Clinical trials: Infection of Bloodstream
Endotoxemia
Blockade of Vascular Potassium Channels During Human Endotoxemia
Background: Activation of NO-synthase and vascular potassium (K) channels may play a role in the sepsis-induced attenuated sensitivity to norepinephrine.
- Trial name
- NCT00185003
- Testing
- endotoxin, Potassium channel blockers: TEA, Quinin, Tolbutamide, L-NMMA
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Neonatal SEPSIS, Prematurity
Neonatal Bacterial Colonization Study
This study will evaluate the effect of skin antisepsis and/or emollient therapy on bacterial colonization dynamics in very low birth weight, hospitalized infants.
- Conditions
- Neonatal SEPSIS, Prematurity, Very Low Birth Weight Baby, Bloodstream Infection
- Trial name
- NCT03896893
- Testing
- Skin antisepsis, Emollient
- Where
- South Africa
- Volunteers
- 80 people
- Sponsor
- University of Stellenbosch
Heart-Assist Devices, Infections
Complications in Pediatric Mechanical Circulatory Assistance: Evaluation of Infection Management.
Heart failure is a major cause of mortality and morbidity in children. Heart transplantation can significantly improve the prognosis of patients with severe heart failure, but access is limited by a shortage of transplants.
- Conditions
- Heart-Assist Devices, Infections, Heart Transplant Infection
- Trial name
- VADINFECT (NCT06464016)
- Testing
- Ventricular Assist Device with Berlin Heart EXCOR
- Where
- France
- Volunteers
- 47 people
- Sponsor
- Claude Bernard University
Intensive Care
Novel Device for Reducing Catheter-Related Infections
This study is a pilot study of the safety, tolerability and efficacy of an investigational central venous catheter device used in conjunction with a standard central venous catheter.
- Trial name
- NCT00878683
- Testing
- silicone catheter boot
- Sponsor
- University of Kansas
Bacteremia
Safety and Efficacy of Dalbavancin Versus Vancomycin in the Treatment of Catheter-Related Bloodstream Infections
This is a study to evaluate a new medication dosed once a week in the treatment of bacterial infections in the blood from intravenous catheters (CR-BSI).
- Trial name
- NCT00057369
- Testing
- dalbavancin
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- Vicuron Pharmaceuticals
Salmonella Infections, Infection of Bloodstream
Reservoir of Invasive Salmonellosis in Children, DRC
Bloodstream infections caused by non-typhoid Salmonella (NTS) are a major killing disease in Sub-Saharan Africa. Despite the high case fatality rate, the main reservoir -human, zoonotic or environmental- for invasive NTS rests…
- Trial name
- NCT03073707
- Testing
- Sample collection
- Where
- Democratic Republic of the Congo
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Institute of Tropical Medicine, Belgium
Staphylococcus Aureus Bacteremia, Staphylococcus Aureus Septicemia
18-fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in S. Aureus Bacteraemia
Having bacteria in the blood can be very dangerous. This is called bacteraemia (or bacteremia) or bloodstream infection. It can lead to problems across the whole body, which is what happens in sepsis.
- Conditions
- Staphylococcus Aureus Bacteremia, Staphylococcus Aureus Septicemia, Sepsis Bacterial, Bloodstream Infection
- Trial name
- PET-SAB (NCT05361135)
- Testing
- PET/CT
- Volunteers
- 820 people
- Sponsor
- University College, London
Aortic Infections and Inflammations
Risk and Incidence of Aortic Graft and Endograft Infection With BSI
What is the risk of aortic vascular graft and endograft infection in patients with aortic vascular graft/endograft and bloodstream infection?
- Trial name
- NCT05521035
- Where
- Sweden
- Volunteers
- 2,000 people
- Sponsor
- Lund University
CRBSI - Catheter Related Bloodstream Infection, Central Venous Catheter
Complications and Failure of Centrally Inserted Central Catheters in Cardiac Surgical Patients
Central venous catheters, or CVCs, are medical devices used to deliver medications and blood products directly into a patient's large veins.
- Conditions
- CRBSI - Catheter Related Bloodstream Infection, Central Venous Catheter, Catheter Failure, Central Venous Catheter Complications
- Trial name
- CICC-CS (NCT07138690)
- Where
- Italy
- Volunteers
- 480 people
- Sponsor
- Azienda Ospedaliero-Universitaria Careggi
Severe Sepsis and Septic Shock
Extracorporeal Immune Support System (EISS) for the Treatment of Septic Patients
The purpose of this study is to investigate the effect of an extracorporeal application of a bed-side bioreactor containing human donor granulocytes on the course and outcome of septic shock in humans.
- Trial name
- EISS-1 (NCT00818597)
- Testing
- EISS
- Where
- Germany
- Volunteers
- 10 people
- Sponsor
- University of Rostock
Staphylococcus Aureus Bloodstream Infection
A Study to Evaluate the Safety and Pharmacokinetics of AZD7760 in Healthy Japanese Adults
The purpose of this study is to evaluate the safety and PK of AZD7760 when given as an intravenous (IV) infusion to healthy Japanese adult participants.
- Trial name
- NCT07612813
- Testing
- AZD7760
- Where
- Japan
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Hematological Malignancy, Hematopoetic Stem Cell Transplantation
Middle East Study of Infections in Patients With Hematological Malignancies
The goal of this prospective observational study is to is to prospectively study the epidemiology of bloodstream infection (BSI) in patients with hematological malignancies (HM) and hematopoietic stem cell transplant (HSCT)…
- Conditions
- Hematological Malignancy, Hematopoetic Stem Cell Transplantation, Bloodstream Infection
- Trial name
- MESI-HM (NCT07900542)
- Testing
- No Intervention: Observational Cohort
- Where
- 9 sites in Jordan, Oman and 3 more
- Volunteers
- 1,000 people
- Sponsor
- Hamad Medical Corporation
Central Line Associated Blood Stream Infections (CLABSI)
Comparing The Safety And Efficacy Of DEFENCATH® In Reducing Central-Line Bloodstream Infections (CLABSIs) In Adults And Adolescent Participants Receiving Total Parenteral Nutrition Through A Central Venous Catheter (CVC)
This is a Phase 3, randomized, double-blind, controlled, adaptive, 2-arm, multicenter study to demonstrate the efficacy and safety of DefenCath in adult and adolescent participants receiving home Total Parenteral Nutrition (TPN)…
- Trial name
- NCT06822426
- Testing
- (taurolidine and heparin) catheter lock solution, Heparin
- Where
- 24 sites in United States, Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- CorMedix Therapeutics
SARS (Severe Acute Respiratory Syndrome), Covid19
Longitudinal Follow-up of a Population Cohort in a French City With High SARS-CoV-2 Circulation, in Early 2020 [COVID-19]
An initial retrospective epidemiological investigation was conducted in a city north of France after the diagnosis of the first case of COVID-19 on February 2020.
- Trial name
- COVID-OISE (NCT04644159)
- Testing
- Human biological samples
- Where
- 2 sites in France
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur
Zoonotic Disease
Viral and Microbial Circulation Between Humans, Domesticated and Wild Animals Along an Ecotone, Democratic Republic of Congo
This study will evaluate the overlap between the intestinal microbiome and virome of wild and domesticated animals and human beings living in close proximity in three sites along an ecotone (ecological gradient) in the Democratic…
- Trial name
- MICROTONE (NCT04012164)
- Testing
- blood sampling, stool collection, Participatory activity and contact investigation
- Where
- Democratic Republic of the Congo
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur
Healthy, Type 2 Diabetes
Study of Renal Blood Flow During Human Endotoxemia
The purpose of the present protocol is to study whether endotoxemia will affect the renal blood flow in type 2 diabetics and healthy volunteers.
- Conditions
- Healthy, Type 2 Diabetes, Endotoxemia
- Trial name
- NCT00413465
- Testing
- Escherichia Coli Endotoxin
- Where
- Denmark
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Healthcare-associated Pneumonia (HCAP), Bloodstream Infections (BSI)
Study of Cefiderocol (S-649266) or Best Available Therapy for the Treatment of Severe Infections Caused by Carbapenem-resistant Gram-negative Pathogens
This study is designed to provide evidence of efficacy of cefiderocol in the treatment of serious infections in adult patients caused by carbapenem-resistant Gram-negative pathogens.
- Conditions
- Healthcare-associated Pneumonia (HCAP), Bloodstream Infections (BSI), Hospital Acquired Pneumonia (HAP), Complicated Urinary Tract Infection (cUTI)
- Trial name
- CREDIBLE - CR (NCT02714595)
- Testing
- Cefiderocol, Best Available Therapy
- Where
- 85 sites in United States, Brazil and 14 more
- Volunteers
- 152 people
- Sponsor
- Shionogi
Catheter Infection, Catheter Infections Related
Preventing Central Catheter-Associated Bloodstream Infections
The research is an algorithm study focused on nursing care in order to prevent Central Catheter-Associated Bloodstream Infections in intensive care units.
- Trial name
- NCT04920877
- Testing
- Infection Prevention
- Volunteers
- 100 people
- Sponsor
- Abant Izzet Baysal University
Bloodstream Infections
Trial of Meropenem Versus Piperacillin-Tazobactam on Mortality and Clinial Response
Infections of the blood are extremely serious and require intravenous antibiotic treatment. When the infection results from antibiotic resistant bacteria, the choice of antibiotic is an extremely important decision.
- Trial name
- MERINO II (NCT02437045)
- Testing
- Meropenem, Piperacillin-tazobactam combination product
- Where
- 6 sites in Australia, Singapore
- Volunteers
- 100 people
- Sponsor
- The University of Queensland
Bloodstream Infection, Sepsis
Clinical Performance Study of Microbio InfectID-BSI for Detection of Bacteria and Yeast With Patient Blood Samples
The objective of the study is to determine the efficacy of the Microbio InfectID-BSI qPCR kit in a clinical laboratory environment using patient whole blood for pathogen detection and identification versus standard of care…
- Conditions
- Bloodstream Infection, Sepsis, Septic Shock
- Trial name
- IID-BSIqPCR (NCT06531031)
- Testing
- InfectID-BSI (Bloodstream Infection) qPCR Assay
- Where
- 8 sites in United States, Australia and 1 more
- Volunteers
- 1,500 people
- Sponsor
- Microbio Co Ltd