Clinical trials: Inflammation Knees
Osteoarthritis of the Knee, Insomnia
Sleep, Pain and Inflammatory Processes in Older Adults With Osteoarthritis
The purpose if the study is to determine whether improving sleep, especially slow wave or "deep" sleep, in older adults with osteoarthritis (OA) and insomnia reduces pain sensitivity and inflammatory responses to pain, and…
- Conditions
- Osteoarthritis of the Knee, Insomnia, Knee Pain
- Trial name
- NCT01683799
- Testing
- Cognitive Behavioral Therapy for Insomnia
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- University of Rochester
Osteo Arthritis Knee, Pain
Exercise-related Irisin on Inflammation and Pain
Osteoarthritis (OA) is a chronic disease that usually starts with cartilage damage in weight-bearing joints and then causes pain and loss of function secondary to damage in surrounding tissues.
- Conditions
- Osteo Arthritis Knee, Pain, Inflammation
- Trial name
- NCT05388994
- Testing
- Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Firat University
Osteoarthritis, Knee
Follow on Extension of XT-150-1-0201
XT-150 safety and efficacy in severe osteoarthritic pain.
- Trial name
- NCT03769662
- Testing
- XT-150
- Where
- Australia
- Volunteers
- 16 people
- Sponsor
- Xalud Therapeutics, Inc.
Activity-Related Knee Discomfort, Joint Discomfort
NT-II™ Collagen for Joint Discomfort and Function
The goal of this clinical trial is to learn whether a natural marine supplement called NT-II™ (Salmon Undenatured Type II Collagen) can help lower knee discomfort caused by physical activity in otherwise healthy adults.
- Conditions
- Activity-Related Knee Discomfort, Joint Discomfort, Functional Joint Pain, Functional Knee Pain
- Trial name
- NTII-JOINT (NCT07119645)
- Testing
- NT-II™ (240 mg), NT-II™ 480 mg, Glucosamine/Chondroitin
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Hofseth Biocare ASA
Knee Injuries, Inflammation Knees
Accute Effect of B-Turmactive Both on Mild and Moderate Knee Pain on Healthy Volunteers
The goal of this study is to assess the short (acutte) effect of B-Turmactive (one week treatment) both on mild/moderate knee pain
- Trial name
- TURMACTIVE (NCT03202901)
- Testing
- B-turmactive
- Where
- Spain
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Technological Centre of Nutrition and Health, Spain
Osteoarthritis, Knee
Combination of Curcuminoid With Acupressure for Inflammation and Pain in the Elderly With Osteoarthritis Genu
The goal of this clinical trial is to to investigate the efficacy of acupressure and standardized curcuminoids from turmeric extract to inflammatory markers, endorphin hormones in the blood and quality of life in elderly patient…
- Trial name
- NCT06105840
- Testing
- Acupressure and Standardized Curcuminoid from Turmeric Extract
- Where
- Indonesia
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Gadjah Mada University
Abnormality in Synovial Tissue
Examination of Biopsies From Healthy Knee Joints
The purpose of the project is to examine what kind of molecular mechanism which causes inflammatory joint diseases. This examination is carried out by a collection and analysis of synovial tissues for patients without…
- Trial name
- NCT02458170
- Where
- Denmark
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Northern Orthopaedic Division, Denmark
Osteoarthritis of the Knee
Apitox, Honeybee Venom Treatment for Osteoarthritis Pain and Inflammation
The study will evaluate Apitox, pure honeybee venom as a treatment for pain and inflammation of osteoarthritis of the knee.
- Trial name
- HBV (NCT00949754)
- Testing
- honeybee venom (Apitoxin (Korea) Apitox (USA))
- Where
- 4 sites in United States
- Volunteers
- 40 people
- Sponsor
- Apimeds, Inc.
Osteoarthritis, Gonarthrosis
Photobiomodulation Therapy to Reduce Pain and Inflammation in Patients With Gonarthrosis
Osteoarthritis (OA) is one of the main causes of chronic pain and physical disability, which directly impacts the quality of life of patients.
- Trial name
- NCT05975957
- Testing
- Photomodulation Therapy with the Light-Aid system, Control
- Where
- Brazil
- Volunteers
- 238 people
- Sponsor
- D'Or Institute for Research and Education
Anesthesia, Knee Osteoarthritis
The Assessment of Postoperative Recovery in Elder Diabetic Patients
Total Knee Replacement (TKR) performed under general anesthesia is a common successful orthopedic procedure. Nonetheless, in elder patients with diabetes mellitus (DM) this procedure can present unique challenges to orthopedic…
- Trial name
- TKRDM2013 (NCT01871012)
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Chinese PLA General Hospital
Osteoarthritis, Knee
Effects of Multicomponent Exercise on Subchondral Bone and Cartilage in Postmenopausal Women With Knee Osteoarthritis
Today, osteoarthritis (OA) is considered a whole-organ disease that is amenable to prevention and treatment in the early stages.
- Trial name
- LuRu2 (NCT06173193)
- Testing
- Multicomponent exercise regimen, Standard rehabilitative management
- Where
- Finland
- Volunteers
- 103 people
- Sponsor
- University of Jyvaskyla
Revision Total Knee Arthroplasty, Osteoarthritis, Knee
Gut Microbiome in Orthopaedics: Revision Total Knee Arthroplasty
Many patients who receive knee replacement surgery must return for a revision (or repeat) surgery due to ongoing pain, stiffness, infection, or implant loosening.
- Trial name
- GUMBO (NCT06951477)
- Testing
- Revision Total Knee Arthroplasty
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Spinal Aneshtesia, General Anesthetic
Effects of Anesthesia Type on Inflammatory Response
In total knee arthroplasty, surgical and anesthetic procedures can lead to a significant increase in systemic inflammation. This procedure is frequently performed under either general or spinal anesthesia.
- Conditions
- Spinal Aneshtesia, General Anesthetic, Inflammation, Neutrophils
- Trial name
- NCT06984315
- Testing
- The effects of the groups on perioperative inflammation changes were compared.
- Where
- Turkey (Türkiye)
- Volunteers
- 849 people
- Sponsor
- Tokat Gaziosmanpasa University
Knee Osteoarthritis
Effect of Probiotic Supplements on Osteoarthritis Outcomes
Dysbiosis of the gut microbiota is believed to contribute to the development and progression of osteoarthritis (OA), suggesting a role for probiotics in the treatment of OA.
- Trial name
- ProOA23 (NCT06459700)
- Testing
- Probiotic supplements
- Where
- Sweden
- Volunteers
- 86 people
- Sponsor
- Lund University
Total Knee Replacement
Influence of Closed Suction Drainage After Total Knee Replacement.
The aim of the study will be to compare functional outcomes, basic morphology results, number of blood transfusions, costs of hospitalization, and inflammation factors, following total knee replacement (with use of one type of…
- Trial name
- TKR (NCT03995160)
- Testing
- Use of closed suction drainage following total knee arthroplasty, Abstain of using a closed suction drainage
- Volunteers
- 100 people
- Sponsor
- Medical University of Warsaw
Osteoarthritis, Knee
Targeting Senescence to Reduce Osteoarthritis Pain and cartilagE Breakdown (ROPE)
Symptomatic knee osteoarthritis (OA) is the most common joint disorder in the U.S. and a leading cause of disability. Increasing age, obesity, and previous injury increase the lifetime risk of knee OA, but these factors are also…
- Trial name
- ROPE (NCT04770064)
- Testing
- High-dose/short-duration Fisetin, Low-dose/sustained-duration Fisetin
- Where
- 2 sites in United States
- Sponsor
- Austin V Stone
Degenerative Joint Disease of Knee, Rheumatoid Arthritis
Intra-Articular Adelmidrol 2%/Hyaluronic Acid 1% With or Without m/umPEA, in Knee Pain Due to Joint Degeneration.
Degenerative knee joint diseases are characterized by chronic pain, inflammation, and functional impairment. In these conditions, mast cell density in the synovial membrane is increased, resulting in an excessive release of…
- Trial name
- NCT07680101
- Testing
- Adelmidrol 2% / Hyaluronic Acid 1%, micronized Palmitoylethanolamide (mPEA) 300mg + ultramicronized Palmitoylethanolamide (umPEA) 600mg
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Universita di Verona
Knee Osteoarthritis
To Evaluate the Performance and Safety of the Medical Device IRADYN in Subjects With Osteoarthritis of the Knee
The benefits of single or repetitive administration (1 to 6) can have similar result in terms of muscular strength and patients' quality of life improvement, benefiting of the advantages of polymerized polynucleotides (IRADYN)…
- Trial name
- IRADYN (NCT05206474)
- Testing
- IRADYN
- Where
- 2 sites in Romania
- Volunteers
- 50 people
- Sponsor
- I.R.A. Istituto Ricerche Applicate S.p.A.
Arthroplasty Complications, Inflammatory Response
Effects of Navigation Versus Conventional Total Knee Arthroplasty on the Levels of Inflammation Markers
Total knee arthroplasty (TKA) is a well-established modality for the treatment of advanced knee osteoarthritis with high satisfaction rate.
- Trial name
- NCT03163888
- Testing
- Navigation TKR
- Volunteers
- 200 people
- Sponsor
- Chang Gung Memorial Hospital
Patellofemoral Osteoarthritis, Knee Osteoarthritis
FDG PET/MRI Imaging of Patellofemoral Joint Osteoarthritis
This project aims to develop an [18F] fluorodeoxyglucose (FDG) positron emission tomography (PET) / magnetic resonance imaging (MRI) method to locate the painful inflammation in PFJ OA associated with joint loading.
- Conditions
- Patellofemoral Osteoarthritis, Knee Osteoarthritis, Knee Pain, Inflamation
- Trial name
- FDG-PFJOA (NCT07625150)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of California, San Francisco