Clinical trials: Incisions, Surgical
Surgical Wound Infection
Vacuum Assisted Closure for Cesarean Section
To study if incisional vacuum-assisted closure can decrease the risk of infection in cesarean section incisions in the obese compared with standard sterile dressing.
- Trial name
- VACCS (NCT02390401)
- Testing
- Vacuum-assisted closure, Standard sterile dressing
- Where
- 4 sites in United States
- Volunteers
- 166 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Laparoscopic Surgery, Laparoscopic Cholecystectomy
Pre-incisional Infiltration With Ropivacaine Plus Triamcinolone for Relieving Postoperative Pain After Laparoscopic Surgery
Incisional infiltration is the simplest, safest, and most effective anesthesia method for preventing incision pain after laparoscopic surgery, but even using long-acting local anesthetics, the effectiveness of postoperative…
- Conditions
- Laparoscopic Surgery, Laparoscopic Cholecystectomy, Appendectomy, Laparoscopic, Hernia Repair
- Trial name
- NCT07591233
- Testing
- Pre-incisional infiltration with ropivacaine plus triamcinolone, Pre-incisional infiltration with ropivacaine alone
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Beijing Tiantan Hospital
Cesarean Section, Surgical Wound
To Explore the Effectiveness and Feasibility of HERADERM Hydrogel Wound Dressing on Caesarean Section Surgical Site
The wound of cesarean section involves multiple layers of tissue and often cause significant postoperative pain. The epidermal wound typically heals within 1 to 2 weeks after surgery.
- Conditions
- Cesarean Section, Surgical Wound, Surgical Wound Infection, Wounds and Injuries
- Trial name
- NCT06558240
- Testing
- HERADERM Hydrogel Wound Dressing (Sterile)
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Postoperative Wound Infection
Effects of Triclosan-coated Sutures in Cardiac Surgery
The purpose of this study is to assess if triclosan-coated sutures reduces wound infections after saphenous vein harvesting in CABG patients.
- Trial name
- NCT01212315
- Testing
- Triclosan coated sutures
- Where
- Sweden
- Volunteers
- 392 people
- Sponsor
- Sahlgrenska University Hospital
Gastrointestinal Tumors, Surgical Wound Infection
Non-Dressing vs. Routine Dressing Change After Gastrointestinal Cancer Surgery
The goal of this randomized non-inferiority trial is to evaluate whether omitting postoperative wound dressings is noninferior to routine dressing changes in patients undergoing gastrointestinal cancer surgery.
- Conditions
- Gastrointestinal Tumors, Surgical Wound Infection, Pain, Postoperative
- Trial name
- Dressing (NCT06263205)
- Testing
- Non-Dressing of Surgical Wound, Regular Dressing Change of Surgical Wound
- Where
- 4 sites in China
- Volunteers
- 1,138 people
- Sponsor
- Fudan University
Healthy Volunteers (HV), Skin Irritation
Safety of Topical Exosome-Containing Liquid in Healthy Volunteers for Future Surgical Wound Use
This Phase 1 split-site pilot study will evaluate the safety and dermal tolerability of a topical exosome-containing liquid in 10 healthy adult volunteers.
- Trial name
- EV-MELSAFE (NCT07707986)
- Testing
- Exosome-Containing Liquid, Vehicle Liquid
- Where
- Kazakhstan
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- West Kazakhstan Marat Ospanov Medical University
Surgical Wound Dehiscence
Trial of Versajet Compared With Conventional Treatment in Acute and Chronic Wounds
It is increasingly recognised that the debridement of devitalised, bacterially contaminated or senescent tissue is an essential component of the effective treatment of delayed healing wounds.
- Trial name
- NCT01050673
- Testing
- VERSAJET, Scalpel or blade
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Smith & Nephew, Inc.
Wound Heal
Topical Timolol: a Comparison of Surgical Outcomes
The use of topical beta-blockers, such as 0.25% timolol, in promoting wound healing is currently emerging in the literature. The investigators will enroll 30 participants in a split scar study who have their skin cancer…
- Trial name
- NCT05114239
- Testing
- Timolol 0.25% Ophthalmic Solution, Standard Wound Care
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Keith G. LeBlanc, Jr, MD
Postoperative Wound Breakdown
Fascial Dehiscence and Mortality
Nationwide cohort study on short- and long-term mortality of patients with and without postoperative fascial dehiscence. The cohort will be comprised of patient undergoing open colonic resection for colonic cancer registered in…
- Trial name
- NCT03008265
- Testing
- Postoperative fascial dehiscence
- Where
- Denmark
- Volunteers
- 9,000 people
- Sponsor
- Kristian Kiim Jensen
Anesthesia and Analgesia, Pediatrics
Erector Spinae Plane Block for Peri-operative Pain Management in Pediatric Open Pyeloplasty Cases
Regional anesthesia decreases the need for intravenous analgesia in the peri-operative period. Erector spinae plane (ESP) and transversus abdominus plane (TAP) blocks are two common regional anesthesia techniques shown to be…
- Conditions
- Anesthesia and Analgesia, Pediatrics, Urologic Surgical Procedures
- Trial name
- ESPPOP (NCT03790566)
- Testing
- Bupivacaine
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Istanbul University
Antibiotic, Bowel Cancer
Mechanical Bowel Preparation With or Without Oral Antibiotics for Colorectal Cancer Surgery
Investigation of the role of adding oral antibiotics to preoperative mechanical bowel preparation before colorectal surgery for cancer.
- Conditions
- Antibiotic, Bowel Cancer, Colorectal Cancer, Surgical Site Infection
- Trial name
- MECCA (NCT03563586)
- Testing
- Bowel Preparation plus antibiotics, Bowel Preparation
- Where
- Greece
- Volunteers
- 210 people
- Sponsor
- National and Kapodistrian University of Athens
Staphylococcus Aureus, Surgical Wound Infection
Risk Factors for Staphylococcus Aureus Surgical Site Infections in Orthopedic and Trauma Surgery
The most commonly identified organism for Surgical Site Infection (SSI) in orthopedic surgery is Staphylococcus aureus but risk factors for mono microbial S.aureus SSI are not well-known.
- Conditions
- Staphylococcus Aureus, Surgical Wound Infection, Orthopedic Disorder, Traumatology
- Trial name
- ISO (NCT03040960)
- Where
- France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Grenoble
Surgery, Pneumonia
Multicenter Infection Surveillance Study Following Open Heart Surgery
The main goals of the study are as follows: (1) to determine the correlation between pain management using continuous infusion of local anesthetics and the incidence of pneumonia and surgical infection in cardiac surgery…
- Conditions
- Surgery, Pneumonia, Surgical Site Infection
- Trial name
- NCT00673712
- Testing
- Continuous Sternal Block, Opioid based analgesia
- Where
- 8 sites in United States
- Volunteers
- 647 people
- Sponsor
- Halyard Health
Pain, Postoperative
Ketolorac Versus Saline at Laparoscopic Incision Sites
Pain control following surgery is a critical aspect of patient care. Pain at incision sites in laparoscopic surgery contributes to overall pain felt by a patient.
- Trial name
- NCT01374828
- Testing
- Ketolorac
- Where
- United States
- Sponsor
- The Cleveland Clinic
Surgical Site Infection (SSI)
Sterile vs Clean Non-Sterile Wound Dressing in Orthopedic Surgery
This randomized interventional pilot study aims to compare the rate of significant Surgical Site Infection (SSI) within the six weeks after elective orthopedic surgery using sterile versus clean non-sterile glove postoperative…
- Trial name
- NCT07436065
- Testing
- Sterile Glove Dressing Technique, Clean Non-Sterile Glove Dressing Technique
- Where
- Qatar
- Volunteers
- 25 people
- Sponsor
- Hamad Medical Corporation
Peritonitis, Surgical Site Infection
Continuous Glucose Monitoring for Emergency Laparotomy
CLUE trial aims to determine the feasibility and predictive value for surgical site infection (SSI) of continuous glucose monitoring (CGM) in emergency laparotomy patients with diffuse peritonitis.
- Conditions
- Peritonitis, Surgical Site Infection, Infections, Hyperglycemia
- Trial name
- CLUE (NCT05641792)
- Testing
- CGM (Dexcom G6)
- Where
- Poland
- Volunteers
- 50 people
- Sponsor
- Medical University of Gdansk
Severe Aortic Valve Disease, Aortic Valve Replacement (AVR)
Comparative Research of Y-Incision vs. Standard Techniques for Aortic Root EnLargement
Abstract Background: Aortic valve replacement (AVR) is crucial for patients with severe aortic valve disease. However, managing those with a small aortic annulus (SAA, i.e., annulus diameter < 22 mm) is challenging because…
- Conditions
- Severe Aortic Valve Disease, Aortic Valve Replacement (AVR), Small Aortic Annulus
- Trial name
- CRYSTAL (NCT07368322)
- Testing
- Y incision Technique (YIT), Standard surgical enlargement techniques
- Where
- Israel
- Volunteers
- 90 people
- Sponsor
- willner nadav MD
Colorectal Cancer
Short-term Effects of LASI Surgery Versus Conventional Laparotomy for Colorectal Liver Metastasis
Surgical resection is still recommended as the optional treatment for colorectal liver metastasis (CLM) patients. There are two main concerns for resectable colorectal liver metastasis which remain controversial: surgical time…
- Trial name
- NCT02350166
- Testing
- laparoscopic surgery
- Where
- 2 sites in China
- Volunteers
- 40 people
- Sponsor
- West China Hospital
Laceration of Skin, Injury Skin
Assessment of DAFILON® Suture Material for Skin Closure
In this non-interventional study (NIS) a polyamide non-absorbable suture (Dafilon®) will be evaluated for skin closure in adult and pediatric patients.
- Trial name
- SKINDA (NCT04617041)
- Where
- 2 sites in Germany, Spain
- Volunteers
- 115 people
- Sponsor
- Aesculap AG
Surgical Site Infection, Hip Fractures
Wound Contamination During Orthopaedic Surgery
In the present study we will compare bacteriological findings and the incidence of SSI in relation to laminar airflow (LAF) ventilated ORs, conventional (also called displacement or mixed) ventilated ORs and conventional…
- Conditions
- Surgical Site Infection, Hip Fractures, Orthopedic Disorder, Implant Infection
- Trial name
- Clean Care (NCT04676841)
- Testing
- Conventional ventilation + instrumental tables with integrated laminar airflow, Conventional ventilation + standard instrumental tables, Laminar airflow ventilation + standard instrumental tables
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- Vastra Gotaland Region
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