Clinical trials: Immune System Tolerance
Vitiligo
Combination of Methotrexate and Phototherapy Versus Phototherapy in Adults With Progressive Vitiligo
This is a phase 2, randomized, double blind, multicenter study evaluating the efficacy and safety of the combination of methotrexate plus UVB TL01 in vitiligo.
- Trial name
- METVI (NCT04237103)
- Testing
- Methotrexate
- Where
- 4 sites in France
- Volunteers
- 32 people
- Sponsor
- University Hospital, Bordeaux
Severe Sepsis or Septic Shock, Fluid Resuscitation
COrporeal Compression at the ONset of Severe Sepsis and Septic Shock
Early and adequate fluid resuscitation (< 6 hours) in patients with circulatory failure is essential but may exacerbate oedema, which may itself: 1) aggravate pulmonary lesions and prolong mechanical ventilation, 2) aggravate…
- Trial name
- COCOON (NCT02656654)
- Testing
- Whole-body compression
- Where
- 2 sites in France
- Volunteers
- 64 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Accelerating the Epithelialization of Split Thickness Skin Graft
Trial to Compare Intra-individually the Efficacy and Tolerance of Oleogel-S10 Versus Moist Wound Healing Dressing Alone in Accelerating the Epithelialization of Split Thickness Skin Graft Donor Sites
In this study the wound reepithelialization of that part of the skin graft donor site, which is treated with Oleogel-S10 compared to that part of the wound, which is covered by moist wound healing dressing alone will be…
- Trial name
- OleoSplit (NCT01294254)
- Testing
- Oleogel-S10, Moist wound healing dressings alone (Mepilex) on the other half of the skin graft donor site
- Where
- 2 sites in Germany
- Volunteers
- 24 people
- Sponsor
- Birken AG
Allergic Rhinitis
Taste and Local Tolerance Study of NLA Nasal Spray in Patients With Allergic Rhinitis
Evaluation of NLA Nasal Spray with regard to taste perversion and local tolerance
- Trial name
- NCT00533637
- Testing
- Cetirizine dihydrochloride (10 mg/ml) liposomal formulation, Cetirizine dihydrochloride (10 mg/ml) buffer solution
- Where
- Sweden
- Volunteers
- 28 people
- Sponsor
- Biolipox AB
Type 2 Diabetes, NAFLD
Nutraceutical Improvement of Glucose Metabolism, NAFLD and Insulin Resistance by Oat-fiber Supplementation in Type 2 Diabetes Mellitus Patients
Cohort studies show an association between increased intake of insoluble (cereal) fiber and decreased risk for cardiovascular disease, type 2 diabetes (T2DM), non-alcoholic fatty liver disease (NAFLD), cancer, infectious and…
- Trial name
- NIMROD (NCT05654805)
- Testing
- Drinking powder supplement
- Where
- Germany
- Volunteers
- 92 people
- Sponsor
- Charite University, Berlin, Germany
Safety Issues, Tolerance
First-in-human Trial to Evaluate the Safety, Tolerability and Pharmacokinetics of C106 in Healthy Subjects
This is a FIH, double-blind, placebo-controlled, within-group randomised, trial designed to evaluate the safety, tolerability, and pharmacokinetics (PK) of single and multiple ascending oral doses of compound 106 (C106) in…
- Conditions
- Safety Issues, Tolerance, Idiopathic Pulmonary Fibrosis, Pulmonary Hypertension
- Trial name
- NCT05427253
- Testing
- C106 solution
- Where
- Sweden
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Vicore Pharma AB
Iron Deficiency Anemia Treatment, Iron Deficiency Anemia
Probiotic Use in Oral Iron Replacement Deficiency Anemia Patients Initiating Oral Iron Replacement
Investigation of gastrointestinal tolerability, treatment compliance and iron status markers in patients with iron deficiency anemia who received oral iron replacement therapy with versus without concomitant probiotic…
- Trial name
- NCT06521879
- Testing
- Lactobacillus plantarum 299v probiotic support
- Where
- Turkey (Türkiye)
- Volunteers
- 295 people
- Sponsor
- Antalya Training and Research Hospital
Pulmonary Disease, Chronic Obstructive
Efficacy of Acupuncture in Exercise Tolerance in Patients With COPD
Chronic Obstructive Pulmonary Disease (COPD) is nowadays the 4th cause of death in the world and it´s expected to become the 3rd cause of death in 2020 and the majority cause of morbidity.
- Trial name
- NCT03767140
- Testing
- acupuncture
- Where
- Portugal
- Volunteers
- 29 people
- Sponsor
- Instituto de Ciências Biomédicas Abel Salazar
Sedation, Tolerance
Randomized Study With Midazolam for Sedation in Flexible Bronchoscopy
The Flexible Bronchoscopy (FB) is a diagnostic and therapeutic procedure which is not usually tolerated by the patient. This makes the examination more difficult and a repetition of the examination, if necessary, resulting in a…
- Conditions
- Sedation, Tolerance, Anxiety, Satisfaction
- Trial name
- NCT01038882
- Testing
- Midazolam, Physiological serum
- Where
- Spain
- Volunteers
- 238 people
- Sponsor
- Hospital Universitario La Fe
Therapeutic Plasma Exchange
TPE in Rennes Hospital
To assess the indications, tolerance and side effects of therapeutic plasma exchange (TPE) performed at a University Hospital over 8 years
- Trial name
- COMPLASMA (NCT03888417)
- Testing
- Therapeutic plasma exchange (TPE)
- Where
- France
- Volunteers
- 190 people
- Sponsor
- Rennes University Hospital
Egg Hypersensitivity
Gradual Egg-tolerance Induction in Hen's Egg Allergic Children Who Tolerate Baked Egg (TETI-II Study)
The investigators want to test the hypothesis that a total period of 12 months of stepwise open egg introduction is not inferior when compared to a total period of 20 months gradual open egg introduction of a certain egg product…
- Trial name
- TETI-II (NCT04677790)
- Testing
- assigned period of specific dietary restrictions
- Where
- 4 sites in Belgium
- Volunteers
- 62 people
- Sponsor
- Dominque Bullens
Hepatocellular Carcinoma
A Phase I Clinical Study on a New Oral Pentamidine Formulation in Hepatocellular Carcinoma
The purpose of this study is to investigate on the Hepatic Uptake, Pharmacokinetics, Safety and Tolerance of a New Oral Pentamidine Formulation in Hepatocellular Carcinoma Subjects Undergoing Thermal Ablation
- Trial name
- NCT02210182
- Testing
- Oral Pentamidine
- Where
- 3 sites in Canada
- Volunteers
- 29 people
- Sponsor
- Oncozyme Pharma Inc.
Allergy, Nut, Pediatric ALL
Efficiency And Tolerance Of Hazelnut Oral Immunotherapy Protocol In Hazelnut Allergic Children
Prevalence of food allergy in the world has been inscreasing in recent years. Among nut allergy, hazelnut allergy is the most widespread in Europe and particularly in France.
- Trial name
- ENOIME (NCT04841850)
- Testing
- Clinical and biological characteristics
- Where
- France
- Volunteers
- 70 people
- Sponsor
- Hospices Civils de Lyon
Spinal Cord Injury, Tetraplegia
Study of the Impact of the Use of a Corset on the Respiratory Function of Patients With Spinal Cord Injury
Corsets are often used in the management of patients with a spinal cord injury. They may help to rigidify the patients' trunk which might help some patients to sit upright; their use may also reduce the sensation of dyspnea some…
- Conditions
- Spinal Cord Injury, Tetraplegia, Paraplegia
- Trial name
- Garchoise (NCT01569360)
- Testing
- Corset
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Healthy
Food Effects of Single Oral Dose of 600mg TR-701
This is an evaluation of the safety, tolerance, and pharmacokinetics of single oral doses of TR-701 given to normal, healthy, adult volunteers in the fed and fasted state.
- Trial name
- NCT00671359
- Testing
- TR-701 600mg
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Trius Therapeutics LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Advanced Bladder Cancer
A Clinical Study on the Safety, Tolerance, and Preliminary Efficacy of γδ-T Cell Injection in the Treatment of Advanced Bladder Cancer
We plan to enroll 20-29 patients with advanced bladder cancer to undergo T-cell therapy. Each treatment cycle consists of three T-cell infusions, with two cycles planned per patient.
- Trial name
- γδ-T-BLADDER (NCT07204496)
- Testing
- Ex Vivo Expanded γδ T Cell Infusion
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Shanghai 10th People's Hospital
Hyperglycemia, Coronary Heart Disease
Paleolithic Diet in the Treatment of Glucose Intolerance
The purpose of this study is to determine whether a paleolithic diet improves glucose tolerance and insulin sensitivity in people with coronary heart disease and impaired glucose tolerance.
- Trial name
- NCT00419497
- Testing
- Paleolithic diet vs Mediterranean diet
- Where
- Sweden
- Volunteers
- 29 people
- Sponsor
- Lund University Hospital
Dysphagia
Acceptability and Tolerance Study of a Thickener
This is a prospective, acceptability study to evaluate the gastrointestinal tolerance and compliance of a thickener for the management of reflux, GORD and dysphagia
- Trial name
- NCT05026476
- Testing
- Resource Thicken up Junior
- Where
- United Kingdom
- Volunteers
- 21 people
- Sponsor
- Société des Produits Nestlé (SPN)
Impaired Glucose Tolerance
Glycemic and Insulinemic Impact of Selected Canadian Beans
The objective of this study is to compare the glycemic and insulinemic response elicited by ½ cup servings of 6 beans to those elicited by ½ cup servings of mashed potato, macaroni, rice and corn.
- Trial name
- MED-beans (NCT02907190)
- Testing
- Bean Type, Starchy Foods
- Where
- Canada
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Guelph Food Research Centre
Hypertension
Metabolic Effects of Antihypertensive Drugs on People With Metabolic Syndrome (The MEAD Study)
High blood pressure, also referred to as hypertension, is a blood pressure level of 140/90 mm Hg or higher. Along with lifestyle changes, various medications are currently used to treat people with hypertension.
- Trial name
- MEAD (NCT00887510)
- Testing
- Hydrochlorothiazide, Trandolapril
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Florida
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