Clinical trials: Infertile Patients
Infertility, Endometriosis
The Influence of Adjuvant Medical Treatment of Peritoneal Endometriosis on the Outcome of IVF. A Prospective Randomized Analysis.
In this study of endometriosis patients we compare a common treatment of surgical therapy and medical treatment for 3 months (Zoladex) with patients receiving only surgical therapy.
- Trial name
- NCT01682642
- Testing
- Zoladex
- Where
- Belgium
- Volunteers
- 120 people
- Sponsor
- AZ Jan Palfijn Gent
Infertility
The Evaluation of Recombinant LH Supplementation in Patients With Suboptimal Response to Recombinant FSH Undergoing ICSI
The investigators aimed to evaluate patients who had In-vitro fertilization treatment and who had COH (controlled ovarian hyperstimulation) cycles applying long protocol with GnRH (gonadotropin-releasing hormone) analogue with…
- Trial name
- LH (NCT02108223)
- Testing
- fix dose r-FSH (Gonal-f), r-LH supplementation, r-FSH (Gonal-f)
- Volunteers
- 137 people
- Sponsor
- Sisli Hamidiye Etfal Training and Research Hospital
Infertility
Follicular Activation in Poor Responders
This study aims to assess whether activation of primordial follicles through ovarian cortex fragmentation may increase the number of antral follicles present in the ovary of patients with diminished ovarian reserve.
- Trial name
- FAPPOR (NCT02354963)
- Testing
- In vitro fragmentation of the ovarian tissue
- Where
- Spain
- Volunteers
- 34 people
- Sponsor
- César Díaz García
Endometriosis
BGS649 Monotherapy in Moderate to Severe Endometriosis Patients
This study will assess the safety and tolerability of BGS649 in women with moderate to severe endometriosis.
- Trial name
- NCT01190475
- Testing
- Active treatment with a high dose of BGS649, Active treatment with a low dose of BGS649
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Mereo BioPharma
Infertility, Male
Assessment of TetraSOD® Efficacy to Improve Semen Parameters in Men With Idiopathic Infertility
TetraSOD® is a unique marine phytoplankton (Tetraselmis chuii) SOD-rich ingredient that is grown under patent-protected technology exclusively designed by the company Fitoplancton Marino, S.L. (Spain).
- Trial name
- NCT04864314
- Testing
- Marine microalgae Tetraselmis chuii with high Superoxide Dismutase (SOD) activity
- Where
- 2 sites in Spain
- Volunteers
- 80 people
- Sponsor
- Fitoplancton Marino, S.L.
Reproductive Sterility
Prednisolone Improves IVF Outcomes in Men With Anti-sperm Antibodies
Corticosteroids have been indicated to treat men with ASAs. Although many studies have confirmed the clinical therapeutic significance of corticosteroids in the treatment of men with ASAs, other studies have not found a…
- Trial name
- NCT02935738
- Testing
- Prednisolone treatment
- Volunteers
- 241 people
- Sponsor
- Barz IVF Center for Infertility Treatment and Embryo Research
In Vitro Fertilization
EXpression PRofile Endometrium Samples Study
This is a Phase IV, pilot, open-label, national, multi-centric study planned to determine the gene expression profiles and histologic changes of the endometrial tissue before and after stimulation with Gonal-f®.
- Trial name
- EXPRESS (NCT01210144)
- Testing
- Gonal -f® [r-hFSH], Ovitrelle® [r-hCG alfa], Gonadotropin-releasing hormone (GnRH) Agonist
- Where
- France
- Volunteers
- 27 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Endometriosis, Infertility
Endometrial Markers and Response of Endometriosis Patients to Prolonged GnRH Agonist Prior to IVF
This prospective randomized trial evaluates whether one can predict which infertile women with endometriosis who are candidates for in vitro fertilization will benefit from prolonged therapy with a GnRH agonist by the…
- Trial name
- IntegrinIVF (NCT00621179)
- Testing
- Leuprolide acetate in depot suspension, No intervention
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Colorado Center for Reproductive Medicine
Infertility, Male
Effect of Ejaculatory Abstinence on Semen Parameters in Male Factor Infertility Patients
The purpose of this study is to compare semen parameters with in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) when male factor infertility patients abstain from ejaculation more than 48 hours (routine care)…
- Trial name
- NCT04206800
- Testing
- Ejaculatory abstinence less than 24 hours
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Boston IVF
Triple Negative Breast Cancer, Breast Neoplasms
Vaccination of Triple Negative Breast Cancer Patients
The purpose of this study is to evaluate a new investigational cancer vaccine, P10s-PADRE in combination with standard neoadjuvant chemotherapy and surgery in patients with clinical stage I, II or III triple negative breast…
- Trial name
- NCT02938442
- Testing
- P10s-PADRE with MONTANIDE™ ISA 51 VG, Doxorubicin, Cyclophosphamide
- Where
- 2 sites in United States
- Volunteers
- 16 people
- Sponsor
- University of Arkansas
Infertility
Tolerability and Satisfaction With Evie
The purpose of this study is to determine patient satisfaction and tolerability of the Evie® slow-release insemination device for US population.
- Trial name
- NCT01969812
- Testing
- Evie Slow-release Insemination Device, Traditional Intrauterine Insemination
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Infertility
Does Endometrial Injury Improve Intrauterine Insemination Outcome?
The investigator suggests that local endometrial injury using pipelle catheter performed in the follicular phase (cycle day 5, 6 or 7) of the stimulation cycle may improve the pregnancy rates among patients undergoing…
- Trial name
- NCT02542280
- Testing
- endometrial injury., intrauterine insemination, ovarian stimulation
- Volunteers
- 360 people
- Sponsor
- Ain Shams Maternity Hospital
Asherman's Syndrome
Reproductive Outcome Affected by Two Adjunctive Treatments in Patients With Severe Intrauterine Adhesions
The purpose of this study is to compare the outcome of loop intrauterine contraceptive device and heart-shaped intrauterine balloon for the adjunctive treatment of severe intrauterine adhesions in patients with infertility.
- Trial name
- ROABTIPWSIUA (NCT02708277)
- Testing
- loop-shaped intrauterine contraceptive device, intrauterine balloon (Cook Medical)
- Volunteers
- 93 people
- Sponsor
- Yuqing Chen
Steroid Refractory Acute Graft Versus Host Disease
Methoxsalen and Extracorporeal Photopheresis (ECP) for the Treatment of Pediatric Participants With Steroid Refractory Acute Graft Versus Host Disease
This is a single-arm, open-label, multicenter study of the efficacy of UVADEX® (methoxsalen) Sterile Solution in conjunction with THERAKOS® CELLEX® Photopheresis Systems (ECP) in pediatric participants with steroid-refractory…
- Trial name
- NCT02524847
- Testing
- Methoxsalen, Extracorporeal Photopheresis (ECP)
- Where
- 32 sites in United States, Austria and 6 more
- Volunteers
- 29 people
- Sponsor
- Therakos, Inc., a Mallinckrodt Company
In Vitro Fertilization
Corifollitropin Alfa in Participants Undergoing Repeated Controlled Ovarian Stimulation (COS) Cycles Using a Multiple Dose Gonadatropin Releasing Hormone (GnRH) Antagonist Protocol (Study 38825)(P05714)
The objective of the trial is to assess the non-immunogenicity and safety of corifollitropin alfa (also known as Org 36286, SCH 900962 and MK-8962) in participants undergoing repeated COS cycles using a multiple dose GnRH…
- Trial name
- Trust (NCT00696878)
- Testing
- Corifollitropin alfa, FSH, GnRH antagonist
- Volunteers
- 682 people
- Sponsor
- Organon and Co
Hemophilia A
Pharmacokinetic Study of ADVATE Reconstituted in 2 mL Sterile Water for Injection
The purpose of this study is to determine the pharmacokinetics and safety of Antihemophilic factor, recombinant, manufactured protein-free (rAHF-PFM) reconstituted in 2 mL sterile water for injection (SWFI) and compare with those…
- Trial name
- NCT00952822
- Testing
- Antihemophilic factor, recombinant, manufactured protein-free (rAHF-PFM). (Antihemophilic factor is also known as Factor VIII)
- Where
- 11 sites in United States
- Volunteers
- 52 people
- Sponsor
- Baxalta now part of Shire
Head and Neck Cancer
Study of Personalized Sterile Humidification Device for Mucositis in Head and Neck Cancer Patients
This is a single arm study of the use of a personalized sterile humidification device for 12 weeks for head and neck cancer patients undergoing radiation therapy to determine if the usage of this humidification system will result…
- Trial name
- NCT01930435
- Testing
- Sterile Humidification Device
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, San Francisco
Infertility
A Study of the Efficacy and Safety of Highly Purified Menotrophin Versus Recombinant Follitropin Alfa
Prospective open label, randomised, parallel group, comparative pilot.
- Trial name
- NCT00257556
- Testing
- Menotrophin, Follitropin alfa
- Where
- 6 sites in Germany, United Kingdom
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Ferring Pharmaceuticals
Breast Cancer, Infertility
RCT of Fixed vs Titrated Letrozole in Breast Cancer Patient Undergoing IVF
The purpose of this study is to compare two different ways to administer Letrozole to determine their effectiveness in blocking estrogen production during ovarian stimulation in patients with breast cancer prior to…
- Trial name
- NCT01035099
- Testing
- Letrozole
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Weill Medical College of Cornell University
Infertility
Progesterone Serum Levels in Subfertile Female Patients Undergoing in Vitro Fertilisation (IVF)
This study is aimed to demonstrate that highly purified Menotrophin produces significant lower progesterone serum levels during the follicular phase in comparison to Follitropin alpha in the treatment of subfertile females…
- Trial name
- PREDICT (NCT01225835)
- Testing
- Menotrophin, Follitrophin alpha, Cetrorelix
- Where
- 8 sites in Germany
- Volunteers
- 124 people
- Sponsor
- Ferring Pharmaceuticals