Clinical trials: Idiopathic Hypogonadotropic Hypogonadism
Kallmann Syndrome, Congenital Hypogonadotropic Hypogonadism
Health Needs of Patients With Kallmann Syndrome
Kallmann syndrome (KS), also known as congenital hypogonadotropic hypogonadism (CHH), is a rare endocrine disorder that is characterized by failure to undergo puberty combined with infertility.
- Conditions
- Kallmann Syndrome, Congenital Hypogonadotropic Hypogonadism, Idiopathic Hypogonadotropic Hypogonadism
- Trial name
- NCT01914172
- Testing
- online questionairres
- Where
- Switzerland
- Volunteers
- 249 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Amenorrhea, Hypogonadotropic Hypogonadism
Baselines in Reproductive Disorders
The purpose of the study is to explore the way in which gonadotropins (pituitary hormones) are released into the body. The knowledge acquired in this study will be used for the diagnosis and treatment of reproductive endocrine…
- Conditions
- Amenorrhea, Hypogonadotropic Hypogonadism, Kallmann's Syndrome
- Trial name
- NCT00456274
- Testing
- Frequent baseline blood sampling
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- Massachusetts General Hospital
Hypogonadotropic Hypogonadism, Kallmann Syndrome
Effect of Varying Testosterone Levels on Insulin Sensitivity in Men With Idiopathic Hypogonadotropic Hypogonadism (IHH)
The investigators are doing this research study to look at the relationship between testosterone (the main sex hormone in men) and insulin (the hormone that controls blood sugar levels) in men with Idiopathic Hypogonadotropic…
- Trial name
- NCT03118479
- Testing
- Anastrozole Pill, Testosterone
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Massachusetts General Hospital
Idiopathic Hypogonadotropic Hypogonadism
Effects of Gonadotropin Replacement Therapy on Metabolic Parameters in Patients With Hypogonadism
Effects of gonadotrophin replacement therapy Lipid Profile and Oxidative Stress Parameters of Patients with Idiopathic Hypogonadotropic Hypogonadism
- Trial name
- NCT02728440
- Testing
- human chorionic gonadotropin, human menopausal gonadotropin
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Gulhane School of Medicine
Type 2 Diabetes Mellitus, Secondary Hypogonadism
Study to Evaluate the Efficacy of Androxal in Controlling Blood Glucose in Men With Type-2 Diabetes Mellitus
The purpose of this study is to determine the effect the investigative drug has on glycemic control in men with type 2 diabetes mellitus (T2DM) and secondary hypogonadism
- Trial name
- NCT01191320
- Testing
- Androxal
- Where
- 18 sites in United States
- Volunteers
- 102 people
- Sponsor
- Repros Therapeutics Inc.
Secondary Hypogonadism
To Evaluate Sperm Parameters in Men With Secondary Hypogonadism Previously Treated With Topical Testosterone
The study was designed to determine if Androxal® would affect sperm parameters (count, concentration, volume) in men with secondary hypogonadism who have been previously treated with topical testosterone.
- Trial name
- NCT00706719
- Testing
- 25 mg Androxal, Testim 1%
- Where
- 2 sites in United States
- Volunteers
- 17 people
- Sponsor
- Repros Therapeutics Inc.
Kallmann Syndrome, Hypogonadism
Investigating the Regulation of Reproductive Hormones in Adult Men
The purpose of the research study is to learn more about the regulation of reproductive hormones in adult men. We would like to understand what role testosterone and estradiol play in controlling the release of LH (lutenizing…
- Conditions
- Kallmann Syndrome, Hypogonadism, Gonadal Disorder
- Trial name
- NCT00392457
- Testing
- ketoconazole, gonadotropin releasing hormone (GnRH)
- Where
- United States
- Volunteers
- 175 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Hypogonadotropic Hypogonadism
Kisspeptin Administration Subcutaneously to Patients With IHH
The goal of this study is to see whether kisspeptin, a naturally occurring hormone, can stimulate the release of other reproductive hormones in men and women with idiopathic hypogonadotropic hypogonadism (IHH).
- Trial name
- NCT05896293
- Testing
- kisspeptin 112-121, leuprolide acetate
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Stephanie B. Seminara, MD
Idiopathic Hypogonadotropic Hypogonadism
The Effects of Gonadotropin Replacement Therapy in Patients With Hypogonadism
Effects of hCG replacement therapy on metabolic syndrome parameters in hypogonadotrophic hypogonadism.
- Trial name
- NCT02042638
- Testing
- hCG 1500 IU three times a week, Pregnyl (hCG) ampule 1500 IU/three times a week
- Where
- Turkey (Türkiye)
- Volunteers
- 16 people
- Sponsor
- Gulhane School of Medicine
Idiopathic Hypogonadotropic Hypogonadism
Efficacy and Safety of Pulsatile Gonadotropin Releasing Hormone Pump Treatment in Patients With Idiopathic Hypogonadotropic Hypogonadism
Idiopathic hypogonadotropic hypogonadism (IHH) is the most common disorders of sex development (DSD).Therapy for IHH includes hormone replacement therapy, gonadotropin therapy and pulsed infusion of gonadotropin releasing hormone…
- Trial name
- NCT02310074
- Testing
- Pulsatile Gonadotropin Releasing Hormone, Human chorionic gonadotropin, Urinary Follicle-Stimulating Hormone
- Volunteers
- 76 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Idiopathic Hypogonadotropic Hypogonadism, Hypothalamic Amenorrhea
Detailed Clinical, Biochemical and Genetic Characterization in Gonadotropin-releasing Hormone (GnRH) Deficiency Disorders
In this study, we will measure levels of reproductive hormones and metabolic markers in subjects with isolated GnRH deficiency disorders and compare them to healthy control populations.
- Trial name
- NCT01165619
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Luteal Phase Deficiency, Luteal Phase Support
An Open Labeled RCT on the Effect of Additional hCG Injection for LPS on Pregnancy Outcomes in IHH Patients
Luteal phase deficiency (LPD) accounts for most failures of assistant artificial reproduction (ART) and early pregnancy loss for patients with idiopathic hypogonadotropic hypogonadism (IHH).
- Conditions
- Luteal Phase Deficiency, Luteal Phase Support, Idiopathic Hypogonadotropic Hypogonadism
- Trial name
- LPS-IHH (NCT05569577)
- Testing
- Additional hCG injection, estrogen and dydrogesterone
- Where
- 2 sites in China
- Volunteers
- 46 people
- Sponsor
- Fudan University
Kallmann Syndrome, Hypogonadotropic Hypogonadism
Examination of Idiopathic Hypogonadotropic Hypogonadism (IHH)and Kallmann Syndrome (KS)
The purpose of the study is to examine how Kallmann syndrome (KS) and idiopathic hypogonadotropic hypogonadism (IHH) affect reproductive hormones.
- Conditions
- Kallmann Syndrome, Hypogonadotropic Hypogonadism, GnRH Deficiency
- Trial name
- NCT00392756
- Testing
- gonadotropin releasing hormone (GnRH)
- Where
- United States
- Volunteers
- 624 people
- Sponsor
- Massachusetts General Hospital
Rare Disorders, Undiagnosed Disorders
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
The Coordination of Rare Diseases at Sanford (CoRDS) is an international patient registry that serves as a centralized resource for rare disease research.
- Conditions
- Rare Disorders, Undiagnosed Disorders, Disorders of Unknown Prevalence, Cornelia De Lange Syndrome
- Trial name
- CoRDS (NCT01793168)
- Where
- United States
- Volunteers
- 20,000 people
- Sponsor
- Sanford Health
Kallmann Syndrome, Idiopathic Hypogonadotropic Hypogonadism
Studying the Effects of 7 Days of Gonadotropin Releasing Hormone (GnRH) Treatment in Men With Hypogonadism
Men with Idiopathic Hypogonadotropic Hypogonadism (IHH) lack a hormone called gonadotropin releasing hormone (GnRH). This hormone is important for starting puberty, maintaining testosterone levels, and fertility.
- Conditions
- Kallmann Syndrome, Idiopathic Hypogonadotropic Hypogonadism, GnRH Deficiency
- Trial name
- NCT00493961
- Testing
- gonadotropin releasing hormone (GnRH)
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Massachusetts General Hospital
Idiopathic Hypogonadotropic Hypogonadism
Plasma RBP Levels in Patients With Idiopathic Hypogonadotrophic Hypogonadism
The aim of the present study was to demonstrate the RBP4 levels, association of RBP4 with insulin resistance and influence of testosterone treatment on this cytokine in patients with idiopathic hypogonadotropic hypogonadism.
- Trial name
- NCT01758094
- Testing
- Sustanon 250 mg ampule (Testosterone esters)
- Where
- Turkey (Türkiye)
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Gulhane School of Medicine
Idiopathic Hypogonadotropic Hypogonadism
To Evaluate Recombinant Human Follicle Stimulating Hormone-CTP Fusion Protein Injection or Placebo Combined With Chorionic Gonadotropin for Injection
This study was conducted to evaluate recombinant human follicle stimulating hormone-CTP fusion protein injection or placebo combined with chorionic gonadotropin for injection
- Trial name
- NCT06561594
- Testing
- recombinant human follicle-stimulating hormone-CTP Fusion protein injection
- Where
- 17 sites in China
- Volunteers
- 60 people
- Sponsor
- Changchun GeneScience Pharmaceutical Co., Ltd.
Idiopathic Hypogonadotropic Hypogonadism
Effects of Medications in Patients With Hypogonadism
The aim of the present study was to demonstrate the influences of three different treatment strategies on biochemical parameters and testicular volume (TV) in patients with idiopathic hypogonadotropic hypogonadism (IHH).
- Trial name
- NCT01601327
- Testing
- Testosterone enanthate (Sustanon 250 mg), Human chorionic gonadotropin (hCG) (Pregnyl 5000 IU), Testosteron gel (Testojel 50 mg)
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 119 people, healthy volunteers welcome
- Sponsor
- Gulhane School of Medicine
Hypogonadotropic Hypogonadism, Kallmann Syndrome
Investigation of the Genetic Causes of Kallmann Syndrome and Reproductive Disorders
The aims of this study are: 1) to identify genes that play a role in human pubertal development and reproduction, 2) to characterize the phenotypic spectrum of patients with these gene defects, and 3) to discern the mode of…
- Conditions
- Hypogonadotropic Hypogonadism, Kallmann Syndrome, Puberty, Delayed, Puberty, Precocious
- Trial name
- NCT00494169
- Where
- United States
- Volunteers
- 4,042 people
- Sponsor
- Massachusetts General Hospital