Clinical trials: Inflammation Function
Cystic Fibrosis
Remotely Supervised Exercise for Adults With Cystic Fibrosis
Cystic fibrosis (CF) is a genetic disease characterized by abnormal chloride transport in epithelial tissues. Inflammation is a key component contributing to the main alterations induced by the disease.
- Trial name
- NCT05173194
- Testing
- Exercise
- Where
- Spain
- Volunteers
- 32 people
- Sponsor
- Universidad Europea de Madrid
Healthy
Trial to Assess the Effects of Different Trans-fatty Acids on Endothelial Function in Humans
The aim of the study is to compare a diet rich in trans fatty acids (TFA) from ruminant sources with a diet rich in TFA from hydrogenated vegetable oils (PHVO) in regard to their effects on cardiovascular risk markers…
- Trial name
- NCT00933322
- Testing
- diet enriched with industrial trans fatty acids, diet enriched with ruminant trans fatty acids, diet without any trans fatty acids
- Where
- Switzerland
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
COVID-19
Impact of Lp299v on Vascular Function in Patients With PASC
Emerging data show that SARS-CoV-2 infection causes gut microbiome changes strongly associated with Post-Acute Sequelae of SARS-CoV-2 (PASC).
- Trial name
- NCT05227170
- Testing
- Lactobacillus Plantarum 299v Freeze Dried Capsule, Freeze Dried Potato Starch Capsule
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Medical College of Wisconsin
Breast Cancer Female, Gynecologic Cancer
Cachexia in Gynecological Cancer and the Preventive Role of Weight Training
The study aim was to compare the effectiveness of combined training (CT; aerobic + resistance exercises) and high-intensity interval body weight training (HIITBW) on body composition, metabolic and inflammatory profile, physical…
- Conditions
- Breast Cancer Female, Gynecologic Cancer, Menopause, Physical Activity
- Trial name
- NCT03200639
- Testing
- Combined training, High intensity interval training with body weight
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Universidade Federal do Triangulo Mineiro
Smoking
Effect of Electronic Cigarettes on Platelets, Endothelium and Inflammation
The primary purpose of this study is to evaluate the acute effects of electronic cigarette (e-cigarette) smoking on measurable biomarkers of platelet function, vascular endothelial function and inflammation in healthy active…
- Trial name
- NCT02662075
- Testing
- E-cigarette/tobacco Smoking Exposure
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- NYU Langone Health
Chronic Migraine
Suppressive Functions of Regulatory T Cells in Migraine
Migraine is a frequent, disabling condition, of great social and economical impact worldwide. This condition is more frequent in women and subjects with autoimmune and/or inflammatory diseases.
- Trial name
- SIIM-reg (NCT07067112)
- Testing
- Blood sampling, questionnaire and phone call
- Where
- France
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Triple Negative Breast Cancer (TNBC)
Evaluating Ovarian Toxicity Outcomes Following Immunotherapy in Patients With Triple-Negative Breast Cancer (TNBC)
This study aims to collect information about the effects of chemotherapy combined with immunotherapy (immune checkpoint inhibitors) for early-stage triple-negative breast cancer (TNBC) on ovarian function and fertility.
- Trial name
- FERTILE (NCT07527819)
- Where
- 9 sites in Australia
- Volunteers
- 75 people
- Sponsor
- Peter MacCallum Cancer Centre, Australia
Athletic Performance, Soccer
The Effect of a Training Programme in the Variation of Fitness Parameters, Physiological, Hematological and Biochemical Indicators of Soccer Players During the Preseason Period
The goal of this study is to investigate the effects of varying friendly match-play exposure during the late pre-season on physiological, biochemical, and performance adaptations in soccer players.
- Conditions
- Athletic Performance, Soccer, Muscle Damage, Inflammation
- Trial name
- NCT07170930
- Testing
- Friendly Match-Play Exposure: extended vs. limited
- Where
- Greece
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Emmanouil D. Zacharakis
Aortic Dissection, Systemic Inflammatory Response Syndrome
Protective Effect of Sivelestat Against Negative Pulmonary Function and Organ Dysfunction After Cardiovascular Surgery (PANDA VI)
Systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction syndrome (MODS) are the major causes of death in patients with cardiovascular diseases.
- Conditions
- Aortic Dissection, Systemic Inflammatory Response Syndrome, Cardiovascular Diseases (CVD)
- Trial name
- PANDA (NCT06195267)
- Testing
- Sivelestat, Blank control
- Where
- 2 sites in China
- Volunteers
- 500 people
- Sponsor
- Nanjing Medical University
Neoplasms, Heart; Disease, Functional
Exercise to Prevent AnthrCycline-based Cardio-Toxicity Study
As the numbers of cancer survivors grow, the long-term adverse effects of cancer therapy are becoming increasingly apparent. Most prominent are the toxic effects on the heart (cardiotoxicity) which may lead to cardiac dysfunction…
- Conditions
- Neoplasms, Heart; Disease, Functional, Inflammation
- Trial name
- EXACT (NCT02471053)
- Testing
- Moderate Intensity Exercise
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- Nova Scotia Health Authority
Long Covid19, Dietary Supplements
IMMUNERECOV CONTRIBUTES TO IMPROVEMENT OF RESPIRATORY AND IMMUNOLOGICAL RESPONSE IN POST-COVID-19 PATIENTS.
Background: COVID-19 left consequences in different organs from months to years requiring different types of rehabilitation. In fact, a severe loss in the lung function, and in the respiratory and peripheral muscle strength is…
- Conditions
- Long Covid19, Dietary Supplements, Respiratory Tract Infections, Inflammation
- Trial name
- IRPC (NCT06166030)
- Testing
- Nutritional blend (ImmuneRecov).
- Where
- 2 sites in Brazil
- Volunteers
- 58 people
- Sponsor
- Federal University of São Paulo
Coronary Heart Disease
Niacin/Laropiprant and Endothelial Function
Primary objective: To evaluate the impact of 12 weeks' administration of extended release niacin/laropiprant (ERN/LRPT) compared to placebo added to statin therapy on endothelial dependant dilatation of the arterial wall assessed…
- Trial name
- NCT01126073
- Testing
- Niacin/laropiprant
- Where
- Slovenia
- Volunteers
- 60 people
- Sponsor
- University Medical Centre Ljubljana
Peripheral Arterial Disease
OMEGA-3-Polyunsaturated Fatty-Acids (N3-Pufa) In Patients With Peripheral Arterial Disease
The principal aim of the study is to determine the effects n3-PUFA on top of standard therapy on surrogate markers of disease severity and/or prognosis in patients with PAD.
- Trial name
- NCT01367145
- Testing
- OMACOR
- Where
- Austria
- Volunteers
- 71 people
- Sponsor
- Medical University of Vienna
Infection, Heart; Surgery, Heart, Functional Disturbance as Result
Device for Bacteremia Prevention in Post Cardiac Surgical Intensive Care Unit Patients
Intravenous catheters are often placed in large (central) veins in critically ill patients to provide special medications or frequent blood sampling.
- Conditions
- Infection, Heart; Surgery, Heart, Functional Disturbance as Result, Bacteremia
- Trial name
- CHG-Lock™ (NCT03309137)
- Testing
- Chlorhexidine flush
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Alison Fox-Robichaud
Asthma
Measuring Small-Airways Disease Improvement After Step-up to Extrafine TRIple or High-dose ICS/LABA in Patients Uncontrolled on Medium Dose ICS/LABA eXploring T2 Inflammation
The goal of this observational study is to investigate the change in small airway function through the R5-R19 index in oscillometry at 12 weeks in adults with asthma.
- Trial name
- MATRIX (NCT07372521)
- Volunteers
- 130 people
- Sponsor
- University Hospital, Ioannina
Inflammation, Mental Health Wellness 1
Adolescent Acts of Kindness Intervention
Adolescents will complete a 4-week intervention, during which they will either complete a kind act for others, complete a kind act for themselves, or report their daily activities three days per week.
- Trial name
- NCT03322397
- Testing
- Self-Focused Acts of Kindness Intervention, Other-Focused Acts of Kindness Intervention, Daily Reports
- Where
- United States
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Anemia Acute, Fatigue
ABC - A Post Intensive Care Anaemia Management Trial
On discharge from intensive care (ICU) patients are often severely anaemic (have a low level of haemoglobin (Hb) in their red blood cells (RBC)). Anaemia can persist for many months making patients feel tired and fatigued.
- Conditions
- Anemia Acute, Fatigue, Physical Disability, Quality of Life
- Trial name
- NCT04591574
- Testing
- Red Blood Cells (Transfusion)
- Where
- United Kingdom
- Volunteers
- 346 people
- Sponsor
- University of Edinburgh
HIV Infections
2000 HIV Human Functional Genomics Partnership Program
Background Chronic HIV infection leads to a dysregulated immune system, even when full viral suppression is achieved. HIV causes persistent immune activation, relating to an array of common non-AIDS-related diseases such as…
- Trial name
- 2000HIV (NCT03994835)
- Where
- 4 sites in Netherlands
- Volunteers
- 1,910 people
- Sponsor
- Radboud University Medical Center
Cardiovascular Prevention, Diabetes Prevention
Randomized, Double-blind Crossover Trial Comparing Low-GI Functional vs. Standard Wholegrain Carbohydrates on Glycolipid Metabolism and Vascular Stress Markers in Adults With Suboptimal Triglyceridemia
Low-glycemic index (GI) carbohydrates help prevent type 2 diabetes and cardiovascular disease by reducing postprandial glucose, insulin spikes, inflammation, and triglyceride synthesis.
- Conditions
- Cardiovascular Prevention, Diabetes Prevention, Inflammation, Nutrition
- Trial name
- GLOW (NCT07198789)
- Testing
- Altograno® Bakery Foods, Standard Whole-Grain Bakery Foods
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Bologna
Bronchiolitis Obliterans
Bronchial Inflammation in Patients With Bronchiolithis Obliterans
The investigators plan to study the variability of lung function parameters and bronchial inflammatory markers in 20 patients with bronchiolitis obliterans at the age of 6 to 25 years compared with an age- and sex-matched control…
- Trial name
- FRABO-02 (NCT01633385)
- Where
- Germany
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Johann Wolfgang Goethe University Hospital