Clinical trials: Inflammation Chronic
Chronic Inflammation, Inflammaging
2021 PMT iAge® Intervention Trial by Edifice Health
This is a decentralized, double-blind, randomized, placebo-controlled study to assess the effectiveness of different dietary supplements in decreasing systemic chronic inflammation (SCI) and lowering inflammatory age (iAge®).
- Trial name
- NCT04983017
- Testing
- Dietary supplement
- Where
- 2 sites in United States
- Volunteers
- 781 people, healthy volunteers welcome
- Sponsor
- Edifice Health
Post-Acute COVID-19 Vaccination Syndrome, Postviral Fatigue
Clinical Laboratory Evaluation, Assessment of Symptoms and Recovery in Patients With Post-COVID-19-Vaccination Syndrome
Some people report persistent health problems after receiving the COVID-19 vaccine. These symptoms persist well beyond typical short-term vaccine side effects and are not attributable to any other known medical conditions.
- Trial name
- CLEAR (NCT07400848)
- Testing
- Blood sampling and analysis, The continuous Reactive Hyperemia Index (InRHI) measured by EndoPAT
- Where
- Switzerland
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Bern
Amyotrophic Lateral Sclerosis, Multiple Sclerosis
Human Amniotic Mesenchymal Cell Secretome for Neurodegeneration and Neuroinflammation
Neurodegenerative diseases are debilitating conditions characterized by chronic inflammation, leading to dysfunction of both the non-neuronal cellular components of the central nervous system and peripheral blood immune cells.
- Trial name
- CONTRASTOME (NCT06551649)
- Testing
- Venous blood draw and skin biopsy
- Where
- 2 sites in Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Preeclampsia
Angiotensin II and Chronic Inflammation in Persistent Microvascular Dysfunction Following Preeclampsia
Women who develop preeclampsia during pregnancy are more likely to develop cardiovascular disease later in life, even if they are otherwise healthy.
- Trial name
- NCT03482440
- Testing
- Salsalate Oral Tablet
- Where
- 2 sites in United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Chronic Disease
The Vegetable Dose Response Study: Effects of Consumption on Inflammation and Oxidative Stress
The investigators have designed a three dose level, cross-over vegetable feeding study using expertise from nutritional sciences and plant sciences to: 1.
- Trial name
- NCT01454674
- Testing
- 2, 5 & 10 Vegetable doses
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Myalgic Encephalomyelitis, Chronic Fatigue Syndrome
Cardiopulmonary Testing in ME/CFS to Improve Diagnostic Accuracy
Circumstantial evidence suggests that patients diagnosed with myalgic encephalopathy/chronic fatigue syndrome (ME/CFS) perform worse on day 2 in a 2-day consecutive cardiopulmonary exercise test (CPET).
- Trial name
- NCT02970240
- Testing
- Cardiopulmonary testing
- Where
- Norway
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University of Oslo
Chronic Obstructive Pulmonary Disease, Exacerbations
Micro-environment Involvement in Muscle Alteration Induced
Chronic Obstructive Pulmonary Disease (COPD) is characterized by persistent airway obstruction and inflammatory response of the lungs and bronchi.
- Conditions
- Chronic Obstructive Pulmonary Disease, Exacerbations, Skeletal Muscle Atrophy
- Trial name
- MicAMI-BPCO (NCT04448626)
- Where
- France
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Heart Diseases, Type2 Diabetes
Psychosocial, Environmental, and Chronic Disease Trends in Puerto Rico
The overall goal is to identify trends and longitudinal associations in psychosocial, food-related, and cardiometabolic risk factors that can guide public health priorities and future research needs aimed at reducing…
- Conditions
- Heart Diseases, Type2 Diabetes, Hypertension, Obesity
- Trial name
- PROSPECT (NCT03794531)
- Where
- Puerto Rico
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- Harvard School of Public Health (HSPH)
Asthma, COPD
Anti-viral Effects of Azithromycin in Patients With Asthma and COPD
The purpose of this study is to investigate the anti-viral effects of low-dose AZM treatment in patients with asthma and COPD with an exacerbation history.
- Conditions
- Asthma, COPD, Exacerbation Copd, Asthma; Eosinophilic
- Trial name
- AZIMUNE (NCT04319705)
- Testing
- Azithromycin
- Where
- Denmark
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Bispebjerg Hospital
Asthma, Chronic Obstructive Pulmonary Disease
Towards Restoring the Physiological Inhibition of Airway Narrowing in Asthma
Asthma and COPD are characterized by airway narrowing. The most potent, physiological mechanism leading to bronchodilation is taking a deep inspiration.
- Trial name
- NCT00279136
- Where
- Netherlands
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Pulmonary Disease, Chronic Obstructive
Evaluate the Effects of the Drug (SB-656933-AAA) on the Body After a Single Dose in Subjects Who Have Inhaled Ozone
A study to evaluate the effect of SB-656933-AAA on the body after a single dose in subjects who have been challenged with ozone.
- Trial name
- NCT00551811
- Testing
- SB-656933-AAA
- Where
- Germany
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Lung Cancer (Diagnosis), Sarcoidosis
Immune Cells Role in Lung Cancer and Their Use in Anticancer Immunotherapies and Inflammatory Lung Disease
This study aims to better understand the role of immune system cells in lung diseases such as lung cancer, sarcoidosis, and chronic obstructive pulmonary disease (COPD).
- Conditions
- Lung Cancer (Diagnosis), Sarcoidosis, Chronic Obstructive Pulmonary Disease, Immunotherapy Resistance
- Trial name
- IMMUNOPUMON2 (NCT07384897)
- Testing
- Peripheral Blood Collection for Immune Profiling
- Where
- Belgium
- Volunteers
- 425 people, healthy volunteers welcome
- Sponsor
- Université Catholique de Louvain
Coronary Artery Disease, Arterial Stiffness, Blood Pressure
Expanded Studies on the SCAPIS Stockholm Reexamination Cohort
The Swedish CArdioPulmonary bioImage Study (SCAPIS) is a unique, large-scale national research initiative involving 30,000 randomly selected individuals aged 50-64, recruited between 2014 and 2018.
- Conditions
- Coronary Artery Disease, Arterial Stiffness, Blood Pressure, AORTIC VALVE DISEASES, Mitral Valve Stenosis and/or Insufficiency
- Trial name
- SCAPIS-ReEx (NCT07476703)
- Testing
- Coronary computer tomography (CCTA), Echocardiograhy and aortic ultrasound, Liver elastography
- Where
- Sweden
- Volunteers
- 1,400 people, healthy volunteers welcome
- Sponsor
- Danderyd Hospital
Post Acute COVID-19 Syndrome
Effects of Immulina TM Supplements With PASC Patients
This is a multi-site study that will try to determine the effects of Immulina ™, a natural dietary supplement, on blood chemicals associated with inflammation that are often increased in patients with long COVID (also called…
- Trial name
- NCT05524532
- Testing
- Immulina TM
- Where
- 9 sites in United States, Puerto Rico
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- University of Mississippi Medical Center
Rheumatoid Arthritis, Ankylosing Spondylitis
PatientSpot Formerly Known as ArthritisPower
Patient Power is a patient research network and database (registry) to collect prospective information about demographics, self-reported diagnoses and medications, and willingness to participate in research from participants with…
- Conditions
- Rheumatoid Arthritis, Ankylosing Spondylitis, Fibromyalgia, Gout
- Trial name
- NCT03840928
- Where
- United States
- Volunteers
- 40,000 people, healthy volunteers welcome
- Sponsor
- Global Healthy Living Foundation
Apical Periodontitis, Healhty
Inflammation-Related Endothelial Barrier Dysfunction in Patients With Apical Periodontitis
Inflammation is a common factor in chronic periodontitis and systemic diseases. However, to date, there is no scientific evidence supporting a causal effect of inflammation caused by apical periodontitis on endothelial barrier…
- Trial name
- NCT07292363
- Testing
- Apical lesions cure
- Where
- 2 sites in Italy
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Turin, Italy
Chronic Kidney Disease
Immunologic Abnormalities, Chronic Inflammation and Oxidative Stress in Chronic Kidney Disease
The common causes of mortality are late stages of chronic kidney disease, cardiovascular disease and infections, are associated with abnormalities of the immune system, an underlying state of chronic inflammation and oxidative…
- Trial name
- NCT00793806
- Testing
- Diffuse Optical Spectroscopy
- Where
- 3 sites in United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of California, Irvine
Multimorbidity, Healthy
Pilot Trial of Fisetin in Healthy Volunteers and Older Patients With Multimorbidity
The accumulation of senescent cells with age is a central mechanism that contributes to the development of chronic diseases, primarily by driving systemic chronic inflammation.
- Trial name
- Fisetin HIGH (NCT06431932)
- Testing
- Fisetin
- Where
- Denmark
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ove Andersen
Cholestasis of Pregnancy
Association of Intrahepatic Cholestasis of Pregnancy and Chronic Placental Inflammation
This observational prospective study will help to determine if an immune process similar to allograft rejection is responsible for the occurrence of an intrahepatic cholestasis of pregnancy (ICP).
- Trial name
- INTREPIDE (NCT05197387)
- Where
- 11 sites in France
- Volunteers
- 322 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest
Polycystic Ovary Syndrome
Effects of Metformin vs Oral Contraceptives on CV Risk Markers in PCOS
Cardiovascular risk factors cluster in hyperandrogenic women - including those presenting with the polycystic ovary syndrome - in association with insulin resistance, obesity, and other metabolic disorders.
- Trial name
- NCT00428311
- Testing
- Metformin, Ethynyl-estradiol plus cyproterone acetate
- Where
- Spain
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Hospital Universitario Ramon y Cajal