Clinical trials: Illness, Critical
Critical Illness, Sepsis
Point-of-Care AI Assistance and Critical Care Outcomes: A Randomized Trial
This is a prospective, unmasked, randomized, multicenter clinical trial evaluating the impact of point-of-care large language model (LLM)-based decision support on diagnostic accuracy and clinical outcomes in adult medical…
- Conditions
- Critical Illness, Sepsis, Acute Respiratory Failure (ARF), Multi-organ Failure
- Trial name
- POC-AI-ICU (NCT07293078)
- Testing
- Point-of-care large language model decision support (ChatGPT-5)
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- MetroWest Artificial Intelligence Research Workgroup
Critically Ill
INTENT-Muscle (A Sub-study of INTENT)
The currently recruiting randomised controlled trial "Intensive Nutrition Therapy Compared to Usual Care in Critically Ill Adults" (INTENT, NCT03292237) is the first multi-centre trial to compare an intensive, individualised…
- Trial name
- NCT04896515
- Testing
- Supplemental parenteral nutrition
- Where
- 6 sites in Australia, New Zealand
- Volunteers
- 21 people
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Delirium, Cognitive Impairment
Illuminating Neuropsychological Dysfunction and Systemic Inflammatory Mechanisms Gleaned After Hospitalization in Trauma-ICU Study
Cognitive skills are essential to live independently, manage finances, maintain employment, and function in society. Loss of these cognitive skills puts a tremendous burden on society as seen with dementias, Alzheimer's disease…
- Conditions
- Delirium, Cognitive Impairment, Alzheimer; Early Onset, Trauma
- Trial name
- INSIGHT-ICU (NCT03098459)
- Testing
- Non-interventional observational prospective cohort study
- Where
- United States
- Volunteers
- 432 people
- Sponsor
- Vanderbilt University Medical Center
Critically Ill
POC Analysis of IO Blood Samples Within Critically Ill Patients
This study aims to investigate whether point-of-care (POC) analysis of intraosseous (IO) blood samples from critically ill emergency patients are accurate enough for emergency decision making, in comparison with arterial…
- Trial name
- NCT03746496
- Testing
- point-of-care laboratory analysis
- Where
- Finland
- Volunteers
- 35 people
- Sponsor
- Helsinki University Central Hospital
Critical Illness
Early Passive Verticalization in Critically Ill Patients
In the critically patient bed rest and inmovilization are some of the responsable of the development of respiratory complications.
- Trial name
- TILT (NCT02270762)
- Testing
- Rest in bed, Passive verticalization
- Where
- Belgium
- Volunteers
- 10 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Weaning Failure
Negative Pressure Ventilation in Paediatric Patients During Weaning
Negative pressure ventilation (NPV) represent a unique form of noninvasive ventilation using negative pressure by specialized cuirass, that evolve negative pressure on the front size of chest and partially abdomen and facilitate…
- Trial name
- NEGWEAN (NCT05035290)
- Testing
- Negative pressure ventilation
- Where
- Czechia
- Volunteers
- 200 people
- Sponsor
- Brno University Hospital
Pressure Sores, Intensive Care
The Effect of Antioxidants on the Immune Response and Wound Healing in Critically Ill Patients
The purpose of this study is to investigate whether the addition of omega-3 and antioxidants to nutritional support in critically ill patients in the intensive care unit influences the immune and anti-inflammatory systems and so…
- Trial name
- NCT00487097
- Testing
- Eicosapentanoic acid, docosahexaenoic acid
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Rabin Medical Center
Food Intake, Critically Ill Patients
Optimization of Oral Diet in Critically Ill Patients
The purpose of the present study is to evaluate the effects of a personalized oral diet in the critically ill patients during ICU stay and after as compared usual oral diet.
- Conditions
- Food Intake, Critically Ill Patients, Nutrition
- Trial name
- NAP-REA (NCT03354260)
- Testing
- Personalized adapted oral diet and nutritional education
- Where
- France
- Volunteers
- 10 people
- Sponsor
- University Hospital, Montpellier
HIV Infection
Early Antiviral Therapy for Critically Ill HIV Infected Patients
The aim of the study is to verify the effect of HAART in critically ill HIV infected patients. The current practice is to begin antiviral therapy after ICU discharge, when the condition of the patient is more stable.
- Trial name
- NCT01455688
- Testing
- early HAART, Late HAART
- Where
- Brazil
- Volunteers
- 115 people
- Sponsor
- Hospital Nossa Senhora da Conceicao
Critically Ill Intensive Care Unit Patients, Physician-Family Communication in Intensive Care Units
The Four Supports Study: Family Support Intervention in Intensive Care Units
The purpose of this study is to test the effectiveness of a multi-faceted communication intervention for family members of critically ill patients to reduce the family members' long-term symptoms of depression and anxiety.
- Conditions
- Critically Ill Intensive Care Unit Patients, Physician-Family Communication in Intensive Care Units, Surrogate Decision-making for Critically Ill Patients
- Trial name
- NCT01982877
- Testing
- Four Supports Intervention, Educational Control Intervention
- Where
- United States
- Volunteers
- 546 people
- Sponsor
- University of Pittsburgh
Thrombosis, Pulmonary Embolism
Association of Anti-factor Xa Activity With Venous Thromboembolism in Critically Ill Patients
The goal of this observational study is to analyse the association between anti-factor Xa activity (antiXa) and the occurence of venous thromboembolism (VTE; either deep vein thrombosis and/or pulmonary embolism) in critically…
- Conditions
- Thrombosis, Pulmonary Embolism, Enoxaparin
- Trial name
- AntiXa-ICU (NCT06357403)
- Testing
- Anti-factor Xa activity calibrated for enoxaparin
- Where
- 3 sites in Austria
- Volunteers
- 1,300 people
- Sponsor
- Medical University of Vienna
Premature Birth of Newborn, Critically Ill
The Use of Methadone in Newborn Infants
This proposed investigation will test the following hypotheses: 1) Enzymatic activity of CYP2B6 characterized by the formation clearance of methadone to EDDP (CLf,EDDP), is directly related to both gestational and postnatal age…
- Trial name
- Methadone (NCT01327079)
- Testing
- Methadone
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- John van den Anker
SARS Virus
Prevalence and Risk Factors for Venous Thromboembolic Events in Critically Ill Patients With COVID-19
The purpose of the study is to assess the frequency of the occurrence of a venous thrombosis in patients with the new Coronavirus disease, who are admitted to the Intensive Care Unit for impending respiratory failure requiring…
- Trial name
- NCT04567927
- Testing
- Ultrasonography
- Where
- Switzerland
- Volunteers
- 80 people
- Sponsor
- Chiesa Alessandro Felice
Nutritional Therapy in an ICU, Critically Ill Patients Requiring Mechanical Ventilation
Will the Use of Respiratory Quotient ''RQ'' Improve Treatment Outcomes for Intensive Care Unit (ICU) Patients?
Introduction and assumptions of the research project: Patients treated in intensive care units (ICUs) require comprehensive treatment. Nutrition is an important and integral part of this therapy.
- Trial name
- RQCal (NCT07457554)
- Testing
- RQ guided nutrition, Standard Treatment (Guideline-Based)
- Where
- Poland
- Volunteers
- 236 people
- Sponsor
- Poznan University of Medical Sciences
Postoperative Complications, Critical Illness
IL-6 and Hemogram-Derived Inflammatory Indices for Mortality Prediction in Postoperative ICU Patients
This prospective observational cohort study aims to evaluate the predictive value of interleukin-6 (IL-6) levels and hemogram-derived inflammatory scores for morbidity and in-hospital mortality in postoperative patients admitted…
- Conditions
- Postoperative Complications, Critical Illness, Inflammation, Intensive Care Unit Admission
- Trial name
- NCT07460141
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people
- Sponsor
- Ezgi Günaydın
Stevens-Johnson Syndrome Toxic Epidermal Necrolysis Spectrum
Nutritional and Metabolic Management of Toxidermia Patients Requiring Intensive Care (TEN Metabolism)
Retrospective observational cohort study including all patients admitted for toxidermia (Lyell syndrome, Stevens-Johnson Syndrome (SJS), or other extensive skin destruction) to the Burn unit of the adult ICU of the Lausanne burn…
- Trial name
- TEN metabolism (NCT05320653)
- Testing
- Medical nutrition
- Volunteers
- 35 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Sepsis, Heart Failure
Mean Systemic Filling Pressure Continuous Diuretics Critical Care Patients
Within clinical settings observation of hemodynamic changes (e.g. mean systemic filling pressure, cardiac output) in critically ill patients with a clinical indication for deresuscitation with intravenous diuretic therapy.
- Conditions
- Sepsis, Heart Failure, Heart Diseases, Septic Shock
- Trial name
- NCT03395951
- Testing
- Diuretics
- Where
- Netherlands
- Volunteers
- 18 people
- Sponsor
- Catharina Ziekenhuis Eindhoven
Critical Illness, Acute Kidney Injury
Continuous Renal Replacement Therapy Circuit Lifespan in Intensive Care Patients
The goal of this retrospective observational study is to evaluate how long continuous renal replacement therapy (CRRT) circuits remain in use in adult intensive care unit patients and to describe how CRRT pressure measurements…
- Trial name
- NCT07842562
- Testing
- Archived CRRT Device Log Data
- Where
- Turkey (Türkiye)
- Volunteers
- 162 people
- Sponsor
- Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
Critical Illness, ICU-acquired Weakness
Beyond Voluntary Effort: Reliability and Validity of Magnetic Femoral Nerve Stimulation for Assessing Quadriceps Strength in Critically Ill Patient
Intensive care unit-acquired weakness (ICU-AW) is a common complication of critical illness and can negatively affect recovery and long-term physical functioning.
- Trial name
- TWITCH FORCE (NCT07891273)
- Testing
- Magnetic Femoral Nerve Stimulation
- Volunteers
- 33 people
- Sponsor
- Daniel Langer
Orotracheal Intubation
AI-Integrated 3D-Printed Videolaryngoscope for Orotracheal Intubation in Critically Ill Patients
Background: Orotracheal intubation is an essential procedure in critically ill patients requiring ventilatory support, and the use of videolaryngoscopy is recommended as the gold standard in clinical practice.
- Trial name
- VL-AI (NCT07592702)
- Testing
- Orotracheal intubation using a 3D videolaryngoscope integrated with artificial intelligence (VL-IA)., Commercially available gold-standard videolaryngoscope (VL-C)
- Where
- 4 sites in Brazil
- Volunteers
- 120 people
- Sponsor
- Federal University of Pelotas
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