Clinical trials: Immunological Tolerance
Cryptosporidiosis, HIV Infections
Open-Label "Compassionate" Use Study of Spiramycin for the Treatment of Diarrhea Due to Chronic Cryptosporidiosis in Immunocompromised Patients
This protocol provides for the availability of spiramycin under compassionate-use conditions for the treatment of chronic diarrhea due to cryptosporidium in patients with a compromised immune system, thus deriving additional…
- Trial name
- NCT00002062
- Testing
- Spiramycin
- Where
- United States
- Sponsor
- Rhone-Poulenc Rorer
Vitiligo
Evaluation of Effect and Tolerance of the Association of Baricitinib and Phototherapy Versus Phototherapy in Adults With Progressive Vitiligo
The purpose of this phase 2 study is to evaluate the effect and the safety of the combination of Baricitinib in combination with phototherapy in adult participants with non-segmental progressive vitiligo.
- Trial name
- BARVIT (NCT04822584)
- Testing
- Baricitinib Oral Product
- Where
- 4 sites in France
- Volunteers
- 49 people
- Sponsor
- University Hospital, Bordeaux
Refractory Chronic Cough
A Study to Assess the Efficacy and Tolerance of HRS-2261 in Subjects With Refractory Chronic Cough
This is a phase II study that will investigate the efficacy, safety and tolerability of HRS-2261 in subjects with refractory chronic cough using a double blind, placebo controlled, randomized study design.
- Trial name
- NCT05733533
- Testing
- HRS-2261 oral tablet
- Where
- China
- Volunteers
- 97 people
- Sponsor
- Guangdong Hengrui Pharmaceutical Co., Ltd
Hepatitis C
Strategic Transformation of the Market of HCV Treatments
This is a Phase II/III, multicenter, multi-country, trial to assess the efficacy, safety, tolerance and pharmacokinetics of sofosbuvir plus ravidasvir for the treatment of HCV infection.
- Trial name
- STORM-C-1 (NCT02961426)
- Testing
- sofosbuvir + ravidasvir
- Where
- 13 sites in Malaysia, Thailand
- Volunteers
- 603 people
- Sponsor
- Drugs for Neglected Diseases
Patient Safety, Resident Work Hours
Assessing the Impact of a Change to the Work Schedule of Resident Physicians: a Mixed Methods Study
The purpose of this study is to determine the impact of eliminating traditional resident work shifts (i.e. greater than 24 hours in length) on patient safety and resident educational outcomes.
- Trial name
- NCT01398878
- Testing
- Intervention work shift
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- University of British Columbia
Metabolic Syndrome, Dyslipidemia
Impact of Consumption of Beta-glucans on the Intestinal Microbiota and Glucose and Lipid Metabolism
The purpose of this study is to investigate if daily consumption of barley beta-glucans effect lipid and glucose metabolism and alter intestinal microbiota composition in participants with metabolic syndrome or with high risk for…
- Conditions
- Metabolic Syndrome, Dyslipidemia, Obesity, Abdominal, Hyperglycemia
- Trial name
- NCT02041104
- Testing
- Bread with added beta-glucans
- Where
- 3 sites in Slovenia
- Volunteers
- 51 people
- Sponsor
- Mlinotest Zivilska Industrija d.d.
Cardiovascular Risk Factor, Lipemia
Effect of Galactose Ingestion on Postprandial Lipemia
This study aims to assess the postprandial triglyceride response to the ingestion of a high-fat meal with co-ingestion of either galactose, or glucose.
- Trial name
- NCT03439878
- Testing
- Galactose, Glucose
- Where
- United Kingdom
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Bath
Cystic Fibrosis, Muscle Strength
Muscle Strength, Functional Capacity, Respiratory Function and Quality Of Life In Cystic Fibrosis Patients
This study was designed to investigate the relationship between upper extremity muscle strength and endurance, functional capacity, and quality of life child and adolescent with cystic fibrosis
- Conditions
- Cystic Fibrosis, Muscle Strength, Pulmonary Function, Functional Capacity
- Trial name
- NCT04734743
- Testing
- cystic fibrosis
- Where
- Turkey (Türkiye)
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Cagtay Maden
Aging, Breast Cancer
The Value of Geriatric Assessments in Older Patients With Breast Cancer
Elderly cancer patients are a special group, often complicated by a variety of chronic diseases, which bring serious obstacles to surgery and adjuvant treatment.
- Conditions
- Aging, Breast Cancer, Chemotherapeutic Toxicity, Survival
- Trial name
- NCT03640117
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Peking University People's Hospital
Bipolar Disorder
DB/Maintenance of Equetro (Carbamazepine) in Children With Acute Manic or Mixed Bipolar 1 Disorder
A phase 4 unequal randomization, double blind study to evaluate the dose tolerance and safety of extended release Equetro (carbamazepine) versus placebo followed by an Open label and long term maintenance treatment in children…
- Trial name
- NCT02623504
- Testing
- Carbamazepine
- Where
- 4 sites in United States
- Volunteers
- 17 people
- Sponsor
- Validus Pharmaceuticals
Bone Sarcoma, Osteosarcoma
Efficacy of Regorafenib Combined With Best Supportive Care as Maintenance Treatment in High Grade Bone Sarcomas Patients
This is a multicenter phase II study concerning patients with high-grade bone sarcoma (HGBS) without complete remission after standard treatment at diagnosis or at relapse.
- Trial name
- REGOMAIN (NCT04698785)
- Testing
- Treatment by regorafenib and best supportive care
- Where
- 16 sites in France
- Volunteers
- 36 people
- Sponsor
- Centre Leon Berard
Aging
Evaluation of Anti-aging Performance and Tolerance of a Hyaluronic Acid-based Filler NCTF135HA®
The NCTF135HA medical device from Laboratoires FILL-MED by FILORGA Company is an injectable solution for the treatment of wrinkles and biorevitalization of injected mature skin using a multi-injection technique with CE marking.
- Trial name
- HEBE2 (NCT05609617)
- Testing
- injection, Cream application
- Where
- France
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- Laboratoires FILLMED
Parkinson Disease
Tolerance to NeuroEPO in Parkinson Disease
Treatment strategies in Parkinson's disease (PD) can improve a patient's quality of life but cannot stop the progression of PD. The investigators are looking for different alternatives that modify the natural course of the…
- Trial name
- NeuroEPO (NCT04110678)
- Testing
- NeuroEPO
- Where
- 2 sites in Cuba
- Volunteers
- 26 people
- Sponsor
- International Center for Neurological Restoration, Cuba
Diabetes
Clinical Trial for Liquid Food (Inslow)
A carbohydrate adjusted liquid formula (Inslow) using palatinose as the major carbohydrate (>50%) was devised. Consumption Inslow for a long term (3-5 months) is reported to improve glycemic control by reducing the postprandial…
- Trial name
- NCT02641743
- Testing
- Inslow, standard balanced formula
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Shanghai Meiji Health Science and Technology Co., Ltd.
Recurrent Glioblastoma, CD147 Positive
CD147-CART Cells in Patients With Recurrent Malignant Glioma.
This is a single-center, single-arm, open label and dose escalation clinical study of anti-CD147 CART cells in patients with recurrent malignant glioma.
- Trial name
- NCT04045847
- Testing
- CD147-CART
- Where
- China
- Volunteers
- 31 people
- Sponsor
- Xijing Hospital
Bronchiectasis, Lower Respiratory Infection
Safety, Efficacy and PK/PD of POL7080 in Patients With Exacerbation of Non-cystic Fibrosis Bronchiectasis.
To test whether POL7080 is effective in patients with exacerbation of non-cystic fibrosis bronchiectasis caused by Pseudomonas aeruginosa infection.
- Trial name
- NCT02096315
- Testing
- POL7080
- Where
- 4 sites in Spain, United Kingdom
- Volunteers
- 20 people
- Sponsor
- Polyphor Ltd.
Gestational Diabetes, Type 2 Diabetes
Abnormal Post-partum Glucose Metabolism After Gestational Diabetes Diagnosed Before or After 24 Weeks of Gestation
The main objective of the study is to estimate and compare the percentage of patients with abnormal glucose metabolism at 4-12 weeks postpartum between two groups: patients diagnosed with gestational diabetes before or after 24…
- Conditions
- Gestational Diabetes, Type 2 Diabetes, Glucose Intolerance
- Trial name
- DG Post-Partum (NCT01839448)
- Testing
- Post-partum oral glucose tolerance test
- Where
- 4 sites in France
- Volunteers
- 500 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Healthy
Comparative Clinical Study of Pharmacokinetics, Tolerance and Safety of BCD-057 and Humira in Healthy Volunteers
This clinical study is a phase 1 study which carried out to establish the pharmacokinetic equivalence and equal safety and tolerability profile of BCD-057 (adalimumab biosimilar candidate manufactured by CJSC BIOCAD, Russia) and…
- Trial name
- NCT02395055
- Testing
- Adalimumab (BCD-057), Adalimumab (Humira)
- Where
- Russia
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Biocad
Type 2 Diabetes Mellitus
The Effect of Exenatide Compared to Lantus Insulin on Vascular Function in Type 2 Diabetes
The main goals of the study are to evaluate the effect of Exenatide on endothelial-dependent vasodilation, as measured by flow mediated dilation (FMD), to evaluate the effect on endothelial-independent vasodilation, as measured…
- Trial name
- NCT00353834
- Testing
- Exenatide, Glargine Insulin
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Joslin Diabetes Center
Prediabetes, Hyperglycemia
Personalized Smartphone-assisted Coaching System to Improve Glucose Homeostasis in Adults With Prediabetes - Main Study
Sweetch is a personalized mobile-health platform coaching system (mobile phone app) designed to promote adherence to physical activity guidelines for people with prediabetes.
- Conditions
- Prediabetes, Hyperglycemia, Postprandial Hyperglycemia, Impaired Glucose Tolerance
- Trial name
- NCT03315663
- Testing
- Sweetch App & DBWS, Sweetch App Alone
- Where
- 2 sites in United States
- Sponsor
- Johns Hopkins University