Clinical trials: Immune Deficiency Disorders
HIV Infections
Safety and Immunogenicity Study of HIV-MAG Vaccine +/- IL-12 and Ad35-GRIN/ENV in HIV-uninfected Volunteers
The purpose of this study is to evaluate the safety, tolerability and immunogenicity of multiantigen HIV (HIV-MAG) plasmid DNA (pDNA) vaccine co-administered with recombinant human IL-12 pDNA (GENEVAX® IL-12) followed or preceded…
- Trial name
- NCT01496989
- Testing
- HIV-MAG (3,000mcg), GENEVAX® IL-12 (100mcg), GENEVAX® IL-12 (1000mcg)
- Where
- 3 sites in Kenya, Rwanda and 1 more
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- International AIDS Vaccine Initiative
HIV Infection, Infection, Human Immunodeficiency Virus
KALETRA Or LEXIVA With Ritonavir Combined With EPIVIR And Abacavir In Naive Subjects Over 48 Weeks
This study will compare the ability of fosamprenavir 700 mg with ritonavir 100 mg twice a day or lopinavir 400 mg with ritonavir 100 mg twice a day both combined with a fixed dose combination tablet of abacavir 600 mg and…
- Trial name
- NCT00085943
- Testing
- LEXIVA (GW433908), Ritonavir, KALETRA
- Where
- 119 sites in United States, Austria and 12 more
- Volunteers
- 866 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
HIV Infections
Safety and Immunogenicity Study of Recombinant Modified Vaccinia Virus Ankara (MVA) Virus to Treat HIV Infection
At the end of 2004 there were more than 40 million people infected worldwide with HIV, with an estimated 16,000 new infections every day (Joint United Nations Programme on HIV/AIDS [UNAIDS], 2004).
- Trial name
- NCT00386633
- Testing
- MVA-mBN32
- Where
- Germany
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Bavarian Nordic
HIV Infections, Sexually Transmitted Diseases, Viral
mLab App Plus: A Randomized Controlled Trial of a Mobile Health (mHealth) Intervention
Men who have sex with men (MSM), especially young men who have sex with men (YMSM), and transgender women (TGW) have some of the highest rates of HIV and syphilis diagnoses in the United States.
- Conditions
- HIV Infections, Sexually Transmitted Diseases, Viral, Syphilis
- Trial name
- NCT06059443
- Testing
- mLab App Plus
- Where
- 2 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Columbia University
Low Birth Weight, Small for Gestational Age
Epigenetic Markers of B-Cell Function in Low Birth Weight Infants
Low birth weight (LBW) status (< 10% for gestational age at birth) is associated with increased risk for diseases such as type II diabetes mellitus, hypertension, chronic obstructive pulmonary disease and coronary artery disease…
- Conditions
- Low Birth Weight, Small for Gestational Age, Immunodeficiency
- Trial name
- NCT00925925
- Testing
- Cord blood collection for analysis
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Utah
Covid19
Prevention and Treatment of Patient Before, During, and After Covid-19 Infection
AntiCov-220 prevents and treats before, during, and after infection with SARS-CoV-2. The composition is fractionally extracted from herbs (Ascorbic Acid, L-Arginine hydrochloride, Adenosma glutinosum extract, Eclipta prostrata…
- Trial name
- AntiCov-220 (NCT05043324)
- Testing
- AntiCov-220
- Where
- 2 sites in United States, Vietnam
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Nguyen Thi Trieu, MD
Lactating Women on Select DOI, Breastmilk Fed Infants of Mothers on Select DOI
Pharmacokinetics of Antiretroviral Drugs in Lactating Women and Breastmilk Fed Infants Under 6 Months of Age in Botswana
The purpose of this study is to characterize the pharmacokinetics (PK) of understudied drugs administered to lactating women, receiving antiretroviral drugs per SOC as prescribed by their healthcare provider, and their…
- Conditions
- Lactating Women on Select DOI, Breastmilk Fed Infants of Mothers on Select DOI, HIV Infections
- Trial name
- BMS02 (NCT04862975)
- Testing
- Dolutegravir, Lamivudine, Emtricitabine
- Where
- 4 sites in South Africa
- Volunteers
- 164 people, healthy volunteers welcome
- Sponsor
- Duke University
Alcohol; Harmful Use, Binge Drinking
Computerized Brief Alcohol Intervention (BI) for Binge Drinking HIV At-Risk and Infected Women
African American (AA) women are disproportionately affected by HIV/AIDs. The major risk factor for HIV acquisition among AA women is high-risk heterosexual sex, including unprotected vaginal and anal sex, and sex with a high-risk…
- Conditions
- Alcohol; Harmful Use, Binge Drinking, Risk Behavior, HIV Infection
- Trial name
- NCT01125371
- Testing
- Computerized brief alcohol intervention + IVR booster calls, Computerized brief alcohol intervention, Attention Control
- Where
- United States
- Volunteers
- 439 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
HIV-1-infection
Kenya HIV Self-Testing in PrEP Delivery
In a three-arm, randomized trial, the investigators will test the use of HIV-1 self-testing to decrease the frequency and burden of clinic visits for PrEP while resulting in equivalent PrEP adherence and HIV testing.
- Trial name
- NCT03593629
- Testing
- 6-month PrEP + blood-based HIV self-test, 6-month PrEP + oral fluid HIV self-test
- Where
- Kenya
- Volunteers
- 790 people, healthy volunteers welcome
- Sponsor
- University of Washington
GVHD, Bone Marrow Transplant Failure
α1-antitrypsin (AAT) Levels and Functions in Allogeneic Bone Marrow Transplantation and Throughout Progression Into GVHD
Create a personalized time and context curve of patient circulating α1-antitrypsin (AAT) levels and functions before hematopoietic stem cell transplantation and throughout progression into GVHD. PRIMARY ENDPOINT 1.
- Conditions
- GVHD, Bone Marrow Transplant Failure, Alpha 1-Antitrypsin
- Trial name
- AATGVHD-MARK (NCT03188601)
- Where
- 4 sites in Israel
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Human Immunodeficiency Virus (HIV)
ComBaCaL HIV Prevention TwiCs
This cluster-randomized intervention is embedded in the ComBaCaL (Community-Based Chronic disease care Lesotho) cohort study (EKNZ ID AO_2022-00058, clinicaltrials.gov ID NCT05596773, Lesotho NH-REC ID 210-2022), a platform for…
- Trial name
- CoPrev (NCT07581600)
- Testing
- CoPrev model, Referral to the nearest responsible health facility
- Where
- 2 sites in Lesotho, Switzerland
- Volunteers
- healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
HIV Infections
Safety of and Immune Response to a DNA Vaccine and a Recombinant HIV-1-MVA Vaccine, Separately and in Combination, in Healthy Adults
The purpose of this study is to determine the safety of and immune response to two experimental vaccines, designed for use in combination, for the prevention of HIV infection in healthy adults.
- Trial name
- NCT00428337
- Testing
- EP-1233, MVA-mBN32
- Where
- 3 sites in United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV Infections, Sexually Transmitted Infections
Evaluation of the Healthy Love Workshop, an HIV Prevention Intervention for African American Women
The purpose of this program evaluation is to determine whether the Health Love Workshop, a group-level HIV behavioral intervention, reduces HIV-related sex risk behaviors and increases HIV protective behaviors of African American…
- Trial name
- NCT00362375
- Testing
- Healthy Love Workshop, HIV/AIDS 101 Workshop
- Where
- United States
- Volunteers
- 313 people, healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention
Autism Spectrum Disorder, Zinc Deficiency
Zinc-AA Supplementation During Pregnancy & Lactation to Assess Effects on ASD Prevalence in Offspring
Autism and associated entities, grouped under the Autism Spectrum Disorders (ASD) is the fastest growing intellectual disability in the world, statistics signal for a 1 to 3% prevalence on infants.
- Conditions
- Autism Spectrum Disorder, Zinc Deficiency, Pregnancy Related
- Trial name
- NCT04983667
- Testing
- Zn-AA
- Where
- Mexico
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- Instituto Tecnologico y de Estudios Superiores de Monterey
AIDS
Safety & Immunogenicity of HIV Vaccines in Healthy Kenyan Adults
The study is part of a long-term aim to develop an effective HIV-1 vaccine and will evaluate safety and immunogenicity of vaccines focusing T cell responses on the conserved region of the HIV-1 proteome.
- Trial name
- HIV-CORE 004 (NCT02099994)
- Testing
- Ad35-GRIN, MVA.HIVconsv, pSG2.HIVconsv DNA
- Where
- Kenya
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Oxford
HIV Infections
Bioequivalence Study of Atazanavir 300 mg Capsule
The purpose of this clinical research study is to assess the bioequivalence of atazanavir administered as a single 300 mg capsule relative to two atazanavir 150 mg capsules in healthy subjects.
- Trial name
- NCT00393328
- Testing
- Atazanavir + Ritonavir
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
HIV Infections, HIV Seronegativity
Effectiveness of an HIV Vaccine in HIV-Negative Adults in North America Who Are at Risk of HIV Infection
The purpose of this study is to see if an HIV vaccine, AIDSVAX B/B, can protect adults who are at risk from becoming infected with HIV.
- Trial name
- NCT00002441
- Testing
- MN rgp120/HIV-1 and GNE8 rgp120/HIV-1
- Where
- 67 sites in United States, Canada and 2 more
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- VaxGen
Acute HIV Infection, HIV Seropositive
Acute Partner and Social Contact Referral: iKnow
The primary purpose of this research is to assess the benefit of an "unaware intervention package" for identifying high risk persons who are unaware of their HIV infection status.
- Conditions
- Acute HIV Infection, HIV Seropositive, Sexually Transmitted Infections
- Trial name
- NCT02467439
- Testing
- Notification cards
- Where
- United States
- Volunteers
- 15,310 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Body Weight Changes, Human Immunodeficiency Virus
Doravirine and Weight Gain in Antiretroviral Naive
The purpose of this study is determine whether different antiretroviral therapy (ART) changes the effects on body fat and predict the weight change in Black and Hispanic females.
- Conditions
- Body Weight Changes, Human Immunodeficiency Virus, ART, Obesity
- Trial name
- DAWN (NCT05457530)
- Testing
- DOR/3TC/TDF, DOR + FTC/TAF, BIC/FTC/TAF
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Prism Health North Texas
HIV Infections
eTest: Real-time, Remote Monitoring System for Home-based HIV Testing Among High-risk Men Who Have Sex With Men
The proposed research will conduct a fully-powered efficacy trial of this approach in areas with large populations of AA and H/L MSM and high HIV incidence: Jackson, MS, Los Angeles, CA, and Boston, MA.
- Trial name
- eTest (NCT03654690)
- Testing
- HIV self-test, Counseling
- Where
- United States
- Volunteers
- 811 people, healthy volunteers welcome
- Sponsor
- Brown University
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