Clinical trials: IGRT
Metastatic Prostate Cancer, Prostate Adenocarcinoma
Single Dose Radiotherapy (SDRT) With or Without Adjuvant Systemic Therapy for Oligometastatic Prostate Cancer
The present study aims to optimize the use of systemic therapy relative to local tumor ablation in a prospective randomized clinical trial and to validate the existence and characterize the clinical and pathology phenotype of…
- Trial name
- NCT04031378
- Testing
- Single Dose Radiotherapy (24 Gy) to all detectable lesions, followed by observation, Single Dose Radiotherapy (24 Gy) to all detectable lesions followed by adjuvant systemic therapy for 6 months
- Where
- Portugal
- Volunteers
- 100 people
- Sponsor
- Fundacao Champalimaud
Cancer Cervix
Tomotherapy vs Conventional Radiation for Adjuvant Pelvic RT in Ca Cervix
The study tests Tomtherapy based Image Guided Radiation against conventional radiation techniques for it's ability to reduce long term small bowel toxicity.
- Trial name
- PARCER (NCT01279135)
- Testing
- Conventional Radiation, Tomotherapy based IGRT
- Where
- India
- Volunteers
- 300 people
- Sponsor
- Tata Memorial Hospital
Prostate Cancer, Prostate Cancer (Adenocarcinoma)
ABlative Radiotherapy (for) Unfavorable Prostate Tumors 2.0
Published clinical evidence confirms that a single dose of 24 Gy provides unprecedented long-term local control in primary and metastatic prostate cancer with safe toxicity profiles, provided that exposure of surrounding healthy…
- Conditions
- Prostate Cancer, Prostate Cancer (Adenocarcinoma), Prostate Cancer Non-Metastatic
- Trial name
- ABRUPT 2 (NCT07407608)
- Testing
- SBRT, SDRT
- Where
- Italy
- Volunteers
- 58 people
- Sponsor
- University of Milano Bicocca
Early Stage Non-small Cell Lung Cancer, Non-small Cell Lung Cancer
Computed Tomography-Guided Stereotactic Adaptive Radiotherapy (CT-STAR) for the Treatment of Central and Ultra-Central Early-Stage Non-Small Cell Lung Cancer
This study will evaluate the impact of CT-guided adaptive stereotactic radiotherapy (CT-STAR) to central and ultra-central early-stage non-small cell lung cancers on grade 3 or greater toxicity.
- Trial name
- NCT05785845
- Testing
- Computed tomography-guided stereotactic adaptive radiotherapy, ETHOS
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Washington University School of Medicine
Non-small Cell Lung Cancer
Phase I/II Study of Fractionated Stereotactic Radiotherapy for Early Stage Non-Small Cell Lung Cancer
A new type of treatment called stereotactic radiotherapy has recently been developed in hopes of improving the success of the treatment and improving the convenience to patients, while reducing the side effects.
- Trial name
- NCT00888823
- Testing
- Stereotactic Radiotherapy
- Where
- 2 sites in Canada
- Volunteers
- 13 people
- Sponsor
- AHS Cancer Control Alberta
Rectal Cancer
Cone Beam Computed Tomography (CT) (CBCT) With and Without a Customized Vacuum Immobilization Device (CVID)
This study is designed to investigate whether or not the use of a customized vacuum immobilization device (CVID) to immobilize rectal cancer patients undergoing preoperative pelvic radiation therapy improves the positional…
- Trial name
- NCT00937248
- Testing
- prone pillow and simple ankle fixation device, Customized Vacuum Immobilization Device (CVID)
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University Health Network, Toronto
Prostate Cancer Adenocarcinoma, Adjuvant Radiotherapy
Stereotactic Hypofractionated Accelerated Radiotherapy Post-Prostatectomy
The present phase I trial evaluates the feasibility of a postoperative stereotactic hypofractionated external beam radiation therapy delivered in patients who underwent radical prostatectomy with adverse pathological features or…
- Conditions
- Prostate Cancer Adenocarcinoma, Adjuvant Radiotherapy, Salvage Radiotherapy, SBRT
- Trial name
- SHARP (NCT02976402)
- Testing
- SBRT
- Where
- Portugal
- Volunteers
- 30 people
- Sponsor
- Fundacao Champalimaud
Head and Neck Cancer, Lung Cancer
Evaluation of a Cone-beam CT Scanner for Image Guided Radiotherapy
This is a feasibility study investigating the image quality of a new, high-performance cone beam CT (CBCT) used for on-couch imaging during radiotherapy treatments.
- Conditions
- Head and Neck Cancer, Lung Cancer, Breast Cancer, Abdominal Cancer
- Trial name
- CONFIGURE (NCT05524454)
- Testing
- Novel CBCT Imaging
- Where
- Netherlands
- Volunteers
- 41 people
- Sponsor
- Varian, a Siemens Healthineers Company
Chimeric Antigen Receptor T-cell Therapy, B Cell Acute Lymphoblastic Leukemia (B-ALL)
Immunoglobulin Replacement Therapy (IgRT) Versus Antibiotic Prophylaxis (PA) in Patients Treated by CD19-targeted Chimeric Antigen Receptor (CAR)T Cells for a B Cell Acute Lymphoblastic Leukemia or a B Cell Lymphoma
B cell (CD19) targeted chimeric antigen receptor modified T Cells (CAR-T) has transformed treatment of relapsed/refractory B-cell acute lymphoblastic leukemia (B-ALL) or B-cell lymphoma (BCL).
- Conditions
- Chimeric Antigen Receptor T-cell Therapy, B Cell Acute Lymphoblastic Leukemia (B-ALL), B Cell Lymphoma, Antibiotic Prophylaxis
- Trial name
- PREV-CART (NCT07754682)
- Testing
- Immunoglobulin, antibiotic prophylaxis
- Volunteers
- 228 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Stage IV Non-Small Cell Lung Cancer
Radical RADiotherapy and Immunotherapy for Metastatic CAncer of the Lung (RRADICAL)
This phase II trial studies how well radical-dose image guided radiation therapy works in treating patients with non-small cell lung cancer that has spread to other places in the body who are undergoing immunotherapy.
- Trial name
- NCT03176173
- Testing
- Image-guided Radiation Therapy, Immunotherapy (physician's choice for standard of care immunotherapy)
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Stanford University
Prostate Cancer
Real-Time MV/kV Image Guided Radiation Therapy
In current radiation therapy, imaging (typically, cone beam CT imaging or two orthogonal X-ray projection imaging) is done for patient setup before radiation dose delivery.
- Trial name
- NCT01260909
- Testing
- Real-time kV/MV Prostate Imaging
- Sponsor
- Stanford University
Bladder Cancer
Study of Tumour Focused Radiotherapy for Bladder Cancer
Bladder cancer is the seventh most common cancer in the UK, with 10,399 new cases diagnosed in 2011. In a quarter of these cases the cancer has infiltrated the muscular wall of the bladder (muscle invasive) and is life…
- Trial name
- RAIDER (NCT02447549)
- Testing
- WBRT, SART, DART
- Where
- 49 sites in Australia, New Zealand and 1 more
- Volunteers
- 345 people
- Sponsor
- Institute of Cancer Research, United Kingdom
Cancer
A Master Trial Assessing the Technical Feasibility of First-In-Human Real-Time Image Guided Radiation Therapy Methods
The goal of this clinical trial is to determine whether Real-Time Image Guided Radiation Therapy is a feasible method for radiation therapy delivery for patients with cancer.
- Trial name
- Real-Time IGRT (NCT06708221)
- Testing
- Real-Time Image Guided Radio Therapy (IGRT)
- Where
- Australia
- Volunteers
- 40 people
- Sponsor
- University of Sydney
Breast Cancer, Lung Cancer
Development of Real-time Image-guided Radiotherapy
The goal is to achieve the maximal radiotherapy tumor dose while sparing the health tissue and critical structures. On-board cone-beam CT (CBCT) scans are routinely acquired prior to dose delivery and matched with simulation CT…
- Conditions
- Breast Cancer, Lung Cancer, Skin Cancer
- Trial name
- NCT03524248
- Testing
- Image guided radiation therapy
- Where
- United States
- Volunteers
- 159 people
- Sponsor
- Fox Chase Cancer Center
Esophageal Neoplasms, Carcinoma, Squamous Cell
Phase I Dose Escalation of Stereotactic Radiosurgical Boost for Locally Advanced Esophageal Cancer
To study the safety and feasibility of stereotactic radiation dose escalation following neoadjuvant chemotherapy with concurrent conventionally fractionated radiation, by evaluating the acute and late toxicity of treatment.
- Conditions
- Esophageal Neoplasms, Carcinoma, Squamous Cell, Adenocarcinoma, Esophageal Cancer
- Trial name
- NCT00368329
- Testing
- Capecitabine (Xeloda), [18-F] Fluorodeoxyglucose (FDG), 5-Fluorouracil (5-FU)
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Stanford University
Lung Cancer
Novel Lung Functional Imaging for Personalized Radiotherapy
The primary objective of this study is to assess the safety and feasibility of personalized radiotherapy with four-dimensional (4D) computed tomography (CT)-based pulmonary ventilation imaging, which selectively avoids…
- Trial name
- NCT02308709
- Testing
- Ventilation image-guided radiotherapy
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- University of California, Davis
Breast Cancer
Image Guided Radiotherapy (IGRT) for Prone Partial Breast Irradiation
Partial breast irradiation (PBI) is becoming a new paradigm for breast cancer radiation.[1] No type I or II evidence is currently available to demonstrate equivalence to standard whole breast radiotherapy, and a prospective…
- Trial name
- PBI (NCT02272400)
- Testing
- IGRT for prone partial breast irradiation (PBI)
- Where
- United States
- Volunteers
- 310 people
- Sponsor
- NYU Langone Health
Non-small Cell Lung Cancer
A Pilot Study of MPDL3280A and HIGRT in Metastatic NSCLC
The purpose of this study is to find out whether a brief course of radiation therapy given to one area affected by the cancer will improve the chances of responding to immuno-therapy in the form of a medicine called MPDL3280A, an…
- Trial name
- NCT02463994
- Testing
- MPDL3280A, Hypofractionated Radiotherapy
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- University of Michigan Rogel Cancer Center
Radiotherapy, Repositonning Pelvic
Assessing the Ompact of Neutral Pelvic Positioning on Bone Repositioning Quality in Pelvic Radiotherapy Patients
This study explores whether achieving a neutral pelvic position improves bone repositioning quality for patients undergoing pelvic radiotherapy.
- Conditions
- Radiotherapy, Repositonning Pelvic, Neutral Pelvic Positioning
- Trial name
- Pelvtilt-RT (NCT06687200)
- Testing
- Setup with neutral pelvic positioning technique, Standard setup
- Where
- 4 sites in France
- Volunteers
- 200 people
- Sponsor
- Centre Leon Berard
Prostate Cancer
MR-based Hypofractionated Adaptive IGRT of Prostate Cancer (M-base HyPro 2.0)
Single-centre single-armed, non-randomized interventional phase II-study of hypofractionated image-guided radiotherapy "IGRT" with weekly magnetic resonance imagings "MRI" for personalized adaptation of the treatment plan…
- Trial name
- Mbase_HyPro (NCT03880851)
- Testing
- Plan adaptation of Radiation Treatment in case of anatomical changes
- Where
- Germany
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen