Clinical trials: ICH - Intracerebral Hemorrhage
Cerebral Hematoma, Traumatic, Intracerebral Hemorrhage, Traumatic
Interest of Real Time Measurement of Autonomous Nervous System for the Detection of Brain Death
Context: A major lack of organ donors is a serious public health problem. It determines a prolonged delay before a transplant can be performed and thus a significant number of deaths of patients waiting for transplantation.
- Conditions
- Cerebral Hematoma, Traumatic, Intracerebral Hemorrhage, Traumatic, Traumatic Brain Hemorrhage, Traumatic Brain Injury
- Trial name
- MEANS (NCT00918970)
- Where
- 3 sites in France
- Volunteers
- 30 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Cerebral Hemorrhage, Cerebral Edema
Conivaptan for the Reduction of Cerebral Edema in Intracerebral Hemorrhage- A Safety and Tolerability Study
The goal of this study is to preliminarily determine/estimate feasibility and whether frequent and early conivaptan use, at a dose currently determined to be safe (i.e., 40mg/day), is safe and well-tolerated in patients with…
- Conditions
- Cerebral Hemorrhage, Cerebral Edema, Intracerebral Hemorrhage, Stroke
- Trial name
- NCT03000283
- Testing
- Conivaptan
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Jesse Corry
Aphasia Following Cerebral Infarction, Aphasia Following Nontraumatic Intracerebral Hemorrhage
TDCS and Aphasia Therapy in the Chronic Phase After Stroke
This study evaluates the neuromodulatory effect of combined tDCS and aphasia therapy in patients in the chronic phase after stroke.
- Trial name
- NCT03305614
- Testing
- tDCS, Aphasia therapy
- Where
- Belgium
- Volunteers
- 25 people
- Sponsor
- University Hospital, Ghent
Intracerebral Hemorrhage
Intracerebral Transplantation of Autologous MSC Combined With Scaffold Product for Chronic Intracerebral Hemorrhage
The goal of this clinical trial is to test intracerebral transplantation of stem cell product in patient with chronic intracerebral hemorrhage.
- Trial name
- RAINBOW-Hx (NCT06361433)
- Testing
- HUFF-01
- Where
- Japan
- Volunteers
- 8 people
- Sponsor
- Hokkaido University Hospital
Intracerebral Hemorrhage, Statins
Statin for Neuroprotection in Spontaneous Intracerebral Hemorrhage
Brain injury after spontaneous intracerebral hemorrhage results from pathophysiologic responses in the brain parenchyma due to hematoma formation, release of clot components, and surrounding edema.
- Trial name
- STATIC (NCT04857632)
- Testing
- Statin
- Where
- 3 sites in China
- Volunteers
- 98 people
- Sponsor
- Capital Medical University
Intracerebral Hemorrhage
Vitamin D for Acute Intracerebral Hemorrhage
Intracerebral hemorrhage (ICH) is the most deadly and debilitating form of stroke. To date, effective treatment that could improve the functional outcome of ICH remained elusive.
- Trial name
- VICToHR (NCT07458815)
- Testing
- Vitamin D
- Where
- Hong Kong
- Volunteers
- 40 people
- Sponsor
- The University of Hong Kong
Atrial Fibrillation, Stroke
Prevention of Stroke by Left Atrial Appendage Closure in Atrial Fibrillation Patients After Intracerebral Hemorrhage
Intracerebral hemorrhage (ICH) in patients with non-valvular atrial fibrillation (NVAF) poses a particular dilemma for thromboprophylaxis.
- Conditions
- Atrial Fibrillation, Stroke, Intracerebral Hemorrhage
- Trial name
- NCT02830152
- Testing
- LAAO, Medical Therapy
- Where
- 17 sites in Denmark, Finland and 2 more
- Volunteers
- 750 people
- Sponsor
- Karolinska Institutet
Stroke, Acute, Hemorrhage
Feasibility of Improving Cerebral Autoregulation in Acute Intracerebral Haemorrhage
In the UK, 23,000 (15%) of the 150,000 people who suffer a stroke each year have bleeding in the brain, also referred to as acute intracerebral haemorrhage (ICH).
- Conditions
- Stroke, Acute, Hemorrhage, Cerebral Brain Hemorrhage, Blood Pressure
- Trial name
- BREATHE-ICH (NCT03324321)
- Testing
- Hypocapnia via Hyperventilation Protocol
- Where
- United Kingdom
- Volunteers
- 18 people
- Sponsor
- University of Leicester
Traumatic Brain Injury, Intracerebral Hemorrhage
Near Infra-red Spectroscopy for Detection of Intracranial Haematoma
Fall with head injury is becoming an epidemic challenge especially with the ageing population. Contributing factors for mortality and poor functional outcome included development of cerebral contusion and delayed traumatic…
- Trial name
- NCT03653728
- Testing
- Near infrared spectroscopy
- Where
- Hong Kong
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Acute Brain Injury, Traumatic Brain Injury
Effect of Central Venous Catheterization on Brain Pressure in Acute Brain Injury Patients
Acute brain injury (ABI) is a serious condition that can cause a dangerous increase in pressure inside the skull (called intracranial pressure, or ICP), which can harm the brain.
- Conditions
- Acute Brain Injury, Traumatic Brain Injury, Intracerebral Hemorrhage, Aneurysmal Subarachnoid Hemorrhage (aSAH)
- Trial name
- CVC-ICP (NCT07704528)
- Where
- 2 sites in China
- Volunteers
- 120 people
- Sponsor
- Beijing Tiantan Hospital
Cerebral Hemorrhage
Decompressive Hemicraniectomy in Intracerebral Hemorrhage
Spontaneous intracerebral hemorrhage (ICH) remains a devastating disease with mortality rates up to 52% at 30 days. It is a major public health problem with an annual incidence of 10-30 per 100'000 population, accounting for 2…
- Trial name
- SWITCH (NCT02258919)
- Testing
- Decompressive craniectomy (DC) and best medical treatment, Best medical treatment
- Where
- 32 sites in Austria, Belgium and 6 more
- Volunteers
- 201 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Intracerebral Hemorrhage
Effects and Mechanisms of Celecoxib on Intracerebral Hemorrhage
This trial is a phase IIa human clinical study, in which 60 patients with intracerebral hemorrhage (ICH) at basal ganglion or thalamus within 6 h after onset will be enrolled.
- Trial name
- NCT05434065
- Testing
- Celecoxib 200mg
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- National Taiwan University Hospital
Hypertensive Intracerebral Hemorrhage
Modified Stereotactic Aspiration and Thrombolysis of Intracerebral Hemorrhage:a Multi-center Controlled Study
The purpose of this study is to evaluate the superiority of effect of the modified micro-invasive aspiration and drainage and conservative medical therapy in the treatment of ICH spontaneously hypertensive scientifically.
- Trial name
- MSATIH (NCT00940745)
- Testing
- Stereotactic Aspiration and Thrombolysis, conservative treatment
- Where
- China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Huazhong University of Science and Technology
Intracerebral Hemorrhage, Hypertension
Antihypertensive Treatment in Acute Cerebral Hemorrhage
The purpose of this trial is to evaluate the safety and effectiveness of lowering blood pressure using nicardipine in persons with acute hypertension associated with intracerebral hemorrhage.
- Conditions
- Intracerebral Hemorrhage, Hypertension, Stroke
- Trial name
- ATACH (NCT00415610)
- Testing
- nicardipine
- Where
- 12 sites in United States
- Volunteers
- 60 people
- Sponsor
- University of Minnesota
Intracerebral Haemorrhage in Cerebellum
Vitamin K1 in the Treatment of Spontaneous Intracerebral Hemorrhage
In order to determine the effectiveness and safety of early vitamin K1 use in reducing the risk of bleeding and improving prognosis in patients with spontaneous intracerebral hemorrhage.
- Trial name
- NCT03388970
- Testing
- Vitamin K 1, normal saline
- Where
- 5 sites in China
- Volunteers
- 400 people
- Sponsor
- HUANG XIANJIAN
Spontaneous Intracerebral Hemorrhage
Stromal Vascular Fraction (SVF) Therapy in Patients With Acute Spontaneous Intracerebral Hemorrhage (SICH).
The purpose of this pilot study is to evaluate the safety of stromal vascular fraction (SVF) therapy in patients with spontaneous intracerebral hemorrhage (SICH).
- Trial name
- NCT05232903
- Testing
- SVF therapy group
- Where
- China
- Volunteers
- 15 people
- Sponsor
- Beijing Tiantan Hospital
Intracerebral Hemorrhage
Antiplatelet Secondary Prevention International Randomised Trial After INtracerebral HaemorrhaGe (ASPIRING)-Pilot Phase
ASPIRING is an investigator-led, multicentre, prospective, randomised, open-label, blind outcome (PROBE), parallel group, clinical trial.
- Trial name
- NCT04522102
- Testing
- Start antiplatelet monotherapy
- Where
- 2 sites in China
- Volunteers
- 80 people
- Sponsor
- The George Institute for Global Health, China
Stroke
Biomarkers Based EArly Diagnosis of STroke Subtype Cohort（Bio-EAST）
Intracerebral hemorrhage carries high rates of mortality and disability, imposes a significant societal burden. Based on findings from our previous multicenter randomized controlled clinical trial (INTERACT4), we revealed that…
- Trial name
- Bio-EAST (NCT07003477)
- Testing
- Detection of peripheral blood biomarkers
- Where
- China
- Volunteers
- 527 people
- Sponsor
- Shanghai East Hospital
Traumatic Brain Injury, Subarachnoid Hemorrhage
NOninVasive Intracranial prEssure From Transcranial doppLer Ultrasound Development of a Comprehensive Database of Multimodality Monitoring Signals for Brain-Injured Patients
This is an observational study in neurocritical care units at University of California San Francisco Medical Center (UCSFMC), Zuckerberg San Francisco General Hospital (ZSFGH), UC Davis, and Emory University.
- Conditions
- Traumatic Brain Injury, Subarachnoid Hemorrhage, Intracerebral Hemorrhage, Liver Failure
- Trial name
- NOVEL ICP (NCT04548596)
- Testing
- Transcranial Doppler
- Where
- 3 sites in United States
- Volunteers
- 162 people
- Sponsor
- Emory University
Acute Brain Injury, Mechanical Ventilation
Regional Ventilation Evaluation During Neuro-injury Weaning Study
This study evaluates changes in regional lung ventilation using thoracic electrical impedance tomography (EIT) during the weaning process from mechanical ventilation in ICU patients with acute brain injury.
- Conditions
- Acute Brain Injury, Mechanical Ventilation, Prolonged Weaning, Traumatic Brain Injury
- Trial name
- ReVENtS (NCT07067671)
- Testing
- Internal Thoracic Impedance
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris