Clinical trials: Inflammation
Neonatal Sepsis
Soluble Urokinase Plasminogen Activator Receptor (suPAR) in Late-onset Neonatal Sepsis
The purpose of the study is to investigate the plasma levels of Soluble Urokinase Plasminogen Activator Receptor (suPAR) at the diagnosis and after treatment of sepsis, and to determine whether it has a diagnostic and prognostic…
- Trial name
- suPAR (NCT01294865)
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Ankara University
Pulmonary Disease, Pulmonary Hypertension
Natural History Study of Biomarkers in Pulmonary Arterial Hypertension
Background: High blood pressure in the lungs, known as pulmonary arterial hypertension (PAH), is a rare disorder. Some people have disease-associated PAH and some have PAH from an unknown cause.
- Trial name
- NCT01730092
- Where
- United States
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Autoinflammatory Disease, Autoimmune Diseases
Flemish Joint Effort for Biomarker PRofiling in Inflammatory Systemic Diseases
A multi-centre, prospective study to study cytokine profiles and other potential disease-specific biomarkers in patients with presumed or confirmed diseases of systemic inflammation The goal of this prospective, observational…
- Conditions
- Autoinflammatory Disease, Autoimmune Diseases, Inflammation
- Trial name
- FEBRIS (NCT05670301)
- Testing
- cytokine and lipidomic profiling
- Where
- 7 sites in Belgium
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Postoperative Dental Pain, Pulp Disease, Dental
Effect of Different Apical Actions on Local Inflammatory Mediators and Pain
The goal of this clinical trial is to determine patients' the inflammation and pain response to different apical actions used in rotary instrumentation during root canal shaping process.
- Conditions
- Postoperative Dental Pain, Pulp Disease, Dental, Pulpitis - Irreversible
- Trial name
- NCT06760312
- Testing
- Root canal shaping with Continuous Rotation, Root canal shaping with Apical Reverse, Root canal shaping is conducted with Apical slow-down kinematic.
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Izmir Katip Celebi University
COVID-19 Infection
ESICM UNITE COVID-19 Project (UNITE-COVID)
COVID-19 is arguably the biggest challenge critical care medicine has been confronted with since its conception. Critical care services around the world are flooded by patients presenting with severe respiratory failure who…
- Trial name
- UNITE-COVID (NCT04836065)
- Where
- Belgium
- Volunteers
- 4,995 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Malaria, Pregnancy Malaria
Cardiac Safety of Dihydroartemisinin-Piperaquine Amongst Pregnant Women in Tanzania
Sulfadoxine-pyrimethamine (SP) is currently recommended by the World Health Organization for use as intermittent preventive treatment against malaria in pregnancy (IPTp) in areas of moderate to high malaria transmission.
- Conditions
- Malaria, Pregnancy Malaria, Cardiotoxicity, Cardiac Safety
- Trial name
- NCT02909712
- Testing
- sulfadoxine-pyrimethamine (SP), dihydroartemisinin-piperaquine (DHA-PQP)
- Where
- Tanzania
- Volunteers
- 201 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Sloughing Skin, Mucosal Inflammation
A Study to Assess the Impact of a Non-SLS Toothpaste Upon Oral Mucosal Desquamation
This study is to compare the effect on oral mucosal desquamation of a non-SLS toothpaste and an SLS-containing toothpaste..
- Trial name
- NCT03598881
- Testing
- Treatment
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Unilever R&D
Aging, Sarcopenia
Effect of Creatine+HMB Supplementation in Physically Active Older Adults
Sarcopenia (SAR) is the loss of muscle strength and mass caused by aging. It is accompanied by a progressive decline in physical and cognitive abilities, increasing the risk of falls.
- Conditions
- Aging, Sarcopenia, Nutrition, Healthy
- Trial name
- CRESHARE (NCT05951439)
- Testing
- CRE + HMB
- Where
- Spain
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universidad de Burgos
Lung Inflammation, Sarcoidosis
Validation of the Analysis Methodology Behind the Use of Quantitative 18F-FDG PET/CT to Assess Lung Inflammation
The purpose of this study is to validate the method of analysing Positron Emission Tomography (PET) images to assess lung inflammation.
- Trial name
- VERIFY (NCT03312712)
- Testing
- PET/CT scan, LPS Challenge, Saline Challenge
- Where
- 2 sites in United Kingdom
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Healthy, Type 2 Diabetes
Study of Renal Blood Flow During Human Endotoxemia
The purpose of the present protocol is to study whether endotoxemia will affect the renal blood flow in type 2 diabetics and healthy volunteers.
- Conditions
- Healthy, Type 2 Diabetes, Endotoxemia
- Trial name
- NCT00413465
- Testing
- Escherichia Coli Endotoxin
- Where
- Denmark
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Treatment of Leg Ulcer, Sharp Debridement
Treatment of Chronic Leg Ulcer in Outpatient's Department and i Primary Care - Wound Size and Inflammation
The purpose of this study is to investigate the rate of wound healing using sharp debridement using curette and to compare between such intensive treatment at hospital and treatment in primary care.
- Conditions
- Treatment of Leg Ulcer, Sharp Debridement, Proinflammatory Cytokines
- Trial name
- NCT01249495
- Testing
- Sharp debridement
- Where
- Norway
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Pulpitis, Pulp Disease, Dental
Bioactive Materials in Pulp Therapy of Primary Teeth
The purpose of this study is to compare the clinical and radiographic success of a new injectable, fast setting bioceramic root repair material (BC RRM) putty with mineral trioxide aggregate (MTA) in pulpotomy procedures of…
- Trial name
- NCT04795830
- Testing
- Bioceramic root repair material as pulp dressing in pulpotomy in primary molars, Mineral Trioxide Aggregate as pulp dressing in primary molars (MTA)
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Schizophrenia
Inflammatory Response In Schizophrenia
Schizophrenia affects a significant proportion of the population and current levels of understanding of the illness is inadequate to treat it effectively.
- Trial name
- IRIS (NCT03093064)
- Testing
- Natalizumab
- Where
- United Kingdom
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- King's College London
Exercise-induced Inflammation
Effect of Combined Fatty Acid Supplementation and Eccentric Exercise Training on Exercise Performance
The aim of the study is to determine whether fish oil (specifically omega-3 long chain polyunsaturated fatty acids [EPA-DHA]) supplementation can enhance eccentric resistance exercise performance when combined with a resistance…
- Trial name
- FAT (NCT03259412)
- Testing
- Fish Oil
- Where
- United Kingdom
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Loughborough University
Metabolic Syndrome
Olive Oil and Nampt on Postprandial Inflammation and Atherosclerosis in the Setting of Metabolic Syndrome
The metabolic syndrome may be defined as the constellation of cardiovascular disease (CVD) risk factors that comprises obesity, type 2 diabetes, dyslipidemia, and hypertension.
- Trial name
- OLNAMS (NCT02061267)
- Testing
- Niacin, Saturated meal, Monounsaturated meal
- Where
- Spain
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- National Research Council, Spain
Multiple Sclerosis
Brain Peripheral Benzodiazepine Receptors in Patients With Multiple Sclerosis
This study will use positron emission tomography (PET) to measure a brain protein called peripheral benzodiazepine receptor (PBR) in patients with multiple sclerosis.
- Trial name
- NCT00432900
- Testing
- [(11)C]PBR28
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Cardiovascular Diseases, Mood Disorders
Evaluating the Effects of Omega-3 Fatty Acids on Heart Disease and Behavior
Omega-3 fatty acids are a certain kind of fish fat that has recently been shown to have health benefits. This study will examine the effectiveness of fish oil supplementation for reducing the early signs of heart disease risk and…
- Conditions
- Cardiovascular Diseases, Mood Disorders, Inflammation
- Trial name
- NCT00663871
- Testing
- Fish Oil
- Where
- United States
- Volunteers
- 272 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Diabetes, Gestational, Insulin Resistance
Metformin in Gestational Diabetes Mellitus
Gestational diabetes (GDM) is a condition that manifests as high blood sugar levels (hyperglycemia) during pregnancy in previously healthy women.
- Trial name
- MetGDM (NCT00681460)
- Testing
- human recombined insulin, metformin
- Where
- Poland
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- K. Marcinkowski University of Medical Sciences
Rheumatoid Arthritis
Inflammation and the Heart
Studies have shown that people with rheumatoid arthritis (RA) have a higher rate of heart disease than people that do not have RA. we believe this is caused by the inflammation produced by RA.
- Trial name
- NCT01589770
- Testing
- cardiac Magnetic Resonance imaging
- Where
- United States
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Cardiovascular Risk Factor, Metabolic Complication
Cold Water Immersion and Atherosclerosis, Inflammation, Fat Accumulation and Lipid Profile Parameters
The impact of the environment on human health is considerable. An important factor is the effect of temperature on the human body, where either the effects of short-term exposure to extreme temperatures (cryotherapy, sauna, etc.)…
- Conditions
- Cardiovascular Risk Factor, Metabolic Complication, Endocrine; Complications, Immune System Diseases
- Trial name
- NCT04642066
- Testing
- Cold water immersion, No cold water immersion
- Where
- Slovakia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Pavol Jozef Safarik University
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