Clinical trials: Implants
Immediate Dental Implant Loading, Denture, Complete
Immediate Loading of 4 Guided Implants Supporting a Maxillary Overdenture Using a Novaloc TiN Retention System
Complete dentures represent the traditional dental treatment for patients without teeth. However, retention and stability of this type of denture are often lacking, so dental implants are indicated in order to improve the…
- Trial name
- NCT06083506
- Testing
- NOVALOC TiN retained maxillary overdenture
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- West Virginia University
Prostheses and Implants
IceExplore TF Liner Alpha Investigation
Single group prospective repeated measures comparing breathable liner and breathable socket to conventional enclosed silicone liner and socket system.
- Trial name
- NCT04787484
- Testing
- IceExplore TF breathable liner and Direct Socket drilled with holes
- Volunteers
- 18 people
- Sponsor
- Össur Iceland ehf
Heart Failure
BATwire Implant Kit Study
The purpose of this clinical investigation is to develop valid scientific evidence for the safety and effectiveness of the Barostim System delivered by the BATwire Implant Kit (BATwire Kit) in subjects with heart failure.
- Trial name
- NCT04600791
- Testing
- BATwire Implant Kit
- Where
- 10 sites in United States
- Volunteers
- 93 people
- Sponsor
- CVRx, Inc.
Jaw, Edentulous, Partially
Short Implants - An Alternative to Bone Grafting?
The study, with the ASTRA TECH Implant System, is comparing short implants (OsseoSpeed™) to standard length implants (OsseoSpeed™) in combination with bone grafting.
- Trial name
- NCT01030523
- Testing
- ASTRA TECH Implant System, OsseoSpeed™ 4.0 S (length: 6 mm), ASTRA TECH Implant System, OsseoSpeed™ implants (lengths: 11, 13, 15 mm) in combination with bone grafting
- Where
- 5 sites in United States, Austria and 3 more
- Volunteers
- 101 people
- Sponsor
- Dentsply Sirona Implants and Consumables
Glaucoma
The Baerveldt Versus ClearPath Comparison Study
This is a randomized prospective study of post-operative surgical outcomes and complication rates in patients with a Baerveldt 350 implant vs the Ahmed ClearPath implant.
- Trial name
- NCT04468633
- Testing
- Baerveldt 350 implant, Ahmed ClearPath 350 implant
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- Duke University
Aortic Valve Disease, Aortic Stenosis
Perceval Sutureless Implant Versus Standard-Aortic Valve Replacement
Prospective, randomized, stratified non blinded multi-center, international, post market trial assessed in a non-inferiority study. The trial has a flexible sample size that will be determined adaptively.
- Trial name
- PERSIST-AVR (NCT02673697)
- Testing
- Perceval valve, other stented biological valve
- Where
- 47 sites in United States, Austria and 10 more
- Volunteers
- 914 people
- Sponsor
- Corcym S.r.l
Dental Implants
Multicenter Retrospective Study Evaluating ATLANTIS™ Abutment Teeth Connected to Implants
The study is designed as a retrospective and multi-center study. The study population is US individuals previously restored with titanium and gold-shaded titanium ATLANTIS abutments.
- Trial name
- NCT02496091
- Testing
- ATLANTIS Abutment
- Where
- 6 sites in United States
- Volunteers
- 144 people
- Sponsor
- Dentsply Sirona Implants and Consumables
Chronic Sinusitis
Safety and Performance of the Steroid-Releasing S8 Sinus Implant
The purpose of this study was to assess the safety and performance of the steroid-releasing S8 Sinus Implant when used in post-sinus surgery patients who presented with recurrent sinus obstruction.
- Trial name
- S8PK (NCT01894503)
- Testing
- S8 Sinus Implant (mometasone furoate, 1350 mcg)
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Intersect ENT
Cardiac Implantable Electronic Device Infection
TYRX™ Envelope for Prevention of Infection Following Replacement With a CRT or ICD
The purpose of this study is to compare the incidence of cardiac implantable electronic device (CIED) infection and CIED mechanical complication after CIED replacement with a high-power cardiac implantable electronic device…
- Trial name
- Centurion (NCT01043705)
- Where
- 52 sites in United States
- Volunteers
- 1,262 people
- Sponsor
- TYRX, Inc.
Cochlear Implant
Place-based Mapping in EAS Listeners
Purpose: Investigate monaural and binaural hearing in electric-acoustic stimulation (EAS) users with place-based versus default maps.
- Trial name
- NCT04722042
- Testing
- place-based mapping, default mapping
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Cartilage or Osteochondral Defects in the Knee, Up to Moderate Osteoarthritis
Agili-C™ Implant Performance Evaluation
The current study compares the efficacy and safety of the Agili-C implant to Surgical Standard of Care treatment in patients suffering from joint surface lesions of the knee.
- Trial name
- NCT03299959
- Testing
- Agili-C implant, SSOC
- Where
- 26 sites in United States, Belgium and 6 more
- Volunteers
- 251 people
- Sponsor
- Smith & Nephew, Inc.
Aortic Valve Stenosis, Valvular Heart Disease
CoreValve Advance-II Study: Prospective International Post-market Study
The CoreValve ADVANCE-II Study is a best practices investigation of patients implanted with the Medtronic CoreValve bioprosthesis.
- Trial name
- Advance-II (NCT01624870)
- Where
- 9 sites in Belgium, Czechia and 4 more
- Volunteers
- 200 people
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure
Acne Vulgaris
Afamelanotide in Patients Suffering With Acne Vulgaris
This study aims to evaluate the effect of afamelanotide on the facial inflammatory acne-related lesions in patients with mild to moderate acne vulgaris, including tolerability of afamelanotide by patients with moderate acne…
- Trial name
- NCT04943159
- Testing
- Afamelanotide
- Volunteers
- 3 people
- Sponsor
- Clinuvel Pharmaceuticals Limited
Glaucoma, Open-Angle, Ocular Hypertension
Randomized Study Comparing Two Models of a Travoprost Intraocular Implant to Timolol Maleate Ophthalmic Solution, 0.5%
Phase III study to compare the safety and efficacy of intraocular implants containing travoprost at two different elution rates versus Timolol Maleate Ophthalmic Solution, 0.5% (timolol) in reducing elevated intraocular pressure…
- Trial name
- NCT03519386
- Testing
- G2-TR intraocular implant containing travoprost
- Where
- United States
- Volunteers
- 590 people
- Sponsor
- Glaukos Corporation
Chronic Rhinosinusitis (Diagnosis)
Steroid Delivery to the Frontal Sinus Opening With a Bioabsorbable Implant vs. a Bioabsorbable Nasal Dressing
The purpose of this study is to compare how two different post-surgical treatments that both deliver steroids to the frontal sinus opening affect your healing after frontal sinus surgery.
- Trial name
- NCT03188822
- Testing
- Bioabsorbable steroid releasing sinus implant, Bioabsorbable nasal dressing impregnated with steroid
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of Rochester
Chronic Sinusitis, Nasal Polyposis
Safety Evaluation of Repeat Placement of the S8 Sinus Implant in Chronic Sinusitis Patients With Nasal Polyps (ENCORE)
The ENCORE Study is designed to evaluate the repeat administration of the S8 Sinus Implant in chronic sinusitis (CS) patients with recurrent nasal polyps.
- Trial name
- NCT03358329
- Testing
- S8 Sinus Implant
- Where
- 9 sites in United States
- Volunteers
- 50 people
- Sponsor
- Intersect ENT
Tibial Shaft Fractures
Carbon Fiber Implants
The investigators will compare intramedullary nailing of open and closed tibia shaft fractures with carbon fiber implant versus titanium implant in a Level I trauma setting.
- Trial name
- NCT03382041
- Testing
- Carbon Fiber Implant, Titanium Implant
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Opioid Dependence
A Study of Adult Outpatients With Opioid Dependence Transitioned From a Daily SL Buprenorphine to Probuphine® Subdermal Implants
The primary objective of the study is to demonstrate maintenance of treatment efficacy when transferring adult outpatients with opioid dependence, who are clinically stabilized on 8 mg or less of sublingual (SL) buprenorphine…
- Trial name
- PRO-814 (NCT02180659)
- Testing
- sublingual buprenorphine tablets, Buprenorphine implant
- Volunteers
- 177 people
- Sponsor
- Titan Pharmaceuticals
Total Knee Arthroplasty, Osteoarthritis
A Study to Compare the NexGen CR and CR-Flex Knee Implants
The purpose of this study is to test for significant differences in functional outcomes, specifically pre-operative ROM and post-operative ROM obtained by using a NexGen CR versus a NexGen CR-Flex knee implant.
- Trial name
- NCT00761956
- Testing
- NexGen CR-Flex Fixed Bearing Knee, NexGen CR Knee
- Where
- 8 sites in United States
- Volunteers
- 189 people
- Sponsor
- Zimmer Biomet
Teeth Loss
Controlled Pilot Study to Assess Soft Tissue Reaction at the Crestal Part of a Dental Implant With ESTA Surface
This study will investigate the effect on the soft tissue that is in contact with a dental implant with a modified surface of the neck (the part of the implant that is above the bone and in contact with the soft gum tissue).
- Trial name
- NCT02159183
- Testing
- Standard Plus ESTA STL Roxolid implant, Standard Plus STL implant
- Where
- 4 sites in Switzerland
- Volunteers
- 43 people
- Sponsor
- Institut Straumann AG