Clinical trials: Infection Prophylaxis
Coronavirus Infection, Disease Prevention
Assessment of N-95 Facemask for Use in COVID-19 Pandemic in Case of Shortage of Personal Protective Equipment
The purpose of this study is to assess the safety and efficiency of an assembled modified mask in protecting health care workers against Coronavirus in case of any personal protective equipment shortage.
- Trial name
- NCT04416919
- Testing
- Assembled mask
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
HIV - Human Immunodeficiency Virus
HIV Prevention With PrEP Among People on Opioid Replacement Therapy
The purpose of this study is to assess the feasibility and acceptability of providing oral pre-exposure prophylaxis (PrEP) and opioid agonist therapy (OAT) simultaneously in existing pharmacy-based programs operating in Alberta…
- Trial name
- OAT-PrEP (NCT07160075)
- Testing
- Simultaneous administration of OAT and oral PrEP at existing pharmacy-based programs
- Where
- 6 sites in Canada
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Cara Spence
Covid19, SARS-CoV Infection
Effectiveness of a Novel Respirator With Chitosan Nanoparticles
The use of nanomaterials in semi-facial respirators could decrease the permeability of particles and promote a biocidal effect compared to conventional respirators (N95) and, therefore, to enhance the filtering power, aiming to…
- Conditions
- Covid19, SARS-CoV Infection, Worker-Patient Transmission, Healthcare
- Trial name
- NCT04490200
- Testing
- VESTA respirator, Conventional N95 respirator
- Where
- Brazil
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Brasilia
HIV/AIDS
Pilot Testing a Behavioral Intervention to Incorporate Advances in HIV Prevention for Black Young MSM in Alabama
The overall goal of this 5-year Mentored Research Scientist Development K01-Award is to support Henna Budhwani, PhD, MPH to become an independent implementation science investigator in the field of HIV prevention.
- Trial name
- NCT03680729
- Testing
- Adapted Brothers Saving Brothers (aBSB), Standard Street Outreach
- Where
- United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Florida State University
HIV Infections
A Safety and Efficacy Trial of Dapivirine Vaginal Ring in Africa
This is a double-blind, randomized, placebo-controlled Phase III study to asses the safety and efficacy of a silicone elastomer vaginal ring containing 25mg of dapivirine.
- Trial name
- NCT01337583
- Testing
- Dapivirine
- Where
- 5 sites in Kenya, Malawi and 1 more
- Volunteers
- healthy volunteers welcome
- Sponsor
- International Partnership for Microbicides, Inc.
SARS CoV 2 Infection
Open-label, Multi-centre, Non-Inferiority Study of Safety and Immunogenicity of BIMERVAX for the Prevention of COVID-19 in Adolescents From 12 Years to Less Than 18 Years of Age.
This is a Phase IIb, open-label, uncontrolled, multi-centre, non-inferiority clinical trial, to assess the safety and immunogenicity of BIMERVAX® as a heterologous booster dose in adolescents.
- Trial name
- NCT06234956
- Testing
- BIMERVAX
- Where
- 7 sites in Spain
- Volunteers
- 242 people, healthy volunteers welcome
- Sponsor
- Hipra Scientific, S.L.U
Herpes Zoster, Postherpetic Neuralgia
Shingles Prevention Study
The incidence and severity of HZ (or shingles), as well as the frequency and severity of its complications, increases markedly with increasing age. More than half of all cases occur in persons over the age of 60.
- Trial name
- SPS (NCT00007501)
- Testing
- Varicella-zoster vaccine
- Where
- 22 sites in United States
- Volunteers
- 38,456 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Intestinal Parasitic Infections, Anaemia
Impact of Hand Hygiene Activities on the Prevention of Intestinal Parasitic Infections and Anaemia Among School Children
Impact exerted by intestinal parasitic infections is much higher in developing countries. School-aged children are at higher risk from the burden of disease, because they specially have many parasitic infections.
- Trial name
- NCT01619254
- Testing
- Hand washing with soap and hand finger nail clipping
- Where
- Ethiopia
- Volunteers
- 365 people, healthy volunteers welcome
- Sponsor
- Mekelle University
Malaria, Plasmodium Falciparum
Immunization With Plasmodium Falciparum Sporozoites Under Chloroquine Versus Mefloquine Prophylaxis
Malaria is one of the major infectious diseases in the world with a tremendous impact on the quality of life, significantly contributing to the ongoing poverty in endemic countries.
- Trial name
- NCT01422954
- Testing
- Chloroquine prophylaxis, Mefloquine prophylaxis, Immunization
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
COVID-19
AZD1222 Vaccine for the Prevention of COVID-19
The purpose of this study is to evaluate safety and immunogenicity of AZD1222 for COVID-19 prevention in the Russian Federation
- Trial name
- NCT04540393
- Testing
- AZD1222
- Where
- 4 sites in Russia
- Volunteers
- healthy volunteers welcome
- Sponsor
- AstraZeneca
Human Immunodeficiency Virus
Simplifying the Shang Ring Technique for Circumcision of Men and Boys
This is a research study in Kenya that will examine the outcomes of participants aged 10-15 and 16 and older; and provider acceptability of the Shang Ring technique for male circumcision that would simplify use.
- Trial name
- NCT02390310
- Testing
- Shang Ring, injectable anesthesia (lidocaine 1%), topical anesthesia (lidocaine 2.5%, prilocaine 2.5% cream)
- Where
- 2 sites in Kenya
- Volunteers
- 574 people, healthy volunteers welcome
- Sponsor
- EngenderHealth
Malaria
Early Childhood Malaria Prevention With Maloprim in The Gambia
A trial was conducted in the 1980s to compare two strategies for control of malaria in young children aged 3-59 months: treatment with chloroquine versus treatment combined with fortnightly chemoprophylaxis with Maloprim.
- Trial name
- NCT00294580
- Testing
- Maloprim
- Where
- The Gambia
- Volunteers
- 2,253 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Mental Health Issue, Hiv
Walk-in Therapy in Low Barrier Primary Care
The goals of the current research are to adapt an effective walk-in psychotherapy clinic intervention for the context of low-barrier primary care; and conduct a pilot implementation study in a low-barrier primary care clinic…
- Conditions
- Mental Health Issue, Hiv, Substance Use
- Trial name
- NCT06552325
- Testing
- Single Session Narrative Therapy
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Washington
Human Immunodeficiency Virus Transmission
PC4PrEP: Integrating PrEP Into Primary Care
Oral pre-exposure prophylaxis (PrEP) has been proven effective in reducing HIV infection in high-risk men who have sex with men, heterosexually active women and men, and injecting drug users.
- Trial name
- PC4PrEP (NCT03617874)
- Testing
- PC4PrEP- Intervention Clinics, Standard of Care Clinics
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Albert Einstein College of Medicine
Covid19, Health Behavior
COVID-19 Preventive Behavior in African Americans
The Center Disease Control has published a set of guidelines to contain the spread of the virus, since it is known to spread from person-to-person.
- Trial name
- NCT04700462
- Testing
- Sm-EMA
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Hepatitis B
Optimizing Hepatitis B Vaccine Response Through the Use of a Topical Immune Modulator
This study will look at what happens to the level of protection against hepatitis B (HB) disease if a 'helper' gel is applied to the skin over the injection site of a small dose of hepatitis B vaccine.
- Trial name
- NCT00175435
- Testing
- Resiquimod gel
- Where
- Canada
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Tetanus, Tetanus Vaccine
Comparative Study of Two Tetanus Toxoid Vaccination Strategies: Cold Chain Versus Controlled Temperature Chain
The purpose of this study is to determine the effectiveness, safety and feasibility of a tetanus toxoid (TT) vaccination strategy relying on the maintenance of vaccines in a controlled temperature chain (CTC).
- Trial name
- NCT01559597
- Testing
- Tetanus toxoid vaccine
- Where
- Chad
- Volunteers
- 2,129 people, healthy volunteers welcome
- Sponsor
- Epicentre
Covid19
Community-based Post-exposure Prophylaxis for COVID-19
Specifically identified Ayurvedic preparations is recommended by ministry of AYUSH as post-exposure prophylaxis to efficaciously prevent a negative person who has come into contact with COVID-19-positive.
- Trial name
- NCT04920773
- Testing
- Guduchi Ghanvati, Standard guidelines
- Where
- 2 sites in India
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- NMP Medical Research Institute
Sexually Transmitted Diseases, Pregnancy
All About Youth: Evaluation of Sexual Risk Avoidance and Risk Reduction Programs for Middle School Students
This study will evaluate the efficacy of two curricula relative to standard care. The first is a sexual risk avoidance curriculum for middle school students that included abstinence until marriage and complies with Title V…
- Conditions
- Sexually Transmitted Diseases, Pregnancy, HIV Infections
- Trial name
- NCT00167505
- Testing
- Risk Avoidance Intervention, Risk Reduction Intervention
- Where
- United States
- Volunteers
- 1,742 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
COVID-19
A Study to Evaluate the Efficacy, Safety and Immunogenicity of SARS-CoV-2 Vaccine (Vero Cells), Inactivated in Healthy Adults Aged 18 Years and Older (COVID-19)
The study will be a multi-national, endpoint-driven, randomized, double-blind, placebo-controlled, adaptive study in which participating adults will be randomized 1:1 to receive 2 doses of either candidate vaccine or placebo on…
- Trial name
- NCT04852705
- Testing
- SARS-CoV-2 Vaccine (Vero Cells), Inactivated
- Volunteers
- 28,000 people, healthy volunteers welcome
- Sponsor
- Shenzhen Kangtai Biological Products Co., LTD
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