Clinical trials: Infection; Cesarean Section
Bacterial Vaginoses
A Randomized Controlled Trial of Treatment of Bacterial Vaginosis
This is a double-blinded, placebo controlled, multi-center randomized trial of 482 pregnant women who are diagnosed with Bacterial Vaginosis (BV) in the late 3rd trimester (>34 weeks).
- Trial name
- NCT04578015
- Testing
- Metronidazole
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Ohio State University
Infection
Timing of Antibiotic Prophylaxis for Cesarean Deliveries
The current standard of care to prevent post partum infectious morbidities is to administer antibiotic prophylaxis to all women undergoing a cesarean delivery.
- Trial name
- NCT00805545
- Testing
- Antibiotic
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of Florida
Wound Complication
Cesarean Skin Incision Trial
The purpose of this study is to determine if there is a difference between Pfannenstiel and midline vertical skin incision at time of cesarean section in preventing wound complications in the morbidly obese patient.
- Trial name
- C-SIT (NCT01897376)
- Testing
- Pfannenstiel incision, vertical skin incision
- Where
- 2 sites in United States
- Volunteers
- 228 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Microbial Colonization
Preterm Infant Intestinal Microbiota Development and Maternal Fecal Transplant
The goal of this clinical trial is to study if a oral maternal fecal transplant given to a premature infant born by cesarean section (CS) is safe.
- Trial name
- PREFLOR (NCT06227845)
- Testing
- Fecal microbiota transplant
- Where
- Finland
- Volunteers
- 36 people
- Sponsor
- Otto Helve
HIV Infections
Blood Levels of Tenofovir Gel in HIV Uninfected Pregnant Women Planning Cesarean Delivery
A new approach to HIV prevention currently being studied includes the use of topical microbicides, substances that kill microbes.
- Trial name
- NCT00540605
- Testing
- Tenofovir 1% vaginal gel
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Infection of Cesarian Section Wound Following Delivery
Antibiotic Prophylaxis for Elective Cesarean Section
A randomized controlled study comparing the effect of administration of 1 gm ceftriaxone in elective cesarean section 30-60 min before skin incision versus after cord clamping.
- Trial name
- TOAPFECSACT (NCT02177994)
- Testing
- ceftriaxone 1gm for intravenous infusion
- Where
- Egypt
- Volunteers
- 328 people
- Sponsor
- Ain Shams Maternity Hospital
Cesarean Section, Surgical Site Infection
Preoperative Application of Chlorhexidine to Reduce Infection With Cesarean Section After Labor
Surgical site infections (SSI) are the second most common cause of nosocomial infections accounting for 15% of all nosocomial infections among hospitalized patients and 38% of nosocomial infections in surgical patients.
- Conditions
- Cesarean Section, Surgical Site Infection, Nosocomial Infection
- Trial name
- PRACTICAL (NCT03423147)
- Testing
- 2% chlorhexidine gluconate cloth, 4% Chlorhexidine gluconate vaginal scrub
- Where
- United States
- Volunteers
- 319 people
- Sponsor
- Angela Bianco
Cesarean Section; Complications, Wound, Infection (Following Delivery)
Patient Reported Experiences and Outcomes Associated with Standard C-Section Wound Closure Versus STRATAFIX/DERMABOND PRINEO Wound Closure (CS-PREO)
The aim of the study is to compare outcomes between patients receiving standard C-section wound closure compared to a wound closure bundle that includes Stratafix sutures and Dermabond PRINEO.
- Trial name
- CS-PREO (NCT06614829)
- Testing
- Stratafix Suture, DERMABOND PRINEO
- Where
- Canada
- Volunteers
- 68 people
- Sponsor
- North York General Hospital
Pregnancy Related, Cesarean Wound Disruption
The Collection and Application of Autologous Amniotic Fluid At Cesarean Delivery Closure.
The purpose of this study is to determine the feasibility of collecting amniotic fluid at delivery that will be immediately processed and then applied as a spray to the various layers of cesarean wound closure.
- Conditions
- Pregnancy Related, Cesarean Wound Disruption, Cesarean Section; Infection
- Trial name
- NCT04359472
- Testing
- Application of Autologous Amniotic Fluid
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Recibio, Inc.
Surgical Wound Dehiscence, Wound Infection
Prevention of Wound Complications After Cesarean Delivery in Obese Women Utilizing Negative Pressure Wound Therapy
Wound complications after Cesarean section (C-section) are common in obese women. Approximately 25% of obese women having a C-section will have a wound complication.
- Trial name
- NCT00654641
- Testing
- Negative pressure wound closure, Standard wound closure
- Where
- 2 sites in United States
- Volunteers
- 54 people
- Sponsor
- West Virginia University
Surgical Site Infection
Subcutaneous Tissue Irrigation With Povidone Iodine in Decreasing the Rate of Surgical Site Infection Following Cesarean Section
This study aims to assess the efficacy of Povidone Iodine (Betadine®) irrigation of subcutaneous tissue prior to skin closure in reducing the incidence of surgical site infection after elective caesarean section and post…
- Trial name
- NCT03549702
- Testing
- Povidone iodine 1% solution
- Where
- Egypt
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Decreased Lung Compliance, Hypoxia
Alveolar Recruitment Maneuver During Cesarean Section Improves Lung Compliance
The investigators tested the hypothesis that alveolar recruitment maneuver during cesarean section and in women under general anesthesia improves lung compliance and gas exchange.
- Conditions
- Decreased Lung Compliance, Hypoxia, Hypercapnia, Atelectasis
- Trial name
- CSRecGHPyr (NCT01826968)
- Testing
- Alveolar Recruitment maneuver
- Where
- Greece
- Volunteers
- 90 people
- Sponsor
- General Hospital Of Pyrgos
Cesarean Section Complications
Clean-CS: A Program to Improve the Safety of C-section
Executive summary: Cesarean delivery, or section (CS), is the single most common surgical procedure performed. Estimates indicate that in low resource settings, CS comprises up to 50% of more of the total volume of operations…
- Trial name
- Clean-CS (NCT04812522)
- Testing
- Clean Cut program
- Where
- 10 sites in Ethiopia
- Volunteers
- 10,506 people, healthy volunteers welcome
- Sponsor
- The Lifebox Foundation
Fetal Infection, Chorioamnionitis
Management of Prelabor Rupture of the Membranes at Term
Prolonged rupture of membranes has been associated with increased risk of chorioamnionitis and endometritis. In this study the investigators will investigate whether an early intervention to augment labor with oxytocin is…
- Conditions
- Fetal Infection, Chorioamnionitis, Endometritis, Cesarean Section Complications
- Trial name
- NCT04307069
- Testing
- Oxytocin
- Where
- Israel
- Volunteers
- 524 people
- Sponsor
- Rambam Health Care Campus
Endometritis, Wound Infection
Timing of Prophylactic Antibiotics for Cesarean Sections
This is a randomized, double-blinded placebo controlled trial of cefazolin timing before cesarean section fo infection prophylaxis.
- Trial name
- NCT00330278
- Testing
- Cefazolin
- Where
- United States
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Endometritis, Wound Infection
Study of Effectiveness and Safety of Azithromycin-based Extended-spectrum Prophylaxis to Prevent Post Cesarean Infection
The Cesarean Section Optimal Antibiotic Prophylaxis (C/SOAP) study is a large pragmatic multi-center randomized clinical trial designed to evaluate the comparative effectiveness and safety of azithromycin-based extended-spectrum…
- Conditions
- Endometritis, Wound Infection, Abscess, Surgical Site Infection
- Trial name
- C/SOAP (NCT01235546)
- Testing
- Azithromycin and standard of care
- Where
- 9 sites in United States
- Volunteers
- 2,013 people
- Sponsor
- Alan Tita
Surgical Site Infection
Prevention of Surgical Site Infection After Cesarean Delivery
There are approximately 1.4 million cesarean deliveries in the United States each year, and an average of 1250 elective cesarean deliveries each year at the Brigham and Women's Hospital (BWH) in Boston, Massachusetts.
- Trial name
- CAPISSI (NCT02027324)
- Testing
- Chlorhexidine-alcohol group, Povidone-Iodine Group
- Where
- United States
- Sponsor
- Brigham and Women's Hospital
Failure of Cervical Dilatation, Complications; Cesarean Section
Is Routine Cervical Dilatation Necessary During Elective Caesarean Section? A Randomised Controlled Trial
The purpose of this prospective randomised study was to determine the effect of routine cervical dilatation during elective caesarean section on maternal morbidity
- Conditions
- Failure of Cervical Dilatation, Complications; Cesarean Section, Wound Infection,, External Causes of Morbidity and Mortality
- Trial name
- NCT01954719
- Testing
- cervix dilated after surgery, control group
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Surgical Wound Infection
Post Cesarian Section Wound Infections At Emergency Room
The goal of this observational study is to compare the incidence of post-cesarean section wound infections between emergency and elective cesarean deliveries at El-hussien Hospital.
- Trial name
- NCT06491381
- Testing
- Cesarean delivery
- Where
- Egypt
- Volunteers
- 220 people
- Sponsor
- Al-Azhar University
Surgical Site Infection
Local Subcutaneous Gentamicin for Prevention of Surgical Site Infection After Elective Cesarean Section
The goal of this clinical trial is to evaluate whether local subcutaneous administration of gentamicin reduces the incidence of surgical site infection (SSI) following elective cesarean section.
- Trial name
- NCT07311395
- Testing
- Gentamicin, Standard antibiotic prophylaxis
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Western Galilee Hospital-Nahariya