Clinical trials: Inflammation
Inflammation, Pregnancy Related
Docosahexaenoic Acid (DHA) Supplementation in High Risk Pregnancies
Purpose: Determine the effects of maternal docosahexaenoic acid (DHA) supplementation during pregnancy on levels of DHA, synaptamide (novel anti-inflammatory metabolite), and inflammatory biomarkers during pregnancy and at…
- Trial name
- NCT04069195
- Testing
- DHA supplement, Corn Oil: Soybean Oil
- Where
- United States
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Walter Reed National Military Medical Center
Athletic Performance, Soccer
The Effect of a Training Programme in the Variation of Fitness Parameters, Physiological, Hematological and Biochemical Indicators of Soccer Players During the Preseason Period
The goal of this study is to investigate the effects of varying friendly match-play exposure during the late pre-season on physiological, biochemical, and performance adaptations in soccer players.
- Conditions
- Athletic Performance, Soccer, Muscle Damage, Inflammation
- Trial name
- NCT07170930
- Testing
- Friendly Match-Play Exposure: extended vs. limited
- Where
- Greece
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Emmanouil D. Zacharakis
Inguinal Hernia
Inflammatory Response: General vs Spinal Anesthesia
Objective: This study aimed to compare the effects of general and spinal anesthesia on the inflammatory response by measuring intercellular adhesion molecule-1 (ICAM-1), P-selectin (SELP), and thrombomodulin (TM) levels in…
- Trial name
- NCT07567534
- Testing
- inflammatory response during inguinal hernia repair.
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Sezen Kumaş Solak
Airway Inflammation
Airborne Ultrafine and Fine Particulate Matter: A Cause for Endothelial Dysfunction in Man?
The purpose of this study is to examine biological pathways of altered blood vessel function resulting from breathing airborne particulate.
- Trial name
- NCT00814281
- Testing
- Montelukast
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Marywood University
Periodontitis, Gingivitis
Endoplasmic Reticulum Stress Response in Periodontal Disease
Periodontal disease causes inflammation and damage to the tissues that support the teeth. This study looks at whether stress inside gum cells contributes to this damage.
- Trial name
- NCT07751419
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Inonu University
Sickle Cell Anemia
Establishment of Functional MRI Imaging Parameters for Use in the Evaluation of Sickle Cell Disease
Patients with sickle cell anemia (SCA) are at an increased risk for damage to brain tissue due to their disease. The investigators are interested in how blood flow and cerebral inflammation are different in SCA patients and how…
- Trial name
- NCT02445144
- Where
- 2 sites in United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Albert Einstein College of Medicine
Aging
The Psychobiological Effects of Participation in a One-Month Insight Meditation Retreat
The purpose of this study was to examine how participation in a 1 month intensive Insight (vipassana) Meditation retreat (a) affects biological markers of cellular aging, social affiliation, and inflammation, which are important…
- Trial name
- NCT03056105
- Testing
- Residential Insight Meditation Retreat
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Triglycerides
Curcumin & Astaxanthin for Lowering Triglyceride Readings and Inflammation
Two dietary supplements are each being compared to a placebo for the ability to help maintain triglycerides in the normal range. The subjects will be adult men and women with moderately high TG values.
- Trial name
- NCT07063056
- Testing
- Curcumin (Longvida™), Half Dose Curcumin (Longvida™), Astaxanthin
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Medinutra LLC
Sepsis
Mediators of Inflammation, Prognostic Markers and Genetic Polymorphisms in Patients With Sepsis
Aims of the study were to find vascular markers of inflammation and endothelial damage during the course of severe sepsis in septic patients and the effects of treatment with anti-inflammatory medication (such as Drotregocin alfa…
- Trial name
- NCT00222222
- Testing
- vein puncture
- Where
- Germany
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Universitätsmedizin Mannheim
Sarcopenia
Trial in Elderly With Musculoskeletal Problems Due to Underlying Sarcopenia - Faeces to Unravel Gut and Inflammation Translationally
The overall aim of the TEMPUS-FUGIT study is to assess gut microbiota composition in older persons without sarcopenia and to determine the relationship with and between intestinal and systemic inflammation and with…
- Trial name
- TEMPUS-FUGIT (NCT05008770)
- Testing
- No intervention
- Where
- Belgium
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Peridontal Disease, Aging
Taurine in Periodontitis and Aging
Aging leads to a decline in physiological functions and increases the risk of chronic diseases. Periodontitis is a chronic inflammatory disease that causes progressive destruction of the tissues supporting the teeth.
- Trial name
- NCT06635369
- Testing
- Periodontal Indices
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital
Chronic Stress, Systemic Inflammation
Assessing the Feasibility of Multi-modal Biosensing for Monitoring Mobility and Cognition in Older Adults
Current health devices often overlook older users, who may face both health challenges and technology barriers. We are investigating the feasibility of wearable sensors to track posture, heart rate, and breathing, alongside a…
- Conditions
- Chronic Stress, Systemic Inflammation, Mobility and Independence
- Trial name
- NCT07217951
- Testing
- Eutectogel Sensors and Microneedle Patches
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Tufts University
Pain, Inflammation
Study of Experimental Models of Pain and Inflammation.
The experimental pain model studied in this proposal show characteristics of an inflamed wound with a pro-inflammatory response.
- Trial name
- NCT01097902
- Testing
- Ibuprofen
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Martin Angst
Waist, Hypertriglyceridemic
Dietary Incorporation of Lentils to Improve Metabolic Health
Approximately 40% of Americans are pre-diabetic or diabetic, mostly in the form of type 2 diabetes (T2D), which is heavily influenced by diet.
- Trial name
- NCT04448067
- Testing
- Dietary Lentil Intake, No Dietary Lentil CONTROL
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Montana State University
Obesity, Abdominal, Glycation End Products, Advanced
Comparison of Plant-based or Animal-based Protein on Anthropocentric and Metabolic Parameters in Obese Subjects
The investigators will try to evaluate the effects of substitution of dietary animal protein by black soybean milk (400 mL x 2) per day on anthropocentric and metabolic parameters in obese subjects.
- Conditions
- Obesity, Abdominal, Glycation End Products, Advanced, Inflammation, Gut Microbiota
- Trial name
- NCT05290519
- Testing
- plant and animal protein
- Where
- Taiwan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National Taiwan Normal University
Sepsis, Amino Acids
Amino Acids Expression Profiling of Patients With Sepsis
The patients with sepsis are in the state of hypermetabolism, increased resting energy expenditure, protein and fat catabolism disorder, negative nitrogen balance, insulin resistance, hyperglycemia, and amino acid metabolism…
- Trial name
- NCT01818830
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Chinese PLA General Hospital
Long COVID, Post Acute Sequelae of COVID-19
PET Imaging of Cyclooxygenase-1 in Participants With Neurological Manifestations of Post-Acute Sequelae of SARS-CoV-2 Infection (PASC)
Background: SARS-CoV-2 is the virus that causes COVID-19. Some people who recover from COVID-19 have long-term symptoms that affect the brain.
- Trial name
- NCT06920628
- Testing
- 11C-PS13
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Septic Shock
Assessment of Microcirculatory Dysfunction in Septic Shock Patients by OCTA
Purpose and rationale: Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. Sepsis and septic shock are major public health problems killing one in every three patients.
- Trial name
- SshOCTA (NCT04593212)
- Testing
- Optical Coherence Tomography Angiography
- Where
- Portugal
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hospital da Luz, Portugal
Idiopathic Pulmonary Fibrosis (IPF), Idiopathic Pulmonary Fibrosis
PET Study of PIPE-791 in Healthy Volunteers and Volunteers With PrMS and IPF
This is a study of PIPE-791, an investigational study drug to treat progressive multiple sclerosis (MS) and idiopathic pulmonary fibrosis (IPF).
- Conditions
- Idiopathic Pulmonary Fibrosis (IPF), Idiopathic Pulmonary Fibrosis, Multiple Sclerosis, Multiple Sclerosis, MS
- Trial name
- NCT06683612
- Testing
- PIPE-791
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Contineum Therapeutics
Healthy Volunteers, C-Reactive Protein
A Study of LY5625575 in Healthy Participants and in Participants With Inflammation (Elevated C-Reactive Protein)
The main purpose of this study is to evaluate the safety and tolerability of LY5625575 in healthy participants (including Japanese and Chinese) and in participants with high levels of a marker for inflammation (C-reactive…
- Trial name
- NCT07801300
- Testing
- LY5625575
- Where
- 2 sites in United States
- Volunteers
- 204 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
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