Clinical trials: Immune Deficiency Disorders
HIV Infections
A Relative Bioavailability and Food-Effect Study of GSK3640254 Tablet and Capsule Formulations in Healthy Participants
This is an open-label, 2 part, single-dose and crossover study conducted to assess the relative bioavailability of a tablet compared to a capsule of GSK3640254 and to assess the effect of food on the GSK3640254 tablet in healthy…
- Trial name
- NCT04263142
- Testing
- GSK3640254 Tablet, GSK3640254 Capsule
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- ViiV Healthcare
Hiv, Transgender Youth
Providing Online Counseling for Home-Based HIV Testing With Transgender Youth
This research study will recruit 200 transgender youths between the ages of 15-24. There are two arms to the research study: the control and the intervention arm. Each eligible participant will be randomized into either arm.
- Trial name
- NCT03185975
- Testing
- at-home test kit, Motivational Interviewing and Certified Testing and Referral
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Vitamin D Deficiency, Immune Health
Estimation of the Dietary Requirement for Vitamin D in Ethnic Groups
The aim of this study is to perform a double-blind, randomised, dose-response trial of vitamin D3 supplementation in United Kingdom (UK)-dwelling adults of white European, South Asian, and black African/Caribbean ethnicity to…
- Conditions
- Vitamin D Deficiency, Immune Health, Muscle Function
- Trial name
- NCT06067477
- Testing
- Vitamin D Supplement
- Where
- United Kingdom
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- University of Surrey
HIV Infections
C2P Mobilization Intervention (Pilot)
Connect to Protect (C2P): Partnerships for Youth Prevention Interventions is a multi-site, three-phase project developed by the Adolescent Medicine Trials Network for HIV/AIDS Interventions (ATN).
- Trial name
- NCT00393575
- Testing
- Community Mobilization
- Where
- 15 sites in United States, Puerto Rico
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Infection, Human Immunodeficiency Virus
A Study to Evaluate the Effects of Calcium Carbonate and Ferrous Fumarate on Pharmacokinetics of Dolutegravir in Healthy Adult Subjects
Human immune virus (HIV) infected subjects may take mineral supplements in combination with their antiretroviral medications. Calcium and Iron supplementations are commonly used and both of these have the potential to interact…
- Trial name
- NCT01762995
- Testing
- Dolutegravir 50 mg, Calcium Carbonate 1200 mg, Ferrous Fumarate 324 mg
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- ViiV Healthcare
Medical Device Complication
Feasibility Study of PrePex Device When Performed on Early Infants & Children Male Population by Physicians
The PrePex is a WHO prequalified medical device for adult male circumcision for HIV prevention. The Government of Rwanda was the first country to implement the PrePex and acts as the leading Center of Excellence providing…
- Trial name
- RMC-06 (NCT02281461)
- Testing
- Male circumcision using a non-surgical device
- Where
- Rwanda
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ministry of Health, Rwanda
HIV Infections
Safety and Immune Response to a Recombinant Adenovirus HIV-1 Vaccine in Healthy Adults
Successful control of the HIV epidemic will require a safe and effective vaccine to be developed. A successful vaccine will need to stimulate a widespread immune response.
- Trial name
- NCT00695877
- Testing
- Ad5.ENVA.48 HIV-1 vaccine
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV, HIV Infections
Preventative Misconception Intervention
This study will carry out a preliminary "proof of concept" to evaluate two types of supplemental information that would serve as an adjunct to the traditional informed consent in a Human Immunodeficiency Virus (HIV) vaccine…
- Trial name
- NCT01049139
- Testing
- 1-sided messages, 2-sided messages
- Where
- 4 sites in United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
HIV Infections, Knowledge, Attitudes, Practice
Home HIV Testing for Older Adults in South Africa
Many older adults in rural South Africa still lack knowledge of their HIV status despite a high probability of infection. Older adults tend to test less for HIV because most HIV testing and prevention programs have been targeted…
- Trial name
- Test@Home (NCT04131465)
- Testing
- Home HIV self-testing, Home HIV rapid testing, Home HIV self-testing and rapid testing
- Where
- South Africa
- Volunteers
- 3,578 people, healthy volunteers welcome
- Sponsor
- Harvard School of Public Health (HSPH)
Mobile Phone Use, Hiv
Mobile HIV Prevention App for Black Women
Black women have a significantly higher risk of acquiring HIV compared to their non-Black counterparts. The purpose of this study is to refine and test a mobile HIV Prevention and Reproductive Health app developed specifically…
- Conditions
- Mobile Phone Use, Hiv, Stigma, Social
- Trial name
- In-the-kNOW (NCT05080972)
- Testing
- in-the-kNOW mobile app, Control
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Emory University
Human Immunodeficiency Virus Exposure, Alcohol; Harmful Use
Game Plan for PrEP
This small pilot randomized controlled trial will test whether a brief, web-based intervention inspired by the principles of motivational interviewing helps high-risk men who take pre-exposure prophylaxis (PrEP) moderate their…
- Trial name
- NCT04973267
- Testing
- Game Plan for PrEP, Attention-Matched Control Lifestyle Habits Videos
- Where
- United States
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Brown University
Hiv, Minority Stress
Developing an Online Mindfulness-based Intervention to Reduce Minority Stress and HIV Risk Among Young Adult MSM - Aim 3
The overall aim of the research study is to develop and test a mindfulness-based program for young adult gay, bisexual, and queer men at risk for HIV (Brown University IRB approved protocol #2004002698).
- Conditions
- Hiv, Minority Stress, Mental Health Wellness 1
- Trial name
- MBQR (NCT05855655)
- Testing
- Mindfulness-Based Queer Resilience (MBQR)
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Brown University
HIV/AIDS
Adolescent Master Protocol
The advances in treatment to prevent maternal HIV transmission to neonates have been groundbreaking. As a result, the number of new perinatally-infected children in the U.S. is now small.
- Trial name
- AMP (NCT01418014)
- Where
- 15 sites in United States, Puerto Rico
- Volunteers
- 678 people, healthy volunteers welcome
- Sponsor
- Harvard School of Public Health (HSPH)
HIV/AIDS
Costs, Efficiency and the Role of Management in HIV Prevention Interventions for Female Sex Workers in Nigeria
This study seeks to measure the costs associated with HIV prevention service delivery to female sex workers (FSW) in Nigeria, as well as examine the relationship between management practices at the community-based organizations…
- Trial name
- NCT03371914
- Testing
- Management training and data feedback
- Where
- Nigeria
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Instituto Nacional de Salud Publica, Mexico
HIV Infections
Prevalence and Risk Factors of HIV Infections in Transgender and Non-binary People in Flanders and Brussels (Belgium)
Background: HIV prevalence and sexual risk have been estimated very high for transgender people. However, the limited sampling and data collection methods used in current research on transgender people potentially led to…
- Trial name
- NCT04930614
- Testing
- Survey on socio-demographic variables and healthcare-seeking, sexual and drug-using behaviour
- Where
- Belgium
- Volunteers
- 1,068 people, healthy volunteers welcome
- Sponsor
- Centre for Evidence-Based Practice, Belgium
HIV Positive
Complementary & Alternative Medicine Use in HIV+ Latinos in the US-Mexico Border
The goal of The investigators community-based participatory research study is to identify the nature and extent of complementary and alternative medicine (CAM) use among HIV-positive Latinos on the San Diego/Tijuana border.
- Trial name
- NCT01152684
- Where
- United States
- Volunteers
- 541 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
HIV/AIDS
Epividian / AHF: Positive Pathways - HIV Retention in Care
The primary objective of this study is to evaluate the effectiveness of a clinical decision support system (CDSS) combined with enhanced patient contact to retain HIV+ patients in care with AIDS Healthcare Foundation.
- Trial name
- NCT04147832
- Testing
- Alert to provider
- Where
- United States
- Volunteers
- 10,521 people, healthy volunteers welcome
- Sponsor
- Epividian
Hiv
Program Refinements to Optimize Model Impact and Scalability Based on Evidence
In New York, the achievement of 90-90-90 goals is jeopardized not by limited access to affordable care and treatment, but by persistent disparities in HIV viral suppression (VS).
- Trial name
- PROMISE (NCT03628287)
- Testing
- Revised Care Coordination Program, Original Care Coordination Program
- Where
- 17 sites in United States
- Volunteers
- 960 people, healthy volunteers welcome
- Sponsor
- City University of New York, School of Public Health
Sexual Transmission of Infection
HIV Prevention Intervention for Young Transgender Women
The purpose of this study is to test the efficacy of a uniquely targeted HIV risk reduction intervention for young transgender women (YTW), ages 16 to 29, at risk for HIV acquisition or transmission.
- Trial name
- LifeSkills (NCT01575938)
- Testing
- HIV prevention intervention, Diet and Nutrition
- Where
- 2 sites in United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
HIV Infections
A Phase I Safety and Immunogenicity Trial of Live Recombinant Canarypox ALVAC-HIV (vCP205) and HIV-1 SF-2 rgp120 in HIV-1 Uninfected Adult Volunteers
To evaluate the safety and immunogenicity of high-titered ALVAC-HIV MN120TMG (vCP205) given sequentially or simultaneously with rgp120/HIV-1SF2 in MF59 adjuvant emulsion in HIV-negative volunteers.
- Trial name
- NCT00000847
- Testing
- ALVAC-HIV MN120TMG (vCP205), ALVAC-RG Rabies Glycoprotein (vCP65), rgp120/HIV-1 SF-2
- Where
- 6 sites in United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
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