Clinical trials: Illness, Critical
Sepsis, Critical Illness
Metabolic and Functional Study of γδ T Cells in Critically Ill Patients
This prospective observational cohort study investigates the subset-specific metabolic adaptation and functional remodeling of cytotoxic γδ T cells in critically ill patients with and without sepsis.
- Conditions
- Sepsis, Critical Illness, Immunosuppression, MODS
- Trial name
- NCT07680816
- Where
- China
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Delirium in the Intensive Care Unit, Sleep Quality in Adult ICU Patients
Virtual Reality to Reduce Anxiety, Agitation and Delirium in Critically Ill Patients
This is a pilot feasibility study examining the use of immersive virtual reality (VR) in adult intensive care unit (ICU) patients.
- Conditions
- Delirium in the Intensive Care Unit, Sleep Quality in Adult ICU Patients, Agitation Associated With Critical Illness, Anxiety Acute
- Trial name
- NCT07649876
- Testing
- Virtual reality (VR) therapy
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
ARDS
NMR Based Metabolomics Kinetics in ARDS Patients
Acute respiratory distress syndrome (ARDS) is a life-threatening condition requiring respiratory support to maintain oxygenation.
- Trial name
- NCT06036056
- Where
- India
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Sanjay Gandhi Postgraduate Institute of Medical Sciences
Critical Illness
ICU Fluid Utilization Survey in Southeast Asia
The objective of this study is to examine the use of different types of fluids for resuscitation in different phases of fluid management in 3 types of critically ill patients including (1) not bleeding, not septic but need volume…
- Trial name
- Fluid-SEA (NCT06034990)
- Testing
- 10-min online survey
- Where
- Thailand
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Chulalongkorn University
Delirium, Critical Illness
Light and Noise: Objectively Assessing Environmental Risk Factors for Delirium in the ICU
Recognition of delirium as a medical entity with relevance to both morbidity and mortality, especially in critically ill patients, is a relatively recent development.
- Trial name
- LANYARD-ICU (NCT06294158)
- Testing
- Brightness measurement, Sound level measurement
- Where
- Austria
- Volunteers
- 315 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Medical Education, Endocrine System Diseases
Integrated PBL-CBL-CTTM Teaching to Enhance Clinical Self-Efficacy in Endocrine Critical Illness Among Internal Medicine Residents: An RCT
This randomized controlled trial evaluates whether an integrated online-offline multimodal teaching approach combining Problem-Based Learning (PBL), Case-Based Learning (CBL), and Case Three-Dimensional Teaching Method (CTTM)…
- Conditions
- Medical Education, Endocrine System Diseases, Critical Illness
- Trial name
- PBL-CBL-CTTM (NCT07801170)
- Testing
- Lecture-based learning (LBL), PBL plus LBL, Integrated PBL-CBL-CTTM
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Chaohu Hospital of Anhui Medical University
Critical Illness, Fasting State
Ketosis, Immune Function and Metabolic Adaptation in Response to Short-term Fasting in Critical Illness
KETO-FAST is a pre-planned translational substudy of the FAST-ICU cluster-randomized cross-over trial. The substudy will characterize ketone body production and associated metabolic, autophagy-related, and immune cellular…
- Conditions
- Critical Illness, Fasting State, Ketosis, Nutrition
- Trial name
- KETO-FAST (NCT07738536)
- Testing
- Delayed nutrition, Standard nutrition, Fasting
- Where
- Sweden
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Karolinska University Hospital
Critical Illness, Gender Equality
Ethnic and Gender Based Admittance Patterns in the ICU
The dominating proportion of patients in the ICU are men. Studies indicate that men receive more mechanical ventilation, vasoactive drugs, renal replacement therapy, invasive monitoring and have longer length of stay in the ICU.
- Conditions
- Critical Illness, Gender Equality, Discrimination, Sex, Discrimination, Racial
- Trial name
- EGAP-ICU (NCT05513456)
- Testing
- Randomization to a different factors in the case descriptions
- Where
- Sweden
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Critical Illness, Metabolism and Nutrition Disorder
Endogenous Energy Production in Critically Ill Patients
The aim of this study is to investigate when critically ill patients transition from a non-suppressible catabolism to a normal response to feeding.
- Trial name
- eEPIC (NCT07059988)
- Testing
- Stable isotope tracers, Parenteral nutrition
- Where
- Sweden
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Karolinska University Hospital
Critical Illness
Lactoferrin Use in ICU Patients
Introduction: Lactoferrin has several uses due to its effects. It has anti-inflammatory, antioxidant, immunomodulatory, antibacterial, antifungal, and antiviral effects. Its safety is proven by food and drug administration.
- Trial name
- RCT (NCT05936528)
- Testing
- Lactoferrin, Antioxidant therapies, Dexamethasone
- Where
- Egypt
- Volunteers
- 660 people, healthy volunteers welcome
- Sponsor
- Mansoura University Hospital
Respiratory Failure, Anxiety
Improving Psychological Outcomes for Acute Respiratory Failure Survivors Using a Self-Management Intervention
A growing number of patients are surviving a stay in the intensive care unit (ICU) but may experience long-lasting psychological problems, but research evaluating such treatment for ICU patients is scant.
- Conditions
- Respiratory Failure, Anxiety, Critical Illness
- Trial name
- SMARA (NCT06341972)
- Testing
- Cognitive behavioral therapy based self-management for anxiety
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Critically Ill, Extubation
Does Tracheal Suction During Extubation in Intensive Care Unit Decrease Functional Residual Capacity
Little is known about the procedure of extubation of patients admitted in Intensive Care Units (ICU). In particular, effects of tracheal suction during extubation have never been evaluated.
- Conditions
- Critically Ill, Extubation, Intensive Care Unit
- Trial name
- NCT03681626
- Testing
- no tracheal suction, tracheal suction
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital, Rouen
Severe Sepsis
Zinc Therapy in Critical Illness
Sepsis is a clinical syndrome often caused by a bloodstream infection that results in a common set of symptoms termed systemic inflammatory response syndrome (SIRS).
- Trial name
- NCT01162109
- Testing
- Zinc sulfate
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of Vermont
Extracorporeal Membrane Oxygenation Complication, ARDS (Acute Respiratory Distress Syndrome)
RECOMMEND Platform Trial
The goal of this platform trial is to determine the efficacy, safety and cost-effectiveness of various interventions in patients with acute cardiorespiratory failure requiring extracorporeal membrane oxygenation (ECMO) The main…
- Conditions
- Extracorporeal Membrane Oxygenation Complication, ARDS (Acute Respiratory Distress Syndrome), Intensive Care Medicine, Cardiac Arrest (CA)
- Trial name
- RECOMMEND (NCT06526533)
- Testing
- Liberal RBC Transfusion, Restrictive RBC Transfusion
- Where
- 3 sites in Australia
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Critical Illness
Multi-component Family Support Tool Intervention (FST)
The National Academy of Medicine and the National Institutes of Health have called for urgent action to improve the care delivered to the nearly 1,000,000 older Americans who die in intensive care units (ICUs) annually or survive…
- Trial name
- FST (NCT05019261)
- Testing
- Multi-component Family Support Intervention
- Where
- 7 sites in United States
- Volunteers
- 1,039 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Fibrinolytic Defect, Sepsis
Point of Care Evaluation of Fibrinolysis in Sepsis
Impaired fibrinolysis in septic patients is associated with worse outcome. The present study investigates fibrinolysis shutdown in septic patients, defined as prolonged ClotPro® TPA lysis time at 30 minutes.
- Conditions
- Fibrinolytic Defect, Sepsis, Critical Illness
- Trial name
- POCEFIS (NCT06312488)
- Testing
- Clot Pro
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Policlinico Hospital
Pre-Eclampsia, Critical Illness
Homocysteine in Critically Ill Preeclampsia
Preeclampsia is a disorder characterized by the new onset of hypertension and proteinuria typically presenting after 20 weeks of gestation.
- Trial name
- NCT06413576
- Testing
- homocysteine measurement
- Where
- 2 sites in Egypt
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Systemic Inflammatory Response Syndrome (SIRS)
Myostatin and Irisin Levels in Predicting the Outcome of Patients With Systemic Inflammation: A Prospective Observational Study
Systemic inflammatory response syndrome (SIRS) is associated with severe metabolic stress that can lead to rapid breakdown of skeletal muscle and the development of stress-related malnutrition.
- Trial name
- NCT07476391
- Where
- Czechia
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Charles University, Czech Republic
Critically Ill, Ventilation Therapy; Complications
Consensus Statements on Airway Clearance Interventions in Intubated Critically Ill Patients--Protocol for a Delphi Study
Intubated critically ill patients are susceptible to secretion accumulation because of compromised airway clearance. Various airway clearance interventions are employed to prevent complication(s) arising from mucus retention.
- Conditions
- Critically Ill, Ventilation Therapy; Complications, Mucus Retention, Airway Clearance Impairment
- Trial name
- ACCorDingly (NCT06649734)
- Testing
- Delphi Study
- Where
- Netherlands
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Critical Illness, Healthy
Assessment of the Repeatability of Sublingual Microcirculation Function Measurements in Healthy Volunteers and Critically Ill Patients
The assessment of microcirculatory function plays a pivotal role in perioperative medicine and intensive care. One promising method for evaluating microcirculatory function is the microscopic analysis of the oral mucosal…
- Trial name
- NCT07397208
- Where
- Poland
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Medical University of Gdansk