Clinical trials: Impulse Control Disorders, open to volunteers
Intermittent Explosive Disorder
Inflammatory Challenge in Human Aggression.
The goal of this clinical trial is to explore the differences in behavioral and cytokine response to a low dose infusion of endotoxin (vs.
- Trial name
- LPSS (NCT06665074)
- Testing
- Endotoxin (E. coli O:113, Reference Endotoxin)
- Where
- United States
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Intermittent Explosive Disorder
Pimavanserin and Aggression and Social Cognition.
The investigators are studying how certain drugs can reduce anger outbursts in people with anger problems. In this study the investigators seek to determine if a single 34 mg (two 17 mg tablets) oral dose of the 5-HT2a receptor…
- Trial name
- NCT05895513
- Testing
- Pimavanserin 34 mg
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Emotion Regulation, Mood Disorders
Neurostimulation Versus Therapy for Problems With Emotions
The primary goal of this clinical trial is to evaluate the unique neural and behavioral effects of a one-session training combining emotion regulation skills training, with excitatory repetitive transcranial magnetic stimulation…
- Conditions
- Emotion Regulation, Mood Disorders, Stress Disorder, Anxiety Disorders
- Trial name
- NCT05712057
- Testing
- Repetitive Transcranial Magnetic Stimulation (rTMS), electrical scalp stimulation, Cognitive Restructuring
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Duke University
Trichotillomania (Hair-Pulling Disorder)
Efficacy of Valbenazine for the Treatment of Trichotillomania in Adults
This trial aims to evaluate the efficacy, safety and tolerability of valbenazine, titrated to the subject's optimal dose of 40mg or 80mg, administered once daily, for 12 weeks, for the treatment of trichotillomania (TTM) in a…
- Trial name
- NCT05207085
- Testing
- Valbenazine Oral Capsule
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Yale University
Obsessive-Compulsive Disorder, Tricholemmoma
Neural Mechanisms of Response Inhibition Training for OCRD
The impaired ability to suppress an inappropriate but pre-potent response (response inhibition; RI) characterizes several debilitating clinical problems, including obsessive-compulsive and related disorders (OCRD) such as…
- Conditions
- Obsessive-Compulsive Disorder, Tricholemmoma, Skin-Picking
- Trial name
- OCRD (NCT05377125)
- Testing
- Computerized cognitive training
- Where
- United States
- Volunteers
- 118 people
- Sponsor
- University of Wisconsin, Milwaukee
Migraine Disorders, Brain, Healthy Adult Participants
Effect of Atogepant on the Vestibulo-Ocular Reflex in Healthy Adults and Adults With Migraine
Researchers want to find out how a substance in the body called CGRP affects balance. CGRP (calcitonin gene-related peptide) is a small protein involved in migraine. Several approved migraine medicines work by blocking it.
- Conditions
- Migraine Disorders, Brain, Healthy Adult Participants, Vestibulo-Ocular Reflex
- Trial name
- VOR-GRIP (NCT07826910)
- Testing
- Atogepant 60 mg
- Where
- Switzerland
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Konrad Peter Weber
Impulse Control Disorder, Parkinson Disease
rTMS Over the Dorsolateral Prefrontal Cortex for the Treatment of Impulse Control Disorders in Parkinson's Disease
This study's objective is to evaluate the effects of repetitive transcranial magnetic stimulation (rTMS) over the dorsolateral prefrontal cortex (dlPFC) of patients with Parkinson's Disease (PD) who experience impulse control…
- Trial name
- NCT06237868
- Testing
- rTMS Active
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- West Virginia University
Behavioural Addiction
NAlmefene Versus Placebo in Addition to Treatment as Usual on Craving in Behavioural Addictions
Behavioural addictions (BAs) [gambling disorder (GD), food addiction (FA), sexual addiction (SA)] may lead to disastrous consequences.
- Trial name
- NABAb (NCT05540288)
- Testing
- Nalmefene
- Where
- 13 sites in France
- Volunteers
- 266 people
- Sponsor
- Nantes University Hospital
Trichotillomania
Technology Assisted Treatment for Trichotillomania
The investigators are testing two digital health interventions for trichotillomania (TTM), via a randomized trial design.
- Trial name
- NCT05118633
- Testing
- Keen2 bracelet, Reminder bracelet, Keen2 app
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- HabitAware Inc.
Binge-eating Disorder
A Study of the Effects of Oxytocin in Adults With Binge-eating Disorder
This study evaluates the impact of intranasal oxytocin vs placebo in patients with binge eating disorder or episodes of binging.
- Trial name
- STROBE (NCT05664516)
- Testing
- TNX-1900 (Tonix Pharmaceuticals)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Massachusetts General Hospital
Alcohol Use Disorder, Intermittent Explosive Disorder
Neural Correlates During Alcohol Intoxication
Alcohol intoxication is responsible for a large proportion of violent crime/assault and personal injury in our society. While a number of variables have been associated with alcohol-related aggression, high trait aggression and…
- Trial name
- NCT06118580
- Testing
- Alcohol (Ethanol)
- Where
- United States
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Parkinson Disease, Impulse Control Disorder
Frontosubthalamic Networks in Parkinson's Disease.
The goal of this experimental study with is to understand the underlying mechanisms behind the increase in impulsivity seen in some patients that undergo deep brain stimulation of the subthalamic nucleus for Parkinson's Disease.
- Trial name
- NCT06485986
- Testing
- DBS on/off
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- University of Oxford
Major Depressive Episode (MDE), Major Depressive Disorder (MDD)
LHC-CIDI-5 in Hong Kong
The World Health Organization Composite International Diagnostic Interview-5th (CIDI-5) is a standardized diagnostic tool used to assess the prevalence of mental and substance use disorders over varying time frames (30 days, 12…
- Conditions
- Major Depressive Episode (MDE), Major Depressive Disorder (MDD), Persistent Depressive Disorder (PDD), Suicidal Ideation
- Trial name
- NCT06804525
- Testing
- CIDI-5, LHC-CIDI-5
- Where
- Hong Kong
- Volunteers
- 2,500 people
- Sponsor
- The University of Hong Kong
Gambling Disorder
COMpulsive Gambling: Efficacy of DEEP Transcranial Magnetic Stimulation With H7 COIL
This study aims to investigate whether a treatment called high-frequency repetitive transcranial magnetic stimulation (rTMS) can help reduce the symptoms of gambling disorder and whether it is safe and well tolerated.
- Trial name
- COMET-7 (NCT07828782)
- Testing
- active r-TMS
- Volunteers
- 60 people
- Sponsor
- Sveti Ivan Psychiatric Hospital
Parkinson's Disease (PD)
PET-MRI of Reward System in Parkinson's Disease With RBD
Impulse control disorders (ICDs) are frequently observed in Parkinson's disease (PD) and can have a major functional impact on the quality of life of both the patient and their entourage.
- Trial name
- RBD Impulse (NCT07213219)
- Testing
- PET-MRI (Positron Emission Tomography - Magnetic Resonance Imaging).
- Where
- 3 sites in France
- Volunteers
- 44 people
- Sponsor
- University Hospital, Clermont-Ferrand
Vestibular Hypofunction, Binocular Vision Abnormalities
Visual Influences on Vestibular Adaptation
The goal of this study is to learn whether a balance-training exercise called incremental vestibulo-ocular reflex adaptation (IVA) is safe and effective for adults with vision impairments, with or without additional vestibular…
- Conditions
- Vestibular Hypofunction, Binocular Vision Abnormalities, Reduced Vision
- Trial name
- NCT07380256
- Testing
- StableEyes: Incremental Vestibulo-Ocular Reflex Adaptation (IVA)
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Emory University
Trichotillomania (Hair-Pulling Disorder), Trichotillomania
Semaglutide (Wegovy) Treatment for Trichotillomania
This research study is testing the effectiveness and safety of semaglutide (Wegovy) in people with trichotillomania, also known as hair-pulling disorder.
- Conditions
- Trichotillomania (Hair-Pulling Disorder), Trichotillomania, Hair Pulling Disorder, Hair Pulling
- Trial name
- NCT07282769
- Testing
- Semaglutide
- Volunteers
- 10 people
- Sponsor
- University of Chicago
Gambling, Shift Work
Interaction Between Atypical Work Schedules and/or Idel Time at Work on At-risk Gambling Practices
At-risk gambling causes individual and social harm, influenced by environmental, psychological, and socioeconomic factors. In France, 5% of adult gamblers show at-risk gambling practices.
- Conditions
- Gambling, Shift Work, Addictive Behavior, Boredom
- Trial name
- PRAT-JEU (NCT07421765)
- Testing
- semi-structured interview
- Where
- 2 sites in France
- Volunteers
- 25 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Behavioral Addictions
A Prospective Clinical Study of a Cohort of Patients Seeking Treatment for a Behavioral Addiction
This research aims to provide a better understanding of the factors associated with the evolution of behavioral addictions, and compliance with care.
- Trial name
- EVALADD (NCT01248767)
- Where
- France
- Volunteers
- 2,720 people
- Sponsor
- Nantes University Hospital
Parkinson Disease
Trial Evaluating the Efficacy of Pimavanserin, a Selective Serotonin 5-HydroxyTryptamine-2A (5HT2A) Inverse Agonist, to Treat Impulse Control Disorders in Parkinson's Disease.
There is no consensus on the treatment of Impulse Control Disorder (ICD) in Parkinson Disease (PD) though it is recommended to reduce the dosage of dopamine agonists (DA).
- Trial name
- RETRO-PIMPARK (NCT06754553)
- Testing
- Assessment of severity of ICD (impulse control disorders), Assessment of motor and non-motors symptoms of PD Evaluation of hyper- and hypodopaminergic behaviors, Assessment of quality of life
- Where
- 16 sites in France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Strasbourg, France