Clinical trials: Implantable Cardiac Defibrillator
Coronary Artery Disease, Acute Myocardial Infarction
A Danish ICD-study in Patients with Coronary Artery Disease Resuscitated from Ventricular Fibrillation
DanICD is a randomized, controlled study to with the aim to assess whether there is a benefit of ICD-implantation in patients with coronary artery disease (including acute myocardial infarction), who survive cardiac arrest due to…
- Conditions
- Coronary Artery Disease, Acute Myocardial Infarction, Ventricular Fibrillation, Ventricular Tachycardia, Sustained
- Trial name
- DanICD (NCT04576130)
- Testing
- Implantable cardioverter defibrillator
- Where
- Denmark
- Volunteers
- 1,200 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Long QT Syndrome, Wide QRS Complexes
ECG Signal Collection From Long QT Syndrome, Wide QRS Complexes, Heart Failure, and Cardiac Resynchronization Patients
The purpose of this study is to collect surface electrograms from standard and several non-standard configurations in patients with long QT syndrome, heart failure, cardiac resynchronization therapy or wide QRS during a routine…
- Conditions
- Long QT Syndrome, Wide QRS Complexes, Heart Failure, Cardiac Resynchronisation
- Trial name
- NCT00399412
- Testing
- subcutaneous ICD
- Where
- United Kingdom
- Volunteers
- 86 people
- Sponsor
- Boston Scientific Corporation
Congestive Heart Failure, Cardiac Resynchronization Therapy
Improvement in Clinical Outcomes in Heart Failure Patients With ICDs That Practice Meditation
This is a trial to examine the effects of meditation on the incidence of ventricular arrhythmias and the psychological profiles in patients with implanted cardiac defibrillators. We wish to test the following hypotheses: 1.
- Trial name
- NCT00611260
- Testing
- Vipassana Meditation practice and instruction, Standard Medical Care
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- University of California, Davis
Ventricular Fibrillation, Ventricular Tachycardia
Implantable Cardioverter Defibrillator (ICD) Support Groups and Veterans
In this study, we will compare the quality of life in veterans having ICD who attend the ICD support groups to those who do not.
- Conditions
- Ventricular Fibrillation, Ventricular Tachycardia, Sudden Cardiac Death
- Trial name
- NCT00846417
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Emory University
Heart Failure, Systolic, Heart Failure
A Multicenter Trial of a Shared DECision Support Intervention for Patients Offered Implantable Cardioverter-DEfibrillators
The investigators goal is to assess real-world effectiveness of patient decision aids (PtDA) for high-risk decisions using the implantable cardioverter-defibrillator (ICD) as a model.
- Trial name
- NCT03374891
- Testing
- Educational video and/or handout
- Where
- United States
- Volunteers
- 790 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Myocardial Infarction, Sudden Cardiac Death
Personalised Risk scOre For Implantation of Defibrillators in Patients With Preserved LVEF>35% and a High Risk for Sudden Cardiac Death
The objective of the study is to demonstrate that in post-MI patients with preserved LVEF>35% but high risk for SCD according to a personalised risk score, the implantation of an ICD (index group) is superior to optimal medical…
- Trial name
- NCT04540289
- Testing
- Optimal Medical Therapy (OMT), Implantable cardioverter-defibrillator (ICD)
- Sponsor
- Helios Health Institute GmbH
Pacemaker Malfunction, Implantable Defibrillator Malfunction
Cardiac Implantable Electronic Device Magnetic Resonance Imaging Registry
This is a prospective registry evaluating the safety of performing magnetic resonance (MRI) scans on patients who have cardiac implanted electronic devices (CIEDs).
- Trial name
- CIED-MRI (NCT02459379)
- Testing
- MRI Scan
- Sponsor
- NYU Langone Health
Right Bundle-Branch Block, Heart Failure With Reduced Ejection Fraction
Bifocal Right Ventricular PAcing in Right Bundle Branch blocK and Heart Failure With Reduced Ejection Fraction. The Study Tests the Superiority of Right Ventricular Bifocal Stimulation Over VVI Implantable Defibrillator in Right Bundle Branch Block and Heart Failure.
RATIONALE: Cardiac resynchronization therapy (CRT) is known to improve cardiac performance and to reduce morbidity and mortality in reduced-ejection fraction heart failure (HFrEF) despite optimal medical therapy (OMT).
- Conditions
- Right Bundle-Branch Block, Heart Failure With Reduced Ejection Fraction, Bifocal Stimulation
- Trial name
- BiPARK-HF (NCT03524001)
- Testing
- Compare VVi mode versus DDD bifocal stimulation through crossover randomization
- Where
- Italy
- Volunteers
- 13 people
- Sponsor
- Azienda Ospedaliero Universitaria Maggiore della Carita
Heart Failure, Systolic
The Effect of Yoga on Cardiac Sympathetic Innervation Evaluated by I-123 mIBG
The purpose of this study is to evaluate if yoga practice will reduce cardiac sympathetic activity and subsequently cardiac arrhythmias.
- Trial name
- NCT03227393
- Testing
- Yoga training
- Where
- United States
- Sponsor
- University of Cincinnati
Heart Failure With Reduced Ejection Fraction, Ventricular Arrhythmia
Circulating RNA Markers of Ventricular Arrhythmias in Remotely Monitored Patients With Post-Infarction Heart Failure and Implanted Cardioverter-Defibrillators
This prospective observational study evaluates whether circulating small non-coding RNAs, particularly microRNAs, are associated with ventricular arrhythmias in patients with post-myocardial infarction heart failure who have an…
- Conditions
- Heart Failure With Reduced Ejection Fraction, Ventricular Arrhythmia, Ischemic Cardiomyopathy
- Trial name
- NCT07795892
- Testing
- Circulating Small RNA Profiling
- Where
- Poland
- Volunteers
- 57 people
- Sponsor
- University of Rzeszow
Ventricular Fibrillation, Tachycardia, Ventricular
European Health Economic Trial on Home Monitoring in ICD and CRT-D Patients (EuroEco)
BIOTRONIK Home Monitoring (HM) service enables the doctors to safely follow up (FU) their ICD and CRT-D patients in a remote fashion, with fewer in-clinic consultations.
- Conditions
- Ventricular Fibrillation, Tachycardia, Ventricular, Ventricular Flutter
- Trial name
- EuroEco (NCT00776087)
- Testing
- Home Monitoring provided by Biotronik ICD and CRT-D devices, No Home Monitoring
- Where
- 17 sites in Belgium, Finland and 4 more
- Volunteers
- 409 people
- Sponsor
- Biotronik SE & Co. KG
Heart Failure, Left Ventricular Systolic Dysfunction
CarDiac MagnEtic Resonance for Primary Prevention Implantable CardioVerter DebrillAtor ThErapy: an International Registry (DERIVATE)
The DERIVATE study was conceived to integrate the information resulted from clinical data, transthoracic echocardiography, and cardiac magnetic resonance (CMR) imaging to provide a more reliable risk stratification in patients…
- Trial name
- DERIVATE (NCT03352648)
- Where
- 29 sites in United States, Belgium and 4 more
- Volunteers
- 4,000 people
- Sponsor
- Gianluca Pontone, MD, PhD
Sudden Cardiac Death, Myocardial Infarction
Prevention Of Sudden Cardiac Death After Myocardial Infarction by Defibrillator Implantation
Patients who have survived a myocardial infarction (MI) are at increased risk for sudden cardiac death (SCD) caused by ventricular tachycardia and ventricular fibrillation.
- Trial name
- PROFID EHRA (NCT05665608)
- Testing
- Implantable cardioverter-defibrillator (ICD), Optimal Medical Therapy (OMT)
- Where
- 86 sites in Austria, Belgium and 11 more
- Volunteers
- 3,595 people
- Sponsor
- Charite University, Berlin, Germany
Ventricular Tachycardia (VT)
Safety and Performance Assessment of the Sphere-9™ Catheter and Affera™ Ablation System for the Treatment of Ventricular Tachycardia (Sphere-9 VT EFS)
Sphere-9 VT EFS is a prospective, multi-center, non-randomized, unblinded feasibility study. Adult subjects with recurrent, sustained, scar-related monomorphic ventricular tachycardia will be enrolled and treated with the…
- Trial name
- NCT06703489
- Testing
- Sphere-9 Catheter with the Affera Mapping and Ablation System
- Where
- 6 sites in United States
- Volunteers
- 60 people
- Sponsor
- Medtronic Cardiac Ablation Solutions
Arrhythmogenic Right Ventricular Cardiomyopathy
Pilot Randomized Trial With Flecainide in ARVC Patients
Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) is an inherited arrhythmia disorder with high risk of ventricular tachycardia or fibrillation, and implantable cardioverter defibrillator remains as therapy of choice.
- Trial name
- NCT03685149
- Testing
- Flecainide Pill
- Where
- 6 sites in United States
- Volunteers
- 22 people
- Sponsor
- University of Rochester
Sudden Cardiac Death
The International SubcutaneouS Implantable Cardioverter Defibrillator Registry (iSuSI)
The entirely subcutaneous implantable defibrillator (S-ICD) (Emblem, Boston Scientific, Marlborough, MA, USA) was introduced as a new therapeutic alternative to the conventional transvenous ICD in 2009 and implantations are…
- Trial name
- iSuSI (NCT05390047)
- Where
- Germany
- Volunteers
- 4,000 people
- Sponsor
- University of Luebeck
Heart Failure
HeartLogic™ in Patients With Heart Failure.
This randomized, multicenter clinical trial will evaluate whether remote management guided by the HeartLogic™ algorithm improves outcomes compared with traditional face-to-face follow-up in adult patients with heart failure…
- Trial name
- HERO (NCT07544771)
- Testing
- Alert-guided remote follow-up, Traditional follow up
- Where
- 15 sites in France
- Volunteers
- 578 people
- Sponsor
- Poitiers University Hospital
Heart Failure, Dilated Cardiomyopathy
Efficacy of Implantable Cardioverter Defibrillator in Patients With Non-ischemic Systolic Heart Failure on Mortality
Primary objective: The primary objective of this study is to determine the efficacy of ICD therapy compared with control on the endpoint of death from any cause.
- Conditions
- Heart Failure, Dilated Cardiomyopathy, Reduced LVEF
- Trial name
- DANISH (NCT00541268)
- Testing
- ICD, Optimal medical treatment
- Where
- 4 sites in Denmark
- Volunteers
- 1,116 people
- Sponsor
- Danish Study Group
Pacemaker, Implantable Cardioverter Defibrillator
Comparison of Upper Extremity Function, Physical Activity Levels and Peripheral Muscle Strength, Fear of Movement, Balance, Activities of Daily Living and Quality of Life in Patients With Pacemakers According to Pacemaker Type
While research and clinical practice have demonstrated the objective benefits of pacemaker use on mortality, morbidity, and quality of life, some patients do not experience the expected level of improvement following device…
- Conditions
- Pacemaker, Implantable Cardioverter Defibrillator, Cardiac Resynchronization Therapy
- Trial name
- NCT06775691
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Erol Olcok Corum Training and Research Hospital
Chronotropic Incompetence, Heart Failure
Rate Adaptive Atrial Pacing in Heart Failure
The ADAPTION trial is an investigator initiated prospective randomized doubleblind cross-over pilot study in a multi-center setting.
- Conditions
- Chronotropic Incompetence, Heart Failure, ICD
- Trial name
- ADAPTION (NCT03235843)
- Testing
- AAIR pacing, DDI-pacing
- Where
- Netherlands
- Volunteers
- 65 people
- Sponsor
- Amsterdam UMC, location VUmc