maternal hemodynamics.
- Conditions
- Hypotension, Cesarean Section, Aortocaval Compression
- Trial name
- NCT05427968
- Where
- Pakistan
- Volunteers
- 38 people
- Sponsor
- Rawalpindi Medical College
Hypotension Drug-Induced
A Prospective Study of Vasopressor on Cerebral Oxygenation During General Anesthesia
The purpose of this study is to investigate whether norepinephrine(N), phenylephrine(P) or ephedrine(E) have different effect on cerebral oxygenation in abdominal surgery with propofol or sevoflurane.
- Trial name
- NCT06334549
- Testing
- Ephedrine-P, Phenylephrine-P, Norepinephrine-P
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Dalian Municipal Central Hospital
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