Clinical trials: Infection Surgical Wound
Surgical Wound Infection
A Comparative Study to Assess the Prevention of Surgical Site Infection (SSI's) in Revision Total Joint Arthroplasty Patients Treated With Single-Use Negative Pressure Wound Therapy (PICO™) or Standard Care Dressings (AQUACEL® Ag SURGICAL Dressing)
The aim of this study is to assess the prevention of incision healing complications in patients undergoing revision TKA and THA treated with either Single-Use NPWT (PICO) compared to standard of care dressings (AQUACEL Ag…
- Trial name
- NCT02664168
- Testing
- Aquacel Ag Surgical Dressing, Single-Use Negative Pressure Wound Therapy (PICO)
- Where
- United States
- Sponsor
- Rothman Institute Orthopaedics
Surgical Wound Infection
Skin Perfusion After Abdominal Surgery
The purpose of this study is to evaluate the consequences of 3 selected surgical procedures on abdominal wall perfusion in order to help to reduce postoperative complication related to inadequate tissue perfusion.
- Trial name
- DIRTSURGERY (NCT03057249)
- Testing
- Dynamic infrared thermography (DIRT)
- Where
- Norway
- Volunteers
- 60 people
- Sponsor
- University Hospital of North Norway
Surgical Incision, Surgery--Complications
Zinc Oxide Versus Petrolatum Following Skin Surgery
Patients undergoing routine surgery in the Department of Dermatology for any indication on non-scalp skin and closed in linear fashion with scar greater than or equal to 4.5cm in length will be invited to participate in this…
- Conditions
- Surgical Incision, Surgery--Complications, Surgical Wound, Surgical Site Infection
- Trial name
- NCT03561376
- Testing
- Topical zinc oxide vs. petrolatum post-surgical scars
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Melissa Pugliano-Mauro
Total Knee Replacement
Comparison of Surgical Site Infection After Skin Closure by Prolene or Staples in Bilateral Knee Arthroplasty Patients
Knee arthroplasty also known as the total knee replacement is an orthopedic surgical procedure done to resurface the knee that has been severely damaged by arthritis.
- Trial name
- NCT04492852
- Testing
- Polypropylene (PROLENE) sutures, Staple Sutures
- Volunteers
- 82 people
- Sponsor
- Indus Hospital and Health Network
30% Oxygen Concentration During Colorectal Surgery, 80% Oxygen Concentration During Colorectal Surgery
Supplemental Oxygen in Colorectal Surgery: A Quality Improvement Project
Our primary objective is to develop a clinical pathway for care of patients having colorectal surgery at the Clinic. In particular, the investigators would like to determine what intraoperative concentration of oxygen is optimal…
- Trial name
- NCT01777568
- Testing
- 30% oxygen, 80% oxygen
- Where
- United States
- Volunteers
- 5,749 people
- Sponsor
- The Cleveland Clinic
Colorectal Surgery
A Single Dose of a Marketed Drug Being Studied for a New Indication to Treat Surgical Site Infection Following Colorectal Surgery as Compared to a Marketed Drug Approved for This Indication (0826-039)
The objective of this study is to evaluate the safety and efficacy of a one time dose of an intravenous marketed drug being evaluated for a new indication as compared to a marketed drug already approved for the prevention of…
- Trial name
- NCT00090272
- Testing
- MK0826, ertapenem sodium, Comparator: cefotetan
- Volunteers
- 952 people
- Sponsor
- Merck Sharp & Dohme LLC
INFECTION
Topical Use of Vancomycin in Reducing Sternal Wound Infection in Cardiac Surgery (SWI Trial)
The purpose of this research is to determine if using the antibiotic vancomycin as a preventative topical (on the surface of the skin) treatment during open-heart surgery will reduce the risk of developing a sternal wound…
- Trial name
- SWI (NCT02374853)
- Testing
- Vancomycin, No Vancomycin
- Volunteers
- 1,037 people
- Sponsor
- University of Alberta
Surgical Site Infection
Comparative Effectiveness and Cost-Benefit Analysis of Vancomycin Powder in High Risk Spine Surgery Patients
Despite the use of prophylactic systemic antibiotics and improved surgical technique, surgical site infections remain a serious concern.
- Trial name
- NCT01566422
- Testing
- Vancomycin powder
- Where
- United States
- Sponsor
- Vanderbilt University Medical Center
Dehiscence of Laparotomy Wound, Surgical Wound Infection
Short Stitch Monomax®
A number of studies identifies abdominal hernia as the most frequent postoperative complication following laparotomy with percentages of 9-20% - depending on duration of follow-up.
- Trial name
- Short-Stitch (NCT01938222)
- Testing
- Short Stitch
- Where
- Germany
- Volunteers
- 351 people
- Sponsor
- Diakonie-Klinikum Schwäbisch Hall gGmbH
Shock, Septic, Hyperlactatemia
Fluid REsponsiveness and Arterial ELASTANCE in Patients With Septic Shock or After Aortic Surgery
The MostCare system, thanks to the Pressure Recording Analytical Method (PRAM; Vygon, Padua, Italy), provides new hemodynamic parameters of the cardiovascular system.
- Conditions
- Shock, Septic, Hyperlactatemia, Oliguria, Aortic Aneurysm, Abdominal
- Trial name
- RELASTANCE (NCT04388267)
- Testing
- Fluid challenge
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Central Hospital, Nancy, France
Breast Neoplasms, Breast-Conserving Surgery
Antibiotic Prophylaxis in Oncological Surgery of Breast
Breast cancer is the most frequent malignancy in the female population Brazilian, except non-melanoma skin tumors. Surgery plays an important role in regional spot disease control and the definition of parameters for the adjuvant…
- Conditions
- Breast Neoplasms, Breast-Conserving Surgery, Wound Infection, Antibiotic Prophylaxis
- Trial name
- NCT02809729
- Testing
- Cefazolin, sterile saline, oncologic breast surgery
- Where
- Brazil
- Volunteers
- 124 people
- Sponsor
- Fabiola Soares Moreira Campos
Wound Infection, Gynecologic Cancer
Prophylactic Negative Pressure Wound Therapy (VAC) in Gynecologic Oncology (G.O.)
A prospective controlled randomized study aimed to prospectively evaluate, the impact and effectiveness of clean incision prophylactic vacuum negative pressure therapy on wound healing (ciNPWT) in women at high risk of developing…
- Trial name
- GO-VAC (NCT04584957)
- Testing
- VAC therapy
- Where
- Italy
- Volunteers
- 196 people
- Sponsor
- Catholic University of the Sacred Heart
Surgical Site Infection
Subcutaneous Tissue Irrigation With Povidone Iodine in Decreasing the Rate of Surgical Site Infection Following Cesarean Section
This study aims to assess the efficacy of Povidone Iodine (Betadine®) irrigation of subcutaneous tissue prior to skin closure in reducing the incidence of surgical site infection after elective caesarean section and post…
- Trial name
- NCT03549702
- Testing
- Povidone iodine 1% solution
- Where
- Egypt
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Healthcare Associated Infectious Disease, Sternal Superficial Wound Infection
Optimizing Prevention of Healthcare-Acquired Infections After Cardiac Surgery
Our Aim is to identify patient risk factors and clinical practices associated with healthcare-acquired infections (HAIs) after cardiac surgery.
- Conditions
- Healthcare Associated Infectious Disease, Sternal Superficial Wound Infection, Sepsis, Pneumonia
- Trial name
- HAI (NCT02068716)
- Where
- United States
- Volunteers
- 911,754 people
- Sponsor
- Dr. Donald Likosky
Infection, Bacterial
Efficacy of Surgical Diathermy in Eradicating Cutibacterium Acnes From Surgical Skin Incision During Shoulder Arthroplasty
Periprosthetic infection following shoulder arthroplasty is a devastating complication. Diagnosing and treating periprosthetic shoulder infection poses a significant challenge.
- Trial name
- Electrocautery (NCT04608916)
- Testing
- Using surgical diathermy to make skin incision, Using scalpel blade to make skin incision
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- University of Missouri-Columbia
Surgical Wound, Diabetes
EO2 Oxygen Delivery To Study Success Rate of Surgically Closed Wounds
The investigators will test the efficacy of the novel oxygen diffusion dressing allows delivery tissue oxygenation via TransCu O2® Oxygen Delivery System for use in caring for patients with surgically closed wounds.
- Conditions
- Surgical Wound, Diabetes, Amputation Wound, Incision Wound
- Trial name
- NCT03960463
- Testing
- Transcu O2®
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Baylor College of Medicine
Acute Appendicitis, Superficial SSI
Laparoscopic vs Open Appendectomy
his randomized controlled trial was conducted to compare the frequency of superficial surgical site infections (SSIs) following laparoscopic appendectomy and open appendectomy in patients undergoing surgical treatment for acute…
- Trial name
- NCT07841444
- Testing
- Laparoscopic appendectomy, Open Appendectomy
- Where
- Pakistan
- Volunteers
- 276 people
- Sponsor
- Quaid-e-Azam Medical College
Abscess
US Guided Versus BlindI&D for Treatment of Soft Tissue Abscesses in the ED
Standard treatment for a soft tissue abscess involves incision over the area of maximum fluctuance with drainage of purulence from the abscess cavity.
- Trial name
- NCT02264392
- Testing
- Ultrasound Guided Incision and Drainage, Blind Incision and Drainage
- Where
- United States
- Volunteers
- 124 people
- Sponsor
- University of Massachusetts, Worcester
Complications
Suprapubic Single-incision Laparoscopic Appendectomy Versus Conventional Appendectomy: a Randomized Controlled Trial
Conventional laparoscopic appendectomy(CLA) is the current standard treatment. To obtain additional benefits such as a better cosmetic outcome, the investigators developed a surgical option termed suprapubic single-incision…
- Trial name
- NCT02499016
- Testing
- suprapubic single-incision laparoscopic appendectomy
- Where
- China
- Volunteers
- 208 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Surgical Site Infection, Complication,Postoperative
Study to Analyze the Surgical Site Infections in a Group of Patients Who Were Randomly Applied a Negative Pressure Therapy Dressing Versus Conventional Dressing
Surgical site complications generate a series of consequences that prolong hospital stay, increase interventions and procedures, and consequently considerably increase healthcare costs.
- Conditions
- Surgical Site Infection, Complication,Postoperative, Surgical Wound Infection, Surgical Complication
- Trial name
- NCT05455801
- Testing
- negative preassure wound therapy
- Where
- Spain
- Volunteers
- 271 people
- Sponsor
- Hospital Universitario Central de Asturias
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