Clinical trials: Implementation
Female Reproductive Problem
The Implementation of MinimAlly Invasive Hysterectomy Trial
Removal of the uterus (hysterectomy) is the most commonly performed major gynaecological procedure in women. Obstetricians and gynaecologist (O\&G) surgeons conduct the majority of hysterectomies.
- Trial name
- IMAGINE (NCT03617354)
- Testing
- Total Laparoscopic Hysterectomy
- Where
- 4 sites in Australia
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Queensland Centre for Gynaecological Cancer
Lower Back Injury
Implementation of a Fitness Education and Training Program to Support Safe Patient Handling and Safe Lifting
This project involves the delivery of education and training sessions to Seven Oaks General Hospital (SOGH) staff, with the goal of workplace injury prevention.
- Trial name
- NCT05834959
- Testing
- An Educational and Training Program
- Where
- Canada
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Functional Constipation
Clinical Implementation of a Pictographic Constipation Action Plan for Children With Functional Constipation
Constipation is a common disorder that globally affects 0.7% to 29.6% of children. The majority of these children receive the diagnosis of functional constipation. Functional Constipation can be challenging to diagnose and treat.
- Trial name
- USCAP (NCT05437523)
- Testing
- Constipation Action Plan, Standard of care without constipation action plan
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Walter Reed National Military Medical Center
DPYD Gene Mutation, Gastrointestinal Cancer
Nudge Strategies for DPYD Testing in Patients With Gastrointestinal Cancers Treated With Fluoropyrimidines
5-fluorouracil and capecitabine, sometimes called 5-FU, fluoropyrimidines, or Xeloda are a type of chemotherapy. Many people have side effects from these drugs like nausea, diarrhea, or blood problems.
- Conditions
- DPYD Gene Mutation, Gastrointestinal Cancer, Health Care Seeking Behavior
- Trial name
- DPYD Nudges (NCT06559462)
- Testing
- Focus Group, Discrete Choice
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Abramson Cancer Center at Penn Medicine
HIV
City-Wide Implementation and Evaluation of the B-OK Bottles for HIV Treatment Adherence Support in the Philadelphia Ryan White Medical Case Management Network
The researchers will conduct a hybrid implementation-effectiveness study of a city-wide B-OK rollout led by PDPH with research and evaluation support from the University of Pennsylvania.
- Trial name
- B-OK PDPH (NCT07807137)
- Testing
- B-OK Bead Bottles
- Volunteers
- 390 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Smoking Cessation
Electronic Health Record-Enabled Evidence-Based Smoking Cessation Quality Improvement Implementation Program
The goal of this quality improvement program is to implement, evaluate, and sustain an evidence-based smoking cessation treatment program with a population-based approach so that all patients at the Siteman Cancer Center…
- Trial name
- NCT04107857
- Testing
- ELEVATE enhancement to electronic health record (EHR) to improve cessation counseling offer, ELEVATE enhancement to electronic health record (EHR) to improve smoking cessation medication offer, Data Driven Feedback reports
- Where
- United States
- Volunteers
- 1,000,000 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Antibiotic Side Effect, Behavioral Changes
Improving Antibiotic Use in Urgent Care Facilities
This study will implement a comprehensive outpatient stewardship program targeting a large network of Urgent Care (UC) clinics within Intermountain Helathcare.
- Trial name
- SCORE_UC (NCT03932708)
- Testing
- CDC Core Elements of Outpatient Stewardship
- Where
- United States
- Volunteers
- 700,000 people, healthy volunteers welcome
- Sponsor
- Intermountain Health Care, Inc.
HIV Prevention, HIV Pre-exposure Prophylaxis
PEP/PrEP Via Pharmacist-Prescribing Implementation (PEPPI)
The goal of this clinical trial is to learn if use of the PEPPI software can improve pharmacist-provided HIV prevention (PEP/PrEP) services. The main questions it aims to answer are: 1.
- Conditions
- HIV Prevention, HIV Pre-exposure Prophylaxis, Access and Linkage to Healthcare, Technology Use
- Trial name
- PEPPI (NCT07683117)
- Testing
- PEPPI Pharmacies
- Where
- United States
- Volunteers
- 195 people, healthy volunteers welcome
- Sponsor
- EMPOWERX INC
Emotion Regulation Abilities, Mental Health
Feasibility and Acceptability of the Asynchronous eParenting CARE Program
This study aims to evaluate the feasibility and acceptability of the eParenting CARE Program, an asynchronous, self-guided emotion-focused parenting intervention for parents of school-aged children (8-13 years).
- Trial name
- NCT07427771
- Testing
- eParenting CARE Program
- Where
- Canada
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Tuberculosis Infection, Latent, Tuberculosis Active
SCAF-TB - Saving Children and Their Families From Tuberculosis: Implementation Research to Improve TB Preventive Treatment Initiation and Completion Rates Among Contact Persons in Tajikistan and Tanzania
The SCAF-TB study aims to evaluate how the WHO-endorsed SIILTIBCY skin test can be best implemented to test close contacts for tuberculosis infection (TBI) in Tajikistan and Tanzania, either facility-based or home-based delivered…
- Conditions
- Tuberculosis Infection, Latent, Tuberculosis Active, TPT
- Trial name
- SCAF-TB (NCT07714707)
- Testing
- CY-TB Patch, Audiblehealth DX
- Where
- 2 sites in Tajikistan, Tanzania
- Volunteers
- 880 people, healthy volunteers welcome
- Sponsor
- KNCV Tuberculosis Foundation
Depression, Anxiety
Implementation of Brief Dynamic Interpersonal Therapy at the VA
The goal of the proposed project is to collect data from clinician files and the electronic medical record to describe the clinical implementation of Brief Dynamic Interpersonal Therapy (DIT), an individual psychotherapy for…
- Trial name
- DIT (NCT03945136)
- Testing
- Dynamic Interpersonal Therapy
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- VA New York Harbor Healthcare System
Orthodontic Appliances, Oral Health Training
Effects Of Training On Brushing Behavior
This study is a single-blind randomized controlled trial on fixed orthodontic appliance candidates (n = 90) assigned into a control group (n = 30) and two different study groups (n = 30 in each).
- Conditions
- Orthodontic Appliances, Oral Health Training, Oral Hygiene
- Trial name
- NCT04018534
- Testing
- Standard Verbal/Written Education, Video Assisted Education, Hands-on Training
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Okan University
Smoking, Adolescent Behavior
ADHAirE : a Randomized Controlled Trial to Improve the Implementation of Tobacco-free School Policies
The goal of this cluster randomized controlled trial is to learn if the set up of an advocacy coalition in secondary schools can improve the implementation of tobacco-free school policies (TFSP) to prevent adolescent smoking.
- Trial name
- NCT06655038
- Testing
- Advocacy coalition, Feedback
- Where
- Belgium
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Université Catholique de Louvain
Breast Cancer, Cervical Cancer
Community Clinic Model to Improve Early Detection of Breast and Cervical Cancers in Kenya
Kenya has a high incidence of breast and cervical cancers, and most women are diagnosed with late-stage disease. The investigators will conduct a study to assess the effectiveness and cost-effectiveness of strategies to increase…
- Trial name
- C3Link (NCT06572774)
- Testing
- C3Link Strategies
- Where
- Kenya
- Volunteers
- 5,400 people, healthy volunteers welcome
- Sponsor
- Implenomics
Human Immunodeficiency Virus
Mater-Bronx Rapid HIV Testing Project.
In the M-BRiHT study we aim to implement a programme of opportunistic HIV screening in the Emergency Department, Mater Misericordiae University Hospital.
- Trial name
- M-BRiHT (NCT01778374)
- Testing
- No participant choice of counselor, Participant choice of counselor
- Where
- Ireland
- Volunteers
- 17,000 people, healthy volunteers welcome
- Sponsor
- University College Dublin
HIV/AIDS
Bridges2Scale: Testing Implementation Strategies
The goal of this clinical trial is to compare two multifaceted strategies (standard vs enhanced) for scaling Bridges in a two-arm Hybrid III effectiveness-implementation cluster randomized controlled trial (RCT) in adolescent and…
- Trial name
- NCT06347146
- Testing
- Financial Literacy Training (FLT) workshops, Mentorship, Income Generation Activity (IGA)
- Where
- Uganda
- Volunteers
- 1,440 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Fall Related Injury, Social Isolation
KOSO (Keep On Stepping On)/ Stepping Online
The overall purpose of this multi-phase study is to develop (Phase 1) and test potential effectiveness and feasibility of Keep On Stepping On (KOSO)/Stepping Online, an online falls prevention maintenance program for Stepping On…
- Trial name
- NCT02774889
- Testing
- Stepping Online
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Malaria
Integrating the Guardian Spatial Emanator Within AVENIR II
This study will evaluate the implementation of integrating Guardian spatial emanators into the existing AVENIR II azithromycin mass drug administration program in Niger.
- Trial name
- GUARD-AV (NCT07712263)
- Testing
- Spatial Emanator
- Where
- Niger
- Volunteers
- 150,000 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Colorectal Carcinoma
Implementation of a ColoRectal Cancer Screening Tool in US Primary Care Practices - Usual Quality Improvement (10 Clinics) vs Normalization Process Theory-Participatory Learning in Action (10 Clinics)
Although implementation intentions (I2)-based tools enhance colorectal cancer (CRC) screening uptake, prior studies have not tested their implementation into routine primary care delivery.
- Trial name
- (PB-iCRC) (NCT06682650)
- Testing
- NPT-PLA, Usual Quality Improvement
- Where
- United States
- Volunteers
- 2,200 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Human Papillomavirus Infection
Implementation of Evidence-Based Strategy (PC TEACH) for the Optimization of HPV Vaccination in Rural Primary Care
This study evaluates the implementation of evidence based strategies to optimize HPV vaccination in rural primary care settings.
- Trial name
- NCT06256718
- Testing
- Educational Intervention
- Where
- United States
- Volunteers
- 203 people, healthy volunteers welcome
- Sponsor
- Roswell Park Cancer Institute