Clinical trials: Induced Abortion
Preterm Birth, Cervical Incompetence
Preventing Preterm Birth With a Negative Pressure Cervical Cup: a Feasibility Study
The goal of this Phase I clinical trial is to generate proof-of-concept data to demonstrate that a cervical cup in combination with vacuum application will create negative pressure on uterine cervical tissue, thereby creating…
- Conditions
- Preterm Birth, Cervical Incompetence, Cervical Insufficiency, Short Cervix
- Trial name
- NCT05512052
- Testing
- Hannah Cervical Cup (2 mm Delta), Hannah Cervical Cup (4 mm Delta), Hannah Cervical Cup (6 mm Delta)
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Galena Innovations, LLC
Pregnancy, High Risk
Use of Dietary Supplements in Patients at Risk of Abortion Treated With Progesterone.
The trial aims to investigate the effect of supplementation with hyaluronic acid, alpha-lipoic acid, magnesium, vitamin D and vitamin B6 in progesterone-treated pregnant women with risk factors for abortion.
- Trial name
- NCT04874285
- Testing
- HA
- Where
- Italy
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Lo.Li.Pharma s.r.l
Early Pregnancy, Early Pregnancy Loss
EARLY-PREG: A Preconception Cohort Study Based on Counterfactuals to Study Maternal-Embryonic Molecular Interactions
EARLY-PREG is an open-cohort clinical study with a preconception, longitudinal, bidirectional and counterfactual design. The aim of this cohort is to investigate the proteomic signatures of maternal-embryonic communication by…
- Conditions
- Early Pregnancy, Early Pregnancy Loss, Childbirth, Healthy
- Trial name
- EARLY-PREG (NCT07358026)
- Testing
- EMBRYO EXPOSURE
- Where
- Chile
- Volunteers
- 223 people, healthy volunteers welcome
- Sponsor
- MELISA Institute Genomics & Proteomics Research SpA
Recurrent Miscarriage
A Study of the Efficacy and Safety of GB-0998 in Patients With Unexplained Recurrent Miscarriage
The present survey was conducted to evaluate the efficacy and safety of GB-0998(immunoglobulin) in the treatment of unexplained recurrent miscarriage in comparison to placebo using a multicenter, double-blind, intergroup…
- Trial name
- NCT02184741
- Testing
- GB-0998
- Where
- Japan
- Volunteers
- 99 people
- Sponsor
- Japan Blood Products Organization
Aneuploidy, Chromosome Abnormality
RCT Study to Validate niPGT-A Clinical Benefit.
Chromosomal aneuploidies are linked with spontaneous miscarriages and abnormal offspring in human pregnancies. In addition, some types of aneuploidies are reported to prevent implantation.
- Conditions
- Aneuploidy, Chromosome Abnormality, Infertility
- Trial name
- niPGT-A_RCT (NCT04000152)
- Testing
- niPGT-A, Morphology criteria
- Where
- 8 sites in Argentina, Brazil and 3 more
- Volunteers
- 296 people
- Sponsor
- Igenomix
Uterine Cervical Incompetence
Dilapan-S Osmotic Dilator in Pre-induction of Labor
Non-interventional prospective data collection designed to evaluate clinical outcome on the efficacy of the use of Dilapan-S in the indication of labor pre-induction in women with/without a history of Caesarean section.
- Trial name
- NCT02098382
- Testing
- Dilapan-S
- Where
- Czechia
- Volunteers
- 125 people
- Sponsor
- Medicem International CR s.r.o.
Pregnancy Related, Abortion
Determining Beta-hCG Levels in Patients Through Alternative Sample Types
This study is to determine if there is any quantifiable correlation between serum beta hCG and dried blood spot (DBS) beta hCG levels.
- Trial name
- NCT06178224
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Simple HealthKit
Infertility, Miscarriage, Recurrent
ANXA5 M2 Haplotyping in IVF Patients and Embryos
This study aims to characterize the association between history of pregnancy complications and M2 carrier status in IVF patients and the utility of M2 haplotype preimplantation genetic testing (PGT) in embryos produced by carrier…
- Conditions
- Infertility, Miscarriage, Recurrent, Pregnancy Complications
- Trial name
- NCT04544462
- Testing
- M2 Test
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Genomic Prediction Inc.
Infertility, Miscarriage
Preimplantation Genetic Diagnosis (PGD) by Array Comparative Genome Hybridization (CGH) and Blastocyst Biopsy
This study evaluates the effect of single embryo transfer (SET) with and without array CGH for the evaluation of the complete chromosome complement of the blastocyst. Patients will be allocated at random into two groups.
- Trial name
- NCT01332643
- Testing
- Preimplantation Genetic Diagnosis
- Where
- Peru
- Volunteers
- 120 people
- Sponsor
- Reprogenetics
Contraception
Bleeding Pattern Difference Between Levonorgestrel Intrauterine System (LNG-IUS) and Copper Intrauterine Devices (IUDs) Immediately Inserted After Abortion
To observe the bleeding patterns of post-abortion immediate insertion of IUS compared to Cu-IUD over the first 6 months.
- Trial name
- POST (NCT01958684)
- Testing
- Levonorgestrel IUS (Mirena, BAY86-5028), Copper-IUD
- Where
- China
- Volunteers
- 512 people
- Sponsor
- Bayer
Miscarriage, Recurrent
Prediction of Recurrent Pregnancy Loss by a New Thrombophilia Based Genetic Risk Score
Recurrent pregnancy loss (RPL) is a clinical problem affecting 1-5% of couples of reproductive age. The contribution of thrombophilia to RPL is disputed.
- Trial name
- TiC-RPL (NCT03336463)
- Where
- 8 sites in Spain, United Kingdom
- Volunteers
- 364 people
- Sponsor
- Ferrer inCode, S.L.
Infertility, Endometritis
Chronic Endometritis in Patients With Recurrent Miscarriages or Repeated Implantation Failures in In-vitro Fertilization
Chronic endometritis is a persistent inflammation of the endometrium. Chronic endometritis is asymptomatic or little symptomatic.
- Conditions
- Infertility, Endometritis, Abortion, Spontaneous
- Trial name
- NCT01762098
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Clinique Ovo
Early Pregnancy Loss
Cell-free DNA Analysis of Chromosome Anomalies in Early Pregnancy Loss
The study assesses the accuracy of cell-free DNA (cfDNA) analysis in detecting whole chromosomal aneuploidies from maternal plasma of patients with early, missed miscarriage.
- Trial name
- NCT04935138
- Testing
- cfDNA analysis
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- Quest Diagnostics-Nichols Insitute
Pregnancy Complications, Pregnancy Outcome
BioThrax® (Anthrax) Vaccine in Pregnancy Registry
The purpose of this study is to determine if inadvertent receipt of the BioThrax vaccine during pregnancy is independently associated with adverse maternal, pregnancy, or infant health outcomes.
- Conditions
- Pregnancy Complications, Pregnancy Outcome, Congenital Abnormalities
- Trial name
- NCT01653392
- Testing
- Observational Intervention
- Where
- United States
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Emergent BioSolutions
Abortion, Induced
Dilapan-S / Dilasoft E-Registry in Induced Abortion
International Observational E-Registry on the use of osmotic dilators DILAPAN-S® / DILASOFT® for cervical priming prior to induced abortion.
- Trial name
- DSREGISTRYIA (NCT02318212)
- Testing
- Dilapan-S
- Volunteers
- 439 people
- Sponsor
- Medicem International CR s.r.o.
Abortion; Attempted, Medical
Feasibility of a Self-performed Urinary Test for the Follow-up on Medical Abortion
This study was a national, longitudinal, prospective, observational survey, carried out in metropolitan France, with a sampling of 21 birth control centres.
- Trial name
- NCT02304835
- Where
- France
- Volunteers
- 322 people
- Sponsor
- Nordic Pharma SAS
Recurrent Miscarriage, Infertility
EmbryoGen/ Blastgen for Couples With Implantation Problems or Previous Miscarriage
EmbryoGen and BlastGen contain the cytokine growth factor Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF), which has been documented to give significant benefit to this difficult group of patients.
- Trial name
- BlastGen (NCT02305420)
- Testing
- EmbryoGen/ BlastGen media, Standard Cook sequential media
- Where
- Australia
- Volunteers
- 100 people
- Sponsor
- FertilitySA
Early Pregnancy Loss, Delayed Pregnancy Loss
CCT-102 or Expectant Management in Delayed Pregnancy Loss
A Phase 3, multi-center clinical trial of a CCT-102 regimen or expectant management to promote uterine evacuation in first trimester non-progressing Delayed Pregnancy Loss (DPL).
- Trial name
- MERMAID (NCT06121063)
- Testing
- CCT-102 A and CCT-102 B
- Where
- 15 sites in United States
- Volunteers
- 183 people, healthy volunteers welcome
- Sponsor
- Conceptra Biosciences, LLC
Pre-Eclampsia
Low Dose Aspirin for Prevention of Early Pregnancy Loss
Preeclampsia is a pregnancy-specific, multisystem disorder affecting 3% to 8% of pregnancies and remains a significant cause of maternal and neonatal morbidity and mortality worldwide.
- Trial name
- NCT06261203
- Testing
- Aspirin
- Where
- Egypt
- Volunteers
- 250 people
- Sponsor
- Egymedicalpedia
Recurrent Pregnancy Loss, Recurrent Miscarriage
A Multi-center, Placebo-controlled Study to Evaluate NT100 in Pregnant Women With a History of Unexplained Recurrent Pregnancy Loss (RPL)
This is a randomised, double blind, multi-center, placebo-controlled study of subcutaneous NT100 in pregnant women with a history of unexplained recurrent pregnancy loss.
- Trial name
- RESPONSE (NCT02156063)
- Testing
- NT100
- Where
- 19 sites in United Kingdom
- Volunteers
- 150 people
- Sponsor
- Nora Therapeutics, Inc.