Clinical trials: Implementation
Cardiovascular Diseases
Innovative Approaches for Personalised Cardiovascular Prevention
The goal of this clinical trial is to study innovative approaches for personalized primary preventive interventions for cardiovascular diseases (CVD) in the population.
- Trial name
- INNOPREV (NCT05883878)
- Testing
- PRS, Digital app and wearable device
- Where
- Italy
- Volunteers
- 1,020 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Lung Cancer
Centralized Screening Unit (CSU) at Montefiore-Einstein
This study proposes to increase Lung-cancer screening (LCS) in the Bronx, New York. Despite strong evidence that Lung-cancer screening (LCS) can reduce Lung cancer (LCa) deaths, low-dose computed tomography (LDCT) referral rates…
- Trial name
- NCT06284408
- Testing
- Centralized Screening Unit Implementation
- Where
- United States
- Volunteers
- 9,460 people, healthy volunteers welcome
- Sponsor
- Albert Einstein College of Medicine
Mass Screening, Colorectal Cancer
SMS Messaging as a Tool to Improve Cancer Screening Programs
The aim of this project is to assess the impact on health and economics of the implementation of text messaging (SMS) in cancer screening programs. Three interventions with SMS will be evaluated through community trials.
- Conditions
- Mass Screening, Colorectal Cancer, Breast Cancer
- Trial name
- M-TICS (NCT04343950)
- Testing
- SMS reminders to enhance colorectal cancer screening, SMS reminders to return the fecal immunochemical test at the pharmacy in CRC screening:, Invitation by SMS to previous participants in breast cancer screening:
- Where
- Spain
- Volunteers
- 44,601 people, healthy volunteers welcome
- Sponsor
- Institut Català d'Oncologia
Traditional Face to Face Training, Family Therapy Training and Implementation Platform (FTTIP)
Family Therapy Training and Implementation Platform (FTTIP): An Innovative Web-based Tool for Long-term Practice Improvement
The goal of this clinical trial is to compare whether mental health therapists trained by a Family Therapy Training and Implementation Platform (FTTIP) or those trained in traditional face-to-face training differ on learning key…
- Trial name
- NCT05772858
- Testing
- Training on CIFFTA competencies using Family Therapy Training and Implementation Platform (FTTIP), Training on CIFFTA competencies using Training and Coaching as Usual (TCAU)., Culturally Informed and Flexible Family-Based Treatment for Adolescents (CIFFTA).
- Where
- 2 sites in United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Training and Implementation Associates
Hearing Loss, Bilateral or Unilateral, Otitis Media With Effusion in Children
Towards Implementation of Universal Newborn Hearing Screening in Kenya
The goal of this observational study is to learn if smartphone hearing screening devices can help to understand the role of ear infections in hearing loss in infants with HIV exposure.
- Trial name
- mTUNE-R33 (NCT07879326)
- Testing
- Hearing and ear health screening
- Where
- Kenya
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of Washington
HIV Infections
The Implementation of Pre-exposure Prophylaxis of Injectable Cabotegravir
Although CAB LA PrEP has been proven efficacious in blinded randomized controlled clinical trials, additional research is needed to evaluate effectiveness in real world settings as well as to identify effective implementation…
- Trial name
- ImPrepCab (NCT05515770)
- Testing
- Cabotegravir Injection
- Where
- Brazil
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Evandro Chagas National Institute of Infectious Disease
Evidence Based Practice
Facilitating Sustainment Through Implementation Feedback: The SIC Coaching Model
This study aims to test the impact of an empirically derived implementation strategy-under real-world conditions and across multiple child service systems-on successful adoption and sustainment of two evidence-based programs that…
- Trial name
- NCT03799302
- Testing
- SIC Coaching
- Where
- United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Oregon Social Learning Center
Personality Disorder, Borderline
Evaluating the Coordinated National Implementation of DBT in Ireland
This study aims to evaluate the coordinated implementation of Dialectical Behaviour Therapy in Community Mental Health Services in Ireland.
- Trial name
- NCT03180541
- Testing
- Dialectical Behaviour Therapy
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Health Service Executive, Ireland
Child Maltreatment, Implementation
A Technology-Enhanced Approach for Implementing Evidence-Based Practices in Child Welfare
In this study, a computer-assisted adaptation of SafeCare, an evidence-based home visiting program, will be developed and tested in child welfare.
- Conditions
- Child Maltreatment, Implementation, Technology
- Trial name
- NCT02430337
- Testing
- Technology-Assisted SafeCare, SafeCare
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Georgia State University
Diabetes Mellitus, Hypertension
Strengthening Primary Healthcare Delivery for Diabetes and Hypertension in Eswatini
The WHO-PEN@Scale project is a three-arm cluster-randomized trial that is investigating the population-level effects of a healthcare reform in Eswatini, which aims to strengthen primary care for diabetes and hypertension.
- Trial name
- NCT04183413
- Testing
- DSD, CDP
- Where
- Eswatini
- Volunteers
- 3,500 people, healthy volunteers welcome
- Sponsor
- University Hospital Heidelberg
Suicide, Depression
Engaging Suicidal Patients in Mental Health Treatment
The investigators will identify characteristics of suicidal patients who do or do not attend a first mental health visit following referral using administrative data.
- Conditions
- Suicide, Depression, Mental Health Impairment, Suicidal Ideation
- Trial name
- NCT05021224
- Testing
- Caring Contacts, Reminders, Informational Poster
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Chronic Disease
Measuring the Implementation of the LiFE Program in Primary Care for Older Adults Aged 75 Years or Older
The goal of this study is to evaluate how to implement an evidence-based lifestyle-integrated strength and balance exercise (LiFE) intervention in primary care to promote increased physical activity (PA) and improvements in…
- Trial name
- Mi-LIFE (NCT02266225)
- Testing
- Lifestyle-integrated Functional Exercise
- Where
- Canada
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Waterloo
Malaria
A Surveillance Study of Diseases Specified as Adverse Events of Special Interest, of Other Adverse Events Leading to Hospitalisation or Death, and of Meningitis in Children in Africa Prior to Implementation of the RTS,S/AS01E Candidate Vaccine
The purpose of this pre-licensure cohort study was to estimate the incidence of adverse events of special interest (AESI), other adverse events (AE) leading to hospitalisation or death, meningitis and malaria in sub-Saharan…
- Trial name
- NCT02374450
- Testing
- Blood collection
- Where
- 5 sites in Burkina Faso, Ghana and 1 more
- Volunteers
- 36,366 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Mental Health, Health Services
BASIS Optimization
The objective of the BASIS R34 pilot study is to test the impact of eBASIS in a randomized controlled trial (RCT). Consistent with IMPACT's IQM, the study tests effects of eBASIS on treatment fidelity and youth outcomes, compared…
- Conditions
- Mental Health, Health Services, Evidence Based Programs in Schools
- Trial name
- BASIS R34 (NCT06672835)
- Testing
- eBASIS, eAttention Control
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Washington
Cancer Colon
Blood-Based Colorectal Cancer (CRC) Screening Implementation Into Clinical Practice Highlands
This is a prospective implementation study that will include patients that are identified as being average risk for colorectal cancer (CRC) according to USPSTF guidelines and who have opted to be screened for CRC.
- Trial name
- NCT06119425
- Testing
- blood-based CRC screening
- Where
- United States
- Volunteers
- 231 people, healthy volunteers welcome
- Sponsor
- Ballad Health
Autism Spectrum Disorder (ASD)
Coaching and Leadership in Autism Support Settings
Schools serve a large number of autistic children, yet face two critical gaps that stifle the delivery of evidence-based practices: 1) an intervention gap characterized by limited availability of evidence-based practices…
- Trial name
- CLASS (NCT07276750)
- Testing
- RUBIES, HELM, Educator Psychoeducation
- Where
- United States
- Volunteers
- 373 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Pre-Exposure Prophylaxis (PrEP)
Impact of Nursing Involvement on Implementation of HIV Prevention Services
Women comprise 20% of new Human Immunodeficiency Virus (HIV) diagnoses in the United States (U.S.) with 86% attributed to heterosexual contact.
- Trial name
- PrEP-RN (NCT05095818)
- Testing
- PrEP-RN
- Where
- United States
- Volunteers
- 440 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Anemia, Nutritional Status
Long-term Effectiveness and Implementation of the Meals, Education, and Gardens for In-School Adolescents Program
The overall objective of the proposed study is to determine the longer-term effectiveness and implementation of an updated school-based nutrition intervention package for reducing adolescent malnutrition.
- Trial name
- MEGA 2 (NCT07092150)
- Testing
- School meals, School gardens, IFA and Deworming
- Where
- Tanzania
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Harvard School of Public Health (HSPH)
Lung Cancer
Tribally Engaged Approaches to Lung Screening (TEALS)
Lung cancer is the leading cause of cancer mortality among American Indians and Alaska Natives (AI/AN), and AI/AN have worse lung cancer incidence rates, survival, and death compared to the general population.
- Trial name
- TEALS (NCT04948060)
- Testing
- Enhanced lung cancer screening services
- Where
- United States
- Volunteers
- 275 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Breast Neoplasms Diagnosis
Breast Cancer Risk Assessment in Night Shift Workers - Implementation of a Personalized Consultation
This study evaluates adherence to a personalized prevention plan in female night shift workers at increased risk of breast cancer.
- Trial name
- NIGHT-SCAN (NCT07630935)
- Testing
- Personalized Prevention Plan
- Where
- France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris