Clinical trials: Infertility/Sterility
Infertility
Autologous Endometrial Coculture (AECCT)
The purpose of this study is to determine if the use of Autologous Endometrial Coculture (AECC) in young in vitro fertilization (IVF) patients with poor ovarian reserve improves pregnancy outcome.
- Trial name
- AECCT (NCT01472861)
- Testing
- AECC (Autologous endometrial coculture), no endometrial biopsy or Autologous endometrial coculture (AECC) performed
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Infertility, Female, Infertility, Male
Cell Free Preimplantation Genetic Testing
This study aims to develop preimplantation genetic testing methods from embryo culture media (cell free). Genetic testing of culture media will be compared to conventional methods based on embryo biopsies.
- Trial name
- NCT04628507
- Testing
- Spent media collection
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Genomic Prediction Inc.
Premature Ovarian Failure
Dehydroepiandrosterone (DHEA) Treatment and Premature Ovarian Failure (POF)
The experimental focus of this project is on the interaction of DHEA treatment on pregnancy in women with open tubes, fertile male partners and evidence of premature ovarian failure.
- Trial name
- DHEAFert2 (NCT00948857)
- Testing
- Dehydroepiandrosterone
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- David H. Barad
Male Infertility, Infertility, Male
The Evaluation of the Effect of Microfluidic Sperm Sorting Chip 'Labs-on-a-chip' on IVF Success in Male Factor
Microfluidic chips are one of the methods of sperm separation to eliminate DNA fragmentation in sperm. It is thought that the separation of sperm by centrifugation in the classical gradient density (Percoll) method used in sperm…
- Trial name
- NCT03960229
- Testing
- MicroFluidic Sperm Sorting Chips, Gradient-Density Centrifugation
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 139 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Infertility
Comparison Between Recombinant Versus Urinary hCG for Ovulation Induction in High Responders
The purpose of this study is to compare the clinical outcomes of recombinant human chorionic gonadotrophin (rHCG) and urinary HCG (uHCG) in patients undergoing IVF cycles.
- Trial name
- NCT00415766
- Testing
- rHCG 250ug, uHCG 5000 IU, uHCG 7500 IU
- Where
- Greece
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Eugonia
Infertility
Efficacy and Safety of Shen Que (RN8) Moxibustion in Unexpected POR
Moxibustion of Shen Que (RN8) can increase the number of embryos available for transfer, thus improving pregnancy outcomes in women of advanced reproductive age who experience unexpected poor ovarian response.
- Trial name
- NCT05653557
- Testing
- Shen Que Moxibustion
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Shandong University of Traditional Chinese Medicine
Infertility
Failure of Implantation After Recurrent Embryo Transfers
We will investigate maternal and embryonic factors in women with recurrent implantation failure, undergoing IVF/ ICSI treatment.
- Trial name
- NCT00351481
- Where
- Netherlands
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Hysteroscopy, Intrauterine Adhesion
Early Outpatient Hysteroscopy Can Prevent Intrauterine Adhesion After Induced Abortion
Background: Intrauterine adhesions are a difficult clinical problem for reproductive infertility. The most common cause is uterine cavity surgery and post-abortion (including abortion and spontaneous abortion).
- Trial name
- NCT04166500
- Testing
- Hysteroscopy
- Where
- Taiwan
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Endometritis; Chronic, Subfertility
The FLORA-project: in Search for the Microbial Cause of Chronic Endometritis and the Most Appropriate Treatment to Obtain a Successful Pregnancy IVF/ICSI
Chronic endometritis is an inflammatory condition of the endometrium. This inflammation can negatively affect fertility and pregnancy. The pathology is frequently (+-10%) observed in women with fertility problems.
- Trial name
- FLORA (NCT05337072)
- Testing
- Microbiome study
- Where
- Belgium
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Infertility, Female, First Trimester Spontaneous Abortion
Determination of Circulating Placental Biomarkers Levels to Predict the Pregnancy Outcome of First Trimester After IVF.
This study will assess the predictive potential of circulating placental biomarkers for spontaneous miscarriage within the following month in an IVF setting.
- Trial name
- NCT04387994
- Testing
- Blood samples collection
- Where
- Portugal
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Instituto Valenciano de Infertilidade de Lisboa
Infertility, Male
Sperm Selection Using Microfluidic Technology
This clinical study has been organised to investigate whether microfluidic technology may be considered as a new procedure for routine sperm preparation during assisted reproduction.
- Trial name
- MSS (NCT04997070)
- Where
- Belgium
- Volunteers
- 1,038 people, healthy volunteers welcome
- Sponsor
- CRG UZ Brussel
Infertility
In Vitro Maturation With in Vitro Fertilization (IVF) Compared to Mild in Vitro Fertilization
Methods of infertility treatment may involve in vitro fertilization or IVF. Though effective, IVF is complex and expensive. Methods using no gonadotropin hormone stimulation of the ovaries are being compared to mild stimulation…
- Trial name
- IVM vs IVF (NCT00867763)
- Testing
- In vitro maturation and in vitro fertilization, Low doses of gonadotropin stimulation.
- Where
- 2 sites in United States
- Volunteers
- 1,440 people, healthy volunteers welcome
- Sponsor
- Batzofin Fertility Services
Infertility
Vitrification Versus Slow Cooling of Human Cleavage Stage Embryos
Human embryos can be preserved for later transfers by freezing. Traditionally the slow cooling method has been used. About 70% of the embryos remain fully intact after thawing.
- Trial name
- NCT00886431
- Testing
- embryo vitrification
- Where
- 2 sites in Belgium, Netherlands
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Metabolic Syndrome X, Infertility
Female Subfertility: a Metabolic and Vascular Profile
Introduction: Overall, 10 - 15% of couples seek specialist help once in their lives when a spontaneous pregnancy does not occur.
- Trial name
- NCT02136472
- Where
- Netherlands
- Volunteers
- 512 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Infertility (IVF Patients), Oocyte Retrieval
Impact of the Operator Performing Oocyte Retrieval on the Cumulative Live Birth Rate
This is a monocentric retrospective observational study. The study investigates the impact of the operator performing the oocyte retrieval on the cumulative live birth rate (CLBR).
- Trial name
- OPU-CLBR (NCT06933901)
- Testing
- Oocyte retrieval
- Volunteers
- 19,500 people, healthy volunteers welcome
- Sponsor
- Istituto Clinico Humanitas
Low Back Pain
Subcutaneous Sterile Water Injection for Relief of Low Back Pain
To compare the effect of subcutenous sterile water injection technique with the subcutaneous saline injection technique in the degree and duration of low back pain-relieving during childbirth
- Trial name
- NCT02813330
- Testing
- Subcutaneous sterile water injection, saline injection
- Volunteers
- 336 people, healthy volunteers welcome
- Sponsor
- Woman's Health University Hospital, Egypt
Infertility, Intrauterine Adhesions
Treatment of Infertility by Collagen Scaffold Loaded With Autologous Bone Marrow Stem Cells
Study of the treatment of infertility caused by severe intrauterine adhesions or endometrial dysplasia by collagen scaffold loaded with autologous bone marrow stem cells, and to provide clinical evidence for the treatment of…
- Conditions
- Infertility, Intrauterine Adhesions, Endometrial Dysplasia
- Trial name
- NCT02204358
- Testing
- autologous bone marrow stem cells
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Pregnancy, Pelvic Floor Dysfunction
Female Reproductive Health in Canadian Armed Forces
This is a mixed-method study aimed at gathering new evidence on reproductive health among female service members in the Canadian Armed Forces (CAF).
- Conditions
- Pregnancy, Pelvic Floor Dysfunction, Military Personnel, Contraception
- Trial name
- BEARH2025 (NCT07524764)
- Where
- Canada
- Volunteers
- 1,121 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Infertility, IVF
Will Autologous Platelet Rich Plasma Able To Restore Ovarian Function?
A-PRP (Autologous Platelet Rich Plasma) is becoming widely used in a variety of medical procedures seeking tissue remodeling and/or healing as an intervention.
- Conditions
- Infertility, IVF, Premature Ovarian Failure, Anti-Mullerian Hormone Deficiency
- Trial name
- NCT04381299
- Testing
- autologous platelet rich plasma, saline solution
- Where
- United Arab Emirates
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- ART Fertility Clinics LLC
Polycystic Ovary Syndrome (PCOS)
Blood Vessel Function in Adolescents and Women With Polycystic Ovary Syndrome
The purpose of this study is to determine if changes in blood vessel health lead to the menstrual irregularities that women with PCOS experience.
- Trial name
- NCT01615562
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
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