Clinical trials: Induction of Labour, active
Preeclampsia, Intrauterine Growth Restriction
sFlt1/PlGF and Planned Delivery to Prevent Preeclampsia at Term.
Preeclampsia (PE) affects ~5% of pregnancies. Although improved obstetrical care has significantly diminished associated maternal mortality, PE remains a leading cause of maternal morbidity and mortality in the world.
- Conditions
- Preeclampsia, Intrauterine Growth Restriction, Maternal Hypertension, Neonatal Outcome
- Trial name
- PE37 (NCT04766866)
- Testing
- sFlt1/PlGF screening in maternal blood at 35 to 36.6 weeks of gestation
- Where
- 21 sites in Belgium, Colombia and 7 more
- Volunteers
- 9,132 people, healthy volunteers welcome
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Labor Pain, Induction of Labor
Induction of Labor by Cervical Ripening and Transcutaneous Electrical Nerve Stimulation (TENS)
This study aims to evaluate the effectiveness of transcutaneous electrical nerve stimulation (TENS) for pain management during labor induction by cervical ripening.
- Trial name
- DETENS (NCT07494539)
- Testing
- Transcutaneous Electrical Nerve Stimulation (TENS), Standard analgesic care
- Volunteers
- 132 people
- Sponsor
- HOT Noémie
Morbid Obesity, Pregnancy
Induction of Labor in Morbidly Obese Patients
The goal of this randomized control trial is to compare different doses of Misoprostol (25 mcg vs 50 mcg) in induction of labor (IOL) in morbidly obese patients with BMI >40.
- Trial name
- NCT06199154
- Testing
- Misoprostol
- Where
- United States
- Volunteers
- 162 people
- Sponsor
- University of Maryland, Baltimore
Oxytocin, Labor Pain
The Stimulation To Induce Mothers Study
The investigators propose a parallel group randomized clinical trial of intrapartum nipple stimulation versus exogenous oxytocin infusion for nulliparous women undergoing induction of labor near term.
- Conditions
- Oxytocin, Labor Pain, Induction of Labor Affected Fetus / Newborn, Physiologic Effects of Drugs
- Trial name
- STIM (NCT05079841)
- Testing
- Electric breast pump, Exogenous oxytocin intravenous infusion without nipple stimulation.
- Where
- 3 sites in United States
- Volunteers
- 933 people, healthy volunteers welcome
- Sponsor
- Yale University
Cesarean Section
Labor Induction in Low-risk Nulliparous Women at 39 Weeks of Gestation to Reduce Cesarean: A Randomized Trial of Induction Versus Expectant Management in France (FRENCH-ARRIVE)
The recent ARRIVE trial conducted in United States of America in 2014-2017 demonstrates that elective induction of labor at 39 weeks for nulliparous women did result in a significantly lower frequency of cesarean delivery with no…
- Trial name
- FRENCH-ARRIVE (NCT04799912)
- Testing
- Elective labor induction
- Where
- France
- Volunteers
- 4,200 people
- Sponsor
- University Hospital, Bordeaux
Induction of Labor Affected Fetus / Newborn
Castor Oil Ingestion and Balloon Catheter for Labor Induction in Nulliparous
The goal of this randomized controlled trial is to examine the efficacy of combining castor oil ingestion with extra-amniotic single balloon catheter for cervical ripening on time from induction to delivery in nulliparous women.
- Trial name
- NCT06325007
- Testing
- Induction of labor
- Where
- 2 sites in Israel
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- Holy Family Hospital, Nazareth, Israel
Labor, Pelvic Floor Disorder
Pelvic Floor Ultrasound Before Induction of Labour and Labour Outcome
Pregnancy and vaginal birth are the main causes of pelvic floor disorders such as urinary incontinence and pelvic organ prolapse.
- Conditions
- Labor, Pelvic Floor Disorder, Labor Stage, Second, Induced Labor
- Trial name
- LEVATOR-IOL (NCT07797387)
- Testing
- Three-dimensional transperineal pelvic floor ultrasound
- Where
- Italy
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Labor Induction
COOKACUPAIN 2 : Impact of Acupuncture on Delay of Delevery During Induced Labor With Cook's Balloon at the Beaumont Maternity in Roubaix
In France, labor induction rate is above 25.8%. Labor induction with Cook's balloon is a non-hormonal mechanical method. At Roubaix's maternity, midewifes can adminitred acupuncture therapy to help to manage this labor induction.
- Trial name
- COOKACUPAIN 2 (NCT07774442)
- Testing
- Acupuncture therapy
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Centre Hospitalier de Roubaix
Bishop Score, Primigravida Women
Bishop Score vs. Cervical Length in Labor Induction
The study population consists of term primigravida women undergoing induction of labor at a tertiary care referral center in Assiut, Egypt.
- Conditions
- Bishop Score, Primigravida Women, Cervical Length
- Trial name
- NCT07208552
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Assiut University
Pregnancy, Uterine Contraction
Calcium Carbonate on Labor Induction
The investigators aim to evaluate the safety and efficacy of administering calcium carbonate to laboring participants undergoing labor inductions.
- Trial name
- NCT06352775
- Testing
- Calcium Carbonate
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Wake Forest University Health Sciences
Pregnant Women
Outpatient Induction of Labour Using a Double Balloon Transcervical Catheter in Low-risk Pregnant Women: a Two-centre Open Prospective Randomised Controlled Trial - OutCRIB
The aim goal of this study is to compare the duration of induction and labor between outpatient and inpatient care in low-risk pregnant women.
- Trial name
- OutCRIB (NCT07265518)
- Testing
- Outpatient, Inpatient
- Where
- 2 sites in France
- Volunteers
- 258 people
- Sponsor
- Nantes University Hospital
Induction of Labor Affected Fetus / Newborn
Cervical Ripening as an Outpatient Method Using the Foley (COMFORT)
A multicenter pragmatic randomized trial of nulliparous women undergoing a term (≥37 weeks) induction of labor wherein the provider intends to use a Foley catheter for cervical ripening.
- Trial name
- COMFORT (NCT05759988)
- Testing
- Outpatient Foley catheter
- Where
- 6 sites in United States
- Volunteers
- 2,300 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Anxiety
Pre-Examination Reflexology for Anxiety and Pain During Pelvic Examination
The purpose of this study is to evaluate whether a brief standardized reflexology session administered before the first pelvic examination reduces maternal state anxiety among term pregnant women admitted for induction of labor.
- Trial name
- NCT07910136
- Testing
- Pre-Examination Reflexology
- Where
- Israel
- Volunteers
- 120 people
- Sponsor
- Goni Sintov
Premature Rupture of Fetal Membranes, Labor, Induced
PGE2 Followed by Oxytocin vs Oxytocin in Term PROM (POXY-PROM)
This study is being done to learn more about the best way to start labor for pregnant women whose water breaks at term before labor begins, a condition called term prelabor rupture of membranes (term PROM).
- Conditions
- Premature Rupture of Fetal Membranes, Labor, Induced, Cervical Ripening
- Trial name
- POXY-PROM (NCT07366359)
- Testing
- Sequential Induction: Dinoprostone Followed by Oxytocin, Immediate Oxytocin Induction
- Where
- Vietnam
- Volunteers
- 450 people
- Sponsor
- National Hospital of Obstetrics and Gynecology
Infections
Azithromycin Before Induction
This is a double blinded randomized control trial involving administration of 2 grams prophylactic azithromycin in third trimester patients undergoing induction of labor at our institution to demonstrate reduction in maternal and…
- Trial name
- NCT06543290
- Testing
- Azithromycin Pill
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Arrowhead Regional Medical Center
Nulliparous Women Who Scheduled for Labor Induction, Pregnancy
Ripening Approaches for Prompt Induction and Delivery - Sequential Versus Concurrent Dilapan-S and Misoprostol to Achieve Vaginal Delivery (RAPID-DS)
The purpose of this study is to compare the effectiveness of sequential versus combined multimodal cervical ripening strategies to achieve vaginal delivery within 24 hours among nulliparous patients with singleton, vertex…
- Trial name
- RAPID-DS (NCT07717502)
- Testing
- Sequential Cervical Ripening, Inpatient Combined Cervical Ripening
- Where
- United States
- Volunteers
- 260 people
- Sponsor
- Ochsner Health System
Premature Rupture of Membranes
I.V Papavrine for Labor Induction in Term PROM
This prospective randomized controlled trial aims to evaluate whether intravenous administration of papaverine 12 hours after term PROM reduces the interval from membrane rupture to delivery and improves maternal and neonatal…
- Trial name
- NCT07517796
- Testing
- Papaverine arm
- Where
- Israel
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Western Galilee Hospital-Nahariya
Post Term Pregnancy, Premature Rupture of Membrane
Dilapan-S®: A Multicenter US E-registry
Objective of this registry is to collect a representative set of real world data on the use of Dilapan-S® for pre-induction cervical ripening in daily clinical practice.
- Conditions
- Post Term Pregnancy, Premature Rupture of Membrane, Fetal Growth Retardation, Oligohydramnios
- Trial name
- NCT04451109
- Testing
- Dilapan-S
- Where
- United States
- Volunteers
- 1,200 people
- Sponsor
- Medicem Technology s.r.o.
Induction of Childbirth
3-hour Versus 12-hour Double-balloon Catheter for Labor Induction
This study aims to demonstrate that a 3-hour ultra-short cervical ripening protocol using a double-balloon catheter significantly reduces the induction-to-birth interval by at least 6 hours compared to the standard 12-hour…
- Trial name
- BAL3H (NCT07492186)
- Testing
- Cook® double-balloon catheter
- Where
- France
- Volunteers
- 280 people
- Sponsor
- Centre Hospitalier de PAU
Labor, Induced, Term Pregnancy
Comparison of Vaginal PGE2 (Dinoprostone) and Vaginal Misoprostol for Induction of Labour in Primigravid Term Pregnancy
This randomized controlled trial was conducted to compare vaginal misoprostol and vaginal PGE2 (dinoprostone) for induction of labour in primigravid women with term pregnancy.
- Conditions
- Labor, Induced, Term Pregnancy, Cervical Ripening
- Trial name
- NCT07559812
- Testing
- Misoprostol, Dinoprostone 3 mg
- Where
- Pakistan
- Volunteers
- 240 people
- Sponsor
- Mayo Hospital Lahore