Clinical trials: Implementation, open to volunteers
Aortic Valve Stenosis, Postoperative Cognitive Dysfunction (POCD)
Prospective Neuropsychological Evaluation of the Implementation of a Heart Valve Unit (HVU-NEURO)
Transcatheter aortic valve implantation (TAVI) is an established treatment for severe aortic stenosis. Despite improved procedural outcomes, neurocognitive complications such as postoperative delirium (POD) and postoperative…
- Conditions
- Aortic Valve Stenosis, Postoperative Cognitive Dysfunction (POCD), Delirium - Postoperative, Neurocognitive Disorders
- Trial name
- HVU-NEURO (NCT07626567)
- Volunteers
- 500 people
- Sponsor
- Heart and Brain Research Group, Germany
Type 1 Diabetes Mellitus
A Hybrid Effectiveness-implementation Trial to Reduce Diabetes Distress in Teenagers
The investigators will assess both effectiveness (primary) and implementation (secondary) outcomes for a distress-reducing intervention, Supporting Teen Problem Solving (STePS). STePS has already undergone an efficacy trial.
- Trial name
- NCT06709755
- Testing
- Supporting Teen Problem Solving, Diabetes Education
- Where
- United States
- Volunteers
- 360 people
- Sponsor
- Jill Weissberg-Benchell, Ph.D.
Mental Disorders
Implementation of REFOCUS Training Program in Mental Health Services
Training of mental health service teams in the orientation of care towards recovery through a 3-day training course: REFOCUS. This training aims to orient care towards recovery.
- Trial name
- RETAFORM (NCT05824234)
- Testing
- Implementation of a training centered around the notions of recovery with mental health services first year, Implementation of a training centered around the notions of recovery with mental health services second year
- Where
- France
- Volunteers
- 760 people
- Sponsor
- Hôpital le Vinatier
Child Sexual Abuse
Parent-focused Primary Prevention of Child Sexual Abuse: An Effectiveness-implementation Hybrid Trial
The goal of this clinical trial is to test the effectiveness of a parent-focused child sexual abuse prevention program (Smart Parents) delivered to parents enrolled in a parent education program (Parents as Teachers; PAT).
- Trial name
- NCT05976867
- Testing
- Parents as Teachers (PAT) as usual, Parents as Teachers (PAT) + Smart Parents
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- New York University
Colorectal Cancer
Implementation of the ERAS in Colorectal Cancer Patients: a Single Arm Study
The goal of this study is to implement and investigate the efficacy of an Early Recovery After Surgery (ERAS) protocol in South Korean colorectal cancer patients.
- Trial name
- NCT06729736
- Testing
- ERAS protocol
- Where
- South Korea
- Volunteers
- 500 people
- Sponsor
- Seoul National University Hospital
Obstructive Sleep Apnea (OSA)
Telehealth for Sleep Apnea: Effectiveness, Implementation, and Cost in the Military Health System
The long-term goal of this research is to improve military health and operational readiness among military service members with sleep disorders.
- Trial name
- TS OSA (NCT07121452)
- Testing
- Sleep Navigator
- Where
- 2 sites in United States
- Volunteers
- 160 people
- Sponsor
- Uniformed Services University of the Health Sciences
Colorectal Cancer (CRC) Screening
A Novel Multi-functional Artificial Intelligence System on Treatment Efficacy and Implementation in Colonoscopy
To overcome non-neoplastic polyp (NNP) resections, computer-aided diagnosis (CADx) systems have been developed. In a meta-analysis, the performance of CADx systems was superior to endoscopists.
- Trial name
- mAInstream (NCT07844252)
- Testing
- CADe/CADx
- Volunteers
- 2,818 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Intubation Complication
Smart Checklist Implementation for Pediatric Tracheal Intubations in the ICU- Multicenter Study
The purpose of the study is to implement a patient-provider dyad tailored, Electronic Health Record (EHR)-informed, digitized Smart Checklist as a Quality Improvement (QI) intervention to support bedside clinician teams to reduce…
- Trial name
- SMART PICU (NCT06085326)
- Testing
- Smart Checklist
- Where
- 6 sites in United States
- Volunteers
- 3,000 people
- Sponsor
- Children's Hospital of Philadelphia
Developmental Language Disorder, Reading; Difficult
Promoting Caregiver Implementation of an Effective Early Learning Intervention
The goal of this study is to examine the impact of a caregiver-implemented shared reading program, Sit Together and Read (STAR), on children ages 4 to 5 with developmental language disorder.
- Trial name
- NCT06275815
- Testing
- Sit Together and Read (STAR), Monetary Reward, Text Encouragement
- Where
- 2 sites in United States
- Volunteers
- 320 people
- Sponsor
- Ohio State University
Sudden Cardiac Death
Skeletal Muscle Multi-omics Analysis and Risk Tailoring in Sudden Cardiac Death
This study is designed as a prospective, single-center, observational cohort study (the SMART-SCD Study, full name: Skeletal Muscle Multi-omics Analysis and Risk Tailoring in Sudden Cardiac Death), which enrolls high-risk…
- Trial name
- SMART-SCD (NCT07476456)
- Where
- China
- Volunteers
- 421 people
- Sponsor
- China National Center for Cardiovascular Diseases
Family Members, Implementation
FAmily Engagement Strategy for Coordinated Specialty Care
Family members/support persons' engagement in mental health services has been linked to reduced burden and stress and improves engagement and outcomes in individuals in the early stages of psychosis.
- Trial name
- FAMES (NCT06945055)
- Testing
- FAMES, Control
- Where
- 4 sites in United States
- Volunteers
- 900 people
- Sponsor
- Washington State University
Suicide
Rapid Personalization of Safety Plans for Psychiatrically Hospitalized Veterans at High-Risk for Suicide
Veterans psychiatrically hospitalized face significantly elevated suicide risk, particularly in the three months post-discharge.
- Trial name
- NCT07507786
- Testing
- Personalized Safety Plans, Safety Plans as Usual + Calls
- Where
- United States
- Volunteers
- 111 people
- Sponsor
- VA Office of Research and Development
Aedes-borne Diseases
Implementation and Evaluation of Vector Control Methods in Kinshasa: The Case of Aedes
Arboviral diseases are viral diseases transmitted by mosquitoes of the Aedes genus and are constantly spreading throughout the world, constituting a significant threat to public health.
- Trial name
- NCT06981442
- Testing
- Community-based environmental management, Vector control against immature stages of Aedes, Vector control against the mature stages of Aedes
- Where
- Democratic Republic of the Congo
- Volunteers
- 2,050 people, healthy volunteers welcome
- Sponsor
- Institute of Tropical Medicine, Belgium
Autism Spectrum Disorder
Effectiveness- Implementation Trial of the Function-Based Elopement Treatment
The goal of this clinical trial is to test whether the Function-Based Elopement Treatment (FBET) can reduce elopement in children aged 4-12 with autism spectrum disorder (ASD), and to assess its feasibility in community-based…
- Trial name
- (FBET) (NCT07194083)
- Testing
- Function-Based Elopement Treatment, Treatment as Usual
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Emory University
Type 2 Diabetes
Implementation of Team Clinic for Type 2 Diabetes (TCT2)
The goal of this clinical trial is to learn if shared medical appointment is an acceptable way to deliver care to youth with type 2 diabetes.
- Trial name
- NCT06923046
- Testing
- Standard of Care, Shared Medical Appointments
- Where
- 2 sites in United States
- Volunteers
- 160 people
- Sponsor
- Children's Hospital Los Angeles
Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia
Digital Patient-Reported Assessment in Older Adults With Acute Leukemia
This pilot study will evaluate the feasibility of implementing a structured digital patient-reported assessment pathway in adults aged 65 years or older with acute leukemia at Hospital Universitario Central de Asturias, Oviedo…
- Trial name
- NCT07597590
- Testing
- Digital Patient-Reported Assessment Pathway
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Fundación para la Investigación Biosanitaria del Principado de Asturias
Cancer, Late Effects
FRAME - Implementation of a PRO Measure to Inform Patient-Centered Survivorship Care in Oncology Outpatient Visits
FRAME is a patient-centered survivorship care model embedded in routine oncology visits. It consists of: (1) a pre-visit patient-reported questionnaire (FRAME-PRO), (2) a clinician-patient dialogue guided by the responses, and…
- Trial name
- FRAME (NCT07281820)
- Testing
- FRAME model (questionnaire + dialogue + management plan)
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- Vejle Hospital
Epilepsy
Implementation and Cost Evaluation of Project UPLIFT
This study tests Project Using Practice and Learning to Increase Favorable Thoughts (UPLIFT) which is a Mindfulness-based Cognitive Behavioral Therapy program teaching participants with epilepsy methods that include challenging…
- Trial name
- NCT06865820
- Testing
- Project UPLIFT
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Emory University
Healthy Aging
Adopting a Health-social Partnership Program to Promote Health and Self-care Management Among Older Adults in the Community
Hong Kong has notably the longest life expectancy in the world. Ever-increasing demand and challenges are posing to the healthcare, social welfare, and elderly care service system.
- Trial name
- NCT05621720
- Testing
- Case management, Social control call and usual are
- Where
- Hong Kong
- Volunteers
- 788 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Older Adults
Social Participation Program for Older Adults in Nursing Homes
The goal of this clinical trial is to learn whether a multi-level social participation program can help improve social engagement and slow down cognitive decline in older adults living in nursing homes.
- Trial name
- NCT07079124
- Testing
- Multi-level Social Participation Intervention, Health Education
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Fujian Medical University
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