Clinical trials: In-Hospital Cardiac Arrest
Cardiac Arrest (CA)
Adapted Cardiopulmonary Resuscitation Study
The goal of this controlled single centre RCT is to compare frequency rates concerning return of spontaneous circulation (ROSC) in prehospital cardiac arrest.
- Trial name
- NCT07754656
- Testing
- aCPR algorithm, ERC ALS 2025
- Where
- Austria
- Volunteers
- 216 people
- Sponsor
- Johannes Kepler University of Linz
out-of Hospital Cardiac Arrest
Pre-Hospital Cerebral Oxygenation and End-Tidal CO2 During Cardiopulmonary Resuscitation (CPR)
Cerebral saturation will be measured pre-hospital during an out-of hospital cardiac arrest with O3TM regional oximetry for Root® (Masimo®).
- Trial name
- CopernicusIb (NCT02850237)
- Where
- Belgium
- Volunteers
- 30 people
- Sponsor
- Hasselt University
Out of Hospital Cardiac Arrest, Cardiac Arrest (CA)
Prehospital ETI in OHCA
This prospective observational study evaluated the association of prehospital endotracheal intubation (ETI) status with return of spontaneous circulation (ROSC), 28-day survival, and favorable neurological outcome in adult…
- Conditions
- Out of Hospital Cardiac Arrest, Cardiac Arrest (CA), Endotracheal Intubation, Prehospital Airway Management in Patients With Cardiac Arrest
- Trial name
- ETIOHCA (NCT07524881)
- Testing
- Demographics, Comorbidities, Prehospital Variables
- Where
- Turkey (Türkiye)
- Volunteers
- 297 people
- Sponsor
- Haseki Training and Research Hospital
Hypothermia, Accidental, Hypothermia Due to Cold Environment
Accidental Hypothermia in Drowning-related OHCA
This study aims to report mortality and neurological outcome 180 days after drowning incident in patients with accidental hypothermia vs normothermia following drowning-related OHCA in Denmark during a six-year period from…
- Conditions
- Hypothermia, Accidental, Hypothermia Due to Cold Environment, Drowning, Out-Of-Hospital Cardiac Arrest
- Trial name
- NCT05908630
- Testing
- Hypothermia
- Where
- Denmark
- Volunteers
- 119 people
- Sponsor
- Prehospital Center, Region Zealand
Heart Arrest
Patient Acuity Rating: a Tool to Prevent In-Hospital Cardiac Arrest
The purpose of this study is to evaluate the accuracy of medical personnel in their ability to predict the likelihood of non-intensive care (ICU), ward patients to clinically deteriorate (defined as a cardiac arrest, unplanned…
- Trial name
- PAR (NCT01082991)
- Testing
- Preemptive Rapid Response Team intervention
- Where
- United States
- Sponsor
- University of Chicago
Out-Of-Hospital Cardiac Arrest, Healthy
Dose-Finding Study of Intranasal Insulin in Healthy Participants Insulin in Healthy Participants
This study is to determine the safety and tolerability of regular insulin (Humulin R) when given intranasally (as drops in nostrils).
- Trial name
- NCT05062785
- Testing
- Intranasal insulin
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Robert Silbergleit
Out-of-Hospital Cardiac Arrest
EMERGEncy Versus Delayed Coronary Angiogram in Survivors of Out-of-hospital Cardiac Arrest
Sudden cardiac death (SCD) remains a major public health issue with a low survival rate. The most common cause of SCD is acute coronary artery occlusion.
- Trial name
- EMERGE (NCT02876458)
- Testing
- Immediate coronary angiogram, Delayed coronary angiogram
- Where
- France
- Volunteers
- 336 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cardiac Arrest
Refractory Out-Of-Hospital Cardiac Arrest Treated With Mechanical CPR, Hypothermia, ECMO and Early Reperfusion
Sudden out-of-hospital cardiac arrest (OHCA) is a leading cause of death in Australia. The most common cause of OHCA is a heart attack.
- Trial name
- CHEER (NCT01186614)
- Testing
- Automated CPR, ECMO, Coronary angiography
- Where
- 2 sites in Australia
- Volunteers
- 24 people
- Sponsor
- Bayside Health
Out of Hospital Cardiac Arrest, Ventricular Fibrillation
Early Double Sequential Defibrillation in Out of Hospital Cardiac Arrest
Some of the patients affected by Out-of-hospital cardiac arrest (OHCA) with ventricular fibrillation (VF)/ventricular tachycardia (VT) do not respond to initial defibrillation.
- Conditions
- Out of Hospital Cardiac Arrest, Ventricular Fibrillation, Defibrillation, CPR
- Trial name
- DOUBLE D (NCT07174986)
- Testing
- Double sequential defibirllation, Standard defibrillation
- Where
- 14 sites in Netherlands, Spain and 1 more
- Volunteers
- 916 people
- Sponsor
- Gabriel Riva
Cardiac Arrest, Coronary Disease
An In-Hospital Family Member Cardiopulmonary Resuscitation (CPR) Education Program
Each year in the United States, 300,000 people suffer from a Cardiac Arrest (CA), and of them, there is a 90% mortality rate. Out-of-Hospital arrests, in particular, have a 1-5% survival to hospital discharge.
- Conditions
- Cardiac Arrest, Coronary Disease, Cardiovascular Risk Factors
- Trial name
- NCT01260441
- Testing
- CPR Training using the Family and Friends CPR Anytime VSI Kit
- Where
- 3 sites in United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Trauma, Cardiac Arrest
Airway Management Study in Physician Manned Helicopter Emergency Medical Services
An international airway management expert group has recently developed an Utstein-style template for uniform reporting of data from prehospital advanced airway management.
- Conditions
- Trauma, Cardiac Arrest, Emergencies
- Trial name
- AIRPORT (NCT01502111)
- Where
- Norway
- Volunteers
- 2,333 people
- Sponsor
- Norwegian Air Ambulance Foundation
Cardiac Arrest, Neurologic Dysfunction
Identification of Neuroprognostic Factors for Out-of-hospital Cardiopulmonary Arrest (MIRA29)
From the informatized prehospital care registry, data will be collected anonymously for all patients' requiring cardiopulmonary resuscitation for an out-of-hospital cardiac arrest within the Norther Finistere sanitary region.
- Conditions
- Cardiac Arrest, Neurologic Dysfunction, Cognitive Impairment
- Trial name
- MIRA29 (NCT06569134)
- Where
- 2 sites in France
- Volunteers
- 1,200 people
- Sponsor
- University Hospital, Brest
Rapid Response System, Vital Signs
The National Early Warning Score: Preceding Dynamics in the Score for Those Who Suffer an In-hospital Cardiac Arrest
To this date no clinical evaluation reports of the dynamics in the National Early Warning Score (NEWS) for those patients who suffer an in-hospital cardiac arrest, IHCA, exists.
- Trial name
- NCT03143062
- Testing
- NEWS
- Where
- Sweden
- Volunteers
- 381 people
- Sponsor
- Region Skane
Out-Of-Hospital Cardiac Arrest
Differential Diagnosis and Cause-specific Treatment During OHCA
Differential diagnosis: ultrasound, blood gas analyse combined with examination of the patient and environment is used during Out Of Hospital Cardiac Arrest (OHCA) to screen possible underlying cause of cardiac arrest.
- Trial name
- NCT04670354
- Where
- Finland
- Volunteers
- 100 people
- Sponsor
- Helsinki University Central Hospital
Pediatric, Cardiac Arrest
Pediatric Out-of-hospital Cardiopulmonary Arrest
The objective of this observational and retrospective study is to determine the predictive factors of in-hospital mortality following an out-of-hospital cardiopulmonary arrest (CPA) in the population under 18 years old.
- Conditions
- Pediatric, Cardiac Arrest, Out-Of-Hospital Cardiac Arrest
- Trial name
- Ped-CPA (NCT05474131)
- Where
- France
- Volunteers
- 137 people
- Sponsor
- Centre Hospitalier Régional Metz-Thionville
Cardiac Arrest, Sudden Cardiac Death
Epidemiological Study of Out-of-hospital Cardiac Arrest in Guangzhou
Aim This was a population-based retrospective cohort study of OHCA. This study intends to retrospectively analyze the data of pre-hospital emergency system in Guangzhou for 10 years, explore the incidence trend of OHCA in…
- Trial name
- NCT06448156
- Testing
- "cardiac arrest" and "sudden death"
- Where
- China
- Volunteers
- 44,375 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Out of Hospital Cardiac Arrest
A Multi-centre Survey of Epidemiology, Treatment and Outcome of Patients Suffering an Out-of-hospital Cardiac Arrest
There is considerable variation in the incidence of out-of-hospital cardiac arrest (OHCA) across Europe. The likelihood of attempted resuscitation also varies.
- Trial name
- EuReCaONE (NCT02236819)
- Where
- Germany
- Volunteers
- 10,682 people
- Sponsor
- German Resuscitation Registry
Out-Of-Hospital Cardiac Arrest
Machine Learning Assisted Recognition of Out-of-Hospital Cardiac Arrest During Emergency Calls.
Emergency medical Services Copenhagen has developed a machine learning model that analyzes the calls to 1-1-2 (9-1-1) in real time. The model are able to recognize calls where a cardiac arrest is suspected.
- Trial name
- NCT04219306
- Testing
- Alert on dispatchers screen 'Suspect cardiac arrest'
- Where
- Denmark
- Volunteers
- 5,242 people
- Sponsor
- Emergency Medical Services, Capital Region, Denmark
Cardiac Arrest (CA)
The Impact of First Responder Intervention on Survival in Out-of-Hospital Cardiac Arrest in Emilia-Romagna Region
Out-of-hospital cardiac arrest (OHCA) is a life-threatening emergency and one of the leading causes of death worldwide. Survival depends critically on how quickly help arrives and whether cardiopulmonary resuscitation (CPR) and…
- Trial name
- FIRSST-RER (NCT07589504)
- Where
- Italy
- Volunteers
- 5,200 people
- Sponsor
- Azienda Usl di Bologna
Pediatric ALL, Cardiac Arrest
Effect of IAM With an I-gel® on Ventilation Parameters in Simulated Pediatric OHCA
Pediatric cardiac arrest occurs most in the prehospital setting. Most of them are due to respiratory failure (e.g., trauma, drowning, respiratory distress), where hypoxia leads to cardiac arrest.
- Conditions
- Pediatric ALL, Cardiac Arrest, Cardiopulmonary Arrest, Resuscitation
- Trial name
- NCT05498402
- Testing
- i-gel ® device, bag-valve-mask ventilation
- Where
- 4 sites in Switzerland
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Geneve TEAM Ambulances