Clinical trials: IBD (Inflammatory Bowel Disease)
Ulcerative Colitis
The Impact of Circadian Misalignment on Colonic Barrier Homeostasis in Ulcerative Colitis
The purpose of this study is to investigate if circadian malalignment (unusual sleeping patterns), such as night shifts (sleeping during the day and being awake during the night time), worsens the inflammation of the gut.
- Trial name
- NCT05180279
- Testing
- 7-day sleep lab
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Ulcerative Colitis
A Study of Asacol Absorption, Metabolism and Excretion in Children and Adolescents With Ulcerative Colitis.
The purpose of this randomized, open-label, parallel-group study is to determine how the body absorbs and eliminates mesalamine following administration of either 30 mg/kg/day, 60 mg/kg/day or 90 mg/kg/day as 400 mg…
- Trial name
- NCT00254618
- Testing
- mesalamine
- Where
- 22 sites in United States
- Volunteers
- 34 people
- Sponsor
- Warner Chilcott
Ulcerative Colitis
Basiliximab Maintenance in Ulcerative Colitis
Primary Objective Safety: assess the safety of basiliximab 40 mg, given every 4 weeks, in subjects with ulcerative colitis who completed previous basiliximab studies.
- Trial name
- NCT01061996
- Testing
- Basiliximab
- Where
- United Kingdom
- Volunteers
- 88 people
- Sponsor
- Cerimon Pharmaceuticals
Crohn's Disease
Early Immunosuppressants in Crohn's Disease
Pluricentric randomized study comparing two therapeutic strategies at beginning of Crohn's disease: early immunosuppressants (prescription within the six first months following diagnosis) vs.
- Trial name
- RAPID (NCT00546546)
- Testing
- early immunosuppressants (azathioprine, methotrexate)
- Where
- 26 sites in France
- Volunteers
- 120 people
- Sponsor
- Groupe d'Etude Therapeutique des Affections Inflammatoires Digestives
Crohn's Disease (CD), Ulcerative Colitis (UC)
Virtual Group Therapy for IBD Patients With Anxiety and Depression
This study is being done to better understand the complex relationship between mental health and Inflammatory Bowel Disease (IBD), with a particular focus on symptoms of depression and anxiety.
- Conditions
- Crohn's Disease (CD), Ulcerative Colitis (UC), Inflammatory Bowel Diseases (IBD), Anxiety
- Trial name
- NCT07796568
- Testing
- Group Psychotherapy Intervention
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of Chicago
Ulcerative Colitis
Pharmacokinetics of Cobitolimod Enemas in Participants With Active Ulcerative Colitis
The purpose of the study is to evaluate the PK, safety and tolerability of cobitolimod ememas (500mg/50mL) given to participants with active left-sided UC.
- Trial name
- NCT05404074
- Testing
- Cobitolimod 500mg
- Where
- Sweden
- Volunteers
- 6 people
- Sponsor
- InDex Pharmaceuticals
Inflammatory Bowel Disease, Colitis, Ulcerative
Biomarkers in Inflammatory Bowel Diseases
Ulcerative colitis (UC) and Crohn's disease (CD) are chronic relapsing inflammatory bowel diseases (IBD). At the time of diagnosis it is not possible to predict the course of the disease, which can range from a few flares in a…
- Conditions
- Inflammatory Bowel Disease, Colitis, Ulcerative, Crohn Disease
- Trial name
- NCT02612103
- Where
- Denmark
- Volunteers
- 193 people, healthy volunteers welcome
- Sponsor
- Line Elberg Godskesen
Complex Perianal Fistula, Crohn Disease
Safety and Efficacy of Adipose-Derived Stem Cells to Treat Complex Perianal Fistulas Patients With Crohn's Disease
The purpose of this study is to determine safety and efficacy of eASCs (expanded adult stem cells) for treatment of complex perianal fistulas in patients with Crohn's disease.
- Trial name
- FATT (NCT01378390)
- Testing
- Expanded autologous adipose-derived adult stem cells (eASCs)
- Where
- 12 sites in Austria, Netherlands and 1 more
- Volunteers
- 56 people
- Sponsor
- Tigenix S.A.U.
Ulcerative Colitis
Efficacy and Safety Study of GED-0507-34-Levo for Treatment of UC
This is a Phase 2, multicenter, randomized, double-blind, placebo-controlled, parallel-group study to evaluate the efficacy and safety of 2 doses of GED-0507-34-Levo in subjects with active, mild-to-moderate UC.
- Trial name
- SEGMENT (NCT02808390)
- Testing
- GED-0507-34-Levo 80 mg, GED-0507-34-Levo 160 mg
- Where
- 60 sites in United States, Bulgaria and 8 more
- Volunteers
- 19 people
- Sponsor
- PPM Services S.A.
Fibrostenotic Crohn's Disease
A Study of PALI-2108 in Healthy Volunteers, Patients With Ulcerative Colitis, and Patients With Fibrostenosing Crohn's Disease
This is a Phase 1b, open-label, exploratory study designed to evaluate the pharmacodynamic effects of PALI-2108, a phosphodiesterase-4 (PDE4) inhibitor, in patients with fibrostenotic Crohn's disease (FSCD).
- Trial name
- NCT07428096
- Testing
- PALI-2108
- Where
- Canada
- Volunteers
- 6 people
- Sponsor
- Palisade Bio
Ulcerative Colitis (UC)
Oral Vitamin D3 Effect on Inflammatory Biomarkers in Ulcerative Colitis Patients
This randomized controlled trial aims to evaluate the effect of oral vitamin D3 supplementation on inflammatory biomarkers and disease activity in Pakistani patients with moderate ulcerative colitis.
- Trial name
- OVDIEIBUCP (NCT07269223)
- Testing
- Vitamin D3
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- University of Veterinary and Animal Sciences, Lahore - Pakistan
Crohn's Disease
Adalimumab for the Induction and Maintenance of Clinical Remission in Subjects With Crohn's Disease
The purpose of this study is to test whether Adalimumab (at two different doses) can induce and maintain clinical remission in subjects with active Crohn's disease when compared to placebo (a substance containing no medication)
- Trial name
- CHARM (NCT00077779)
- Testing
- Adalimumab
- Where
- 43 sites in United States
- Volunteers
- 854 people
- Sponsor
- Abbott
Ulcerative Colitis
Mesalazine 4g Once Daily Versus 4g in Two Divided Doses in Active Ulcerative Colitis.
The purpose of this study was to demonstrate that mesalazine 4g orally per day once daily (QD) is non-inferior to the reference regimen, mesalazine 4g per day in two divided doses (BID) (2g x 2 per day), in patients with active…
- Trial name
- NCT00737789
- Testing
- Mesalazine slow-release granules, Mesalazine liquid enema
- Where
- 66 sites in Belgium, France and 2 more
- Volunteers
- 206 people
- Sponsor
- Ferring Pharmaceuticals
Crohn Disease, Rectal Fistula
A Study of the Quality of Life in Adults With Crohn's Disease With Complex Perianal Fistulas
The main aim of the study is to assess the quality of life of people with Crohn's disease after treatment for complex perianal fistulas (CPF) in a standard clinic setting.
- Trial name
- CONFLICT (NCT04876690)
- Where
- 5 sites in Portugal
- Volunteers
- 15 people
- Sponsor
- Takeda
Ulcerative Colitis
Efficacy and Safety of BBT-401-1S in Ulcerative Colitis
This is randomized, placebo-controlled, dose-escalation, multicenter, Phase 2 study to evaluate the efficacy and safety of BBT-401-1S in patients with active ulcerative colitis.
- Trial name
- NCT03800420
- Where
- 11 sites in United States
- Volunteers
- 16 people
- Sponsor
- Bridge Biotherapeutics, Inc.
Inflammatory Bowel Disease, Ulcerative Colitis Type
A Multicenter Clinical Trial: Efficacy, Safety of Fecal Microbiota Transplantation for Inflammatory Bowel Disease
There are many limitations in the current treatments of Inflammatory bowel disease(IBD). Some patients have no or little reaction to the traditional drugs.
- Trial name
- NCT04521205
- Testing
- fecal microbiota capsule
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Zhongshan Hospital Xiamen University
Crohn's Disease
Endoscopic Relapse Risks Evaluation After Ileocolic Resection for Crohn's Disease
Aim of the study: To evaluate risk factors of endoscopic relapse after ileocolic resection in a cohort of Crohn's disease patients treated with anti-TNF agents.
- Trial name
- RIC-1 (NCT06299631)
- Testing
- Ileocolic resection
- Where
- France
- Volunteers
- 133 people
- Sponsor
- University Hospital, Montpellier
Crohn Disease
Standardized Microbiota Transplant Therapy in Crohn's Disease
Crohn's disease (CD) develops because of a disruption of homeostasis between the gut microbiota and the host immune system resulting in excessive inflammation in the intestinal tract.
- Trial name
- NCT06631586
- Testing
- MTP-101C, MTP-101S
- Where
- 3 sites in United States
- Volunteers
- 120 people
- Sponsor
- University of Minnesota
Crohn´s Disease, Ulcerative Colitis
Endocytoscopy for in Vivo Determination of Mucosal Inflammatory Cells and Intestinal Disease Activity in Inflammatory Bowel Disease (IBD)
Precise activity assessment of inflammatory bowel disease (IBD) is essential to determine the extent and severity of the disease for further specific therapy.
- Trial name
- NCT01289366
- Testing
- Endocytoscopy
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Inflammatory Bowel Disease, Crohn's Disease
Study of Participants With Crohn's Disease and Ulcerative Colitis in Eastern Europe, Middle East, and North Africa (P08166)
This study is being done to assess the clinical course and treatment options for Crohn's Disease (CD) and ulcerative colitis (UC) in the populations of Eastern Europe, Middle East, and North Africa.
- Conditions
- Inflammatory Bowel Disease, Crohn's Disease, Ulcerative Colitis
- Trial name
- NCT01293656
- Testing
- No intervention.
- Sponsor
- Merck Sharp & Dohme LLC
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