Clinical trials: In Vitro Fertilization Implantation Failure
Infertility
Intralipid Therapy for Women 35-40 Years With Positive Natural Killer Cells Undergoing Intracytoplasmic Sperm Injection (ICSI)
Intralipid can suppress natural killer cells that are known to be involve in repeated implantation failure and recurrent miscarriages.Intralipid is made of purified soybean oil, egg phospholipids, glycerol and water.
- Trial name
- NCT01916798
- Testing
- Intralipid infusion
- Where
- Egypt
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Cairo University
Fertilization in Vitro, Pregnancy Loss
IVF Failure and Pregnancy Loss on Couples' Psychological Stress
The goal of this observational study is to learn about The purpose of this study was to compare the psychological differences between couples after IVF transplant failure and IVF pregnancy loss, including the differences in…
- Conditions
- Fertilization in Vitro, Pregnancy Loss, Psychological Stress, Post-traumatic Stress
- Trial name
- NCT06385444
- Where
- China
- Volunteers
- 150 people
- Sponsor
- The First Hospital of Jilin University
Recurrent Implantation Failure, Endometriosis
Effect of Granulocyte Colony-stimulating Factor on Clinical Pregnancy Rate in Patients With Endometriosis
The aim of this study is to evaluate the effect of granulocyte colony-stimulating factor on clinical pregnancy rate in patients with endometriosis undergoing in-vitro fertilization after recurrent implantation failure.
- Trial name
- NCT03549728
- Testing
- Granulocyte Colony-Stimulating Factor, Intrauterine infusion of normal saline
- Volunteers
- 88 people
- Sponsor
- Amira Magdi Guergues Selim
Infertility, Recurrent Implantation Failure
Endometrial Biopsy Protocol for In Vitro Fertilization (IVF)
Endometrial biopsy has been shown to improve IVF pregnancy and live birth rates. The optimal time of performing the biopsy is yet to be established.
- Trial name
- NCT01278706
- Testing
- endometrial biopsy/ies
- Where
- 2 sites in Israel
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Kaplan Medical Center
Endometriosis, In Vitro Fertilization Implantation Failure
The In Vitro Fertilization - Lipiodol Uterine Bathing Effect Study
The hypothesis of this study is that Lipiodol uterine bathing improves the success rate of in vitro fertilization (IVF) for women with endometriosis or recurrent IVF implantation failure.
- Trial name
- NCT00894946
- Testing
- Lipiodol + IVF, IVF
- Where
- New Zealand
- Volunteers
- 350 people
- Sponsor
- University of Auckland, New Zealand
Infertility Implantation Failure
r-hLIF for Improving Embryo Implantation in IVF
This study was designed to obtain pilot clinical evidence of the efficacy, safety and acceptability of r-hLIF administered during the luteal phase after IVF/intra-cytoplasmic sperm injection (ICSI) and ET for improving embryo…
- Trial name
- NCT00504530
- Testing
- Emfilermin, recombinant human leukemia inhibitory factor (r-hLIF)
- Volunteers
- 50 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Implantation Failure, Infertility
Endometrial Biopsy Prior to IVF in Those Patients With Prior Implantation Failure
This proposed research is a single center, prospective, single-blinded, randomized controlled trial, designed to evaluate IVF pregnancy outcomes following endometrial injury in 254 patients with implantation failure.
- Trial name
- EMBX/IVF (NCT01800513)
- Testing
- Endometrial Biopsy
- Where
- United States
- Volunteers
- 254 people
- Sponsor
- Shady Grove Fertility Reproductive Science Center
Recurrent Implantation Failure, In Vitro Fertilization
Azathioprine in Recurrent Implantation Failure
Azathioprine increase pregnancy rate in patients with recurrent implantation failure
- Conditions
- Recurrent Implantation Failure, In Vitro Fertilization, Intracytoplsmic Sperm Injection
- Trial name
- NCT03498703
- Testing
- Azathioprine Pill
- Where
- 2 sites in Egypt
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Focus of Study Instead
Endometrial Injury Increases Implantation and Pregnancy Rates
Objective To evaluate the effect of local injury to the endometrium for implantation, pregnancy and live birth rates in ICSI -ET cycles with recurrent implantation failure. Design Randomized controlled clinical study.
- Trial name
- NCT01340560
- Testing
- Endometrial biopsy
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Selcuk University
Infertility
PGS Using Microarray in IVF Patients With Repeated Implantation Failure
This project intends to use preimplantation genetic screening (PGS) with the microarray technique to determine the chromosome composition of fertilized eggs, so that only chromosomally normal embryos are transferred during IVF.
- Trial name
- NCT02265614
- Testing
- PGS
- Where
- Sweden
- Volunteers
- 130 people
- Sponsor
- IVF Research Sweden
Infertility Implantation Failure
A Multicentre, Randomised, Double-blind, Placebo-controlled Proof of Concept Study to Compare the Efficacy and Safety of r-hLIF (Emfilermin) for Improving Embryo Implantation Following in Vitro Fertilization (IVF) and Embryo Transfer (ET) in Women With Recurrent Implantation Failure
The primary objective of the study was to provide further clinical and statistical evidence of the efficacy of r-hLIF, in comparison with placebo, administered during the luteal phase after IVF and ET for improving embryo…
- Trial name
- NCT00504608
- Testing
- Emfilermin, recombinant human leukemia inhibitory factor (r-hLIF)
- Volunteers
- 150 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Implantation Failure
Effect of Fire-Needle Combined With Regular Acupuncture on Pregnancy Outcome in Patients With Recurrent Implantation Failure Undergoing In Vitro Fertilization
This study aims to evaluate whether fire-needle combined with regular acupuncture improves pregnancy outcomes in patients with recurrent implantation failure (RIF), compared to no or regular acupuncture.
- Trial name
- NCT07462754
- Testing
- no acupuncture, regular acupuncture, Fire needle combination group
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Huazhong University of Science and Technology
Recurrent Pregnancy Loss, Recurrent Implantation Failure
Use of Metabolomics for the Identification of Endometrial Biomarkers for IRPL and RIF After in Vitro Fertilization
It is a case-control study composed of 3 groups : 2 cases groups (RIF and IRPL) already composed as part of a pre-existing research project and 1 control group including patients undergoing ART for male factor infertility.
- Trial name
- ENDOMETAB (NCT03690830)
- Testing
- metabolomics analysis
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Angers
Infertility (IVF Patients), Acupuncture
Evaluation of Acupuncture's Effectiveness on Pregnancy Outcomes in Women with Recurrent Implantation Failure RIF: a Large Cohort Study
Title: Evaluating the Effectiveness of Acupuncture on Pregnancy Outcomes in Recurrent Implantation Failure (RIF) Patients Undergoing In Vitro Fertilization (IVF): A Large Cohort Study Objective: This study aims to assess the…
- Trial name
- AcupunctureRIF (NCT06708923)
- Testing
- Intervention Name: Acupuncture Therapy Before and After Embryo Transfer Description: The intervention involves acupuncture therapy performed at two key time points during the IVF cycle: 25 minutes be
- Where
- Vietnam
- Volunteers
- 1,969 people, healthy volunteers welcome
- Sponsor
- Hung Vuong Hospital
Infertility, Recurrent Implantation Failure
Effect of Reproductive Tract Microbiota on Pregnancy Outcome in IVF/ICSI
A single center，observational cohort study to explore the relationship between reproductive tract microbiota and pregnancy outcome in the patients accepted IVF/ICSI.
- Conditions
- Infertility, Recurrent Implantation Failure, Recurrent Miscarriage
- Trial name
- NCT04293068
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Peking University Third Hospital
Subfertility
BAP-EB as a Predictive Tool for Endometrial Receptivity and Pregnancy Outcome of IVF Treatment
To determine the predictive value of attachment rate of human embryonic stem cells (hESC)-derived trophoblast spheroids (BAP-EB, embryo surrogate) onto endometrial epithelial cells (EEC) on success of IVF treatment and to use the…
- Trial name
- NCT02713854
- Testing
- endometrial biopsy
- Where
- China
- Volunteers
- 240 people
- Sponsor
- The University of Hong Kong
Repeated IVF Failure, Microbiota
The Role of the Physiological Endometrial Microbiota in Assisted Reproduction Outcomes
The goal of this observational study is to investigate the influence and contribution of the normal composition and balance of the endometrial microbiota on the achievement of embryo implantation and the maintenance of pregnancy…
- Trial name
- no exist (NCT07606053)
- Where
- Greece
- Volunteers
- 80 people
- Sponsor
- Assisting Nature
Infertility, Fertilization in Vitro
Low Molecular Weight Heparin in Recurrent Implantation Failure
Recurrent implantation failure is the failure to achieve a pregnancy after multiple attempts with in vitro fertilization treatment. The reason is usually obscure.
- Conditions
- Infertility, Fertilization in Vitro, Recurrent Implantation Failure
- Trial name
- NCT00750451
- Testing
- low molecular weight heparin (enoxaparine sodium), crinone 8% gel
- Where
- Turkey (Türkiye)
- Sponsor
- V.K.V. American Hospital, Istanbul
Sterility
Low Molecular Weight Heparin to Improve Pregnancy Outcome in Patients With Recurrent Implantation Failure
The objective of this study is to determine the effect of Bemiparin, a low molecular weight heparin, on implantation rate in women with unexplained recurrent implantation failure undergoing IVF/ICSI treatment.
- Trial name
- BRIF (NCT02607319)
- Testing
- Bemiparin sodium
- Where
- Lebanon
- Volunteers
- 165 people
- Sponsor
- American University of Beirut Medical Center