Clinical trials: Immunomodulation
Immunomodulation Effect
Effect of Autologous Cord Blood-mononuclear Cells Infusion on Immune Microenvironment in Infants Born Very Preterm in NICU
Multi-omics (analysis of peripheral blood immune cells subset, peripheral blood MNCs transcriptome, soluble inflammatory cytokine profile in blood and airway secretion, lung and gut microbiota, and the interaction) analysis was…
- Trial name
- NCT05087498
- Testing
- autologous cord blood mononuclear cells, normal saline
- Where
- China
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Guangdong Women and Children Hospital
Upper Respiratory Tract Infections
Three Arm Trial of Immune Effects of Echinacea
The goal of this study is to determine if either of two, commercially available, Echinacea purpurea products stimulate the immune system.
- Trial name
- NCT01129128
- Testing
- Echinacea purpurea product
- Where
- United States
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- University of Washington
Stroke, Immunoregulation
Vinpocetine Inhibits NF-κB-dependent Inflammation in Acute Ischemic Stroke Patients
Immunity and inflammation play critical roles in the pathogenesis of acute ischemic stroke. Therefore, immune intervention, as a new therapeutic strategy, is worthy of exploration.
- Conditions
- Stroke, Immunoregulation, Inflammation, Vinpocetine
- Trial name
- NCT02878772
- Testing
- vinpocetine, Aspirin
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Tianjin Medical University General Hospital
Ischemia Reperfusion Injury, Ischaemia Reperfusion Injury
Immune Modulation by Ischemic Pre-conditioning in Healthy Individuals: Intracellular Signalling in Regulatory Cells
The aim of the study is to investigate how phosphorylation of STAT3, p38 mitogen-activated protein kinase (MAPK), extracellular signal-regulated kinase (ERK) and protein kinase B (AKT) reacts to remote ischemic conditioning (rIC)…
- Trial name
- KONDI-immun (NCT03541239)
- Testing
- Single Cuff Tourniquet 8000
- Where
- Denmark
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Dry Eye Syndrome (DES), Sjogren's Syndrome
Exosomes Proteomic for Sjogren's Syndrome and Dry Eye Syndrome
By analyzing the differential proteins in exosomes, this study aims to understand the pathological mechanisms of SJS and DES, identify potential diagnostic and therapeutic methods, and advance the diagnosis and treatment of these…
- Conditions
- Dry Eye Syndrome (DES), Sjogren's Syndrome, Xerophthalmia
- Trial name
- NCT06771427
- Testing
- acupuncture GB20 or GB20 plus BL2, Chinese herbal tea TBDESJS
- Where
- Taiwan
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Human Papillomavirus Infection
Efficacy and Immunomodulation Study of Simultaneous Human Papillomavirus/ Hepatitis B (HPV/HBV) Vaccination
Rationale: In march 2009 the Dutch Health Council advised to introduce general infant hepatitis B (HBV) vaccination in the Dutch national immunization program (NIP) {Gezondheidsraad 2009 #16914}.
- Trial name
- TANGO (NCT01082861)
- Testing
- Cervarix, Engerix-B
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Institute for Public Health and the Environment (RIVM)
Hymenoptera Venom Allergy
Virtual-reality Induced Immune Modulation in Allergic Patients
This study investigates whether immersive virtual reality (VR) exposure to allergen-related stimuli can modulate behavioural, neurophysiological, psychophysiological, and immune responses in adults with bee or wasp venom allergy.
- Trial name
- NCT07721233
- Testing
- Allergen-related immersive virtual reality exposure, Control immersive virtual reality exposure
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- University of Geneva, Switzerland
Type 1 Diabetes
Stem Cell Educator Therapy in Type 1 Diabetes
The translational potential to the clinical applications of cord blood stem cells has increased enormously in recent years, mainly because of its unique advantages including no risk to the donor, no ethical issues, low risk of…
- Trial name
- NCT01350219
- Testing
- Stem Cell Educator
- Where
- 4 sites in China, Spain
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Throne Biotechnologies Inc.
Immune Surveillance
Acute Immune Modulation by Probiotic Strain
Clinical proof-of-concept study, comparing the acute immune impacts of 3 doses of a probiotic strain to a placebo. This study involves twenty-four participants, composed of healthy adults, who will be taking a placebo and 3…
- Trial name
- NCT06754228
- Testing
- Probiotic Agent
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Natural Immune Systems Inc
Covid19
IMUNOR® Preparation in the Prevention of COVID-19
The aim of the study is to achieve prevention of COVID-19 disease in healthcare professionals with the administration of the IMUNOR® preparation, and decreasing the symptoms should the disease appear.
- Trial name
- NCT04710381
- Testing
- IMUNOR
- Where
- Czechia
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University Hospital Ostrava
Healhty
Human Milk Oligosaccharides, Gut Bifidobacterium, Vitamin D, and Infant Immunity
The goal of this observational study is to learn how certain natural sugar components in breast milk may be linked with vitamin D level, healthy gut bacteria, and immune markers in healthy breastfed infants.
- Trial name
- HMO-BIFIDI (NCT07570329)
- Where
- Indonesia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Hasanuddin University
Immunomodulation, Respiratory Tract; Infection, Upper (Acute)
Effect of an Immune-boosting Food Supplement on the Severity and Frequency of Pediatric Respiratory Tract Infections
The goal of this clinical trial is to evaluate the efficacy of the product in developing immune reinforcement that results in decreased susceptibility to respiratory infections of viral origin in children aged 3 to 10 years with…
- Trial name
- NCT06218225
- Testing
- Verum
- Where
- Italy
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliera Universitaria Policlinico "G. Martino"
Aspirin, Pregnancy Complications
Immunomodulation During Pregnancy
The goal of this observational study is to learn about the effects of low dose aspirin in immunity Pregnant women taking aspirin for other reasons (preeclampsia prevention) will be studied.
- Conditions
- Aspirin, Pregnancy Complications, Immunology
- Trial name
- NCT06882850
- Where
- Portugal
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Unidade Local de Saúde de Coimbra, EPE
Infections, Total Parenteral Nutrition
Immune Modulation by Parenteral Lipids
Immune modulating properties of parenteral lipid emulsions seem to contribute to the increased risk for infections which remains associated with the use of total parenteral nutrition.
- Trial name
- NCT00734916
- Testing
- Parenteral lipid emulsion (Omegaven), Parenteral lipid emulsion (Intralipid), Parental lipid emulsion (Saline 0.9%)
- Where
- Netherlands
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Actinic Keratosis, Photodynamic Therapy
Photodynamic Therapy-Induced Immune Modulation: Part III
This study is designed as a double-blinded proof of concept of feasibility study to define if the immunosuppression associated with photodynamic therapy (PDT) can be blocked by treatment with cyclo-oxygenase-2 (COX-2) inhibitor…
- Trial name
- NCT03643744
- Testing
- Celecoxib 200mg
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Wright State University
Capsular Contracture Associated With Implant, Foreign-Body Reaction
Experimental and Clinical Investigation of the Implant Surface Roughness Reduction Effect on Early-stage Fibrosis
The goal of this single-center, randomised double-blinded trial is to compare the early stage fibrosis progression around conventional textured expander and the SmoothSilk® expander with reduced surface roughness in women…
- Conditions
- Capsular Contracture Associated With Implant, Foreign-Body Reaction, Wounds and Injuries, Tissue Expander Disorder
- Trial name
- NCT05648929
- Testing
- Patient Satisfaction Questionnaire, Pregnancy test, Blood draw
- Where
- Austria
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Medical University Innsbruck
Vogt Koyanagi Harada Disease (VKH)
Corticosteroid Combining Noncorticosteroid Systemic Immunomodulatory Therapy in VKH
The aim of this study is to evaluate the efficacy and safety of corticosteroidcombining noncorticosteroid systemic immunomodulatory therapy (NCSIT) for the treatment of Vogt Koyanagi Harada disease (VKH).
- Trial name
- NCT05120687
- Testing
- noncorticosteroid systemic immunomodulatory therapy (NCSIT)
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Traumatic Brain Injury
Effects of Intravascular Administration of Mesenchymal Stromal Cells Derived from Wharton's Jelly of the Umbilical Cord on Systemic Immunomodulation and Neuroinflammation After Traumatic Brain Injury.
Traumatic brain injuries (TBI) are one of the leading causes of death and disability worldwide. These patients are burdened by physical, cognitive, and psychosocial deficits, leading to an important economic impact for society.
- Trial name
- TRAUMACELL (NCT06146062)
- Testing
- Mesenchymal Stromal Cells (MSC)
- Where
- 3 sites in France
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Vitamin d Deficiency
Peripheral Immunological Effects of High-dose Vitamin D Treatment in Healthy Subjects
Vitamin D deficiency is associated with the risk of developing MS. Vitamin D treatment has therefore been tested as a background treatment for this pathology, with a seemingly modest clinical effect.
- Trial name
- VDSS (NCT05654818)
- Testing
- Vitamin D
- Where
- France
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Use of Stem Cells for COVID-19 Treatment
Treatment of COVID-19 Patients Using Wharton's Jelly-Mesenchymal Stem Cells
The purpose of this study is to investigate the potential use of Wharton's Jelly Mesenchymal stem cells (WJ-MSCs) for treatment of patient diagnosed with Corona Virus SARS-CoV-2 infection, and showing symptoms of COVID-19.
- Trial name
- NCT04313322
- Testing
- WJ-MSCs
- Where
- Jordan
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Stem Cells Arabia