Clinical trials: Impaired Synaptic Plasticity
Depression, Mild Cognitive Impairment
Single-dose Ketamine Treatment to Improve Depression in Mild Cognitive Impairment
Ketamine is a NMDA-receptor antagonist that promotes synapse formation and has been shown to rapidly improve symptoms in depression.
- Trial name
- NCT06069843
- Testing
- IV Ketamine
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Impaired Synaptic Plasticity, Impaired Cognition
Synaptic Plasticity and Cognitive Function in RASopathies
The project is targeting cognitive impairment, one of the main health problems of patients with RAS pathway disorders. The aim of this study is to translate findings of animal studies to humans.
- Trial name
- SynCoRAS (NCT03504501)
- Testing
- Lovastatin, Lamotrigine
- Where
- Germany
- Volunteers
- 16 people
- Sponsor
- Technical University of Munich
Alzheimer Disease and Related Dementias, Cognition
Home-Based Brain Stimulation for Motoric Cognitive Risk Syndrome
The objective of this study is to determine the effects of a 6-month, home-based personalized transcranial direct current stimulation (tDCS) intervention targeting the left dorsolateral prefrontal cortex on cognitive function…
- Conditions
- Alzheimer Disease and Related Dementias, Cognition, Mobility Disability
- Trial name
- TDCS4MCR (NCT06821568)
- Testing
- Personalized Transcranial Direct Current Stimulation (tDCS)
- Where
- 2 sites in United States, Israel
- Volunteers
- 128 people
- Sponsor
- Hebrew SeniorLife
Math Learning Disability, Child Development
Interventions in Mathematics and Cognitive Skills
The purpose of this study is to investigate neurocognitive mechanisms underlying response to intervention aimed at enhancing, and remediating weaknesses in, numerical skills in children, including those with mathematical learning…
- Conditions
- Math Learning Disability, Child Development, Developmental Disability, Learning Disabilities
- Trial name
- NCT05201534
- Testing
- Interventions in Mathematics and Cognitive Skills - Experimental, Interventions in Mathematics and Cognitive Skills - Active Comparator
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Stanford University
Multiple Sclerosis
Function Magnetic Resonance Imaging to Assess Two Therapeutic Strategies in Multiple Sclerosis (NeuroRehEM).
Multiple sclerosis (MS) is an autoimmune disease that causes cognitive and motor disabilities and contributes to decrease patients life quality.
- Trial name
- NeuroRehEM (NCT05270239)
- Testing
- N-back Cognitive Training, Virtual Reality Motor and Cognitive Training
- Where
- Spain
- Volunteers
- 94 people
- Sponsor
- Universitat Jaume I
Autism Spectrum Disorder (ASD), Central Auditory Processing Disorder
Mental And Speech Developmental Delay Autism Spectrum-Type Behavioral Disorder
FAMILY SYSTEM CITADEL 2060.METHODOLOGY "VOICE OF SLEEP MAMABEE 2026-2085 Systemic work with brain neurons through training modules at the border of sleep in clinical, psychological and strategic logic.
- Conditions
- Autism Spectrum Disorder (ASD), Central Auditory Processing Disorder, Nervous System Disorder, Neurological Disorder
- Trial name
- NCT07670000
- Testing
- Audio fairy tales
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Natalia Poluektova
Stroke (CVA) or TIA, Stroke/Brain Attack
Music Therapy After Stroke (Subacute Phase)
The goal of this longitudinal, single-subject study is to investigate the role of motivation in music therapy for stroke patients within the subacute phase, who experience upper limb and/or attention deficits.
- Trial name
- NCT06291480
- Testing
- Neurologic Music Therapy
- Where
- Netherlands
- Volunteers
- 16 people
- Sponsor
- Universiteit Leiden
Cognitive Impairment, Bipolar Disorder
Effects of Altitude-like Cognition Training on Neuroplasticity and Cognitive Functions
The goal of this clinical trial is to investigate the effects of a three-week altitude-like cognition training intervention in healthy individuals (substudy 1) and symptomatically stable patients with mood disorders (depression…
- Conditions
- Cognitive Impairment, Bipolar Disorder, Depression
- Trial name
- ALTIBRAIN (NCT06121206)
- Testing
- Altitude-like hypoxia (12% O2), Normoxia (20% O2), Cognitive training
- Where
- Denmark
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Mental Health Centre Copenhagen, Bispebjerg and Frederiksberg Hospital
Bipolar Disorder (BD), Depression - Major Depressive Disorder
Epigenetic Enhancement of Cognitive Training in Aging Mood and Schizophrenia Spectrum Disorder Populations
The aim of this clinical trial is to investigate the effects of a three-week virtual reality-based cognitive remediation training (VR-CRT) programme in combination with daily intake of a histone deacetylase inhibitor (HDACi)…
- Conditions
- Bipolar Disorder (BD), Depression - Major Depressive Disorder, Cognitive Impairment, Schizophrenia Disorders
- Trial name
- EPIC (NCT07404085)
- Testing
- Virtual Reality-based cognitive remediation therapy (VR-CRT), Virtual Reality-based control treatment (VR-CT), HDACi butyrate
- Where
- Denmark
- Volunteers
- 160 people
- Sponsor
- Mental Health Centre Copenhagen, Bispebjerg and Frederiksberg Hospital
Mild Cognitive Impairment (MCI)
Effects of Transcranial Temporal Interference Stimulation on Cognitive Function in Mild Cognitive Impairment
To explore the effects of transcranial temporal interference stimulation (tTIS) on cognitive function and dual-task walking performance, as well as its underlying neuroimaging mechanisms, in individuals with mild cognitive…
- Trial name
- TIS-MCI (NCT07519798)
- Testing
- Active Temporal Interference Stimulation (TIS)
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Shanghai University of Sport
Neurodevelopmental Disorders, Neurodevelopmental Disorders (NDD)
Intensive Multimodal Neurorehabilitation Targeting Neuroplasticity in Pediatric Neurodevelopmental and Chromosomal Disorders
This observational study evaluates functional and developmental outcomes in pediatric participants undergoing a two week intensive multimodal neurorehabilitation program.
- Conditions
- Neurodevelopmental Disorders, Neurodevelopmental Disorders (NDD), Neurodevelopmental Disorders and Developmental Abnormalities, Developmental Delay (Disorder)
- Trial name
- GEN-HOPE (NCT07493096)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Healing Hope International
Traumatic Brain Injury
PC-Based Cognitive Rehabilitation for Traumatic Brain Injury (TBI)
The investigators evaluated whether it was possible to improve the measurement of memory, attention, and executive function in patients who have suffered traumatic brain injury through the use of computer-based testing.
- Trial name
- NCT00927576
- Testing
- Digit span testing, Spatial span testing, Finger tapping
- Volunteers
- 265 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Mild Cognitive Impairment
Vision-based Speed of Processing Cognitive Training and Mild Cognitive Impairment
This project seeks to identify neural changes that occur in adults with mild cognitive impairment (MCI) after engagement in computerized cognitive training.
- Trial name
- NCT02559063
- Testing
- Vision-based speed of processing training, Mental leisure activities
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Mild Cognitive Impairment
A Health Game Intervention for Cancer and Post-ICU Patients Suffering From Acute Cognitive Impairment
Millions of patients each year suffer from acute cognitive impairment caused by traumatic brain injury, stroke, Parkinson's disease, etc.
- Trial name
- NCT07596940
- Testing
- VR cognitive training platform
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of Cincinnati
Mild Cognitive Impairment
The Effects of Exercise on Synaptic Plasticity in Individuals With Mild Cognitive Impairment and in Healthy Aging.
The research is focused on ameliorating cognitive decline in aging and in individuals diagnosed with Mild Cognitive Impairment (MCI).
- Trial name
- NCT05663918
- Testing
- Self- determined Intensity Interval Training
- Where
- 6 sites in Canada
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- McMaster University
Schizophrenia
D-cycloserine Augmentation of Cognitive Remediation in Schizophrenia
This study seeks to examine the effects of D-cycloserine augmentation on cognitive remediation for patients diagnosed with schizophrenia.
- Trial name
- NCT00963924
- Testing
- D-cycloserine, Cognitive Remediation
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Massachusetts General Hospital
Retinitis Pigmentosa (RP), Rod Cone Dystrophy
Brain Stimulation Effects on Orientation and Mobility Skills in Adults With Vision Impairment
This pilot clinical trial evaluates whether non-invasive brain stimulation improves the orientation and mobility (O\&M) skills of individuals with constricted visual fields in both eyes. The study is composed of three visits.
- Conditions
- Retinitis Pigmentosa (RP), Rod Cone Dystrophy, Visually Impaired Persons, Peripheral Visual Field Defect of Both Eyes
- Trial name
- NCT07341763
- Testing
- Active hf-tRNS.
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of Waterloo
Stroke, Hemiplegia
Brain Stimulation and Rehabilitation for Adults With Chronic, Severe Arm Motor Impairment After Stroke
This pilot study will examine a combination therapy for adults with chronic, severe motor impairment of an arm after stroke. The intervention will combine brain stimulation with physical rehabilitation of the arm on the side of…
- Conditions
- Stroke, Hemiplegia, Hemiparesis
- Trial name
- NCT03538795
- Testing
- iTBS&eCIMT
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Alabama at Birmingham
Stroke, Gait Impairment
Transcranial Direct Current Stimulation for Post-stroke Gait Rehab
Stroke affects upwards of 800,000 Americans every year and has an enormous impact on the well-being of the American Veteran population with 6,000 new stroke admissions every year.
- Trial name
- NCT03666533
- Testing
- Active transcranial Direct Current Stimulation
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- VA Office of Research and Development
Schizophrenia
Once Weekly D-cycloserine for Schizophrenia
This is a parallel-group, placebo-controlled trial examining the cognitive effects at weeks 1, 4, \& 8 of once-weekly oral D-cycloserine 50 mg added to a stable dose of antipsychotic for 8 weeks in adult outpatients with…
- Trial name
- NCT00964041
- Testing
- D-cycloserine
- Where
- United States
- Sponsor
- Massachusetts General Hospital