Clinical trials: Impairment
Obesity, Healthy Aging
Sukalmena InAge: Nutritional-culinary Programme to Promote Adherence to a Healthy Dietary Pattern.
Currently, one of the main health challenges of public health is to improve the quality of life of people with chronic non-communicable diseases, through new strategies that promote healthy eating habits and lifestyles.
- Conditions
- Obesity, Healthy Aging, Cognitive Impairment
- Trial name
- Sukalmena (NCT04908163)
- Testing
- Mediterranean diet-based nutritional education intervention, Mediterranean diet-based culinary intervention
- Where
- Spain
- Volunteers
- 56 people
- Sponsor
- Basque Culinary Center Fundazioa
Neurodegenerative Diseases, Cognitive Decline
The Efficacy of VESPA 2.0 for Cognitive Rehabilitation in Patients With Mild Cognitive Impairment
VESPA 2.0 is based on an integrative and ecological approach used for the treatment of cognitive dysfunction in patients with MCI or other neurodegenerative disorders.
- Conditions
- Neurodegenerative Diseases, Cognitive Decline, Parkinson Disease Dementia, Alzheimer Disease
- Trial name
- NCT06281314
- Testing
- Vespa software
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- IRCCS Centro Neurolesi Bonino Pulejo
Hemiplegia, Spasticity
Upper Limb Nerve Cryoneurolysis is Non Inferior to the Usual Care and Has Therapeutic Add Value in Dealing With Shoulder Pain and Functional Problems Caused by Spasticity and Motor Impairment
This trial is part of the spastiCRYO clinical research project. The primary objective of this clinical trial is to test the hypothesis: "Upper limb nerve cryoneurolysis is non inferior to the usual care and has therapeutic add…
- Conditions
- Hemiplegia, Spasticity, Shoulder Spasticity, Shoulder Stiffness
- Trial name
- spastiCRYO-UL (NCT06782464)
- Testing
- Treatment
- Where
- Luxembourg
- Volunteers
- 50 people
- Sponsor
- Centre National de Rééducation Fonctionnelle et de Réadaptation
Primary Brain Tumour, Radiation Toxicity
Cognitive Function After Radiation Therapy for Primary Brain Tumours
This study will assess cognitive function in patients with a primary brain tumour treated with radiation therapy (RT) to generate radio-sensitivity and volume effect parameters for the development of cognitive dysfunction.
- Conditions
- Primary Brain Tumour, Radiation Toxicity, Cognitive Impairment
- Trial name
- NCT04306432
- Testing
- Cognitive tests and Patient Reported Outcomes
- Where
- 5 sites in Denmark
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Obesity, Insulin Resistance
The Importance of the Gut Microbiota in Body Weight Control and Insulin Sensitivity
BACKGROUND: The relation between gut microbiota and obesity originates from animal studies, showing that the change of gut microbiota can induce changes in both insulin resistance and body composition.
- Trial name
- ANTIBIOTICS (NCT02241421)
- Testing
- Amoxicillin, Vancomycin
- Where
- Netherlands
- Volunteers
- 57 people
- Sponsor
- Maastricht University Medical Center
Participants Must be Women Aged 25 Years or Older, Participants Should Have no Self-reported History of Heart Disease or Stroke
RCT of HeartBot in Women
The goal of this clinical trial is to find out whether an app-based program called HeartBot II, which uses an artificial intelligence (AI) chatbot, can help improve women's awareness and knowledge of heart attacks in women.
- Conditions
- Participants Must be Women Aged 25 Years or Older, Participants Should Have no Self-reported History of Heart Disease or Stroke, Participants Should Have no Terminal Illness or Diagnosed Cognitive Impairment, Including Alzheimer's Disease, Participants Should Not be a Healthcare Professionals or Healthcare Trainees
- Trial name
- HeartBot II (NCT07416734)
- Testing
- HeartBot II Program, Waitlist Control
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Language Development Disorders
Improving STEM Outcomes for Young Children With Language Learning Disabilities Via Telehealth
In this study the investigators focus on a subset of at-risk students who find the language of science to be a barrier to the learning of science. These are the nearly 3 million children in the U.S.
- Trial name
- NCT04775199
- Testing
- Language Intervention
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Karla McGregor
Cerebral Palsy, Parent-Child Relations
Association Between Functional Impairment and Parenting Stress Among Children Diagnosed with Diplegic Cerebral Palsy
1. To find out the relation between the severity of ADL limitation in diplegic CP children and the level of parents' stress. 2. To detect the correlation between the PS level to the different domains of ADL limitation. 3.
- Trial name
- NCT04938063
- Testing
- Assessing the correlation between Functional Impairment and Parenting Stress
- Where
- Egypt
- Volunteers
- 107 people
- Sponsor
- Cairo University
Heart Arrest, Cardiac Arrest
Resuscitation Outcomes in the Netherlands
The Resuscitation Outcomes in the Netherlands - study assesses one-year survival and quality of life after In-Hospital Cardiac Arrest(IHCA).
- Conditions
- Heart Arrest, Cardiac Arrest, Cardiac Arrest as A Complication of Care, Outcome, Fatal
- Trial name
- ROUTiNE (NCT03120507)
- Where
- 12 sites in Netherlands
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Erasmus Medical Center
Menstrual Cycle, Exercise Performance Impairment
Eccentric Exercise, Muscle Damage, and Oxygen Uptake Across Menstrual Cycle Phases
The existing literature examining the effect of female sex hormones across the phases of the menstrual cycle on muscle microdamage and oxygen uptake is limited.
- Trial name
- EEMDO-MC (NCT07581067)
- Testing
- Isokinetic eccentric exercise using knee extensors of the right lower limb, Isokinetic eccentric exercise using knee extensors of the left lower limb
- Where
- Greece
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- National and Kapodistrian University of Athens
Mild Cognitive Impairment (MCI), Amyloid Pathology
Using Light Therapy for Mild Cognitive Impairment
The goal of this clinical trial is to test whether transcranial photobiomodulation (tPBM), a non-invasive brain stimulation technique using near-infrared light, can improve brain blood flow regulation (neurovascular coupling) and…
- Trial name
- LTMC (NCT07651787)
- Testing
- Active Vielight Neuro RX-Duo device -Active transcranial photobiomodulation
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Oklahoma
Myopathy, Cognitive Impairment
Critical Illness Myopathy as a Cause of Debilitating ICU-Acquired Weakness
ICU-acquired weakness represents a common and often devastating disease process which affects greater than 50% of critically ill patients.
- Trial name
- MUSIC Plus (NCT00937001)
- Testing
- Biopsy/Ultrasound
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Vanderbilt University
Mild Cognitive Impairment
Probiotic Intervention on Gut Microbiota and Cognitive Functioning in Older Adults With a Mild Cognitive Impairment
Recent studies suggest that gut microbiota is linked to cognitive performance and modulating gut microbiota is a safe and promising approach to enhance cognition.
- Trial name
- NCT05859230
- Testing
- Experimental: The probiotic drink study group
- Where
- Singapore
- Volunteers
- 50 people
- Sponsor
- National University of Singapore
Depression
Prevention of Depression in Spouses of People With Cognitive Impairment
This study evaluates the effectiveness of a problem-solving training program in preventing depression in the spouses or family caregivers of persons with mild cognitive impairment or early dementia.
- Trial name
- NCT00321971
- Testing
- PST-MCI/AD Caregiving, NT-MCI/AD Caregiving
- Where
- 2 sites in United States
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Anesthesia, General
Efficacy, Pharmacokinetics and Safety of Org 25969 in Subjects With Normal or Impaired Renal Function (19.4.304)(P05948)(COMPLETED)
The purpose of this study is to compare the efficacy and pharmacokinetics of Org 25969 in subjects with normal or impaired renal function and to evaluate the safety of Org 25969 in subjects with impaired renal function.
- Trial name
- NCT00482599
- Testing
- Sugammadex
- Volunteers
- 30 people
- Sponsor
- Merck Sharp & Dohme LLC
Sensorineural Hearing Loss
OTO-413 in Subjects With Speech-in-Noise Hearing Impairment
The purpose of this study is to evaluate the safety, tolerability, and exploratory efficacy of OTO-413 administered as an intratympanic injection for the treatment of speech-in-noise hearing impairment.
- Trial name
- NCT04129775
- Testing
- OTO-413
- Where
- 8 sites in United States
- Volunteers
- 110 people
- Sponsor
- Otonomy, Inc.
Non-healing Wound
Mechanisms Underlying Impaired Diabetic Wound Healing
The overall aim of this research is to utilize wound derived inflammatory cells from diabetic versus non diabetic human chronic wounds to understand mechanisms that are responsible for disregulated inflammation in individuals…
- Trial name
- WoundVAC (NCT00777712)
- Testing
- Blood draw
- Where
- 2 sites in United States
- Volunteers
- 250 people
- Sponsor
- University of Pittsburgh
Depression Mild, Depressive Disorder, Major
Cognitive Fitness for Depression in Older Adults
This research is being done to determine if computerized administered cognitive fitness activities will improve thinking and depression in older depressed adults who are being treated with antidepressants.
- Conditions
- Depression Mild, Depressive Disorder, Major, Mild Cognitive Impairment
- Trial name
- NCT04790630
- Testing
- Computerized Cognitive Remediation of Executive Functioning (CCR-EF), Active Control
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- UConn Health
Mild Cognitive Impairment, Alzheimer's Disease
Aftobetin-HCl and Fluorescence Detection Measured by Sapphire II to Determine the Number and Timing of Administrations
This is an open-label study to evaluate Aftobetin-HCl and florescence detection as measured by the Sapphire II device. Performance of Part I of the study has been completed (15 subjects received a single administration of…
- Trial name
- NCT02928211
- Testing
- Sapphire II, Aftobetin-HCl, Positron Emission Tomography
- Where
- United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Cognoptix, Inc.
Hearing Impairment, Deafness
RoboHear™ Device: Advanced Haptic Technology That Allows the Deaf to Understand Speech
Pilot study to test the feasibility of translating the English language into haptics (touch sensations)
- Trial name
- NCT03966144
- Testing
- RoboHear Device
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Arkansas
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.