Clinical trials: Imaging Guided
Non-enhancing Cerebral Gliomas
Intraoperative Sonographically Guided Resection of Non-enhancing Gliomas
The purpose of the study is to determine whether intraoperative ultrasound guided resection of glioma without contrast enhancement in magnetic resonance imaging can achieve higher extent of resection than surgery without…
- Trial name
- SONOGLIO (NCT05470374)
- Testing
- Intraoperative sonography
- Where
- Russia
- Volunteers
- 96 people
- Sponsor
- Sklifosovsky Institute of Emergency Care
Regional Anesthesia
ESP Volunteer LA Spread Controlled by MRI
Background and Objectives: The Thoracic Erector Spinae Plane Blockade (ESPB) is a regional anesthesia technique recently described by Forero M in November 2016 , whereby local anesthetic (LA) is injected in the inter Fascial…
- Trial name
- ESP-MRI (NCT03751358)
- Testing
- Unilateral Erector spinae plane block
- Where
- Vietnam
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Vinmec Healthcare System
Evaluate Requirements of 2% Prilocaine in MR-UF Prostate Biopsy
ED50 of Intratecal Prilocaine in Ultrasound Fusion Prostate Biopsy
The aim of the present study was to determine the ED50 and ED90 of intrathecal hyperbaric 2% prilocaine (HP) for patients undergoing ambulatory prostate biopsy via magnetic resonance imaging (MRI)/ultrasound fusion.
- Trial name
- NCT05649020
- Testing
- Dose of prilocaine
- Where
- 2 sites in Spain
- Volunteers
- 90 people
- Sponsor
- Hospital General Universitario Gregorio Marañon
Portal Hypertension
Non-Invasive Portal and Hepatic Vein Pressure Estimation
Background Portal hypertension (PH) is a spectrum of complications of end-stage liver disease (ESLD) and cirrhosis, with severe manifestations including ascites and gastroesophageal varices.
- Trial name
- NONEEDLES (NCT06210178)
- Testing
- Magnetic Resonance Imaging
- Where
- Netherlands
- Volunteers
- 50 people
- Sponsor
- Leiden University Medical Center
Complications; Catheter, Mechanical, Catheterization, Central Venous
Ultrasound-guided Subclavian Vein Catheterisation With a Needle Guide
OBJECTIVES The primary objective is to compare if the addition of a needle guide can reduce the number of central venous catheter (CVC) insertions with >1 skin puncture in ultrasound-guided catheterization of the subclavian vein…
- Trial name
- ELUSIVE (NCT05513378)
- Testing
- Needle guide
- Where
- Sweden
- Volunteers
- 300 people
- Sponsor
- Thomas Kander
Breast Cancer Early Stage Breast Cancer (Stage 1-3)
Cellular-Level Fluorescence Imaging for Intraoperative Margin Assessment in Breast Cancer
Accurate intraoperative margin assessment in breast cancer surgery remains challenging. Current reliance on frozen section pathology is limited by prolonged processing time, sampling constraints, and resource intensity…
- Trial name
- FLASH (NCT07311317)
- Where
- 3 sites in China
- Volunteers
- 165 people
- Sponsor
- West China Hospital
Prostatic Neoplasms
Functional MR-guided Stereotactic Body Radiation Therapy of Prostate Cancer
To improve radiation therapy of prostate cancer, the investigators must be able to accurately identify the tumour. By using advanced functional imaging techniques available on state-of-the-art MRI scanners to clearly show the…
- Trial name
- NCT01976962
- Testing
- Stereotactic body RT with MR-guided boost
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- CancerCare Manitoba
Ventilator-Induced Lung Injury, Sepsis Syndrome
CT for Personalized Mechanical Ventilation
The goal of this study is to compare two different ways of helping patients with a condition called sepsis who need help breathing using a machine called a ventilator.
- Conditions
- Ventilator-Induced Lung Injury, Sepsis Syndrome, Mechanical Ventilation Complication
- Trial name
- NCT05977153
- Testing
- PEEP (positive end-expiratory pressure) - maximum, PEEP (positive end-expiratory pressure) - standard
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Columbia University
Head and Neck Cancer
MR-Linac for Head and Neck SBRT
This study will evaluate the feasibility and safety of using MR-guided adaptive Head and Neck stereotactic radiotherapy (SBRT) at each fraction on the 1.5T MR-Linac.
- Trial name
- NCT04809792
- Testing
- SBRT on the MR-Linac
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Sunnybrook Health Sciences Centre
Imaging Guided Breast Biopsy
Improving Biopsy Experiences Study for Women
The goal of this study is to examine whether a guided meditation intervention will reduce anxiety and distress as compared to a music intervention or radiologist supportive dialogue in women undergoing imaging-guided core needle…
- Trial name
- IBEST (NCT01811043)
- Testing
- Guided Meditation, Music, Supportive Dialogue
- Where
- United States
- Volunteers
- 243 people
- Sponsor
- Duke University
Partial-edentulism
Reconstruction of Localized Alveolar Ridge Defects
The aim of the present prospective randomized controlled study is to compare the clinical, radiological, micro-circulation, and histology of a novel, semi-thick, and conventional full-thickness mucoperiosteal flap technique…
- Trial name
- NCT05538715
- Testing
- Split-thickness group, Full-thickness group
- Where
- Hungary
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Semmelweis University
Prostate Cancer, Magnetic Resonance Imaging
Detection of Clinically Significant Prostate Cancer Using Transperineal Targeted Biopsy Compared to Standard Transrectal Biopsy
Prostate biopsies are currently the gold standard for the diagnosis of prostate cancer. Many biopsies, however, are unnecessary or cannot detect significant prostate cancer (PCa).
- Conditions
- Prostate Cancer, Magnetic Resonance Imaging, Target Lesion, Fusion Biopsy
- Trial name
- NCT03044197
- Testing
- MRI/ultrasound transperineal prostate biopsy, transrectal ultrasound-guided prostate biopsy
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Arrhythmias, Cardiac
Ablation Guided Via Precision Imaging Using Electromechanical Wave Imaging
Atrial and ventricular cardiac arrhythmias are serious public health problems in the United States, affecting over 5% of Americans and are major causes of stroke and heart failure leading to increased morbidity and mortality.
- Trial name
- AGAPE (NCT06577714)
- Testing
- Electromechanical wave imaging (EWI)
- Where
- United States
- Volunteers
- 322 people
- Sponsor
- Columbia University
Hypoparathyroidism Postprocedural, Hypocalcemia
Near Infrared (NIR) Autofluorescence Image-guided Thyroid Surgery
The objective of this ongoing randomized controlled trial is to examine whether the use of intra-operative NIR(near infrared) camera can reduce the number of patients who experience transient or persistent hypoparathyroidism…
- Conditions
- Hypoparathyroidism Postprocedural, Hypocalcemia, Surgery--Complications
- Trial name
- NCT04193332
- Testing
- NIR optical imaging camera
- Where
- 2 sites in Denmark
- Volunteers
- 214 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Brain Tumor
Magnetic Resonance Temperature Imaging & Imaging-Guided Laser Induced Thermal Therapy for Treatment of Metastatic Brain Tumors
The goal of this clinical research study is to learn about a new therapy device called the Visualase® Thermal Therapy System (a device that uses a laser to kill tumor cells and is guided using magnetic resonance thermal imaging…
- Trial name
- NCT00720837
- Testing
- Visualase® Thermal Therapy System
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- M.D. Anderson Cancer Center
Breast Cancer
A Pilot Study of Tomographic Optical Breast Imaging (DBT-TOBI) to Monitor Response to Neoadjuvant Therapy
This research study is evaluating whether the use of digital breast tomosynthesis and near-infrared tomographic optical breast imaging (DBT-TOBI) scans can predict the response of triple negative or HER2+ breast cancer to…
- Trial name
- NCT03822312
- Testing
- DBT-TOBI, MRI-TOBI
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Massachusetts General Hospital
Prostate Cancer
PRostate Evaluation for Clinically Important Disease: MRI vs Standard Evaluation Procedures
The aim of this study is to assess the efficacy of MRI-targeted biopsy compared to standard of care systematic TRUS guided biopsy in the detection of clinically significant and clinically insignificant prostate cancer in men…
- Trial name
- PRECISE (NCT02936258)
- Testing
- Standard of Care, MRI, MRI Targeted Biopsy
- Where
- 5 sites in Canada
- Volunteers
- 450 people
- Sponsor
- Canadian Urology Research Consortium
Prostate Cancer
MRI Guided Prostate Cancer Focal Laser Ablation
The study is a prospective, single-arm, non-randomized, unblinded trial to determine the safety and efficacy of MRI guided focal laser ablation of localized low and intermediate risk prostate cancer.
- Trial name
- NCT03634579
- Testing
- MRI Guided Focal Laser Interstitial Thermal Ablation
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Emory University
Systolic Heart Failure, Dysynchrony
Imaging Study of Allocation of Pacing Targets in Cardiac Resynchronization Therapy
This randomized controlled trial will assess a cardiac MRI derived 4D digital cardiac model to optimized left and right ventricular lead delivery to improve response to cardiac resynchronization therapy.
- Conditions
- Systolic Heart Failure, Dysynchrony, Image Guidance, Digital Twins
- Trial name
- NCT01640769
- Testing
- 4D Model guided delivery of cardiac pacing leads, Standard CRT lead delivery
- Where
- 5 sites in Canada
- Volunteers
- 210 people
- Sponsor
- Libin Cardiovascular Institute of Alberta
Prostate Cancer
Cognitive and Fusion Prostatic Biopsy
The goal of this study is to compare two different prostate biopsy techniques used to detect prostate cancer. These techniques are cognitive-targeted biopsy (CTB) and magnetic resonance imaging-ultrasound fusion-targeted…
- Trial name
- CTB-FTB (NCT07306741)
- Testing
- Cognitive-targeted prostate biopsy
- Where
- 2 sites in Egypt
- Volunteers
- 80 people
- Sponsor
- Menoufia University