Clinical trials: Hypotension
Anesthesia Complication, Vasopressor
Management of Postspinal Anesthesia Hypotension During Elective Cesarean Section: Baby Norepinephrine Versus Ephedrine
Background : Spinal anesthesia emerges as the preferred anesthesia technique for elective cesarean section . It offers a preferable alternative to general anesthesia because it provides better maternal safety and neonatal…
- Conditions
- Anesthesia Complication, Vasopressor, Cesarean Section Complications, Hypotension During Surgery
- Trial name
- NCT06498076
- Testing
- Norepinephrine, Ephedrine
- Where
- Tunisia
- Volunteers
- 196 people, healthy volunteers welcome
- Sponsor
- Hopital Charles Nicolle
Parkinson Disease, Parkinsonism
Head-up Tilt Sleeping to Alleviate Orthostatic Hypotension, Supine Hypertension and Nocturia in Parkinson's Disease
Autonomic dysfunction is common and often underrecognized in Parkinson's disease (PD). Orthostatic hypotension (OH) affects up to a third of PD patients and often coincides with supine hypertension.
- Trial name
- NCT05551377
- Testing
- Head-up tilt sleeping
- Where
- 2 sites in Netherlands
- Volunteers
- 50 people
- Sponsor
- Radboud University Medical Center
Circulatory Shock, Hemodynamic Instability
Peripheral pULSe Assessment and Arterial pRessure (PULSAR)
This prospective multicenter observational study aims to investigate the relationship between palpable peripheral pulses and simultaneously measured arterial blood pressure in adult patients with circulatory shock or impending…
- Conditions
- Circulatory Shock, Hemodynamic Instability, Hypotension, Shock
- Trial name
- PULSAR (NCT07609095)
- Testing
- Peripheral Pulse Palpation
- Where
- Sweden
- Volunteers
- 5,000 people
- Sponsor
- Region Stockholm
18-45 Range of Age, Cesarean Section
Is Elective Caesarean Sections for Predicting Post-spinal Hypotension Role of Overactive Bladder?
It is to predict postspinal hypotension that may develop in patients diagnosed with overactive bladder who will undergo elective cesarean section under spinal-epidural anesthesia.
- Conditions
- 18-45 Range of Age, Cesarean Section, Primigravid
- Trial name
- NCT05624671
- Testing
- bupivacaine,fentanyl
- Where
- Turkey (Türkiye)
- Volunteers
- 143 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Desaturation, Bradycardia
Validation of the NTX Wireless Patient Monitoring System
Reduction in time to detection of Clinically Significant events Reduction of time to Intervention during Clinically Significant events Reduction in the number of admissions to Intensive Care
- Conditions
- Desaturation, Bradycardia, Tachycardia, Hypertension
- Trial name
- TATRC (NCT00644644)
- Testing
- Rapid Response Team (NTX wireless monitoring system)
- Where
- United States
- Volunteers
- 1,303 people
- Sponsor
- Vanderbilt University Medical Center
Hypotension
Diastolic Performance and Norepinephrine in Spinal-Induced Hypotension for Cesarean Delivery
Background and rationale: The best agent to prevent spinal-induced hypotension is still uncertain but norepinephrine showed fewer effects on heart rate and cardiac output.
- Trial name
- NORA-CS (NCT04560634)
- Testing
- Norepinephrine, ClearSight®, Edwards Lifescience, Irvine, CA
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Hypotension
Comparisons Between Dexmedetomidine and Magnesium Sulfate in Controlled Hypotension During Rhinoplasty Surgeries
General anesthesia organizes the best option for controlled blood pressure during rhinoplasty surgery. The primary agent applied in controlling hypotension should have particular unique characteristics.
- Trial name
- NCT05880693
- Testing
- Dexmedetomidine, Magnesium sulfate
- Where
- Egypt
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- mohamed
Hypotension
Study of Dopamine Versus Vasopressin for Treatment of Low Blood Pressure in Low Birth Weight Infants
Low blood pressure or hypotension is a very important problem that is often seen in premature babies, especially those with low birth weight.
- Trial name
- NCT01318278
- Testing
- Dopamine, Arginine Vasopressin
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Baylor College of Medicine
Hypotension During Surgery
Goal-directed Fluid Therapy During Deep Inferior Epigastric Perforator (DIEP) Free Flap Breast Reconstruction
Adequate free flap perfusion during Deep Inferior Epigastric Perforator (DIEP) flap breast reconstruction surgery requires maintaining blood pressure above 100 mmHg and avoiding excessive fluid administration.
- Trial name
- GDFT DIEP-flap (NCT06080178)
- Testing
- Plasma-lyte (static group), Norepinephrine (static group), Plasma-lyte (dynamic group)
- Where
- Belgium
- Volunteers
- 82 people
- Sponsor
- Algemeen Ziekenhuis Maria Middelares
Caesarean Section
Use of Vasopressors in Hypotension Associated With Spinal Anaesthesia in Caesarean Sections
This study was designed as a prospective randomised study. In this study, the researchers planned to evaluate the effect of intravenous vasopressor agents administered to patients undergoing caesarean section under spinal…
- Trial name
- NCT07384455
- Testing
- Patients who received 10 mg of ephedrine intravenously after spinal anaesthesia during caesarean section, Patients who received 8 mcg intravenous norepinephrine after spinal anaesthesia during caesarean section
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Hypotension, General Anesthesia Induced Hypotension
Perfusion Index-derived Parameters as Predictors Post-induction Hypotension.
The perfusion index (PI) is a numerical value for the ratio between pulsatile and non-pulsatile blood flow measured by a special pulse oximeter.
- Trial name
- NCT04217226
- Testing
- Perfusion index derived parameters
- Where
- Egypt
- Volunteers
- 93 people
- Sponsor
- Cairo University
Hypotension
Effects of Ephedrine, Phenylephrine, Norepinephrine and Vasopressin on Contractility of Human Myometrium and Umbilical Vessels: An In-vitro Study
Hypotension is one of the most common adverse effects of spinal anesthesia for cesarean deliveries, affecting as many as 55-90% of mothers.
- Trial name
- NCT04053478
- Testing
- Ephedrine, Phenylephrine, Norepinephrine
- Where
- Canada
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Hypotension, Hypoxia
Increasing Dose Safety Study of Hemospan in Orthopedic Surgery Patients
The purpose of this study is to evaluate the safety and possible effectiveness of Hemospan solution in patients undergoing elective orthopedic surgery who receive spinal anesthesia.
- Trial name
- NCT00494949
- Testing
- Hemospan (MP4OX), Ringer's lactate
- Where
- 2 sites in Sweden
- Volunteers
- 30 people
- Sponsor
- Sangart
Hypertension
Treatment of Supine Hypertension in Autonomic Failure
Supine hypertension is a common problem that affects at least 50% of patients with primary autonomic failure. Supine hypertension can be severe, and complicates the treatment of orthostatic hypotension.
- Trial name
- NCT00223717
- Testing
- Clonidine, Nitroglycerin transdermal, Dipyridamole/ Aspirin (Aggrenox)
- Where
- United States
- Volunteers
- 152 people
- Sponsor
- Vanderbilt University
Sepsis, Intraoperative Hypotension
Risk Factors of Post-ERCP Sepsis
For the treatment of numerous biliary and pancreatic problems, the procedure known as endoscopic retrograde cholangiopancreatography (ERCP) is regarded as a crucial therapeutic intervention.
- Conditions
- Sepsis, Intraoperative Hypotension, Bacteremia Sepsis
- Trial name
- NCT06187168
- Testing
- exposure to hypotension during the Endoscopic Retrograde Cholangiopancreatography (ERCP) for obstructive jundice.
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Mansoura University
End Stage Renal Disease, Hypertension
Blood Pressure Slopes and Ultrafiltration in Hemodialysis Patients
Kidney failure has been recognized as one of the most costly chronic conditions among United States Veterans. Approximately 13,000 Veterans develop kidney failure each year, and most require hemodialysis initiation.
- Conditions
- End Stage Renal Disease, Hypertension, Extracellular Volume Overload, Intradialytic Hypotension
- Trial name
- NCT04163614
- Testing
- IBPS-Guided Ultrafiltration
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- VA Office of Research and Development
Hypotension, Valve Surgery
Preoperative Ephedrine Attenuates the Hemodynamic Responses of Propofol During Valve Surgery: A Dose Dependent Study
The prophylactic use of small doses of ephedrine may be effective in obtunding of the hypotension responses to propofol with minimal hemodynamic and ST segment changes.
- Trial name
- NCT01006863
- Testing
- Ephedrine, Phenylephrine
- Where
- 2 sites in Egypt, Saudi Arabia
- Volunteers
- 150 people
- Sponsor
- King Faisal University
Blood Pressure, Hypotension
Hypotensive Effect of Anaesthesia With TCI
Hypotension will often complicate induction of anaesthesia. The investigators want to test the hypothesis that Target Controlled Infusion, as opposed to Velocity Controlled Infusion, leads to less degree of hypotension.
- Trial name
- HEAT (NCT02733406)
- Testing
- Target Controlled Infusion, Velocity Controlled Infusion
- Where
- Sweden
- Volunteers
- 76 people
- Sponsor
- Umeå University
Hypertension, Frailty
The Effects of Medication Induced Blood Pressure Reduction on Cerebral Hemodynamics in Hypertensive Frail Elderly
Rationale: Systolic hypertension represents the leading risk for burden of disease among older adults (age >70 years), with an increasing prevalence due to the increase in lifespan.
- Conditions
- Hypertension, Frailty, Old Age; Dementia, Orthostatic Intolerance
- Trial name
- BLUEBERRY (NCT05529147)
- Testing
- Antihypertensive Agents
- Where
- Netherlands
- Volunteers
- 15 people
- Sponsor
- Radboud University Medical Center
Hypotension
Assessment of Automatic Relays by Intensive Basis Advantage Compared With Manual Relays, on the Hypotension Risks, During Noradrenalin Administration
Circulatory failures are the main cause of admissions in the intensive care unit. It is recommended to prescribe to these patients an intravenous injection of catecholamine to correct this dysfunction and to keep an hemodynamic…
- Trial name
- ARIBA (NCT01127152)
- Testing
- Measure of arterial pressure
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier Departemental Vendee