Clinical trials: Illness, Critical
Gram-Positive Bacterial Infections
Daptomycin Pharmacokinetics in Critically Ill Patients Undergoing Continuous Veno-venous Hemodiafiltration, a Dose Finding Study
Daptomycin kinetics in CRRT Trial with medicinal product
- Trial name
- NCT01212432
- Testing
- Daptomycin
- Where
- Switzerland
- Volunteers
- 15 people
- Sponsor
- University of Zurich
Critical Illness and Mechanical Ventilation
Early Goal-Directed Sedation Compared With Standard Care in Mechanically Ventilated Critically Ill Patients
The Use of sedative drugs in intensive care is widespread. A cohort study conducted in Australia and New Zealand in 2010 revealed a high prevalence of deep sedation within the first 48 hours of mechanical ventilation which was…
- Trial name
- SPICE III RCT (NCT01728558)
- Testing
- Early goal Directed Sedation, Standard care sedation
- Where
- 74 sites in Australia, Ireland and 6 more
- Volunteers
- 4,000 people
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Critically Ill
Continuous Temperature Measurement by Thermal Imaging Camera
This study explores the significance of body temperature monitoring in hospitalized patients, particularly in critical care environments.
- Trial name
- TermoCamUCI (NCT06256978)
- Volunteers
- 224 people
- Sponsor
- Universidad Europea de Madrid
Critical Illness
Optimization Dose Study on Pharmacokinetics and Pharmacodynamics of Colistin in Critically Ill Patients
Phase II clinical trial, open-labelled, prospective and single-center study directed to obtain blood samples in experimental detailed conditions in order to compare and optimize the dose of colistin in critically ill patients…
- Trial name
- COLPHAR (NCT02408185)
- Testing
- Colistin 6 million units + 240mg/8h, Colistin 6 million units + 360mg/12h
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Infection, Sepsis
A Study to Compare the Efficacy and Safety of Extended and Intermittent Infusion of Beta-lactams in Critically Ill Paediatric Patients
The goal of this clinical trial is to examine the success and safety of administering certain antibiotics (beta-lactams) given in a longer 3-hour infusion to children (0-17 years) who are critically ill and have severe infection.
- Conditions
- Infection, Sepsis, NICU, PICU
- Trial name
- PEBBLE (NCT07484633)
- Testing
- Extended infusion time of the following beta-lactam: meropenem, Short-term infusion time of the following beta-lactam: meropenem, Extended infusion time of the following beta-lactam: piperacillin/tazobactam
- Where
- 2 sites in Hungary
- Volunteers
- 110 people
- Sponsor
- Semmelweis University
AKI - Acute Kidney Injury
The Relationship Between Measured Creatinine Clearance and Acute Kidney Injury in Critically Ill Patients
With this study, the investigators want to find out how well different stages of acute kidney injury (AKI), match with the actual filtering ability of the kidneys in very sick adults in the intensive care unit (ICU).
- Trial name
- NCT07624721
- Where
- Belgium
- Volunteers
- 1,416 people
- Sponsor
- University Hospital, Ghent
Acute Respiratory Distress Syndrome, Vitamin D Deficiency
Vitamin D to Improve Outcomes by Leveraging Early Treatment
Vitamin D deficiency is a common, potentially reversible contributor to morbidity and mortality among critically ill patients. We conducted a randomized, double-blind, placebo-controlled, phase 3 trial of early vitamin D3…
- Conditions
- Acute Respiratory Distress Syndrome, Vitamin D Deficiency, Critical Illness
- Trial name
- VIOLET (NCT03096314)
- Testing
- Vitamin D3
- Where
- 47 sites in United States
- Volunteers
- 1,358 people
- Sponsor
- Massachusetts General Hospital
Critically Ill
Diaphragmatic Function in Ventilated Patients
Animal studies showed that controlled mechanical ventilation (CMV) can induce dysfunction of the diaphragm, resulting in an early-onset and progressive decrease in diaphragmatic force-generating capacity, called…
- Trial name
- NCT00786526
- Where
- 2 sites in France
- Volunteers
- 55 people
- Sponsor
- University Hospital, Montpellier
Pneumonia
Pulmonary-Specific Enteral Nutrition in Mechanically Ventilated Patients With Pneumonia
Pneumonia is a major cause of critical illness and respiratory failure, particularly among patients requiring invasive mechanical ventilation.
- Trial name
- NCT07892521
- Testing
- Pulmonary-Specific Enteral Nutrition, Standard Hospital Enteral Nutrition
- Where
- Indonesia
- Volunteers
- 56 people
- Sponsor
- Universitas Indonesia
Acute Kidney Failure
Effect of Citrate on the Coagulation System in Patients Receiving CRRT
The aim of this study is to evaluate the effect of regional citrate anti-coagulation on different pathways of the coagulation system in critically ill patients with acute kidney injury.
- Trial name
- Citroco (NCT02486614)
- Testing
- CRRT
- Where
- United Kingdom
- Volunteers
- 22 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Shock, Critical Illness
Enteral Versus Parenteral Nutrition During Recovery After Shock
This study compares enteral nutrition and parenteral nutrition in critically ill adult patients recovering from shock while receiving decreasing doses of vasopressors in the intensive care unit.
- Conditions
- Shock, Critical Illness, Nutritional Support, Vasopressor Therapy
- Trial name
- NCT07411014
- Testing
- enteral nutrition, Parenteral Nutrition
- Where
- South Korea
- Volunteers
- 1,150 people
- Sponsor
- Samsung Medical Center
Hemodynamic Instability
Hemodynamic Optimalization in Pediatric Patients
Hemodynamic unstability, defined by macrocirculation and/or microcirculation dysfunction or alteration is common in critically ill pediatric patients.
- Trial name
- HOPED (NCT04227821)
- Testing
- Vasopressor and/inotrope therapy
- Where
- Czechia
- Volunteers
- 100 people
- Sponsor
- Brno University Hospital
Gastrointestinal Disease, Constipation
Gastrointestinal Dysfunction During Enteral Nutrition in Critically Ill Patients
Gastrointestinal (GI) motility disorders in intensive care patients remain relatively unexplored. Nowadays, the frequency, risk factors and complications of GI dysfunction during enteral nutrition (EN) become more questionable.
- Conditions
- Gastrointestinal Disease, Constipation, Intolerance; Nutritional, Diarrhea
- Trial name
- NCT04014816
- Testing
- MDR bacteria positivity, negative fluid balance
- Volunteers
- 137 people
- Sponsor
- Ayancık State Hospital
Pneumonia, Ventilator-Associated
Tobramycin Nebulization to Prevent Multidrug-Resistant Ventilator-Associated Pneumonia
The TOP-MDRVAP trial will test whether inhaled tobramycin can safely prevent pneumonia caused by multidrug-resistant bacteria in adults who need a breathing machine. Tobramycin is an antibiotic.
- Trial name
- TOP-MDRVAP (NCT07856355)
- Testing
- Tobramycin inhalation solution
- Where
- China
- Volunteers
- 574 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Acute Kidney Injury KDIGO 3, Continuous Renal Replacement Therapy Initiated by the Clinician in Charge Without Emergency
Is Myocardial Stunning Induced by Continuous Renal Replacement Therapy a Reality in Critically Ill Patients?
Myocardial stunning during chronic intermittent hemodialysis is a well-described phenomenon. Little case series of patients presenting myocardial stunning during renal replacement therapy for acute kidney injury in critically ill…
- Conditions
- Acute Kidney Injury KDIGO 3, Continuous Renal Replacement Therapy Initiated by the Clinician in Charge Without Emergency, Myocardial Stunning
- Trial name
- MS-CRRT (NCT05209230)
- Testing
- Continuous renal replacement therapy, Control group
- Where
- 3 sites in France
- Volunteers
- 42 people
- Sponsor
- Hospices Civils de Lyon
Fluid Shifts, Critical Care
Effects of Fluid Balance Control in Critically Ill Patients
Most ICU patients develop a positive fluid balance, mainly during the two first weeks of their stay. The causes are multifactorial: a reduced urine output subsequent to shock state, positive pressure mechanical ventilation, acute…
- Trial name
- POINCARE (NCT02765009)
- Testing
- diuretics, albumin, fluid restriction
- Where
- 11 sites in France
- Volunteers
- 1,411 people
- Sponsor
- Central Hospital, Nancy, France
Sepsis, Septic Shock
Comparing Blood-Based Ratios for Predicting Outcomes in Sepsis and Septic Shock
Sepsis and septic shock are serious conditions associated with a high risk of organ dysfunction and death. Simple laboratory-based markers may help identify critically ill patients who are at greater risk of poor outcomes.
- Trial name
- NCT07819708
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Benha University
Pharmacokinetics
Cefiderocol Plasma Concentrations in Patients Receiving Renal Replacement Therapy
Continuous renal replacement therapies (CRRT) such as continuous venovenous hemofiltration are used to provide renal support for critically ill patients with acute kidney injury (AKI), particularly patients who are…
- Trial name
- NCT05373615
- Testing
- Cefiderocol
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Hartford Hospital
Brain Injuries, Stroke
Effects of Prolonged and Chronic Critical Illness Induced by Brain Injury on Metabolic State
Brain injuries, including acute stroke (AS) and traumatic brain injury (TBI), are prevalent pathologies with severe consequences.
- Conditions
- Brain Injuries, Stroke, Malnutrition, Critical Illness
- Trial name
- NCT06545825
- Testing
- Standard enteral nutrition
- Where
- Russia
- Volunteers
- 30 people
- Sponsor
- Federal Research and Clinical Centre of Intensive Care Medicine and Rehabilitology
Enteral Nutrition, COVID-19 Acute Respiratory Distress Syndrome
Early Versus Delayed Enteral Nutrition in Critically Ill Adults With COVID-19
The goal of this observational study is to determine the relationship between the nutritional profile of critically ill patients diagnosed with COVID-19 and disease severity, prognosis, and survival, to assess the ability to meet…
- Trial name
- NCT06134674
- Where
- Turkey (Türkiye)
- Volunteers
- 135 people
- Sponsor
- Ankara City Hospital Bilkent
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