Clinical trials: Hypotension and Shock
Septic Shock, Fluid Therapy
Fluid Balance in the ICU - Interventions to Minimize Fluids in Patients With Septic Shock
The purpose of the study is to determine if a protocol that assesses patients' daily fluid intake and output can decrease the overall amount of fluid patients receive during the first five days in the ICU.
- Conditions
- Septic Shock, Fluid Therapy, Hypotension
- Trial name
- NCT02473718
- Testing
- Fluid minimization protocol, Ultrasound
- Volunteers
- 82 people
- Sponsor
- Washington University School of Medicine
Cardiac Surgery With Cardiopulmonary Bypass
Evaluation of Plasma Renin Concentrations in Cardiac Surgery
The purpose of this research is to learn more about how renin (a blood test) is affected by cardiopulmonary bypass, the heart-lung machine used during open heart surgery.
- Trial name
- NCT06895213
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Mayo Clinic
Hypotension, Shock
Brachial Artery Peak Velocity Variation to Predict Fluid Responsiveness
The investigators designed this study to determine the predictive value for predicting fluid responsiveness of noninvasive evaluation of respiratory variation of peak velocity in brachial artery, in mechanically ventilated…
- Trial name
- NCT00890071
- Testing
- Fluid administration
- Where
- Spain
- Volunteers
- 38 people
- Sponsor
- Hospital del SAS de Jerez
Hypotension, Shock
Transcutaneous pO2, Transcutaneous pCO2 and Central Venous SO2 Variations to Define Fluid Responsiveness
Fluid challenge is often carried out in critical ill patients. Its responsiveness usually requires invasive monitoring. To use non-invasive methods is very tempting.
- Conditions
- Hypotension, Shock, Fluid Challenge, Fluid Responsiveness
- Trial name
- NCT01941472
- Testing
- fluid challenge
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Peking Union Medical College Hospital
Septic Shock, Sepsis
VBI-S for the Treatment of Hypotension in Hypovolemic Septic Shock Patients
This study is being conducted to evaluate the safety and effectiveness of VBI-S in elevating the blood pressure of septic shock patients with absolute or relative hypovolemia.
- Conditions
- Septic Shock, Sepsis, Hypovolemia
- Trial name
- NCT04257136
- Testing
- VBI-S
- Where
- 8 sites in United States
- Volunteers
- 20 people
- Sponsor
- Vivacelle Bio
Septic Shock
Hypotension in the Weaning From Vasopressor Drugs
Although there is consensus in the literature on hemodynamic management of septic shock in the resuscitation phase, the best way to conduct the weaning of vasopressor drugs in the stabilization phase remains open.
- Trial name
- RENOVA (NCT05506319)
- Testing
- Norepinephrine, Vasopressin
- Where
- Brazil
- Volunteers
- 78 people
- Sponsor
- Hospital Nossa Senhora da Conceicao
Hypotension, Poor Peripheral Perfusion
Effect of Vasopressin on Tissue Oxygen Saturation in Cardiac Surgery Patients During Cardiopulmonary Bypass
The objective of this research is to compare the effect of a low dose Vasopressin infusion or placebo during cardiopulmonary bypass on vasopressor requirements, hemodynamics and tissue oxygen saturation and its recovery using…
- Trial name
- NCT01532505
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Mohamed Ismail
Hypoxic-Ischemic Encephalopathy, Asphyxia
Hydrocortisone Therapy Optimization During Hypothermia Treatment in Asphyxiated Neonates
This is a prospective, single center, pharmacokinetic study of intravenous hydrocortisone therapy for systemic low blood pressure during hypothermia treatment in asphyxiated newborns.
- Conditions
- Hypoxic-Ischemic Encephalopathy, Asphyxia, Hypotension, Circulatory Failure Neonatal
- Trial name
- UniCort (NCT05836610)
- Testing
- Hydrocortisone
- Where
- Hungary
- Volunteers
- 50 people
- Sponsor
- Semmelweis University
Hypotension and Shock, Hypertension
Accuracy of Non-Invasive Blood Pressure Measurements at the Arm, Calf , and Finger
The present study was designed to assess, in a population of patients admitted to the intensive care unit and already carrying an indwelling arterial catheter, the ability of combined continuous (ClearSight™) and intermittent…
- Conditions
- Hypotension and Shock, Hypertension, Intensive Care Unit
- Trial name
- PANIC (NCT04269382)
- Testing
- Combined non-invasive intermittent (oscillometric arm cuff), non-invasive continuous (finger cuff and ClearSight device), and invasive continuous (intra-arterial catheter) BP measurements
- Where
- 3 sites in France
- Volunteers
- 133 people
- Sponsor
- Centre Hospitalier Régional d'Orléans
Dyspnea, Coma
The Use of a Point-of-care Thoracic Ultrasound Protocol for Hospital Medical Emergency Teams
Study to assess the possible effects of the use of a point-of-care thoracic ultrasound protocol for hospital medical emergency teams (MET)
- Conditions
- Dyspnea, Coma, Hypotension and Shock
- Trial name
- METUS (NCT03214809)
- Testing
- ultrasound protocol
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- Rijnstate Hospital
Hypotension
Use of Ultrasonography to Determine Fluid-responsiveness for Shock in a Population of Intensive Care Unit Patients
The objective of our study is to determine the correlation of transthoracic ultrasonographic indices of fluid responsiveness to changes in direct measures of cardiac output and to compare them to other established predictors of…
- Trial name
- NCT01680770
- Where
- United States
- Volunteers
- 124 people
- Sponsor
- University of Chicago
Extracorporeal Life Support, Hypotension
Hypotension During Extracorporeal Circulatory Support Indicated for Cardiogenic Shock
The cardiogenic shock is characterized by an alteration of organs function following a decrease in cardiac output linked to an impairment of cardiac performance. The prognosis remains poor with mortality between 40 and 50%.
- Conditions
- Extracorporeal Life Support, Hypotension, Vasoplegia
- Trial name
- RetroECMO-VP (NCT03968926)
- Testing
- Arterial pressure management during circulatory support by VA-ECMO
- Where
- France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Montpellier
Shock, Hypotension
Point of Care Ultrasonography In The Management of Shock: A Pilot Study
This project aims to determine the feasibility of conducting a randomized controlled trial investigating point of care ultrasound guided resuscitation compared with usual care in the management of shock at the Critical Care…
- Trial name
- NCT03296891
- Testing
- PoCUS Guided Resuscitation of Shock
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Western University, Canada
Postspinal Hypotension
Diastolic Shock Index for Predicting Postspinal Hypotension
This prospective observational study aims to evaluate the diagnostic performance of the preoperative Diastolic Shock Index in predicting postspinal hypotension and to compare its performance with other shock indices, including…
- Trial name
- NCT07765342
- Testing
- Spinal Anesthesia
- Volunteers
- 85 people
- Sponsor
- Istinye University
Anesthesia Induced Hypotension, Hypotension Drug-Induced
Comparison of Pleth Variability Index vs. Diastolic Shock Index for Predicting Hypotension During Anesthesia Induction
This study aims to explore the frequent occurrence of hypotension during anesthesia induction due to anesthetic drugs or fasting. Predicting this condition is important for patient safety and anesthesia management.
- Trial name
- NCT06589674
- Testing
- Pulse variability index measurement, Diastolic shock index
- Where
- Turkey (Türkiye)
- Volunteers
- 126 people
- Sponsor
- Kocaeli City Hospital
Shock, Sepsis
Single Dose Enteral Tranexamic Acid in Critically Ill Patients
The premise of this study is that enteral tranexamic acid will help to maintain small bowel integrity, which is often compromised by critical illness due to inadequate cardiovascular perfusion (i.e., shock), and that maintenance…
- Conditions
- Shock, Sepsis, Hypotension, Critical Illness
- Trial name
- NCT01683747
- Testing
- Tranexamic Acid, Control Intervention (Carrier fluid only)
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- San Diego Veterans Healthcare System
Hypotension, Shock, Septic
Midodrine During Recovery From Septic Shock
The purpose of this study is to determine whether midodrine administration decreases duration of intravenous vasopressors and intensive care unit length of stay for patients in septic shock.
- Conditions
- Hypotension, Shock, Septic, Sepsis
- Trial name
- NCT02771158
- Testing
- Midodrine
- Sponsor
- Northwell Health
Arterial Hypotension, Shock
Cerebral Circulation in Critically Ill Children
The principal purpose of this study is to describe the changes in cerebral circulation (assessed by transcranial ultrasound) and oxygenation (assessed by Near InfraRed spectroscopy, NIRS) during resuscitation for hemodynamic…
- Conditions
- Arterial Hypotension, Shock, Cerebral Lesion
- Trial name
- CIRCU-REAPED (NCT03731104)
- Testing
- Near InfraRed Spectroscopy assessment, Transcranial Doppler Ultrasound assessment, Cardiac output assessment
- Where
- 3 sites in France
- Volunteers
- 27 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Spinal Anesthesia, Cesarean Section
Predicting Spinal Hypotension in Cesarean Section
This prospective observational study investigates the predictive value of anthropometric and hemodynamic indices for spinal anesthesia-induced hypotension (SAIH) during cesarean section.
- Conditions
- Spinal Anesthesia, Cesarean Section, Hypotension
- Trial name
- prediction (NCT07499947)
- Where
- Turkey (Türkiye)
- Volunteers
- 321 people
- Sponsor
- TC Erciyes University
Hypotension, Shock
Fluid Responsiveness Prediction at the Bedside
The purpose of this study is to verify the accuracy and applicability of predictors of fluid administration efficacy in hypotensive critically ill patients.
- Trial name
- NCT00721604
- Testing
- fluid administration
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Fondazione Poliambulanza Istituto Ospedaliero