Clinical trials: Impaired Glucose Tolerance in Obese
Obesity, NAFLD
Low-Calorie Diet in People With Prediabetes/Metabolic Syndrome
Significant weight reduction, achieved by low-calorie diet (LCD), will mobilise ectopic fat (visceral and particularly liver fat), improving insulin sensitivity and other metabolic syndrome components, with secondary beneficial…
- Conditions
- Obesity, NAFLD, Fatty Liver, Pre Diabetes
- Trial name
- CALIBRATE (NCT04786418)
- Testing
- Standard of care, Low-calorie diet
- Where
- United Kingdom
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Liverpool
Insulin Resistance, Impaired Glucose Tolerance
The Effects of an Obesogenic Lifestyle in Recreationally Active, Young Adults
This clinical trial aims to learn about the alterations in insulin resistance and metabolic flexibility following a transition to an obesogenic lifestyle in fit young men and women. The main questions it aims to answer are: 1.
- Conditions
- Insulin Resistance, Impaired Glucose Tolerance, Obesity, Metabolic Disturbance
- Trial name
- NCT05912348
- Testing
- Low Physical Activity and Added Carbohydrate Group, Low physical Activity Control, High Physical Activity and Added Carbohydrate Group
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of New Hampshire
Obesity, Metabolic Syndrome X
Drug Therapy Induced Weight Loss to Improve Blood Vessel Function in Subjects With Obesity
Obesity is common (>30% of US adults), contributes to substantial morbidity and mortality, but is difficult to treat. Partly this is due to the transient, arduous and modest nature of lifestyle interventions.
- Trial name
- REVIVE (NCT01351753)
- Testing
- Metformin, Orlistat, Topiramate
- Where
- United States
- Volunteers
- 128 people
- Sponsor
- University of Iowa
Prediabetic State, Insulin Resistance
Effect of Empagliflozin + Linagliptin + Metformin + Lifestyle in Patients With Prediabetes
Type 2 diabetes is a worldwide epidemic disease, and preventive strategies are needed to face this health problem. The goal of this trial is to evaluate the effect of empagliflozin + linagliptin + metformin + lifestyle on…
- Trial name
- 4T (NCT04131582)
- Testing
- Linagliptin + metformin and Empagliflozin + metformin, Metformin
- Where
- Mexico
- Volunteers
- 34 people
- Sponsor
- Universidad de Guanajuato
Diabetes Prevention in Women After GDM Who Are at High-risk
Dapagliflozin and Metformin,Alone and in Combination, in Overweight/Obese Prior GDM Women
Women with a history of gestational diabetes (GDM) are at substantially increased risk of type 2 diabetes mellitus (T2DM). Compared with the general population, these women are more likely to be overweight or obese.
- Trial name
- DAPA-GDM (NCT02338193)
- Testing
- DAPA/MET XR, DAPA, MET XR
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Woman's
Neurodevelopmental Disorders, Irritability
AP Metabolism Transcriptomics
It is known from the literature that treatment with antipsychotic drugs (AP) induces, even before changes in blood chemistry parameters, changes in gene transcription that are evident at the level of peripheral blood mononuclear…
- Trial name
- NCT06814314
- Testing
- Transcriptomic investigation
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- IRCCS Eugenio Medea
Nutrition Disorders, Hypertension
Assessment of Progranulin and FAM19A5 Protein Blood Levels in Metabolic Syndrome
The main objective of the study is to assess the serum levels of progranulin and FAM19A5 protein in adults with metabolic syndrome.
- Conditions
- Nutrition Disorders, Hypertension, Dyslipidemias, Glucose Intolerance
- Trial name
- PROG-FAM (NCT04451616)
- Testing
- Blood sample collection, Hair sample collection, Urine sample collection
- Where
- Poland
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Poznan University of Medical Sciences
Obesity, Pre-diabetes
Chromium Effects on Insulin and Vascular Function in People at Risk for Diabetes
The purpose of this study is to investigate the effects of Chromium on glucose tolerance and endothelial function in people at risk for type II diabetes.
- Conditions
- Obesity, Pre-diabetes, Insulin Resistance, Impaired Glucose Tolerance
- Trial name
- NCT00067626
- Testing
- Chromium
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Griffin Hospital
Menopause, Prediabetes
Effects of Novel Estrogens on Glucose and Lipids in Postmenopausal Prediabetic Women Veterans
The purpose of this study is to determine the effect of a novel menopause hormone therapy on blood sugar (glucose) and blood and liver fats (lipids) in obese menopausal women Veterans.
- Conditions
- Menopause, Prediabetes, Obesity
- Trial name
- CE/BZA (NCT05073237)
- Testing
- conjugated estrogens/bazedoxifene (CE/BZA)
- Where
- United States
- Sponsor
- VA Office of Research and Development
Pre Diabetic, Obesity & Overweight
The Impact of Continuous Glucose Monitoring on Glucose Variability and Weight Loss in Individuals With Prediabetes and Obesity
This randomized, crossover interventional study evaluates the effects of real-time (open) versus blinded continuous glucose monitoring (CGM) on glycemic variability, lifestyle behaviors, and metabolic outcomes in adults with…
- Trial name
- CGM (NCT07423065)
- Testing
- Continuous Glucose Monitoring (CGM)
- Where
- 3 sites in Slovenia
- Volunteers
- 34 people
- Sponsor
- University of Primorska
Pre Diabetes, Obesity
Study of the Food Order Behavioral Intervention in Prediabetes
Investigators have previously shown that eating carbohydrates after protein or vegetables resulted in reduced glucose and insulin excursions over 180 min in patients with T2DM and in individuals with prediabetes as well.
- Trial name
- NCT03896360
- Testing
- Food order behavioral intervention plus standard care, Standard Care
- Where
- United States
- Volunteers
- 79 people
- Sponsor
- Weill Medical College of Cornell University
Fatty Liver, Overweight/Obesity
Effects of Testosterone Undecanoate vs Placebo on Intrahepatic Fat Content in Overweight/Obese Men With T2DM or Prediabetes and Hypogonadism
The epidemics of obesity, MeTSy, T2DM and CVD are increasing worldwide. Non-alcoholic fatty liver disease (NAFLD) is becoming recognized as a condition possibly involved in the pathogenesis of these diseases.
- Conditions
- Fatty Liver, Overweight/Obesity, Prediabetes/Type2 Diabetes Mellitus, Hypogonadism, Male
- Trial name
- Test2Func (NCT03851627)
- Testing
- Testosterone Undecanoate
- Where
- Austria
- Volunteers
- 32 people
- Sponsor
- Alexandra Kautzky-Willer
Healthy, Obesity & Overweight
Growth Hormone Resistance of Beta-cells
The purpose of the research study is to better understand how beta-cells (cells in the pancreas that make insulin and help regulate blood sugar) respond to growth hormone in people with impaired fasting glucose or impaired…
- Conditions
- Healthy, Obesity & Overweight, Impaired Fasting Glucose (IFG), Impaired Glucose Tolerance (Prediabetes)
- Trial name
- GHRB-C (NCT07581860)
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Diabetes Mellitus, Type 2, PreDiabetes
18F-FDOPA PET/CT Imaging in Patients Undergoing Metabolic Surgery
The aim of the study is to compare the endocrine function of pancreas between pre and post metabolic surgery in patients with type 2 diabetes or prediabetes.
- Conditions
- Diabetes Mellitus, Type 2, PreDiabetes, Obesity
- Trial name
- NCT03821961
- Testing
- Metabolic Surgery
- Where
- South Korea
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Korea University Anam Hospital
Overweight and Obesity, PreDiabetes
Effects of Yogurt With Spirulina on Cardiometabolic Risk Markers
The effects of yogurt with spirulina consumption compared to conventional yogurt (without spirulina) on several cardiometabolic and anthropometric parameters in individuals at risk of cardiovascular disease
- Conditions
- Overweight and Obesity, PreDiabetes, Hypertension, Dyslipidemias
- Trial name
- NCT06114563
- Testing
- Spirulina yogurt, Conventional yogurt
- Where
- Greece
- Volunteers
- 64 people
- Sponsor
- Agricultural University of Athens
Prediabetic State, Glucose Intolerance
Impact of Sorghum Rice on Beta-Cell Function and Insulin Resistance in Prediabetes
Prediabetes is a condition where blood sugar levels are higher than normal but not yet high enough to be diagnosed as diabetes. Without lifestyle changes, people with prediabetes often develop type 2 diabetes, a serious disease…
- Conditions
- Prediabetic State, Glucose Intolerance, Insulin Resistance, Obesity and Overweight
- Trial name
- NCT07298304
- Testing
- Sorghum Rice, white rice
- Where
- Indonesia
- Volunteers
- 26 people
- Sponsor
- Dr. Soetomo General Hospital
Obesity & Overweight, Circadian Rhythm Disorders
Effects of Akkermansia Muciniphila and Berberine Supplementation on Insulin Sensitivity in Night-shift Workers
Night shift work is associated with an increased risk of obesity, insulin resistance, and cardiometabolic disorders, largely due to circadian misalignment, disrupted sleep, and altered eating patterns.
- Conditions
- Obesity & Overweight, Circadian Rhythm Disorders, Gut Microbiota Modulation, Prediabetes (Insulin Resistance, Impaired Glucose Tolerance)
- Trial name
- Shift2Health (NCT07440147)
- Testing
- Verum (A)
- Where
- Austria
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- FH Joanneum Gesellschaft mbH
Glucose Intolerance, Insulin Resistance
Extracellular Vesicle Cargo in Obesity and Type 2 Diabetes
The purpose of this research is to obtain blood samples before and after a bariatric procedure to better understand the reasons for glucose intolerance and insulin resistance (diabetes) in the obesity, and the reasons for…
- Conditions
- Glucose Intolerance, Insulin Resistance, Diabetes
- Trial name
- NCT06401876
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Mayo Clinic
Obesity, Type 2 Diabetes
GOAL Life-Style Change Intervention to Prevent Type 2 Diabetes
Life-style change achieved in controlled experimental condition has been shown to prevent type 2 diabetes. The purpose of this study is to evaluate to what extent the life-style change can be achieved in a routine health care…
- Trial name
- NCT00398060
- Testing
- Cognitive-behavioral life-style counseling
- Where
- Finland
- Volunteers
- 389 people
- Sponsor
- Finnish Institute for Health and Welfare
Overweight, Glucose Intolerance
Diabetes Prevention In Estrie
This study compared the efficacy at one year of an interdisciplinary approach including individual counseling and group seminars versus group seminars alone to induce weight loss in subjects at high risk of developing type 2…
- Trial name
- NCT00991549
- Testing
- interdisciplinary intervention or meeting-seminars
- Where
- Canada
- Volunteers
- 53 people
- Sponsor
- Université de Sherbrooke