Clinical trials: Hypotension, Controlled
Orthostatic Hypotension, Autonomic Failure
Automated Abdominal Binder for Orthostatic Hypotension
The automated inflatable abdominal binder is an investigational device for the treatment of orthostatic hypotension (low blood pressure on standing) in patients with autonomic failure.
- Conditions
- Orthostatic Hypotension, Autonomic Failure, Pure Autonomic Failure, Multiple System Atrophy
- Trial name
- NCT03482297
- Testing
- automated abdominal binder, Midodrine
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Vanderbilt University Medical Center
Spinal Anesthesia
Norepinephrine for Spinal-induced Hypotension
Norepinephrine (NE) infusion is used prophylactically to counteract the vasodilator effect of spinal anesthesia. prophylactic use of NE infusion is expected to decrease bouts of hypotension, vomiting and increase patient…
- Trial name
- NE in spianl (NCT03308708)
- Testing
- Norepinephrine infusion
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Mansoura University
Hypotension
Ondansetron in the Prevention of Hypotension in Patients Undergoing Spinal Anesthesia
Ondansetron, a potent 5-HT 3 receptor antagonist commonly used as an antiemetic. The main objective of the present study is to verify the hypothesis that blocking type 3 serotonin receptors with intravenous ondansetron reduces…
- Trial name
- NCT03973411
- Testing
- Prophylactic ondansetron
- Where
- Brazil
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Hospital de Base
Cesarean Section
Two Syringe Spinal Anesthesia Technique for Cesarean Section: A Simple Way to Achieve More Satisfactory Block and Less Hypotension
Background: Poor spinal anaesthesia block is common and is difficult to manage; so a technique to minimize its incidence is advisable. Hypotension is the commonest problem with spinal anesthesia.
- Trial name
- NCT02577432
- Testing
- fentanyl, Hyperbaric bupivacaine
- Volunteers
- 124 people
- Sponsor
- Dr. Soliman Fakeeh Hospital
Hypotension
Sequential Compression Device (SCD) for Stabilizing Hemodynamics in the Beach Chair Position
This study is a 3-legged randomized study examining whether during shoulder surgery performed in the beach chair position active compressions of the lower leg with a sequential compression device (SCD) have a superior effect on…
- Trial name
- NCT01680393
- Testing
- Sequential compression device, TED stockings
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- Bispebjerg Hospital
Spinal Induced Hypotension, Geriatric Population
Spinal-Induced Hypotension in Geriatric Patients
The study will be conducted to asses preoperative condition of venous system by VExUS score and it's relation with the incidence of spinal induced hypotension in geriatric patients undergoing surgery with spinal anaesthesia.
- Conditions
- Spinal Induced Hypotension, Geriatric Population, Intravascular Volume
- Trial name
- NCT05862298
- Testing
- venous excess ultrasound score
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Tanta University
Anaphylaxis, Hypotension
A Randomized, Double-Blind, Placebo-Controlled Study of Omalizumab for Idiopathic Anaphylaxis
Background: Omalizumab is an approved drug for the treatment of asthma by the Food and Drug Administration. Researchers are now studying this drug in a double-blind placebo-controlled manner to assess efficacy in patients with…
- Conditions
- Anaphylaxis, Hypotension, Bronchospasm, Angioedema
- Trial name
- NCT00890162
- Testing
- Epinephrine, Omalizumab (Xolair)
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Drug-induced Hypotension
Study of Maraviroc (MVC) and Epzicom (ABC/3TC) Once-Daily in ART-Naive & First Switch Patients
Hypotension does not occur with Maraviroc at a dose of 600 mg/day
- Trial name
- NCT02626923
- Volunteers
- 51 people
- Sponsor
- Nicholaos C Bellos, MD
Hematoma Intracranial, Hydrocephalus
Subgaleal Drains in Decompressive Craniectomies
This research is about the use of subgaleal drains to prevent accumulation of blood under the skin in patients undergoing surgery to remove part of the skull(craniectomy) and its associated complications.
- Conditions
- Hematoma Intracranial, Hydrocephalus, Surgical Site Infection, Wound Breakdown
- Trial name
- VADER (NCT03777774)
- Testing
- Passive Redon subgaleal drains, Vacuum Redon subgaleal drains, No Redon subgaleal drains
- Where
- 2 sites in Malaysia
- Volunteers
- 78 people
- Sponsor
- Universiti Sains Malaysia
Cirrhosis, Liver, Sepsis
Volume Resuscitation in Cirrhosis With Sepsis Induced Hypotension
In critically ill patients with liver disease like cirrhosis or ACLF, fluid therapy needs to be instituted after identification of patients who will be fluid responsive and initiate appropriate inotropes early to prevent the…
- Conditions
- Cirrhosis, Liver, Sepsis, Acute on Chronic Liver Failure
- Trial name
- NCT05059795
- Testing
- Albumin + electrolyte solution, POCUS guided fluid resuscitation
- Where
- 2 sites in India
- Volunteers
- 350 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Intraoperative Hypotension
Hypotension Prediction Index for Blood Pressure Management
Design: Single-center randomized comparison of invasive arterial pressure monitoring vs. arterial pressure monitoring combined with Acumen Hypotension Prediction Index (HPI) software guidance on intraoperative hypotension…
- Trial name
- HPI (NCT03610165)
- Testing
- Acumen HPI-enabled EV1000 screen, Control
- Where
- United States
- Volunteers
- 214 people
- Sponsor
- The Cleveland Clinic
Liver Cirrhosis
Efficacy of 5% Albumin v/s Plasmalyte in Combination With 20% Albumin for Fluid Resuscitation in Cirrhosis With Sepsis Induced Hypotension
Cirrhotic patients with sepsis represent a very sick subset of patients and septic shock in such patients is associated with high mortality.
- Trial name
- NCT06076330
- Testing
- 20% Albumin, 5% Albumin, Plasmalyte
- Where
- India
- Volunteers
- 120 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Hypotension, Tachycardia
Passive Leg Raising Attenuates and Delays Tourniquet Deflation-induced Hypotension and Tachycardia
Background: The pneumatic tourniquet is frequently used in total knee arthroplasty. Tourniquet deflation may result in hypotension and tachycardia caused by the rapid shift of blood volume back to the ischemic limb and a decrease…
- Trial name
- NCT01592669
- Testing
- passive leg raising
- Where
- Taiwan
- Volunteers
- 35 people
- Sponsor
- Tri-Service General Hospital (TSGH)
Hypotension, Spinal Anesthesia Induced Hypotension
Perfusion Index and Spinal Hypotension in Day-Case Knee Arthroscopy
This prospective observational study aims to investigate the role of the baseline perfusion index (PI) in predicting spinal anesthesia-induced hypotension (SAIH) in ASA I-II patients undergoing day-case knee arthroscopy.
- Conditions
- Hypotension, Spinal Anesthesia Induced Hypotension, Anesthesia, Spinal, Arthroscopy
- Trial name
- NCT07747441
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Ankara Etlik City Hospital
Hemorrhage
Controlled Hypotension During Functional Endoscopic Sinus Surgery
It is very important to decrease the bleeding during functional endoscopic sinus surgery (FESS) in order to increase the visibility of the surgical site.
- Trial name
- NCT01956981
- Testing
- Magnesium Sulfate, Dexmedetomidine
- Volunteers
- 60 people
- Sponsor
- TC Erciyes University
Spinal Cord Injury, Orthostatic Hypotension
ARC Therapy to Restore Hemodynamic Stability and Trunk Control in People With Spinal Cord Injury
The goal of this interventional study is to evaluate the safety and preliminary effectiveness of the ARC-IM Therapy to improve hemodynamic management in people with sub-acute or chronic spinal cord injury.
- Trial name
- HemON-NL (NCT05941819)
- Testing
- ARC-IM Thoracic System implantation
- Where
- Netherlands
- Volunteers
- 16 people
- Sponsor
- ONWARD Medical, Inc.
Pregnancy Related, Hypotension
The Effect of HPI to Reduce Intraoperative Hypotension in Caesarean Sections
During caesarean section, blood pressure variations especially a reduction in blood pressure (or hypotension) can bring harmful effects to mother and baby. This usually occurs after spinal anaesthesia is administered.
- Conditions
- Pregnancy Related, Hypotension, Maternal-Fetal Relations, Cesarean Section Complications
- Trial name
- NCT06892665
- Testing
- Hypotension prediction index, Non invasive Blood Pressure Monitoring
- Where
- Malaysia
- Volunteers
- 100 people
- Sponsor
- National University of Malaysia
Cardiac Surgery Patients
HPI for Prevention of Hypotension During Cardiac Surgery
Hypotension prediction index (HPI) was applied in various types of non-cardiac surgery with convincing benefits of preventing hypotensive events and clinical sequelae.
- Trial name
- NCT06137547
- Testing
- Hypotension prediction index (HPI)
- Where
- Taiwan
- Volunteers
- 110 people
- Sponsor
- Mackay Memorial Hospital
Hypotension, Anesthesia
Development of Advanced Double Intravenous Vasopressor Automated (ADIVA) System
Maternal hypotension during spinal anaesthesia for Caesarean delivery may bring various adverse effects. It is therefore important to closely monitor hypotension during spinal anaesthesia, however current technology does not…
- Trial name
- ADIVA (NCT03620942)
- Testing
- Phenylephrine, Ephedrine, ADIVA System
- Where
- Singapore
- Volunteers
- 173 people
- Sponsor
- KK Women's and Children's Hospital
Shock, Sepsis
Single Dose Enteral Tranexamic Acid in Critically Ill Patients
The premise of this study is that enteral tranexamic acid will help to maintain small bowel integrity, which is often compromised by critical illness due to inadequate cardiovascular perfusion (i.e., shock), and that maintenance…
- Conditions
- Shock, Sepsis, Hypotension, Critical Illness
- Trial name
- NCT01683747
- Testing
- Tranexamic Acid, Control Intervention (Carrier fluid only)
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- San Diego Veterans Healthcare System