Clinical trials: IVf
Infertility, Embryo Transfer
Progesterone as Luteal Support in Frozen IVF Natural Cycles
The ProFET study aims to investigate if luteal phase support by vaginal progesterone, is superior to no luteal phase support, in terms of live birth rate per woman after a frozen embryo transfer (FET), in a natural cycle (NC)…
- Trial name
- ProFET (NCT04725864)
- Testing
- Progesterone vaginal tablet
- Where
- Sweden
- Volunteers
- 1,800 people
- Sponsor
- Vastra Gotaland Region
In Vitro Fertilization, Postoperative Recovery
Estrogen Levels and Postoperative Recovery in IVF Patients
This prospective observational study aims to evaluate the relationship between supraphysiologic serum estrogen levels and postoperative recovery quality in patients undergoing IVF procedures under general anesthesia.
- Conditions
- In Vitro Fertilization, Postoperative Recovery, Estrogens, Anesthesia Recovery Period
- Trial name
- NCT06925633
- Where
- Turkey (Türkiye)
- Volunteers
- 98 people
- Sponsor
- Konya City Hospital
Endometrium
Endometrial Dating by Ex-vivo Imaging of Endometrial Biopsies of In-vitro Fertilization Candidate Participants
To evaluate the correlation between cycle day determination by clinical signs, study participant testimony, endometrium histopathology biopsy and ex-vivo imaging of the uterus endometrium.
- Trial name
- NCT04288843
- Where
- 2 sites in Israel
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Fertigo Medical Ltd
GDM, Insulin Resistance
In Vitro Fertilization Impact on Metabolic Parameters
A quantitative prospective cohort study will be conducted, where blood samples will be collected at different timings during the IVF protocol, to assess the impact of fertility medications on metabolic parameters of patients…
- Conditions
- GDM, Insulin Resistance, Glucose Intolerance, PCOS
- Trial name
- IVF (NCT03426228)
- Testing
- HbA1C
- Where
- United Arab Emirates
- Volunteers
- 344 people, healthy volunteers welcome
- Sponsor
- University of Warwick
Infertility
Long Protocol and Growth Hormone in Poor Responders
The long down regulation protocol is widely used in the in vitro fertilization cycles, now it will be assessed regarding its efficacy, in poor responder females undergoing in vitro fertilization cycles, alone and after the…
- Trial name
- NCT02338206
- Testing
- Growth hormone
- Where
- Egypt
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Woman's Health University Hospital, Egypt
Diminished Ovarian Reserve, IVF Outcomes
The Effect of VitC on IVF Outcome of DOR Patients
In the context of the accelerating aging population and the continuous decline in birth rates nationwide, delaying reproductive aging in women and protecting the fertility of women of childbearing age have become urgent issues…
- Trial name
- DORIVF-VC (NCT06794047)
- Testing
- Vitamin C
- Where
- 6 sites in China
- Volunteers
- 1,100 people
- Sponsor
- Peking University Third Hospital
Pregnancy Rates
Different Strategies in Frozen IVF/ICSI Cycles
In the absence of robust contemporary data, investigators decided to perform a multicenter cohort study of various IVF centers, to compare the different modalities used for pregnancy rates following frozen-thawed embryo transfer…
- Trial name
- NCT03965949
- Testing
- Hormone Replacement cycle 1, Hormone Replacement cycle 2
- Where
- Greece
- Volunteers
- 311 people, healthy volunteers welcome
- Sponsor
- National and Kapodistrian University of Athens
Infertility
Safety and Efficacy of Pre-defined, Fixed Dose of Gonal-f Pen Based on Subject Baseline Characteristics in Subjects Undergoing in Vitro Fertilization (IVF)
Clinical validation of the assisted reproductive technology (ART) treatment guidelines, which determine the optimal dose of recombinant human follicle stimulating hormone (r-hFSH) based on subject baseline…
- Trial name
- CONSORT (NCT00249834)
- Testing
- Gonal-f, Recombinant human chorionic gonadotrophin (r-hCG)
- Where
- France
- Volunteers
- 166 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
In Vitro Fertilization
Transvaginal vs Transabdominal Ultrasound Guided Embryo Transfer
Embryo transfer is the last step in the IVF process. it is now recognized that this step should be done carefully and that it affects success rates. in recent years, sonographic guidance appears to increase success rates.
- Trial name
- TVUSET (NCT00826332)
- Testing
- transabdominal ultrasound, transvaginal ultrasound
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- Hadassah Medical Organization
Pregnancy, Ovarian
Clinical and Live Birth Rates After Following Long Antagonist Protocol Versus Long Agonist Protocol
A prospective study of the evaluation of the clinical IVF (in vitro fertilization) results after following Long Antagonist protocol for Controlled Ovarian Stimulation (COS) versus following Long Agonist protocol
- Trial name
- NCT03693534
- Testing
- Clinical Pregnancy Rate
- Where
- Greece
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Assisting Nature
Polycystic Ovary Syndrome, Assisted Reproduction
Mitochondrial DNA in Fresh Versus Frozen Embryo Culture Media of PCOS Women Undergoing In Vitro Fertilization
Ninety women with PCOS candidate for ICSI were randomized to 2 groups:Group A: fresh samples of PCOS patients undergoing IVF (no= 45) and Group B: frozen samples of PCOS patients undergoing IVF (no= 45).
- Trial name
- NCT03820167
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Cairo University
Subfertility, Assisted Reproduction
Evaluation of the Role of Follicular Sensitivity Index in the Prediction of Pregnancy in Women Undergoing ICSI/IVF Without Polycystic Ovarian Syndrome
1000 women with infertility who are already decided to be treated with ICSI will be subjected to full history taking and clinical examination.
- Trial name
- NCT02158026
- Where
- 2 sites in Egypt
- Volunteers
- 1,000 people
- Sponsor
- Cairo University
Premature Ovarian Insufficiency, Infertility, Female
Ovarian PRP (Platelet Rich Plasma) Injection for Follicular Activation
The primary objective is to investigate the efficacy, defined as an increase in oocyte numbers upon ovarian stimulation, and safety of a single intra-ovarian PRP injection vs.
- Conditions
- Premature Ovarian Insufficiency, Infertility, Female, Sterility, Female, PRP
- Trial name
- OPIF (NCT05279560)
- Testing
- autologous PRP (platelet rich plasma), Saline solution (NaCL) Injection
- Where
- Germany
- Volunteers
- 114 people
- Sponsor
- University of Luebeck
Diminished Ovarian Reserve
The Effeciency of NMN in Improving IVF/ICSI-ET Pregnancy Outcomes in Patients With DOR
The purpose of the study is to understand the effect of nicotinamide mononucleotide (NMN) on patients with diminished ovarian reserve and the outcomes of IVF/ICSI-ET.
- Trial name
- NCT06426355
- Testing
- NMN
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Peking University Third Hospital
Infertility
A Comparative Study of Sibling Oocytes: ICSI vs. the IMSI Sperm Selection Method
The aim of this research is to compare sibling oocytes using two sperm selection methods for choosing the best quality spermatozoa before they are injected into oocytes and the influence of each of these methods on embryo quality…
- Trial name
- NCT03240276
- Testing
- Standard ICSI procedure for sperm injection into oocyte, MSOME, IMSI Procedure
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Hillel Yaffe Medical Center
Infertility
Safety Evaluation of the HyperSperm Sperm Preparation Procedure for In Vitro Fertilization
Prospective, multicenter, randomized clinical study evaluating the safety of a novel sperm preparation method for in vitro fertilization (IVF), compared to standard sperm preparation procedures.
- Trial name
- NCT07478549
- Testing
- Standard Sperm Preparation, HyperSperm
- Where
- 2 sites in Argentina
- Volunteers
- 202 people
- Sponsor
- Fecundis Lab SL
Polycystic Ovary Syndrome
Impact of Metformin on In Vitro Fertilization Outcomes in Overweight and Obese PCOS Women
RCT to investigate whether metformin co-treatment would improve IVF outcomes in overweight and obese women with PCOS.
- Trial name
- NCT02910817
- Testing
- Metformin
- Where
- Egypt
- Volunteers
- 102 people
- Sponsor
- Assiut University
Infertility, IVF
Outcomes of 36 vs 38 Hour Intervals From Ovulation Trigger To Oocyte Pick-Up:A Multi-Center Randomized Controlled Trial
Women who undergo assisted reproduction technology (ART) treatment will be eligible for this study. The goal of this randomized clinical trial is to compare the outcomes of ART treatment between women who have 36 and 38 hours…
- Trial name
- NCT05803655
- Testing
- 36-hour duration between ovulation triggering and oocyte pick-up procedure, 38-hour duration between ovulation triggering and oocyte pick-up procedure
- Where
- 7 sites in Turkey (Türkiye)
- Volunteers
- 850 people
- Sponsor
- Koç University
IVF
RIOTC: Reducing the Impact of Ovarian Stimulation. Novel Approaches to Luteal Support in IVF-Study 2
The goal of the randomised controlled study (RCT) is to identify novel strategies that can improve the luteal phase endocrinology after ovarian stimulation, with the aim of using less or no luteal support in IVF while making the…
- Trial name
- RIOTC (NCT04524026)
- Testing
- Letrozole 5 mg
- Where
- 2 sites in Denmark
- Volunteers
- 25 people
- Sponsor
- Nicholas Macklon
Polycystic Ovary Syndrome
L-carnitine and COH in PCOS Women Undergoing IVF/ICSI Cycles
The aim of this study was to evaluate the effect of oral L-carnitine supplementation during controlled ovarian stimulation (COS) in patients with polycystic ovary syndrome (PCOS) in a double-blind randomized clinical trial.
- Trial name
- NCT04672720
- Testing
- L-carnitine 1000 Mg
- Where
- Iran
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Royan Institute
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