Clinical trials: ICU Ill Patients
Carbapenem-Resistant Enterobacteriaceae Infection
Ceftazidime-Avibactam Use in Critically Ill Patients With Carbapenem-Resistant Enterobacteriaceae Infections
Carbapenem-Resistant Enterobacteriaceae (CRE) infections are a growing national and international challenge in healthcare settings.
- Trial name
- AVI-ICU (NCT05258851)
- Testing
- Ceftazidime-avibactam, Colistin
- Where
- Saudi Arabia
- Volunteers
- 29 people
- Sponsor
- King Faisal Specialist Hospital & Research Center
Sleep Quality, Critically Ill Patient
Assessment of Sleep Quality of Hospitalized Patients Treated With EEG-guided Protection Procedures: Application in Intensive Care Unit
Sleep of critically ill patients is highly disturbed with a high sleep fragmentation; patients spend most of their sleep in very short sleep episodes, lasting less than 10 minutes.
- Conditions
- Sleep Quality, Critically Ill Patient, Intensive Care Unit
- Trial name
- SleepScan (NCT05963672)
- Testing
- EEG-guided sleep protection, Control condition
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Poitiers University Hospital
Critical Illness
Daily Sedative Interruption in Critically Ill Patients Being Managed With a Sedation Protocol.
The purpose of this study is to determine whether the use of both a nurse-driven sedation protocol and daily sedative interruption, compared with a sedation protocol alone, result in better outcomes for mechanically ventilated…
- Trial name
- SLEAP (NCT00675363)
- Testing
- Protocolized Sedation, Protocolized sedation, with daily interruption
- Where
- 16 sites in United States, Canada
- Volunteers
- 410 people
- Sponsor
- Mount Sinai Hospital, Canada
Critical Illness, Energy Supply; Deficiency, Severe
GLUCOSAFE 2 - A New Tool for Nutritional Management and Insulin-therapy in the Intensive Care Unit (ICU)
The survival and the outcomes of critically ill patients are strongly influenced by insulin-therapy and nutritional support. The GLUCOSAFE 2 pilot study, aims to test the performance and the security of the new GLUCOSAFE 2…
- Conditions
- Critical Illness, Energy Supply; Deficiency, Severe, Protein Deficiency, Hypoglycemia
- Trial name
- NCT03890432
- Testing
- GLUCOSAFE 2, Local protocol control group with routine care, Historical control group with routine care
- Where
- 2 sites in Switzerland
- Volunteers
- 213 people
- Sponsor
- HEIDEGGER CP
Thromboprophylaxis, Critical Illness
Pharmacokinetic Profiles of Subcutaneous Enoxaparin for Thromboprophylaxis in Critically Ill Patients With Renal Failure Treated or Not With Continuous Veno-veinous Hemofiltration.
Thromboprophylaxis is recommended for critically ill patients without contraindications and is usually achieved by the subcutaneous daily administration of a low dose of low molecular weight heparin (LMWH).
- Conditions
- Thromboprophylaxis, Critical Illness, Intensive Care (ICU)
- Trial name
- AKI-ENOXA (NCT07384598)
- Testing
- Anti-Xa profiles after the subcutaneous administration of a prophylactic dose of enoxaparin
- Volunteers
- 60 people
- Sponsor
- Clinique Saint Pierre Ottignies
Critical Care Nursing
Speech-to-speech Voice-cloning Care (SVCC) to Improve ICU-acquired Anxiety for Critically Ill Patients
The goal of this clinical trial is to learn the effect of Speech-to-speech Voice-Cloning Care (SVCC) on improving ICU-acquired anxiety for critically ill patients.
- Trial name
- NCT06743321
- Testing
- Speech-to-speech Voice-Cloning Care (SVCC)
- Where
- China
- Volunteers
- 234 people
- Sponsor
- Peking Union Medical College Hospital
Acute Kidney Failure, Critical Illness
Effect of Protein Dosage on Persistent Acute Renal Failure in Critically Ill Patients.
Background: Acute kidney injury (AKI) is common in critically ill patients and is associated with worse outcomes, including longer ICU stay, need for dialysis, and higher mortality.
- Conditions
- Acute Kidney Failure, Critical Illness, Protein Intake, Nutritional Support
- Trial name
- NCT07631221
- Where
- 6 sites in Argentina
- Volunteers
- 344 people
- Sponsor
- Hospital Italiano de Buenos Aires
Chronic Disease, Neoplasm Metastasis
Facilitating Communication Study
This study is a randomized clinical trial of an intervention to improve outcomes for patients and their family by using ICU nurse facilitators to support, model, and teach communication strategies that enable patients and their…
- Conditions
- Chronic Disease, Neoplasm Metastasis, Lung Neoplasm, Pulmonary Disease, Chronic Obstructive
- Trial name
- FCS2 (NCT03721952)
- Testing
- Facilitator-Based Intervention
- Where
- 3 sites in United States
- Volunteers
- 977 people
- Sponsor
- University of Washington
Critical Illness, Hyperglycemia
Relationship Between PTEN and Glycemic Variability and Outcome in Critically Ill Patients
Glycemic variability in critically ill patients is a recognized negative prognostic factor. The molecular mechanisms determining inter-patients variability in glucose metabolism during stress are not fully understood.
- Trial name
- GLUPTEN (NCT01796847)
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- University of Roma La Sapienza
Radial Artery Catheterization
Comparison of the Modified and Conventional Approach of Radial Artery Cannulation Under Short-axis Ultrasound Guidance in ICU Hypotensive Patients.
Radial artery cannulation can be performed under short-axis ultrasound guidance. However, the first puncture success rate was low in patients with hypotensive patients.
- Trial name
- NCT04806932
- Testing
- The modified approach, The conventional approach
- Where
- China
- Volunteers
- 102 people
- Sponsor
- Shanghai Zhongshan Hospital
Intensive Care Unit (ICU) Acquired Weakness (ICU - AW), Critical Illness
Effectiveness of Virtual Reality in Improving Upper Limb Function in Critically Ill Patients
Millions of people are hospitalized every year in Intensive Care Units (ICUs) with severe health conditions due to various causes and categories of diseases, such as stroke, Traumatic Brain Injuries (TBI), polytrauma, sepsis, and…
- Trial name
- EVOLUTION (NCT07901855)
- Testing
- Conventional Physiotherapy and Occupational Therapy, Fully Immersive Virtual Reality Training
- Where
- Greece
- Volunteers
- 48 people
- Sponsor
- National and Kapodistrian University of Athens
Sepsis
Serum CD14 and CD88 Mointoring in ICU
The present study will be conducted to determine the dynamic changes of serum soluble CD14 and the corresponding changes of serum CD88 and their correlation in critically ill sepsis and SIRS patients.
- Trial name
- NCT02120534
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Tanta University
Vitamin D Deficiency, Hyperparathyroidism
Abnormally High Parathyroid Hormone Levels Worsens Outcomes in Vitamin D Depleted Critical Care Patients
This study aims to investigate the impacts of abnormally elevated PTH levels on clinical outcomes among critically ill patients with vitamin D depletion.
- Conditions
- Vitamin D Deficiency, Hyperparathyroidism, Critically Ill Patients Admitted in ICU
- Trial name
- NCT06711874
- Where
- Taiwan
- Volunteers
- 320 people
- Sponsor
- National Taiwan University Hospital
Vitamin D Deficiency, Critical Illness
Cholecalciferol Supplementation in Critically Ill Patients With Severe Vitamin D Deficiency.
The purpose of the research study is to determine whether a single high dose of vitamin D is helpful in reducing critical illness related complications in intensive care patients who are having sever vitamin D deficiency.
- Trial name
- NCT02868827
- Testing
- Cholecalciferol, Milk (Nestle)
- Where
- Saudi Arabia
- Volunteers
- 127 people
- Sponsor
- King Abdullah Medical City
Risk Factor, Cardiovascular, Covid19
ICU Trial in Critical Ill COVID-19 Patients
The aim of our study is to observe the intensive care course in 30-50 COVID-19 patients with regard to cardiovascular risk factors and biomarkers.
- Conditions
- Risk Factor, Cardiovascular, Covid19, Critical Illness, Course Illness
- Trial name
- POINT-C (NCT04349982)
- Testing
- Biomarker (TropT, Myoglobin, CK, CK-MB, LDH, D-dimer, CRP, PCT)
- Where
- Austria
- Volunteers
- 31 people
- Sponsor
- Medical University of Graz
Critical Illness, Muscle Weakness
Diaphragm Protective Ventilation in the Intensive Care Unit
Due to an accident, pneumonia or surgery, patients can have severe shortness of breath or lung damage to such an extent that it compromises vital functions. At such times, mechanical ventilation can be lifesaving.
- Conditions
- Critical Illness, Muscle Weakness, Muscle Damage, Respiration, Artificial
- Trial name
- DiaPro (NCT03527797)
- Testing
- Titration of support level
- Where
- Netherlands
- Volunteers
- 41 people
- Sponsor
- Amsterdam UMC, location VUmc
Respiratory Insufficiency
Ventil Device Usefulness in Mechanically Ventilated ICU Patients
During Covid-19 pandemic many patients require mechanical ventilation due to disastrous impact of SARS-CoV-2 on lungs. In several countries there is a shortage of ICU beds and ventilators.
- Trial name
- NCT04355754
- Testing
- Ventil - a gas flow divider
- Where
- Poland
- Volunteers
- 40 people
- Sponsor
- Medical University of Gdansk
Anxiety Disorder/Anxiety State
The ICU is a Complex Setting Where Critically Ill Patients Are Treated, Impacting Caregivers' Mental Health, Leading to Anxiety and Depression .we Aim to Identify the Prevalence of Anxiety and Depression Among Family Members of ICU Patients in a Tertiary-Level Hospital in Nepal
a prospective observational study conducted in ICU of tertiary hospital under the guidance of mentors of department of critical care medicine TUTH to identify the Prevalence of Anxiety and Depression Among Family Members of ICU…
- Trial name
- HADS (NCT06835673)
- Where
- Nepal
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Tribhuvan University Teaching Hospital, Institute Of Medicine.
Mechanical Ventilation Complication
National Approach to Standardize and Improve Mechanical Ventilation
This is a pre-post implementation cohort study. This is a data driven quality improvement project which aims to improve the care of mechanically ventilated patients through the implementation of a bundle of evidence based…
- Trial name
- NASAM (NCT03790150)
- Testing
- Evidence-based practices
- Where
- 2 sites in Saudi Arabia
- Volunteers
- 27,966 people
- Sponsor
- King Abdullah International Medical Research Center
Critical Illness, ICU
Effects of Melatonin on Sleep Architecture of Critically Ill Patients in the ICU
This is a pilot study to examine the effects of melatonin on the sleep patterns of critically ill patients. Patients will have their sleep patterns measured with a device attached to their head with a headband then be given a…
- Conditions
- Critical Illness, ICU, ICU Hospitalization, Melatonin
- Trial name
- NCT07691996
- Testing
- Melatonin
- Volunteers
- 30 people
- Sponsor
- Rutgers, The State University of New Jersey