Clinical trials: Inflammation
To Determine Whether Estrogen Influences the Effects of Training on Glycemic Control and Insulin Sensitivity
Does Estrogen Blunt the Effects of Exercise Training on Glycemic Control
Previous research has found that males and females respond differently to exercise training, particularly with respect to improvements in blood sugar control and immune system health.
- Trial name
- NCT07791394
- Testing
- EXERCISE TRAINING WITH OR WITHOUT MEDICATION
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Waterloo
Sepsis
Mediators of Inflammation, Prognostic Markers and Genetic Polymorphisms in Patients With Sepsis
Aims of the study were to find vascular markers of inflammation and endothelial damage during the course of severe sepsis in septic patients and the effects of treatment with anti-inflammatory medication (such as Drotregocin alfa…
- Trial name
- NCT00222222
- Testing
- vein puncture
- Where
- Germany
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Universitätsmedizin Mannheim
Sepsis, Critical Illness
Provider Perspectives on Beta-lactam Therapeutic Drug Monitoring Programs in the Critically Ill
The purpose of the study is to characterize various healthcare practitioners' perspectives on implementation of beta-lactam therapeutic drug monitoring in critical care practice.
- Trial name
- NCT04755777
- Where
- 3 sites in United States, Australia
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Airway Inflammation, Peripheral Blood Inflammation Markers
Lung Function and Airway Inflammation in Portland Cement Workers
The aim of the study is to examine inflammation in the airways and in peripheral blood, in workers in a cement plant i Norway.
- Conditions
- Airway Inflammation, Peripheral Blood Inflammation Markers, Cement Dust Exposure
- Trial name
- SPUTUM (NCT00455377)
- Where
- Norway
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Sykehuset Telemark
Inflammation, Hypertriglyceridemia
Impact of Foods on Bile Acids, Metabolites, and Inflammation
Dietary incorporation of pulse crops may be an effective way to lower unhealthy elevations in serum bile acids. These elevations play a direct role in promoting obesity-related diseases estimated to be present in about one third…
- Conditions
- Inflammation, Hypertriglyceridemia, Metabolic Disease, Lipid Metabolism Disorder
- Trial name
- NCT05245357
- Testing
- Lentil, Control
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Montana State University
Dermatophagoides Farinae Allergy, Asthma
Evaluation of a Nasal Allergen Challenge Procedure Using Dust Mite Extract
The purpose of this study is to serve as a pilot safety study for nasal allergen challenges.
- Conditions
- Dermatophagoides Farinae Allergy, Asthma, Healthy
- Trial name
- Dusty (NCT00927329)
- Testing
- dust mite inhalation
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Periodontitis, Diabetes Mellitus, Type 2
Effect of Periodontal Treatment on Adipokine Levels
The present study aimed to determine the effect of non-surgical periodontal treatment (NSPT) on serum and salivary adipokine and interleukin-1β levels in periodontitis patients with or without type 2 Diabetes Mellitus (T2DM).
- Trial name
- NCT06225154
- Testing
- Non-surgical periodontal treatment
- Where
- 2 sites in Finland, Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Marmara University
Healthy Volunteers, Sepsis
The Role of the P2Y12 Receptor in Tissue Factor Induced Coagulation
Severe sepsis still carries a high mortality rate despite advantages in intensive care medicine and antimicrobial therapy. The inflammatory and procoagulant host response to infection are intricately linked and interactions…
- Trial name
- NCT01099566
- Testing
- Prasugrel
- Where
- Austria
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Crohn's Disease, Olfactogustatory Perception
Olfactogustatory Perception, Eating Behaviour and Inflammation in Crohn's Disease
This study will improve our understanding of the mechanisms underlying anorexia in persons with Crohn's disease flare-ups. The practical spin-off from this research is potentially very important for the management of nutritional…
- Trial name
- Smell&Crohn (NCT02859675)
- Testing
- triangular test, blood sampling, Questionnaires
- Where
- France
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Dijon
Depression, Anxiety
The Influence of Probiotic Supplementation on the Severity of Anxiety and Depressive Symptoms, as Well as the Function and Composition of Gut Microbiota, Metabolic, Inflammation, and Oxidative Stress Markers in Patients With Depression
The aim of this study is to gather empirical evidence which will enable to evaluate the impact of probiotic supplementation on the severity of anxiety and depressive symptoms, function, and composition of gut microbiota…
- Trial name
- NCT05717946
- Testing
- Probiotic composed of two bacteria strains: Lactobacillus helveticus Rosell and Bifidobacterium longum Rosell., control group
- Where
- Poland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Medical University of Lodz
Chronic Periodontitis, Aggressive Periodontitis
IL-34 Levels in Various Types of Periodontitis
The objective of this study is to 1) identification of the impact of IL-34 on the pathogenesis of periodontal disease and determine whether any relationship among the existing levels of Gingival crevicular fluid (GCF) Interleukin…
- Trial name
- NCT04223869
- Testing
- non-surgical periodontal treatment
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Bulent Ecevit University
Systemic Inflammation, Hydration
The Effect of Water With Anti-Inflammatory Capabilities on the Inflammatory Response to Heavy Resistance Exercise
The purpose of this research is to assess the anti-inflammatory effects of berry-flavored water in response to an acute bout of exercise.
- Conditions
- Systemic Inflammation, Hydration, Resting Metabolism
- Trial name
- WAC (NCT07456683)
- Testing
- We made a water with berry essence volatiles (cranberry, blackberry, and blueberry). This was consumed for 6 weeks.
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Arkansas, Fayetteville
Triglycerides
Curcumin & Astaxanthin for Lowering Triglyceride Readings and Inflammation
Two dietary supplements are each being compared to a placebo for the ability to help maintain triglycerides in the normal range. The subjects will be adult men and women with moderately high TG values.
- Trial name
- NCT07063056
- Testing
- Curcumin (Longvida™), Half Dose Curcumin (Longvida™), Astaxanthin
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Medinutra LLC
Alcohol Use Disorder
Imaging Inflammation With Alcohol Use Disorder: an [18F]NOS Study
Study to enroll up to 90 individuals, those with an alcohol use disorder (AUD) (up to n=60) and non-dependent healthy volunteers (HV) (up to n=30).
- Trial name
- AUD (NCT05885594)
- Testing
- [18F]NOS
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Rheumatoid Arthritis, Periodontal Disease
Periodontal Inflammation and Immunity in Preclinical Rheumatoid Arthritis
The purpose of this study is to evaluate the association of Rheumatoid Arthritis (RA)-related antibodies and periodontal inflammation in subjects at-risk for Rheumatoid Arthritis.
- Trial name
- NCT02794012
- Where
- United States
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Healthy
The Effects of Ginger Supplementation on Inflammation in Exercising Individuals
The purpose of our graduate student research study is to observe the effects of ginger on hsCRP, IL-6, and TNF-α levels in exercising individuals based on their level of activity.
- Trial name
- NCT03219463
- Testing
- Ginger
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Loma Linda University
Seroma
Traditional Electrosurgery System Versus Low Thermal Tissue Dissection System for Total Mastectomy
Breast cancer is one of the most common cancer among women nowadays. There are lots of modality of treatment and one of them is Mastectomy.
- Trial name
- NCT03167944
- Testing
- Low thermal electrosurgery system, Conventional Electrocautery
- Where
- Thailand
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Allergic Rhinitis
Effects of Multiple Nasal Exposures to House Dust Mite Allergen on Nasal and Body Inflammation and Airway Sensitivity
This study will evaluate whether multiple nasal antigen challenges with dust mite allergen produces increases in nasal symptoms and local allergic inflammatory cells in the nose and the blood.
- Trial name
- NCT00513487
- Testing
- Dust mite extract, Fluticasone, Methacholine
- Where
- Australia
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Novartis
Overweight, Obesity
Effect of Reduction of Inflammatory Status on Glucose Metabolism in Overweight Men
Overweight increases the risk to develop chronic diseases including type-2 diabetes and cardiovascular disease. The low-grade inflammatory status often seen in overweight subjects is thought to play an important role in disease…
- Conditions
- Overweight, Obesity, Inflammation
- Trial name
- NCT00221052
- Testing
- Diclofenac
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- TNO
Corticobasal Syndrome(CBS), Primary Progressive Aphasia(PPA)
Neuroinflammation in FTLD
The goal of this observational study is to investigate the role of neuroinflammation in frontotemporal lobar degeneration (FTLD). The main aims of this study are: 1.
- Conditions
- Corticobasal Syndrome(CBS), Primary Progressive Aphasia(PPA), Progressive Supranuclear Palsy(PSP), Behavioral Variant Frontotemporal Dementia (bvFTD)
- Trial name
- NCT06870838
- Testing
- 7T MRI scan, CSF, Blood withdrawal
- Where
- 2 sites in Netherlands
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center