Clinical trials: In-hospital Cardiac Arrest
Morality, Hypothermic Circulatory Arrest Time
A Comparative Study of Different Hypothermic Circulatory Arrest Strategies on Aortic Surgery.
By comparing the clinical outcome of patients underwent different hypothermic circulatory arrest (mild hypothermic versus moderate hypothermic) during aortic arch surgery, this study aims to determine the optimal hypothermic…
- Conditions
- Morality, Hypothermic Circulatory Arrest Time, Aortic-cross Clamping Time, Cardiopulmonary Bypass Time
- Trial name
- NCT03454633
- Testing
- the temperature of hypothermic circulatory arrest
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Xiaoping Fan. MD
Out-Of-Hospital Cardiac Arrest, Neurological Injury
NFL Dynamics as a Predictor Factor in Patients With Out of Hospital Cardiac Arrest
To investigate the pharmacodynamics of light chain of NFL in patients with out-of hospital cardiac arrest after successful resuscitation and determine the difference in the serum levels of NFL in patients with favorable…
- Trial name
- NCT05218278
- Where
- Slovenia
- Volunteers
- 60 people
- Sponsor
- University Medical Centre Maribor
Cardiac Arrest
Prehospital Cerebral Oxygenation During Cardiopulmonary Resuscitation (CPR)
Near infrared spectroscopy (NIRS) is a technique that measures regional cerebral oxygenation in a non-invasive manner. Through the use of near infrared light, the difference between oxygenated and deoxygenated hemoglobin can be…
- Trial name
- NCT01806844
- Where
- 5 sites in Belgium
- Volunteers
- 200 people
- Sponsor
- Hasselt University
Cardiac Arrest, Cardiopulmonary Resuscitation
Compression Is Life In Cardiac Arrest - Human Study (CILICA-HS).
The management of out-of-hospital cardiac arrest is complex and multifactorial. With an incidence between 5 and 15 per 10,000 (46,000 patients per year in France) and a survival rate of only 5% to 15%, the room for improvement…
- Trial name
- CILICA-HS (NCT03817892)
- Testing
- Guidance of the External Chest Compression, Rhythm of a relay 4 minutes
- Where
- 11 sites in France
- Volunteers
- 51 people
- Sponsor
- University Hospital, Caen
Cardiac Arrest
Outcome of Cardiac Arrest Patients Following Guidelines Implementation Over the Years
The study aims to evaluate the level of local implementation of the new interventions introduced by the guidelines for post-cardiac arrest management and their impact on the survival of patients resuscitated from cardiac arrest…
- Trial name
- IMPACT-ACC (NCT06608771)
- Where
- 2 sites in Italy
- Volunteers
- 693 people
- Sponsor
- Mauro Panigada
Out-of-Hospital Cardiac Arrest, Extracorporeal Cardiopulmonary Resuscitation
Left Ventricular Ejection Fraction in Cardiac Arrest Survivors Treated With Extracorporeal Cardiopulmonary Resuscitation
Extra-hospital cardiac arrest is a major public health problem, with approximately 46,000 cases per year. Nearly 71% of the patients for whom resuscitation was initiated did not present a return of spontaneous circulation on…
- Trial name
- FEVGECMO (NCT06046339)
- Testing
- Collection of data from the patient's medical file
- Where
- France
- Volunteers
- 116 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Heart Arrest, Out-Of-Hospital, CardioPulmonary Resuscitation
Ventilation in Cardiac Arrest Resuscitation Study
Out-of-hospital cardiac arrest (OHCA) is a major public health problem, with around 40,000 victims each year in France. Their survival rate remains dramatically low, at less than 10%.
- Conditions
- Heart Arrest, Out-Of-Hospital, CardioPulmonary Resuscitation, Basic Cardiac Life Support
- Trial name
- VECARS (NCT05992454)
- Testing
- EOLIFE
- Where
- France
- Volunteers
- 120 people
- Sponsor
- French Defence Health Service
Out of Hospital Cardiac Arrest, Extracorporeal Cardiopulmonary Resuscitation
The CPR, Pre-hospital ECPR and Early Reperfusion Study: A Target Trial Emulation
CHEER4TTE is a target trial emulation, designed to simulate a randomised controlled trial by utilising data from pre-existing data sources.
- Trial name
- CHEER4TTE (NCT07679737)
- Testing
- Extracorporeal cardiopulmonary resuscitation
- Where
- Australia
- Volunteers
- 250 people
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Cardiac Arrest (CA), Cardiopulmonary Resuscitation (CPR)
The OXY-VENT Study
Effective ventilation during cardiopulmonary resuscitation is essential but can be difficult to achieve consistently. Current practice relies on visible chest rise to guide ventilation volume, although this may not always…
- Trial name
- OXY-VENT (NCT07870551)
- Testing
- Ventilation Feedback Device (Active), Control (Recording-Only)
- Where
- Netherlands
- Volunteers
- 515 people
- Sponsor
- Jeroen van Eijk
Out-of-Hospital Cardiac Arrest
Arizona Prehospital CPR Quality Improvement Project
The quality of cardiopulmonary resuscitation (CPR) provided to patients with out-of-hospital cardiac arrest (OHCA) is often suboptimal.
- Trial name
- NCT01258244
- Testing
- Audiovisual Feedback
- Where
- 2 sites in United States
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Valleywise Health
Coronary Artery Disease, Acute Myocardial Infarction
A Danish ICD-study in Patients with Coronary Artery Disease Resuscitated from Ventricular Fibrillation
DanICD is a randomized, controlled study to with the aim to assess whether there is a benefit of ICD-implantation in patients with coronary artery disease (including acute myocardial infarction), who survive cardiac arrest due to…
- Conditions
- Coronary Artery Disease, Acute Myocardial Infarction, Ventricular Fibrillation, Ventricular Tachycardia, Sustained
- Trial name
- DanICD (NCT04576130)
- Testing
- Implantable cardioverter defibrillator
- Where
- Denmark
- Volunteers
- 1,200 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Extracorporeal Membrane Oxygenation, Cardiac Arrest
ON-SCENE Initiation of Extracorporeal CardioPulmonary Resuscitation During Refractory Out-of-Hospital Cardiac Arrest
Hypothesis: Implantation of on-scene ECPR by the HEMS teams in patients with sustained out-of-hospital cardiac arrest, results in the rapid return of circulation and, thus, improved survival and less neurological impairment…
- Trial name
- ON-SCENE (NCT04620070)
- Testing
- ECPR
- Where
- 4 sites in Netherlands
- Volunteers
- 221 people
- Sponsor
- Erasmus Medical Center
Mental Health, Stress Disorder, Post Traumatic
Psychological Stress and Support Needs of Volunteer First Responders After Smartphone-based Cardiac Arrest Alerts
Out-of-hospital cardiac arrest is a serious emergency. In many areas, trained volunteers are alerted by a smartphone app to help before emergency services arrive.
- Trial name
- BRAVE (NCT07607808)
- Testing
- Structured Debriefing
- Where
- Germany
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University Hospital, Aachen
Unexpected Hospital Mortality, Death, Sudden, Cardiac
Prevention of Serious Adverse Events in Acute Care Hospitals by Afferent Limb and Response Method Intervention - the ALARM Intervention Study.
1. Summary Growing evidence suggests that a significant proportion of in-hospital patient deaths occur after serious adverse events (SAE's).
- Conditions
- Unexpected Hospital Mortality, Death, Sudden, Cardiac, Unplanned Intensive Care Unit Admission
- Trial name
- ALARM (NCT01949025)
- Testing
- ALARM intervention
- Where
- Belgium
- Volunteers
- 69,656 people, healthy volunteers welcome
- Sponsor
- Universiteit Antwerpen
Cardiac Death, Cardiac Arrest
Quality of Cardiopulmonary Resuscitation Pre- and Intra Hospital
The survival after intrahospital cardiac arrest has been reported to 15%. In Norway this varies between 16 and 23%.). Many factors are associated with survival after cardiac arrest, both intra- and prehospital.
- Conditions
- Cardiac Death, Cardiac Arrest, Cardiac Arrhythmia, Cardiac Disease
- Trial name
- NCT04295291
- Volunteers
- 300 people
- Sponsor
- Ostfold University College
Heart Arrest, Heart Arrest, Out-Of-Hospital
An Educational Program to Improve Cardiac Arrest Diagnostic Accuracy of Ambulance Telecommunicators
Cardiac arrest is the number one cause of death in Canada. It is often the first symptom of cardiac disease for the victims. Eighty-five percent of victims collapse in their own home.
- Conditions
- Heart Arrest, Heart Arrest, Out-Of-Hospital, Cardiac Arrest, Death, Sudden, Cardiac
- Trial name
- NCT03894059
- Testing
- Educational Intervention
- Where
- Canada
- Volunteers
- 12,224 people
- Sponsor
- Ottawa Hospital Research Institute
Cardiopulmonary Resuscitation, Echocardiography
Correlation Between End-tidal CO2 and Degree of Compression of Heart During CPR Measured by Ultrasound
Individual optimization of cardiopulmonary resuscitation (CPR) in real time may increase the success rate of the procedure. End-tidal CO2 (EtCO2) levels reflect cardiac output induced by CPR.
- Trial name
- NCT03852225
- Testing
- Intra-arrest echocardiography
- Where
- Czechia
- Volunteers
- 20 people
- Sponsor
- Emergency Medical Service of the Central Bohemian Region, Czech Republic
Acute Kidney Failure, Renal Replacement Therapy for Acute Kidney Injury in ICU
Effects of Sedation, TEmperature and Pressure After Cardiac Arrest and REsuscitation on Major Adverse Kidney Events (STEPCARE-MAKE)
The STEPCARE-MAKE study is a predefined sub-study of the large Sedation, TEmperature and Pressure after Cardiac Arrest and REsuscitation (STEPCARE) trial, which evaluates the effects of three interventions in comatose adult…
- Conditions
- Acute Kidney Failure, Renal Replacement Therapy for Acute Kidney Injury in ICU, Sedation in Intensive Care Unit Patients, Sedation in the ICU
- Trial name
- STEPCARE-MAKE (NCT07579390)
- Testing
- Feedback-controlled temperature device, High MAP, Deep sedation
- Where
- 52 sites in Australia, Belgium and 12 more
- Volunteers
- 3,500 people
- Sponsor
- Helsinki University Central Hospital
Out-of-Hospital Cardiac Arrest, Cardiopulmonary Resuscitation
Improving Bystander CPR Quality Through Dispatcher-assisted Basic Life Support Education Program
In an attempt to enhance OHCA survival by increasing bystander CPR rate, this study will assess the effectiveness of the new basic life support with dispatch assistance (DA-BLS) education program through a simulation experiment.
- Trial name
- NCT02527473
- Testing
- Dispatcher-Assisted Basic Life Support CPR Education
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Out-Of-Hospital Cardiac Arrest
International Termination of Resuscitation Practices
Neither the international nor the interregional variation in survival following OHCA is fully understood, but may rely on multiple factors such as: organization of the Emergency Medical Service (EMS) system bystander…
- Trial name
- NCT05029180
- Testing
- Termination of resuscitation
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of Southern Denmark