Clinical trials: Induction Chemotherapy
Breast Cancer, Doxorubicin Induced Cardiomyopathy
99mTc-rhAnnexin V-128 Imaging and Cardiotoxicity in Patients With Early Breast Cancer
This was a single center, proof-of-concept (PoC), Phase II study. Patients with histologically confirmed early stage (Stage I, II or III) HER-2 negative breast cancer and scheduled to receive doxorubicin-based (neo)adjuvant…
- Trial name
- NCT02677714
- Testing
- 99mTc-rhAnnexin V-128
- Where
- Canada
- Volunteers
- 14 people
- Sponsor
- Advanced Accelerator Applications
Medulloblastoma, Central Nervous System Embryonal Tumors
HeadStart4: Newly Diagnosed Children (<10 y/o) With Medulloblastoma and Other CNS Embryonal Tumors
This is a prospective randomized clinical trial, to determine whether dose-intensive tandem Consolidation, in a randomized comparison with single cycle Consolidation, provides an event-free survival (EFS) and overall survival…
- Trial name
- NCT02875314
- Testing
- Induction, Single Cycle Intensive Chemotherapy, Tandem 3 Cycle Intensive Chemotherapy
- Where
- 62 sites in United States, Canada and 1 more
- Volunteers
- 250 people
- Sponsor
- Parth Patel
Breast Cancer, Osteoporosis
Zoledronate, Calcium, and Vitamin D in Preventing Bone Loss in Women Receiving Adjuvant Chemotherapy for Breast Cancer
RATIONALE: Zoledronate plus calcium and vitamin D may prevent bone loss in patients receiving adjuvant chemotherapy for breast cancer. It is not yet known which regimen is more effective in preventing bone loss.
- Trial name
- NCT00022087
- Testing
- calcium salts, cholecalciferol, zoledronic acid
- Where
- 107 sites in United States
- Volunteers
- 439 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Chemotherapy-induced Febrile Neutropenia
Study Investigating How Physicians Assess the Risk of Patients Developing Febrile Neutropenia During Chemotherapy.
This is a prospective observational study investigating how physicians assess the risk of febrile neutropenia (FN) developing in patients who will receive chemotherapy.
- Trial name
- NCT01813721
- Where
- 90 sites in Australia, Austria and 9 more
- Volunteers
- 1,007 people
- Sponsor
- Amgen
Chemotherapy Induced Peripheral Neuropathy (CIPN)
Assessing Functional Impairments in Patients With Chemotherapy-Induced Peripheral Neuropathy
Chemotherapy-induced peripheral neuropathy (CIPN) is a severe side effect of several anti-cancer agents. Typical symptoms include tingling and hypoesthesia in the fingertips and/or toes, which substantially impair patients'…
- Trial name
- Assess CIPN (NCT07315334)
- Testing
- Questionnaire and Physical Exam
- Where
- Austria
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Paracelsus Medical University
Chemotherapy-induced Nausea and Vomiting
Re-examination Study of EMEND (Aprepitant) (MK-0869-184)
This survey is conducted for preparing application materials for re-examination under the Pharmaceutical Affairs Laws and its Enforcement Regulation.
- Trial name
- NCT01074255
- Testing
- EMEND
- Volunteers
- 3,546 people
- Sponsor
- Merck Sharp & Dohme LLC
Solid Tumor Malignancies, Cancer, CTIT-Chemotherapy Induced Thrombocytopenia
A Multicenter, Open-label, Randomized Controlled Trial Evaluating the Efficacy and Safety of Romiplostim N01 in the Treatment of Thrombocytopenia Associated With Concurrent/Sequential Chemoradiotherapy and Chemotherapy Combined With/Without Immunotherapy in Solid Tumors
The purpose of this clinical trial is to evaluate the safety and efficacy of Romiplostim N01 in patients with solid tumors who are undergoing concurrent/sequential radiotherapy and chemotherapy（combined with/without…
- Conditions
- Solid Tumor Malignancies, Cancer, CTIT-Chemotherapy Induced Thrombocytopenia, Thrombocytopenia
- Trial name
- NCT07185893
- Testing
- Human Interleukin-11, Romiplostim N01
- Where
- China
- Volunteers
- 106 people
- Sponsor
- Jun wang
Lymphoma, Mantle Cell, Mantle Cell Lymphoma
EPOCH-R Chemotherapy Plus Bortezomib to Treat Mantle Cell Lymphoma
This study will evaluate the effectiveness of etoposide, prednisone, vincristine, cyclophosphamide, doxorubicin-rituximab (EPOCH-R) chemotherapy plus bortezomib for treating mantle cell lymphoma, a cancer of white blood cells…
- Trial name
- NCT00114738
- Testing
- Rituximab (R), EPOCH, Bortezomib (B)
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- National Cancer Institute (NCI)
Nausea With Vomiting Chemotherapy-Induced
BMT-08: A Comparative Effectiveness Study of Transdermal Granisetron to Ondansetron
Patients undergoing either an autologous or allogeneic hematopoietic stem cell transplant (HSCT) and receiving preparative chemotherapy experience a considerable amount of chemotherapy-induced nausea and vomiting (CINV).
- Trial name
- NCT04150614
- Testing
- Granisetron Transdermal Patch, Intravenous Dexamethasone, Ondansetron
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- University of Illinois Chicago
Breast Neoplasms
Phase 3 Study of Acupression's Bracelets in Nausea and Vomiting Induced by FEC100 Chemotherapy's Sort.
The purpose of this study is to demonstrate a betterment of the digestive symptomatology by the anti-emetic acupression's bracelets's use associated with hygiene and dietetic advices.
- Trial name
- NCT00268125
- Testing
- Acupression's bracelet, Hygiene and dietetic advices
- Where
- 3 sites in France
- Volunteers
- 347 people
- Sponsor
- Institut Claudius Regaud
Chemotherapy-Related Cognitive Impairment, Chemotherapeutic Toxicity
Investigating Cognitive Impairment in Young Patients With Cancer Prospectively
The MyBrain study investigates the brain function of children, adolescents and young adults during and after chemo treatment for cancer.
- Conditions
- Chemotherapy-Related Cognitive Impairment, Chemotherapeutic Toxicity, Chemo-brain, Cancer
- Trial name
- MyBrain (NCT05840575)
- Where
- Denmark
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Carcinoma, Non-Small-Cell Lung
Study Using Induction Chemotherapy and Intensity-Modulated Radiation Therapy Guided by Combined CT and PET Imaging for Patients With Non-Small Cell Lung Cancer
Lung cancer is the leading cause of cancer-related mortality in the United States (US) and Canada. Because of the high incidence and mortality of this disease, small improvements in the management of this disease translates into…
- Trial name
- NCT00128999
- Testing
- Intensity-Modulated Radiation Therapy
- Where
- Canada
- Volunteers
- 5 people
- Sponsor
- Alberta Health services
Gynecologic Cancers
Homoeriodictyol Sodium Mouthwash to Reduce Chemotherapy Induced Bitter Taste Disorders
Background: More than 75% of women with cancer experience taste disorders during adjuvant chemotherapy. Bitter phantogeusia is particularly limiting.
- Trial name
- HED (NCT07573787)
- Testing
- homoeriodictyol sodium
- Where
- Austria
- Volunteers
- 15 people
- Sponsor
- Christoph Grimm
Gastric Adenocarcinoma
S-1, Cisplatin-based Chemoradiotherapy, Induction Chemotherapy, Locally Advanced Gastric Adenocarcinoma
Currently, for further improved survival outcome, new cytotoxic compounds such as irinotecan and docetaxel have been combined with 5-FU/cisplatin.
- Trial name
- NCT02495493
- Testing
- Induction DCS chemotherapy
- Where
- South Korea
- Volunteers
- 42 people
- Sponsor
- Yonsei University
Prevention of Nausea and Vomiting Caused by Highly Emetogenic Chemotherapy
Clinical Study of HR20013 for Injection in Patients With Malignant Solid Tumors
To evaluate the efficacy and safety of HR20013 for injection for prevention of chemotherapy-induced nausea and vomiting after highly emetogenic chemotherapy.
- Trial name
- NCT05509634
- Testing
- HR20013 for injection；dexamethasone, fosaprepitant dimeglumine for injection；palonosetron hydrochloride injection；dexamethasone
- Where
- China
- Volunteers
- 754 people
- Sponsor
- Fujian Shengdi Pharmaceutical Co., Ltd.
Breast Cancer
Pilot Study to Evaluate the Prevention and Safety of Doxorubicin-induced Cardiomyopathy Using Extracorporeal Shock Waves
Until now, patients receiving doxorubicin chemotherapy should use only the cumulative dose related to known cardiotoxicity, or if cardiotoxicity occurs below the known cumulative dose, use of doxorubicin as chemotherapy should be…
- Trial name
- NCT05584163
- Testing
- Extracorporeal shock waves
- Where
- South Korea
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Ewha Womans University Mokdong Hospital
Chemotherapy-induced Peripheral Neuropathy, Pain
Transcutaneous Electrical Nerve Stimulation (TENS) for Chemotherapy Induced Peripheral Neuropathy (CIPN)
The purpose of this pilot study is to examine the acceptability and proof of concept effectiveness of a wireless Transcutaneous Electrical Nerve Stimulation (TENS) technology to address Chemotherapy Induced Peripheral Neuropathy…
- Conditions
- Chemotherapy-induced Peripheral Neuropathy, Pain, Neuropathy
- Trial name
- NCT06324344
- Testing
- High-Dose TENS, Low-Dose TENS
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Baylor College of Medicine
Nasopharyngeal Carcinoma
Chemoradiotherapy for Patients With Locally Advanced Nasopharyngeal Carcinoma Using Raltitrexed-Cisplatin
The purpose of this study is to evaluate the efficacy and safety of raltitrexed and cisplatin neoadjuvant chemotherapy followed by concurrent radiotherapy with raltitrexed and cisplatin in patients with locally advanced…
- Trial name
- NCT02562599
- Testing
- raltitrexed-cisplatin, Intensity-modulated radiotherapy (IMRT)
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Hubei Cancer Hospital
Drug Allergy
Study of Omalizumab as Adjuvant Therapy in Chemotherapy Desensitization
This research study is evaluating a drug called omalizumab (brand name 'Xolair') as a potential treatment to be used in conjunction with drug desensitization to prevent reactions from recurring and allowing the participant to be…
- Trial name
- NCT02118987
- Testing
- Omalizumab
- Where
- 2 sites in United States
- Volunteers
- 5 people
- Sponsor
- Dana-Farber Cancer Institute
Chemotherapy-induced Peripheral Neuropathy (CIPN), Neuropathic Pain
Use of PEA and Scutellaria in Synergy With Therapeutic Exercise in Chemotherapy-induced Peripheral Neuropathy (CIPN): a Clinical Trial
This study aims to find out if taking specific dietary supplements (PEA and Scutellaria) along with therapeutic exercise can help reduce nerve pain and damage caused by chemotherapy.
- Trial name
- NCT07352514
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Palermo
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