Clinical trials: Impairment
Ultrasound Therapy, Hepatic Impairment
PVB Versus TAP in Hepatic Patients Undergoing Laparoscopic Cholecystectomy
The Era of using ultrasound guided blocks provides an attractive and more or less safe alternative to other techniques. Among these blocks is ultrasound-guided transverse abdominis plane block (USG-TAP block) that controls pain…
- Conditions
- Ultrasound Therapy, Hepatic Impairment, Laparoscopic Cholecystectomy
- Trial name
- NCT04208165
- Testing
- ultrasound-guided nerve block PVB, ultrasound-guided nerve block TAB
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Theodor Bilharz Research Institute
Cognitive Impairment
GAME Veterans With PTSD Using Computer-Based Cognitive Training
The investigators hypothesis are as follows: H1a: OEF/OIF veterans with PTSD who perform cognitive training (CT) will demonstrate greater objective improvements on standard (untrained) neurocognitive measures, with the largest…
- Trial name
- NCT01087775
- Testing
- Cognitive Training
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Karen Seal
Patient Satisfaction, Neurocognitive Disorders
COgilus Remediation in Alzheimer Patients (CORA)
This study evaluates the usability of a new tablet PC application to stimulate cognitive functions. Patients hospitalized in a geriatric ward (day or complete hospitalisation) but also their informal and professional caregivers…
- Trial name
- CORA (NCT04113577)
- Testing
- usability survey
- Where
- France
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University Hospital, Angers
Symptomatic Menopause, Cognitive Impairments
Attention & Memory Impairments in Menopausal Women
The purpose of this study is to determine whether a medication called Vyvanse® (lisdexamfetamine; LDX) has an impact on cognitive functioning, specifically measures of sustained attention, verbal encoding and recall and working…
- Trial name
- NCT01324024
- Testing
- Lisdexamfetamine
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Advanced Dementia
Panel Study Investigating Status of Cognitively Impaired Elderly in Singapore
Dementia affects 10% of the elderly population in Singapore. However, there is a lack of systematic information regarding end of life (EOL) care received by patients dying with severe dementia (PDSD), PDSD's EOL direct and…
- Trial name
- PISCES (NCT03382223)
- Where
- 9 sites in Singapore
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Duke-NUS Graduate Medical School
Contrast Enhancement in Magnetic Resonance Imaging
A Study to Evaluate the Pharmacokinetics (How it Moves Into, Through and Out From the Body) of a New Gadolinium-based Contrast Agent (GBCA) After Injection and How Safe it is in Participants With Normal and Impaired Renal Function
Researchers in this study want to learn how a new contrast agent for magnetic resonance imaging (MRI) called BAY1747846 moves into, through and out of the body (pharmacokinetics) after injection in participants with normal and…
- Trial name
- NCT05061979
- Testing
- BAY1747846
- Where
- 2 sites in United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Bayer
Blindness
The Impact of Rehabilitation on Quality of Life in Visually Impaired
The project has four primary objectives: 1) Determine if blind rehabilitation improves the quality of life of legally blind veterans; 2) Determine the relationship between quality of life and visual function; 3) Determine if…
- Trial name
- NCT00013403
- Testing
- Blindness
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- US Department of Veterans Affairs
Type2 Diabetes Mellitus, Cognitive Impairment, Mild
The Effect of Multidomain Dietary Education in Type 2 Diabetic Adults
The goal of this clinical trial is to [learn about cognitive stimulation by multidomain dietary education including the dietary board game via LINE in non-dementic type 2 diabetic adults.
- Trial name
- NCT05892861
- Testing
- cognitive stimulation, as usual care
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- National Kaohsiung Normal University
Developmental Language Disorder, Specific Language Impairment
Retrieval-Based Word Learning in Developmental Language Disorder During Book Reading
Children with developmental language disorder (DLD; also referred to as specific language impairment) experience a significant deficit in language ability that is longstanding and harmful to the children's academic, social, and…
- Conditions
- Developmental Language Disorder, Specific Language Impairment, Language Development
- Trial name
- NCT06026124
- Testing
- Retrieval-based word learning: Repeated Spaced Retrieval condition, Retrieval-based word learning: Repeated Study condition
- Where
- 2 sites in United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Purdue University
Cognitive Impairment, Child Autism
Exercise and Cognition in Children With ASD
Physical exercise is widely reported to be beneficial to executive functions (EFs) in children with autism spectrum disorder (ASD).
- Trial name
- NCT05503459
- Testing
- Bicycle learning, Stationary cycling
- Where
- Hong Kong
- Volunteers
- 82 people
- Sponsor
- Education University of Hong Kong
Hepatic Impairment, Cirrhosis
Hepatic Impairment With Cirrhosis Due to Cholestatic Liver Disease
A Phase 1, Open-label Extension Groups Study in Subjects having Hepatic Impairment with Cirrhosis due to Cholestatic Liver Disease
- Conditions
- Hepatic Impairment, Cirrhosis, Cholestatic Liver Disease
- Trial name
- NCT05045482
- Testing
- Saroglitazar Magnesium 1 mg, Saroglitazar Magnesium 2 mg
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Zydus Therapeutics Inc.
Speech Impairment
Software for Alternative Communication
The aim of this study is evaluate a software developed for alternative communication designed for people with speech difficulties.
- Trial name
- NCT02847923
- Testing
- Presentation of alternative communication application, Familiarization with the software interface, Test of the software
- Where
- 2 sites in Brazil
- Volunteers
- 30 people
- Sponsor
- University of Mogi das Cruzes
Urge Urinary Incontinence
The Long Term Outcomes of Rehabilitation and Drug Treatment for in Urgency Urinary Incontinence
Urinary Urge Incontinence (UUI) is the involuntary urine loss associated with a strong sensation to void. UUI usually associated with reduced bladder capacity. The pathophysiology is unclear.
- Trial name
- UUI (NCT00498888)
- Testing
- tolterodine, bladder training, pelvic floor muscle training
- Where
- Israel
- Volunteers
- 164 people, healthy volunteers welcome
- Sponsor
- Assuta Hospital Systems
Obstructive Sleep Apnea, Mild Cognitive Impairment
Sleep Apnea and Cognitive Function in Subjects With Subjective or Mild Cognitive Impairment
Obstructive sleep apnea (OSA) is recurrent episodes of partial or complete obstruction of the upper airway during sleep that causes intermittent hypoxia and sleep fragmentation and leads to cardiometabolic and neurocognitive…
- Conditions
- Obstructive Sleep Apnea, Mild Cognitive Impairment, Subjective Cognitive Impairment
- Trial name
- NCT06089096
- Testing
- Home Sleep Apnea test (HSAT)
- Where
- Hong Kong
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Cognitive Impairment, Dementia
Home Alone: An Intervention for People With Cognitive Impairment Who Live Alone
The goal of this clinical trial is to evaluate a program for adults who live alone and have some cognitive impairment (CI) to see if it is useful and acceptable.
- Conditions
- Cognitive Impairment, Dementia, Memory Loss
- Trial name
- NCT05746390
- Testing
- Home Alone
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- University of Minnesota
Mild Cognitive Impairment, Dementia
Validation of acceXible's Automated Speech Analysis Method for the Early Detection and Monitoring of Patients With Mild Impairment or Dementia in Primary Care
Dementia, especially dementia caused by Alzheimer's disease, is considered one of the most severe health problems of our time. It is currently known that the disease begins many years before clinical symptoms appear.
- Trial name
- NCT05380297
- Testing
- Speech analysis
- Where
- Spain
- Volunteers
- 273 people, healthy volunteers welcome
- Sponsor
- Accexible
Healthy, Hepatic Insufficiency
A Study of LY3437943 in Participants With Impaired and Normal Liver Function
The main purpose of this study is to measure how much of LY3437943 gets into the bloodstream and how long it takes the body to eliminate it in participants with mild, moderate and severe impaired liver function compared to…
- Trial name
- NCT05916560
- Testing
- LY3437943
- Where
- 5 sites in United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Solid Tumours
A Phase I Topotecan Study in Subjects With Cancer and Impaired Renal Function
To determine the effect of renal impairment and prior platinum-based chemotherapy on the safety and blood levels of topotecan administered orally
- Trial name
- NCT00483860
- Testing
- Topotecan
- Where
- 6 sites in United States, Netherlands and 1 more
- Volunteers
- 59 people
- Sponsor
- GlaxoSmithKline
Mild Cognitive Impairment, The Cognitive Normal Elderly
The Effects of Multidomain Non-pharmacological Interventions on the Elderly With or Without Mild Cognitive Impairment
The study aiming to investigate the efficacy, safety, and potential mechanism of a multimodal intervention on cognitive function in individuals with MCI or the cognitive normal elderly living in a community.
- Trial name
- NCT05483790
- Testing
- the multimodal intervention
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Huashan Hospital
Age-related Cerebral White Matter Changes, Cognition Disorder
Chronic Remote Ischemic Conditioning in Vascular Cognitive Impairment: A Dose Escalation Study
To evaluate the dose-response of relevant blood biomarkers to remote ischemic conditioning in patients with age-related cerebral white matter hyperintensities on MRI, in preparation for a subsequent larger efficacy trial.
- Trial name
- NCT06179797
- Testing
- remote ischemic conditioning
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Augusta University
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