Clinical trials: Impairment
Mental Health Impairment
Effectiveness of Tracking Goals in Counselling
Recent evidence suggests that focusing on positive goals rather than problems to avoid, may be associated with better psychological health and attainment of goals.
- Trial name
- Goals in MIND (NCT03000153)
- Testing
- Completing the Goals Form
- Where
- United Kingdom
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- University of Roehampton
Blindness, Blindness, Acquired
Advanced Spatiomotor Rehabilitation for Navigation in Blindness & Visual Impairment
One of the most challenging tasks for blind and visually impaired individuals is navigation through a complex environment. The goal of the present multidisciplinary study is to increase spatial-cognition abilities in people who…
- Conditions
- Blindness, Blindness, Acquired, Low Vision, Blindness, Complete
- Trial name
- NCT05377853
- Testing
- Cognitive-Kinesthetic Navigational Training
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Smith-Kettlewell Eye Research Institute
Renal Impairment
Fruquintinib Renal Impairment Study
A multicenter, open label, single-dose, single-period, sequential study to assess the effect of renal impairment on the pharmacokinetics of Fruquintinib
- Trial name
- NCT05216354
- Testing
- Fruquintinib
- Where
- 2 sites in United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Hutchmed
Stroke
Proximal Priority Versus Distal Priority Robotic Priming Effects in Patients With Chronic Stroke
This is a single-blind randomized comparative efficacy study involving 54-72 participants with chronic stroke. Participants will be randomized into proximal priority robotic group or distal priority robotic group and receive 18…
- Trial name
- NCT04446273
- Testing
- Bi-Manu-Track
- Where
- 4 sites in Taiwan
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Mild Cognitive Impairment, Mild Cognitive Impairment Due to Alzheimer's Disease
UK Based Remote Brain Health Clinic (BHC) for Patients With Mild Cognitive Impairment (MCI)
This project aims to understand the feasibility, acceptability and real-world evidence of a novel UK-based remote brain health clinic for patients with mild cognitive impairment (MCI).
- Trial name
- BHC (NCT06379594)
- Where
- United Kingdom
- Volunteers
- 200 people
- Sponsor
- South London and Maudsley NHS Foundation Trust
Dementia, Sleep Disorder
Develop Novel Phototherapy for Health Care of Patients With Sleep Disorder, Mild Cognitive Impairment, or Dementia
Investigators aim to collaborate with the division of neurology, ophthalmology and dermatology at the Kaohsiung Medical University, and make a new phototherapy for participants suffering from dementia, sleep disorder, mild…
- Conditions
- Dementia, Sleep Disorder, Mild Cognitive Impairment, Phototherapy
- Trial name
- NCT04407351
- Testing
- Green LED light
- Where
- Taiwan
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Kaohsiung Medical University
Stroke, Acute
Effectiveness of High-intensity Aerobic Interval Training on Impairments and Activity Limitations in the Acute Phase of Stroke in Benin
This clinical trial aims to examine the effects of combining HIIT on a semi-recumbent cycle ergometer (HIIT-RCE) with conventional physiotherapy on impairments and activity limitations in early subacute stroke.
- Trial name
- NCT06179173
- Testing
- HIIT-RCE, Conventional physiotherapy
- Where
- Benin
- Volunteers
- 40 people
- Sponsor
- Hasselt University
Mild Cognitive Impairment
Exergame Balance Training for Patients With Mild Cognitive Impairment
This study will be a randomized control trial, which will be conducted on older adults with mild cognitive impairment. A specially designed Exergame balance training will be used for cognitive enhancement in patients with MCI.
- Trial name
- NCT04959383
- Testing
- Low complexity Exergaming group, Moderate complexity Exergaming group, High complexity Exergaming group
- Where
- Pakistan
- Volunteers
- 90 people
- Sponsor
- Riphah International University
Low Vision, Orientation
SmartHMD for Improved Mobility
The National Eye Institute estimated about 3 million people over age 40 in the US had low vision in 2010 and projects an increase to nearly 5 million in 2030 and 9 million in 2050.
- Conditions
- Low Vision, Orientation, Mobility Limitation, Navigation, Spatial
- Trial name
- NCT03781583
- Testing
- SmartHMD version 1, SmartHMD version 2, SmartHMD version 3
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- James Weiland
Mild Cognitive Impairment
Effects of a Nutraceutic Compound on Cognitive Impairment
The study is designed to evaluate the effects of choline bitartrate on cognitive impairment in frailty patients. The study will analyze the impact of 4 weeks treatment randomized with a nutraceutical compound in a double-blind…
- Trial name
- ENUCCI (NCT06200883)
- Testing
- Choline Bitartrate
- Where
- Italy
- Volunteers
- 58 people
- Sponsor
- Federico II University
Cognitive Decline
MASCoD - Multidimensional Assessment of Subjective Cognitive Decline
Subjective cognitive decline-SCD is a subclinical cognitive impairment subjectively experienced without being detectable from a diagnostic and neuropsychological perspective.
- Trial name
- NCT05815329
- Testing
- cognitive training
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA
Intrinsic Capacity, Frailty
Project ICOPE Brazil: Assessment of Intrinsic Capacity in Brazilian Older Adults
The ICOPE Brazil study aims to understand aging trajectories in Brazil, especially healthy aging trends based on intrinsic capacity, a collective of mental and physical capacities one may have to maintain their functional ability…
- Conditions
- Intrinsic Capacity, Frailty, Aging, Healthy Aging
- Trial name
- ICOPE-BR (NCT06968702)
- Volunteers
- 3,838 people
- Sponsor
- University of Sao Paulo
Mild Cognitive Impairment, Alzheimer's Disease
Comparison of PET Amyloid Imaging in Japanese and Western Subjects
This was a Phase 2, multicenter study to assess the extent and patterns of [18F] flutemetamol uptake in the brains of 3 groups of Japanese subjects: healthy volunteers (HV), amnestic mild cognitive impairment (aMCI), and probable…
- Conditions
- Mild Cognitive Impairment, Alzheimer's Disease, Healthy
- Trial name
- NCT02813070
- Testing
- [18F] Flutemetamol
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- GE Healthcare
Stroke
the Clinical Effect of TCM Sniffing Therapy Combined With Electroacupuncture in PSCI
The patients with cognitive impairment after stroke were divided into control group, electroacupuncture group, olfactory therapy group, electroacupuncture combined with olfactory therapy group, and sham group with 35 people in…
- Trial name
- NCT06313866
- Testing
- control, Electronuchal acupuncture group treatment, Smell therapy group treatment
- Where
- China
- Volunteers
- 220 people
- Sponsor
- Hangzhou Medical College
Cardiac Surgery Subjects
Effect of PEEP on Cardiac Function
The purpose of this single-center, prospective study is to evaluate the physiologic effect of changes in PEEP on biventricular mechanics and RV-pulmonary arterial (RV-PA) coupling in adult patients undergoing cardiac surgery.
- Trial name
- NCT07531602
- Testing
- EIT Guided PEEP Trial
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Beth Israel Deaconess Medical Center
Alzheimer Disease, Preclinical Alzheimer's Disease
Amyloid Prediction in Early Stage Alzheimer's Disease Through Speech Phenotyping
The primary objective of the study is to evaluate whether a set of algorithms analysing acoustic and linguistic patterns of speech can detect amyloid-specific cognitive impairment in early stage Alzheimer's disease, as measured…
- Conditions
- Alzheimer Disease, Preclinical Alzheimer's Disease, Prodromal Alzheimer's Disease, Alzheimer's Disease (Incl Subtypes)
- Trial name
- AMYPRED-US (NCT04928976)
- Where
- United States
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Novoic Limited
Chronic Nonmalignant Pain, Cognitive Impairment
Cognitive Function Before and After Opioid Reduction in Patients With Chronic Pain
This study aims to investigate the cognitive function of patients in the opioid reduction programme at the multidisciplinary pain centre at Zealand University Hospital Køge.
- Conditions
- Chronic Nonmalignant Pain, Cognitive Impairment, Opiate Dependence
- Trial name
- coffee-cup (NCT03036917)
- Where
- 2 sites in Denmark
- Volunteers
- 50 people
- Sponsor
- Zealand University Hospital
Parkinson's Disease, Mild Cognitive Impairment
Longitudinal Study of Mild Cognitive Impairment in Parkinson's Disease
Parkinson's disease (PD) is known for its motor symptoms and affects more than 100,000 Canadians. However, PD patients also show cognitive deficits and neuropsychiatric problems that significantly impair their quality of life.
- Trial name
- PD-MCI (NCT02637089)
- Where
- Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Parkinson Disease, Neurological Disorders
Amyloid Beta and Cognition in Parkinson Disease
The investigators propose to study persons with Parkinson Disease (PD) with detailed clinical, cognitive and imaging at the time of study entry and repeat these assessments 2 years later.
- Trial name
- NCT01754168
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- University of Michigan
Renal Insufficiency
Afatinib in Subjects With Kidney Dysfunction
The primary objective of the current study is to investigate the influence of moderate to severe renal impairment on the pharmacokinetics and safety of a single dose afatinib in comparison to a control group with normal renal…
- Trial name
- NCT02096718
- Testing
- Afatinib healthy, Afatinib severe renally impaired, Afatinib moderate renally impaired
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
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