Clinical trials: Infertility Unexplained
Infertility Unexplained, Infertility, Male
Comparison of the Effect of Microchip and Density Gradient Methods in Intrauterine Insemination Cycles
Microfluidic chips are one of the methods of sperm separation to eliminate DNA fragmentation in sperm. It is thought that the separation of sperm by centrifugation in the classical gradient density (Percoll) method used in sperm…
- Trial name
- NCT04144244
- Testing
- MicroFluidic Sperm Sorting Chips, Gradient-Density Centrifugation
- Where
- Turkey (Türkiye)
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Unexplained Infertility
Possible Action of Resveratrol in Improving the Outcomes of IVF/ICSI in Couples With Unexplained Infertility
Based on available evidence and given the potential beneficial effects of resveratrol in folliculogenesis and in oocyte development, the investigators designed a randomized, controlled, double-blind, single-center trial, whose…
- Trial name
- RECOS (NCT06481696)
- Testing
- Resveratrol-based multivitamin supplement, Folic acid, IVF/ICSI
- Where
- Italy
- Volunteers
- 90 people
- Sponsor
- Andros Day Surgery Clinic
Unexplained Infertility
The Effects of Using Fertile Chip in Sperm Selection for Intracytoplasmic Sperm Injection in Unexplained Infertility
The aim of the current study is to evaluate to effectiveness of sperm selection by using fertile chip in unexplained infertile couples on intracytoplasmic sperm injection (ICSI) cycles.
- Trial name
- NCT02488434
- Testing
- fertile chip
- Where
- Turkey (Türkiye)
- Volunteers
- 122 people
- Sponsor
- Baskent University
Endometriosis, Unexplained Infertility
Elagolix for Fertility Enhancement Clinical Trial
Studies suggest that undiagnosed endometriosis results in poor reproductive outcomes in the setting of In Vitro Fertilization and Embryo Transfer (IVF-ET).
- Trial name
- EFFECT (NCT04039204)
- Testing
- Elagolix, Ortho Cyclen
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Wake Forest University Health Sciences
Infertility
Metformin Use and Clinical Pregnancy Rate in Women With Unexplained Infertility
The aim of this study is to asses the effect of metformin on clinical pregnancy rate in women with unexplained infertility (randomized controlled trial).
- Trial name
- NCT03681197
- Testing
- Metformin, Clomiphene Citrate
- Where
- Egypt
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Elham Raafat
Depression, Anxiety
The Effect of Selective Serotonin Reuptake Inhibitor (SSRI) Treatment on Affective Symptoms and Fertility Treatment Outcome in Women Undergoing in Vitro Fertilization (IVF)
Women undergoing IVF show a high prevalence of depressive and anxiety symptoms. Furthermore, stress has harmful consequences on IVF and pregnancy outcomes. An immunological cascade was suggested to be involved in the process.
- Conditions
- Depression, Anxiety, In Vitro Fertilization
- Trial name
- NCT00989053
- Testing
- escitalopram
- Where
- Israel
- Volunteers
- 120 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Polycystic Ovary Syndrome, Infertility, Female
Effect of Nitric Oxide Donors on Uterine and Subendometrial Blood Flow in Patients With Unexplained Infertility
The purpose of the study to evaluate effect of nitroglycerin trans-dermal patches on uterine and sub-endometrial blood flow in women with unexplained infertility.
- Trial name
- NCT03481582
- Testing
- Nitroglycerin, Three dimensional power doppler
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Infertility
Cabergoline As An Adjuvant To Clomiphene Citrate For Management Of Unexplained Infertility
Infertility refers to an inability to conceive after having regular unprotected sex. Infertility can also refer to the biological inability of an individual to contribute to conception, or to a female who cannot carry a pregnancy…
- Trial name
- NCT03549741
- Testing
- Clomiphene Citrate 50mg, Cabergoline Oral Tablet
- Volunteers
- 120 people
- Sponsor
- Assiut University
Infertility Unexplained, Oligospermia
Evaluation of Treatment With Coenzyme Q10 and L-Carnitine on Semen Parameters in Infertile Men With Idiopathic Oligoasthenoteratospermia
Evaluation of treatment with Coenzyme Q10 and L-Carnitine on Semen Parameters in Infertile men with Idiopathic Oligoasthenoteratospermia
- Trial name
- infertility (NCT06342856)
- Testing
- co enzyme Q10 , L- Carnitine
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Ain Shams University
Infertility Unexplained
Effect of Oral Zinc Sulfate Supplementation on Enzymes of Urate Pathway
Although many reports have investigated the relationship between subfertility and uric acid levels in semen, to the best of author knowledge, there is no study have been published to yet focus on the effects of asthenospermia…
- Trial name
- NCT03361618
- Testing
- Zinc Sulfate
- Where
- Iraq
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Babylon University
Subfertility
Endometrial Scratching in Couples With Unexplained Subfertility
Endometrial scratching in luteal phase of a spontaneous menstrual cycle may increase pregnancy rate in women with unexplained infertility.
- Trial name
- ESUS (NCT01412606)
- Testing
- scratching
- Where
- Egypt
- Volunteers
- 105 people
- Sponsor
- Mansoura University
Infertility, Infertility Unexplained
PMA-FERTITHEQUE Biocollection
Creation of a patient library in Medically Assisted Procreation to allow the implementation of further research with the following objectives: To identify new relevant biomarkers in patients who will carry a pregnancy to term To…
- Trial name
- FERTITHEQUE (NCT05599724)
- Testing
- Biocollection
- Where
- France
- Volunteers
- 250 people
- Sponsor
- University Hospital, Brest
Infertility
Perifollicular Vascularity Assessment in in-Vitro Fertilization
On February 2004, a law (n. 40/2004) regulating assisted reproduction techniques (ARTs) was approved in Italy. This law aimed to regulate the treatment of infertility in Italy, contains several restrictions, such as the…
- Trial name
- NCT00458380
- Testing
- Controlled ovarian stimulation, perifollicular vascularity assessment, IVF, embryo transfer.
- Where
- Italy
- Volunteers
- 116 people
- Sponsor
- University Magna Graecia
Pre-Implantation Embryo Recovery, Genetic Diseases, Inborn
Uterine Irrigation Method in Infertility Patients Who Require PGD
The study will involve up to 30 pairs of male and female sexually intimate partners who are carriers for a genetic disease (e.g Sickle Cell Disease or Thalassemia) and at high risk of transmitting the gene.
- Trial name
- NCT02676479
- Testing
- Uterine Lavage Group
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Istanbul University
Infertility, Female
Infections and Unexplained Infertility
1. Background: In women, unexplained infertility has been associated with a range of cellular and molecular defects in the endometrium, adverse immune responses and immunological factors.
- Trial name
- NCT03581617
- Testing
- NK cell analysis, Herpesvirus detection, sHLA-G analysis
- Volunteers
- 143 people, healthy volunteers welcome
- Sponsor
- University Hospital of Ferrara
Infertility, Female, Infertility Unexplained
Effects of Age and Infertility on Ovarian Granulosa Cell Function
Infertility is a life changing disorder, affecting 1 in 7 couples within the UK. Treatment options pose a significant cost burden to both the NHS and patient when NHS-funded treatment options are exhausted.
- Conditions
- Infertility, Female, Infertility Unexplained, Infertility of Tubal Origin, Infertility
- Trial name
- NCT04945265
- Volunteers
- 500 people
- Sponsor
- King's College London
Male Infertility, Unexplained Infertility
Impact of Sperm DNA Integrity on In Vitro Cycles
Sperm DNA integrity will be measured via the Toluidine Blue Assay (TBA) for patients undergoing In Vitro Fertilization (IVF); the study will determine correlations, if any, between IVF success and sperm DNA integrity.
- Conditions
- Male Infertility, Unexplained Infertility, Abortion, Habitual
- Trial name
- TBA on IVF (NCT01232465)
- Where
- United States
- Volunteers
- 420 people
- Sponsor
- Northwell Health
Infertility
In Vitro Maturation With in Vitro Fertilization (IVF) Compared to Mild in Vitro Fertilization
Methods of infertility treatment may involve in vitro fertilization or IVF. Though effective, IVF is complex and expensive. Methods using no gonadotropin hormone stimulation of the ovaries are being compared to mild stimulation…
- Trial name
- IVM vs IVF (NCT00867763)
- Testing
- In vitro maturation and in vitro fertilization, Low doses of gonadotropin stimulation.
- Where
- 2 sites in United States
- Volunteers
- 1,440 people, healthy volunteers welcome
- Sponsor
- Batzofin Fertility Services
Subfertility, Female
Effect of Sildenafil Citrate Compared to Estrogen as Adjuvant Therapy for Unexplained Infertility
. This study aimed to determine and compare the effect of vaginal sildenafil citrate and estradiol valerate on endometrial thickness, blood flow and pregnancy rates in infertile women.
- Trial name
- NCT05753098
- Testing
- estrogen therapy, Sildenafil, Clomiphene Citrate 50mg
- Where
- Egypt
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Beni-Suef University
Unexplained Female Infertility
Protein S Activity in Women With Unexplained Infertility
This study will add: Finding out an association between Protein S activity and unexplained female infertility. Aim: Study hypothesis: In women with unexplained infertility protein S activity may be low.
- Trial name
- NCT03670758
- Testing
- Protein S activity
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Esraa Gamal Ahmed